Affinage

CIRBP

Cold-inducible RNA-binding protein · UniProt Q14011

Length
172 aa
Mass
18.6 kDa
Annotated
2026-04-28
100 papers in source corpus 48 papers cited in narrative 48 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CIRBP is a stress-responsive RNA-binding protein that functions both intracellularly as a post-transcriptional regulator of mRNA stability and translation, and extracellularly as a damage-associated molecular pattern (DAMP) that amplifies inflammation through innate immune receptors. In the nucleus, CIRBP binds UTRs of target mRNAs—including those encoding p27Kip1, HIF-1α, CTNNB1, PSD95, GluR1, OGFR, TERC, and Atp5g3—to stabilize transcripts or stimulate their translation, thereby influencing cell-cycle progression, telomerase activity, Wnt signaling, synaptic function, and mitochondrial bioenergetics (PMID:29361038, PMID:34465343, PMID:26673712, PMID:34419133, PMID:34715218). Its expression is induced by cold, hypoxia, and DNA damage through Sp1-dependent transcription at a mild-cold responsive element and regulated primarily by temperature-dependent splicing efficiency, while nuclear import is mediated by TNPO1 (via RG/RGG NLS) and TNPO3 (via RSY NLS), with SRPK1 phosphorylation of the RGG domain impairing import and promoting stress granule partitioning (PMID:23046908, PMID:27633015, PMID:32234784, PMID:34738012). Upon inflammatory injury, CIRBP is released extracellularly—partly through lactylation-triggered secretion—and signals as a DAMP by engaging TLR4–MD2, TREM-1, and IL-6Rα on macrophages, neutrophils, and endothelial cells, activating NF-κB, STAT3, and STING/TBK1-IRF3 pathways to drive cytokine production, NETosis, METosis, ferroptosis, and PANoptosis in models of sepsis, hemorrhagic shock, and ischemia–reperfusion injury (PMID:24097189, PMID:32027618, PMID:32027619, PMID:34291735, PMID:39465383).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 1997 High

    Identification of CIRBP as a cold-shock protein established that mammalian cells possess a dedicated RNA-binding protein whose expression is rapidly induced by mild hypothermia.

    Evidence cDNA cloning, Northern/Western blot after temperature downshift in multiple human cell lines

    PMID:9434172

    Open questions at the time
    • RNA targets and functional consequences of cold induction unknown
    • mechanism of temperature sensing unresolved
  2. 1998 Medium

    Nuclear localization in neurons and constitutive expression in spermatocytes demonstrated that CIRBP operates in specific physiological contexts—circadian rhythm regulation and spermatogenesis—beyond generic cold stress.

    Evidence Immunohistochemistry in brain (SCN, cortex) and testis, light/dark cycle and cryptorchidism models in rodents

    PMID:9422546 PMID:9571190

    Open questions at the time
    • Direct mRNA targets in these tissues unidentified
    • mechanism linking CIRBP to circadian clock genes unclear
  3. 2004 High

    Demonstration that hypoxia induces CIRBP transcription independently of HIF-1 revealed a second major stress-induction axis distinct from canonical oxygen-sensing pathways.

    Evidence Nuclear run-on assays and actinomycin-D chase in HIF-1α/β-deficient cell lines

    PMID:15075239

    Open questions at the time
    • Identity of the hypoxia-responsive transcription factor driving CIRBP induction unknown
    • relationship to cold-induction pathway unclear
  4. 2006 High

    Reconstitution of Cirp in knockout fibroblasts showed it protects cells from TNF-α-induced apoptosis by activating ERK, establishing CIRBP as a cytoprotective factor rather than merely a stress marker.

    Evidence Cirp transduction into KO fibroblasts, p-ERK Western blot, caspase-8 assay, ERK inhibitor PD98059 rescue

    PMID:16569452

    Open questions at the time
    • Whether ERK activation is direct or via an intermediary unknown
    • intracellular vs. extracellular action not distinguished
  5. 2009 High

    Identification of the Sp1-binding MCRE element and cold-specific alternative 5′-UTR transcripts with IRES activity resolved how CIRBP transcription and translation are selectively upregulated at low temperature.

    Evidence ChIP, EMSA, reporter mutagenesis for MCRE; 5′-RACE and IRES reporter assays in NIH-3T3 cells

    PMID:19398494 PMID:23046908

    Open questions at the time
    • Post-transcriptional layer (splicing efficiency) not yet appreciated
    • IRES trans-acting factors unidentified
  6. 2012 High

    Discovery that Cirp directly binds and inhibits Dyrk1b to stabilize cyclin D1 and destabilize p27, driving spermatogonial cell-cycle progression, provided the first defined intracellular protein–protein mechanism with physiological consequence in KO mice.

    Evidence Cirp-KO mice, co-IP, GST pulldown, flow cytometry for cell cycle in spermatogonia

    PMID:22711815

    Open questions at the time
    • Whether this protein-level interaction operates in somatic cells unknown
    • structural basis of Cirp–Dyrk1b binding unresolved
  7. 2012 Medium

    RIP-Chip in testis identified a broad mRNA target repertoire bound through (Un)n≥2 motifs, establishing CIRBP as a general mRNA stabilizer rather than a single-target regulator.

    Evidence RIP-Chip (RNA immunoprecipitation-microarray) and biotin pull-down in mouse testis

    PMID:22819822

    Open questions at the time
    • Motif specificity not validated by mutagenesis of endogenous targets
    • target overlap with RBM3 unclear
  8. 2013 High

    The landmark discovery that extracellular CIRP acts as a DAMP by binding TLR4–MD2 transformed the field by revealing a second, inflammation-driving function entirely distinct from its intracellular RNA-binding role.

    Evidence SPR for eCIRP–TLR4/MD2 binding, peptide mapping (residues 106–125), CIRP-KO mice in hemorrhage/sepsis, recombinant CIRP injection

    PMID:24097189

    Open questions at the time
    • Mechanism of CIRP secretion not defined
    • whether RNA-binding and DAMP functions are mutually exclusive unclear
  9. 2015 High

    CIRBP's association with the telomerase complex via direct TERC binding and regulation of TERT mRNA levels extended its intracellular role to telomere maintenance and Cajal body biology.

    Evidence IP-MS, co-IP, CRISPR-Cas9 KO, telomerase activity assay, telomere length measurement

    PMID:26673712

    Open questions at the time
    • Whether CIRBP is a stable telomerase subunit or transient accessory factor unknown
    • structural basis of CIRBP–TERC interaction unresolved
  10. 2016 High

    Genome-wide kinetic analysis revealed that temperature-dependent CIRBP accumulation is primarily controlled by splicing efficiency rather than transcription rate, revising the earlier promoter-centric model.

    Evidence Approach-to-steady-state mRNA kinetics with mathematical modeling in NIH3T3 cells under temperature oscillation

    PMID:27633015

    Open questions at the time
    • Identity of the temperature-sensitive splicing factor(s) unknown
    • integration with Sp1/MCRE transcriptional control not quantified
  11. 2018 High

    Direct binding of CIRBP to the 5′-UTR of p27Kip1 mRNA to stimulate its translation during hypothermia established a defined UTR-specific translational activation mechanism with cell-cycle consequence.

    Evidence RIP, luciferase 5′-UTR reporter, CIRP shRNA, p27-KO MEFs, cold-shift epistasis

    PMID:29361038

    Open questions at the time
    • Whether IRES or cap-independent mechanism is involved not determined
    • generalizability beyond hypothermia context unknown
  12. 2020 High

    Structural and biophysical characterization of two nonclassical NLSs recognized by TNPO1 and TNPO3, and the finding that SRPK1 phosphorylation impairs nuclear import and phase separation, defined the molecular logic of CIRBP's stress-regulated nucleo-cytoplasmic partitioning.

    Evidence NMR, ITC for NLS–transportin binding; SRPK1 in vitro kinase assay; LLPS reconstitution; SG recruitment in cells

    PMID:32234784 PMID:34738012

    Open questions at the time
    • In vivo phosphorylation stoichiometry under physiological stress not measured
    • whether phosphorylation triggers extracellular release unknown
  13. 2020 High

    Identification of TREM-1 and IL-6Rα as additional eCIRP receptors—beyond TLR4—expanded the extracellular signaling repertoire and explained how eCIRP drives STAT3-dependent immunosuppression and NETosis.

    Evidence SPR and FRET for eCIRP–TREM-1 and eCIRP–IL-6Rα binding; TREM-1-/- mice; IL-6R neutralization; ICAM-1-/- neutrophils

    PMID:32027618 PMID:32027619 PMID:32506691

    Open questions at the time
    • Relative contribution of each receptor in vivo not dissected
    • whether eCIRP signals as monomer or oligomer unknown
  14. 2021 High

    Mapping eCIRP's downstream effector cascades—STING/TBK1-IRF3 for type I IFN, caspase-1/GSDMD for METs, GPX4 suppression for ferroptosis, and STAT3–βPIX for phagocytic impairment—defined the molecular basis of eCIRP-driven organ injury in sepsis and hemorrhage.

    Evidence Genetic epistasis in STING-/-, TLR4-/-, MyD88-/-, TRIF-/- macrophages/mice; GSDMD/caspase-1 inhibitors; ferrostatin-1 rescue; STAT3–βPIX co-IP

    PMID:34291735 PMID:35003095 PMID:35844517 PMID:36471113

    Open questions at the time
    • Temporal hierarchy among parallel downstream pathways not established
    • whether these pathways operate in non-immune cell types in vivo not fully tested
  15. 2021 High

    Expansion of the intracellular target mRNA catalog—CTNNB1, PSD95, GluR1, OGFR, Atp5g3—via direct UTR binding demonstrated CIRBP's broad post-transcriptional influence on Wnt signaling, synaptic function, cardioprotection, and mitochondrial bioenergetics.

    Evidence RIP and UTR reporter assays for each target; CIRBP-KO mice; in vivo overexpression rescue for PSD95 and OGFR; mRNA stability assays

    PMID:34419133 PMID:34465343 PMID:34715218 PMID:35541895

    Open questions at the time
    • Global target landscape in non-testis/non-brain tissues not mapped by CLIP
    • selectivity determinants for stabilization vs. destabilization unresolved
  16. 2023 High

    Discovery that the eCIRP RRM binds poly(A) RNA tails and that a synthetic poly(A) mimic (A12) competitively blocks eCIRP–TLR4 interaction revealed that the RNA-binding surface itself mediates receptor engagement, mechanistically linking intracellular and extracellular functions.

    Evidence In vitro binding competition assay (A12 vs. eCIRP RRM), macrophage NF-κB/MAPK assays, CLP model

    PMID:37585248

    Open questions at the time
    • Whether endogenous RNA competes with TLR4 binding in vivo unknown
    • structural model of RRM–TLR4 interface lacking
  17. 2024 High

    Demonstration that lactylation triggers CIRP release, and that internalized eCIRP stabilizes ZBP1 by outcompeting TRIM32 to drive RIPK3-dependent PANoptosis, connected metabolic reprogramming to CIRBP secretion and defined a novel cell-death pathway downstream of eCIRP.

    Evidence Four-genotype mouse epistasis (Casp8-/-, Ripk3-/-, Zbp1-/-), co-IP of eCIRP–ZBP1 and ZBP1–TRIM32 competition, lactylation assay, TLR4 endocytosis tracking

    PMID:39465383

    Open questions at the time
    • Lactylation site(s) on CIRBP not mapped
    • whether lactylation-driven release is a general DAMP secretion mechanism unknown
  18. 2024 High

    CIRBP deficiency in aged hearts abrogates hypothermic cardioprotection by reducing DHODH expression and ubiquinone biosynthesis, triggering ferroptosis—linking age-dependent CIRBP loss to organ vulnerability during transplantation.

    Evidence Cirbp-KO and aged rat heart transplantation, RNA-Seq, DHODH activity/ubiquinone measurement, ferroptosis markers, Cirbp overexpression rescue

    PMID:38690728

    Open questions at the time
    • Whether CIRBP binds DHODH mRNA directly not demonstrated
    • translational relevance to human cardiac transplant outcomes not confirmed

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: the structural basis of eCIRP–receptor interfaces, the selectivity rules determining which mRNAs CIRBP stabilizes versus destabilizes, the identity of the temperature-sensitive splicing factor(s) upstream of CIRBP, and the in vivo stoichiometry and post-translational regulation (phosphorylation, lactylation, methylation) controlling nucleo-cytoplasmic partitioning and extracellular release.
  • No high-resolution structure of eCIRP bound to TLR4, TREM-1, or IL-6Rα
  • genome-wide CLIP-seq in primary immune cells not performed
  • in vivo measurement of CIRBP phosphorylation/lactylation dynamics under sepsis lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 13 GO:0048018 receptor ligand activity 3 GO:0098772 molecular function regulator activity 2
Localization
GO:0005576 extracellular region 5 GO:0005634 nucleus 4 GO:0005829 cytosol 2
Pathway
R-HSA-168256 Immune System 13 R-HSA-8953854 Metabolism of RNA 9 R-HSA-162582 Signal Transduction 5 R-HSA-5357801 Programmed Cell Death 5 R-HSA-1640170 Cell Cycle 2
Partners
DYRK1BELAVL1IL6RSRPK1TLR4TNPO1TNPO3TREM1
Complex memberships
telomerase complex

Evidence

Reading pass · 48 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 Human CIRP (CIRBP) encodes an 18-kDa protein with an N-terminal RNA-binding domain and a C-terminal Gly-rich domain; its mRNA and protein are upregulated within 12 h of temperature downshift from 37°C to 32°C in multiple human cell lines, establishing it as a cold-shock protein. cDNA cloning, Northern blot, Western blot, temperature-shift experiments in multiple cell lines Gene High 9434172
1998 Cirp protein is localized to the nucleus of neurons and is diurnally regulated in the suprachiasmatic nucleus and cerebral cortex in a light-dependent manner, implicating it in biological rhythm regulation. Northern blot, immunohistochemistry, constant-darkness controls Biochemical and biophysical research communications Medium 9571190
1998 CIRP expression is constitutively high in male germ cells (primarily in nuclei of primary spermatocytes) and is downregulated within 6 hours by elevated temperature (experimental cryptorchidism or scrotal heating), linking CIRP to temperature-dependent regulation during spermatogenesis. Northern blot, immunohistochemistry, experimental cryptorchidism mouse model The American journal of pathology High 9422546
1999 H2O2 dose-dependently inhibits cold-induced CIRP mRNA expression in PC12 cells, indicating that reactive oxygen species suppress CIRP induction; ischemia decreases CIRP mRNA specifically in hippocampus but not cortex. In situ hybridization, Northern blot, PC12 cell culture with H2O2, rat forebrain ischemia model Free radical biology & medicine Medium 10641716
2004 CIRP (and RBM3) are transcriptionally upregulated by hypoxia via a HIF-1-independent, mitochondria-independent mechanism, as demonstrated in HIF-1α-deficient and HIF-1β-deficient cell lines; regulation occurs at the level of gene transcription (confirmed by actinomycin-D block and nuclear run-on assays). HIF-1-deficient cell lines (Z-33, Hepa-1 c4), actinomycin-D chase, in vitro nuclear run-on assay, Northern blot Journal of cell science High 15075239
2006 Cirp protects cells from TNF-α–induced apoptosis by activating the ERK signaling pathway: Cirp transduction into Cirp-deficient fibroblasts increased phospho-ERK and suppressed caspase-8 activation; ERK inhibitor PD98059 reversed Cirp's cytoprotective effect. Cirp transduction into knockout fibroblasts, Western blot for p-ERK, caspase-8 assay, ERK inhibitor (PD98059) Biochimica et biophysica acta High 16569452
2009 Cold-induced CIRP expression is controlled by an octanucleotide mild-cold responsive element (MCRE, 5'-TCCCCGCC-3') in the cirp promoter that is bound by the transcription factor Sp1; nuclear Sp1 enrichment at the CIRP regulatory region increases at 32°C, and Sp1 overexpression or knockdown bidirectionally regulates CIRP expression. Reporter gene assay, EMSA, chromatin immunoprecipitation, Sp1 overexpression/knockdown in multiple cell lines BMC biotechnology High 23046908
2009 CIRP expression is controlled by alternative 5'-UTR transcripts with different transcription start sites; the major 37°C transcript does not encode full-length CIRP ORF, whereas two major 32°C transcripts do; the longest 32°C transcript exhibits IRES-like activity. 5'-RACE, reporter gene (IRES activity), Northern blot, transcript stability assays in NIH-3T3 cells RNA (New York, N.Y.) High 19398494
2012 Cirp directly binds to Dyrk1b/Mirk, inhibiting Dyrk1b's binding to p27 (resulting in decreased p27 phosphorylation and destabilization of p27) and inhibiting Dyrk1b-mediated phosphorylation of cyclin D1 (resulting in cyclin D1 stabilization), thereby promoting cell-cycle progression from G0/G1 to S phase in undifferentiated spermatogonia. Cirp-KO mice, co-immunoprecipitation, GST pulldown, immunolocalization, spermatogonial cell line knockdown, flow cytometry (cell cycle), busulfan recovery assay Proceedings of the National Academy of Sciences of the United States of America High 22711815
2012 CIRP binds to mRNAs in the mouse testis through a (Un)n≥2 recognition sequence and increases the stability of bound mRNAs; target mRNAs are enriched for translation regulation, antioxidant activity, and reproduction functions. RIP-Chip (RNA-binding protein immunoprecipitation-microarray), biotin pull-down assay FEBS letters Medium 22819822
2013 CIRP is released from macrophages into the extracellular space under hypoxic stress (translocating from nucleus to cytosol first), and extracellular CIRP acts as a DAMP that stimulates TNF-α and HMGB1 release from macrophages via the TLR4-MD2 complex; surface plasmon resonance confirmed CIRP binding to TLR4-MD2, TLR4, and MD2 individually, with residues 106-125 binding MD2 with high affinity. Surface plasmon resonance, macrophage stimulation assay, CIRP-KO mice (hemorrhage/sepsis model), antisera blockade, recombinant CIRP injection in vivo Nature medicine High 24097189
2013 Cirp deficiency in mice reduces susceptibility to dextran sodium sulfate-induced intestinal inflammation and tumorigenesis, with decreased TNF-α, IL-23, Bcl-2, Bcl-xL, and Sox2 in colonic lamina propria cells; bone marrow transplant experiments show Cirp in hematopoietic cells drives this effect. Cirp-KO mice, DSS/AOM-DSS colitis-associated cancer model, bone marrow transplantation, qPCR/Western blot Cancer research High 25187386
2013 TNF and TGF-β, but not IL-1β, IL-6, IFNα or IFNγ, impair Cirbp expression in fibroblasts and neuronal cells; Cirbp depletion increases susceptibility to TNF-mediated inhibition of high-amplitude clock gene expression, placing CIRBP downstream of cytokine signaling in circadian rhythm regulation. Cirbp knockdown in fibroblasts/neuronal cells, cytokine treatment, circadian reporter assays The Journal of biological chemistry Medium 24337574
2015 CIRP/hnRNP A18 associates with the active telomerase complex by directly binding the RNA subunit TERC, regulates Cajal body localization of telomerase, and controls TERT mRNA levels; CIRP inhibition via CRISPR-Cas9 or siRNA reduces telomerase activity and shortens telomeres. IP-MS, co-immunoprecipitation, CRISPR-Cas9 KO, siRNA knockdown, telomerase activity assay, telomere length measurement, Cajal body localization by fluorescence microscopy Nucleic acids research High 26673712
2015 CIRP inhibits DNA damage-induced apoptosis by reducing p53 protein levels: CIRP knockdown increases p53, upregulating pro-apoptotic and downregulating anti-apoptotic genes; CIRP overexpression has the opposite effect. CIRP overexpression and knockdown, etoposide-induced DNA damage, Western blot for p53, qPCR for apoptosis genes Biochemical and biophysical research communications Medium 26188505
2016 Temperature-dependent accumulation of Cirbp mRNA is controlled primarily by regulation of splicing efficiency (fraction of pre-mRNA processed into mature mRNA), not transcription rate, as shown by genome-wide 'approach to steady-state' kinetics in NIH3T3 cells exposed to simulated body temperature cycles. Genome-wide approach-to-steady-state mRNA kinetics, temperature oscillation experiments in NIH3T3 cells, mathematical modeling Genes & development High 27633015
2017 CIRP induction requires the ion channel TRPV4: cold, DNA damage, hypoxia, cycloheximide, and hypotonicity all induce CIRP (and RBM3 and SRSF5) expression in a TRPV4-dependent but ion-channel-activity-independent manner. TRPV4 knockdown/inhibition experiments, multiple stress stimuli, Western blot and qPCR Scientific reports Medium 28536481
2017 CIRP induces lung ER stress markers (BiP, pIRE1α, sXBP1, CHOP, cleaved caspase-12) through TLR4 activation, causing sepsis-associated acute lung injury; this is absent in TLR4-KO mice injected with recombinant CIRP. CIRP-KO and TLR4-KO mice, CLP sepsis model, recombinant CIRP injection, Western blot for ER stress markers Scientific reports High 28128330
2018 CIRP selectively binds the 5' UTR of p27Kip1 mRNA and stimulates its translation; during mild hypothermia, CIRP induction correlates with increased p27Kip1 protein accumulation and reduced proliferation; CIRP knockdown prevents cold-induced p27Kip1 translation, and p27Kip1-KO MEFs fail to reduce proliferation in response to cold. RNA binding assay (RIP), luciferase reporter for 5'UTR, shRNA CIRP knockdown, p27-KO MEFs, cold-shift experiments, Western blot Nucleic acids research High 29361038
2018 CIRBP binds the 3'-UTR of HIF-1α mRNA in bladder cancer cells, increasing HIF-1α mRNA stability and thereby inducing HIF-1α protein expression to promote cancer progression. RNA immunoprecipitation, 3'-UTR reporter assay, CIRBP knockdown/overexpression, mRNA stability assay Cell death & disease Medium 30315244
2018 eCIRP-derived peptide C23 competitively inhibits CIRP's binding to TLR4 and blocks NF-κB nuclear translocation and IκBα degradation in macrophages, reducing sepsis-induced organ injury and improving survival in CLP mice. Macrophage TNF-α assay, NF-κB nuclear translocation assay, IκBα Western blot, CLP mouse model, dose-response Scientific reports High 29434211
2018 CIRBP directly binds to pre-miR-329 (but not pri-miR-329) in ischemic muscle tissue, playing a role in posttranscriptional regulation of 14q32 microRNAs after hindlimb ischemia. RNA pull-down SILAC mass spectrometry, RBP immunoprecipitation, CRISPR/Cas9 HADHB-/- cells Molecular therapy. Nucleic acids Medium 30665182
2019 Chronic hypoxia causes hypermethylation of the Cirbp promoter region in cardiomyocytes, suppressing CIRBP expression and its response to cold stress; CIRBP is required for hypothermic cardioprotection by maintaining ubiquinone (CoQ10) biosynthesis. Cirp-KO and transgenic rats, CPB model, methylation analysis, cardiac proteomics, CoQ10 measurement, neonatal rat cardiomyocytes, patient specimens Science translational medicine High 31019028
2020 Both Transportin-1 (TNPO1) and Transportin-3 (TNPO3) mediate nuclear import of CIRBP via two nonclassical NLSs: TNPO1 recognizes an RG/RGG-rich region, and TNPO3 recognizes an RSY-rich region; these interactions regulate CIRBP nuclear localization, phase separation, and stress granule recruitment. Biophysical binding assays (NMR, ITC), mutagenesis of NLS regions, cell imaging for nuclear localization and stress granule recruitment Proceedings of the National Academy of Sciences of the United States of America High 32234784
2020 eCIRP is a novel endogenous ligand of TREM-1; surface plasmon resonance showed strong binding affinity, and FRET confirmed interaction in macrophages; TREM-1 siRNA, decoy peptide LP17, or TREM-1-/- mice dramatically reduced eCIRP-induced inflammation. Surface plasmon resonance, FRET, TREM-1-/- mice, siRNA knockdown, decoy peptide LP17, macrophage stimulation JCI insight High 32027618
2020 eCIRP induces macrophage endotoxin tolerance via IL-6R-mediated STAT3 activation: Biacore, FRET, and co-localization assays confirmed strong eCIRP-IL-6R binding; IL-6R blockade reversed eCIRP-induced STAT3 phosphorylation and M2 polarization. Biacore (SPR), FRET, immunostaining co-localization, STAT3 inhibitor (Stattic), IL-6R neutralizing antibody, macrophage polarization assay JCI insight High 32027619
2020 eCIRP generates ICAM-1+ neutrophils via TREM-1 signaling; these ICAM-1+ neutrophils use Rho GTPase to promote NETosis; ICAM-1 blockade reduces Rho activation and NET formation. TREM-1-/- mice and BMDN, rmCIRP treatment, ICAM-1-/- neutrophils, Rho activation assay, PAD4 inhibitor, flow cytometry FASEB journal High 32506691
2021 CIRBP interacts with ELAVL1 (verified by co-immunoprecipitation and fluorescence colocalization) and promotes ELAVL1-dependent ferritinophagy activation, leading to ferroptosis in renal tubular epithelial cells during ischemia-reperfusion injury. Co-immunoprecipitation, fluorescence colocalization, siRNA knockdown (CIRBP, ELAVL1), autophagy inhibitor, in vivo anti-CIRBP antibody treatment Journal of cellular and molecular medicine Medium 34114349
2021 CIRBP directly binds the 3'- and 5'-UTRs of CTNNB1 mRNA (β-catenin), enhancing mRNA stability, translation, and IRES-mediated protein synthesis, thereby activating Wnt/β-catenin signaling and downstream oncogenes in non-small cell lung cancer cells. RNA immunoprecipitation, biotin pull-down, mRNA decay analysis, luciferase reporter (3'UTR and IRES), CIRP overexpression/knockdown Journal of experimental & clinical cancer research : CR High 34465343
2021 SRPK1 phosphorylates the RG/RGG region of CIRBP in vitro at two novel sites; phosphorylation impairs CIRBP's liquid-liquid phase separation and TNPO1 binding in vitro, and interferes with stress granule association in cells; arginine methylation of the RG/RGG region regulates SRPK1-mediated phosphorylation. In vitro kinase assay (SRPK1), biophysical LLPS assay, TNPO1 binding assay, SG recruitment in cells, methylation-phosphorylation interplay Frontiers in molecular biosciences High 34738012
2021 eCIRP induces macrophage extracellular trap (MET) formation through caspase-1-dependent activation of gasdermin D (GSDMD); caspase-1 and GSDMD inhibitors block rmCIRP-induced MET formation. Time-lapse fluorescence microscopy, colorimetry, ELISA for extracellular DNA/citrullinated histone/MPO, Western blot for cleaved GSDMD and caspase-1, pharmacological inhibitors Frontiers in immunology High 35003095
2021 eCIRP decreases GPX4 expression and increases lipid ROS in macrophages via TLR4, inducing ferroptosis; GPX4 suppression and lipid peroxidation are attenuated in TLR4-/- macrophages and in CIRP-/- septic mice; ferroptosis inhibitor ferrostatin-1 rescues eCIRP-induced cell death. TLR4-/- macrophages, CIRP-/- mice (CLP model), rmCIRP stimulation, lipid ROS assay, ferrostatin-1 rescue, Western blot for GPX4 Frontiers in immunology High 35844517
2021 eCIRP activates STING through TLR4/MyD88/TRIF pathways, driving TBK1-IRF3 phosphorylation and type I IFN production, exacerbating inflammation after hemorrhagic shock; STING-/- mice are protected from eCIRP-induced type I IFN responses. STING-/-, TLR4-/-, MyD88-/-, TRIF-/- macrophages and mice, rmCIRP injection, hemorrhagic shock model, Western blot for pTBK1/pIRF3 JCI insight High 34291735
2021 Cirbp directly binds the 3'UTR of Atp5g3 mRNA and sustains protein levels of mitochondrial respiratory chain complexes II (SDHB) and IV (MT-CO1), maintaining ATP biogenesis under hypoxia; Cirbp knockdown impairs mitochondrial homeostasis and energy production. RNA binding assay (3'UTR), Western blot for respiratory chain complexes, ATP measurement, Cirbp knockdown The Science of the total environment Medium 34715218
2021 Cirbp post-transcriptionally regulates PSD95 by binding to the PSD95 mRNA 3'-UTR region; Cirbp overexpression in mouse hippocampus rescues hypobaric hypoxia-induced PSD95 downregulation, dendritic spine morphology changes, and cognitive deficits. 3'UTR binding assay, Cirbp hippocampal overexpression (viral), behavioral testing, dendritic spine morphology Molecular brain Medium 34419133
2021 eCIRP impairs macrophage bacterial phagocytosis by inducing STAT3 phosphorylation, which promotes STAT3-βPIX complex formation; this prevents βPIX from activating Rac1, thereby reducing ARP2 and p-cofilin expression and impairing actin remodeling-dependent phagocytosis. STAT3 inhibition with stattic restores phagocytosis. Co-immunoprecipitation (STAT3-βPIX complex), Rac1 activation assay, STAT3 inhibitor (stattic), Western blot for ARP2/p-cofilin, CIRP-/- mice, in vivo bacterial load measurement Cellular & molecular immunology High 36471113
2021 eCIRP induces inflammation in alveolar type II (ATII) cells via TREM-1: rmCIRP increases TREM-1 expression in ATII cells; TREM-1-/- ATII cells produce less IL-6 and CXCL2 after rmCIRP stimulation; TREM-1 antagonist peptides M3 and LP17 attenuate the response. Primary ATII cell isolation, TREM-1-/- mice, flow cytometry, ELISA, TREM-1 antagonist peptides Frontiers in cell and developmental biology Medium 32984356
2021 CIRBP directly binds OGFR mRNA and represses OGFR expression by reducing mRNA stability; CIRBP-mediated suppression of the OGF/OGFR axis protects cardiomyocytes against doxorubicin-induced apoptosis and cardiac dysfunction. RIP for CIRBP-OGFR mRNA interaction, mRNA stability assay, CIRBP-KO/OE in vivo (mouse myocardium delivery), OGFR-specific antagonist NTX rescue International journal of biological sciences High 35541895
2021 eCIRP activates Cdk5 via the IL-6Rα/STAT3/p25 pathway in neurons; surface plasmon resonance showed eCIRP-derived peptide C23 blocks eCIRP binding to IL-6Rα, and C23 reverses eCIRP-induced STAT3 phosphorylation and p25 levels. Surface plasmon resonance, N2a cell stimulation, STAT3 phosphorylation assay, p25 Western blot, dose-response Molecular neurobiology Medium 33783711
2022 CIRBP directly binds p53 RNA (RIP), and cold induction of CIRBP modulates p53 and GPX4 expression to promote ferroptosis in pancreatic cancer cells; cold treatment increases Fe2+ accumulation and ROS while inhibiting GPX4. RIP (CIRBP antibody enriches p53 RNA), Western blot for p53/GPX4/DPP4/NOX1, Fe2+ and ROS assays, ferroptosis inhibitor rescue Journal of immunology research Medium 36061308
2023 Extracellular CIRP binds poly(A) RNA tails through its RNA-recognition motif; a synthetic stabilized poly(A) mimic (A12) selectively competes with this interaction and prevents eCIRP's binding to TLR4, reducing NF-κB and MAPK activation in macrophages. In vitro binding assay (A12 vs. eCIRP RRM), macrophage NF-κB/MAPK activation, in vivo CLP model, cytokine ELISA Journal of immunology (Baltimore, Md. : 1950) High 37585248
2023 eCIRP triggers Ca2+ release from ER stores via IL-6Rα/PLC/IP3 pathway in neurons, activating cytosolic calpain 1, which cleaves p35 to p25 and thereby hyperactivates Cdk5; IP3R inhibitors, PLC inhibitor, and IL-6Rα neutralization each block this cascade. Cytosolic Ca2+ imaging (HT22 cells), calpain activity assay, IP3R inhibitors (2-APB, X-C), PLC inhibitor (U73122), IL-6Rα antibody, calpain 1 siRNA, p25 Western blot Molecular neurobiology High 36853429
2024 Lactate-induced lactylation of CIRP in macrophages promotes its release; internalized eCIRP in pulmonary vascular endothelial cells (via TLR4-mediated endocytosis) competes with TRIM32 for ZBP1 binding, blocking TRIM32-mediated proteasomal degradation of ZBP1 and thereby stabilizing ZBP1 to drive RIPK3-dependent PANoptosis. CLP sepsis model in WT, Casp8-/-, Ripk3-/-, Zbp1-/- mice; CIRP lactylation assay; co-immunoprecipitation (eCIRP-ZBP1, ZBP1-TRIM32); TLR4 endocytosis tracking; Western blot for ZBP1/RIPK3 Military Medical Research High 39465383
2024 CIRBP deficiency in aged donor hearts attenuates hypothermic cardioprotection during transplantation by reducing DHODH expression, compromising DHODH-mediated ubiquinone reduction, and thereby triggering ferroptosis (lipid peroxidation) in cardiomyocytes. Cirbp-KO and aged rat heart transplantation model, RNA-Seq, cardiac proteomics, DHODH activity/ubiquinone measurement, ferroptosis markers, Cirbp overexpression rescue The Journal of clinical investigation High 38690728
2024 Decreased CIRP binding to GluR1 (AMPA receptor subunit) mRNA under hypobaric hypoxia reduces GluR1 protein stability on the neuronal membrane, leading to decreased synaptic density, dendritic spine loss, and memory impairment; Tat-C16 peptide (CIRP residues 110-125) rescues GluR1 surface expression and cognitive function. CIRP-KO mice, hypobaric hypoxia model, RIP/binding assay (CIRP-GluR1 mRNA), membrane fractionation, behavioral testing, Tat-C16 peptide rescue CNS neuroscience & therapeutics Medium 39315498
2021 eCIRP induces inflammation in pulmonary fibroblasts via TLR4 and accessory proteins MD2 and MyD88 (TLR4-dependent manner), contributing to the inflammatory-to-fibrotic transition in bleomycin-induced pulmonary fibrosis. TLR4 knockdown in fibroblasts, transcriptome analysis, bleomycin lung fibrosis model, gene expression profiling at multiple time points Frontiers in immunology Medium 34367191
2021 CIRBP knockdown in pancreatic cancer cells promotes tumour malignancy and gemcitabine resistance by upregulating DYRK1B expression; CIRBP-mediated suppression of DYRK1B increases ERK/p38 activity ratio. CIRBP siRNA knockdown in PANC-1/SW1990 cells, DYRK1B Western blot, ERK/p38 activity assay, gemcitabine sensitivity, in vivo tumor growth Frontiers in cell and developmental biology Medium 34490236
2018 TGF-β2 and TGF-β3 (but not TGF-β1) downregulate CIRBP mRNA and protein expression in germ cells both in vivo and in vitro; TGF-β antagonist administration in heat-stressed mouse testis attenuates CIRBP downregulation and histological damage. Testicular hyperthermia mouse model, TGF-β antagonist injection, GC2-spd cell TGF-β treatment, qPCR and Western blot Andrology Medium 30461215

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis. Nature medicine 372 24097189
2004 Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism. Journal of cell science 216 15075239
2019 Extracellular CIRP (eCIRP) and inflammation. Journal of leukocyte biology 180 30645013
2016 Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold. Cellular and molecular life sciences : CMLS 171 27147467
1997 Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene. Gene 139 9434172
2020 Extracellular CIRP as an endogenous TREM-1 ligand to fuel inflammation in sepsis. JCI insight 121 32027618
2006 Cirp protects against tumor necrosis factor-alpha-induced apoptosis via activation of extracellular signal-regulated kinase. Biochimica et biophysica acta 103 16569452
1998 Decreased expression of cold-inducible RNA-binding protein (CIRP) in male germ cells at elevated temperature. The American journal of pathology 99 9422546
2018 CIRP increases ICAM-1+ phenotype of neutrophils exhibiting elevated iNOS and NETs in sepsis. Journal of leukocyte biology 98 29345380
2017 Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress. Scientific reports 82 28128330
2015 The Cold-Inducible RNA-Binding Protein (CIRP) Level in Peripheral Blood Predicts Sepsis Outcome. PloS one 76 26361390
2012 Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice. Proceedings of the National Academy of Sciences of the United States of America 72 22711815
1999 Effects of ischemia and H2O2 on the cold stress protein CIRP expression in rat neuronal cells. Free radical biology & medicine 71 10641716
2013 Effects of moderate and deep hypothermia on RNA-binding proteins RBM3 and CIRP expressions in murine hippocampal brain slices. Brain research 70 23415676
2021 CIRBP promotes ferroptosis by interacting with ELAVL1 and activating ferritinophagy during renal ischaemia-reperfusion injury. Journal of cellular and molecular medicine 64 34114349
2009 Cold-inducible RNA binding protein (CIRP) expression is modulated by alternative mRNAs. RNA (New York, N.Y.) 64 19398494
2014 Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer. Cancer research 63 25187386
2021 Emodin Alleviates Severe Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting the Cold-Inducible RNA-Binding Protein (CIRP)-Mediated Activation of the NLRP3/IL-1β/CXCL1 Signaling. Frontiers in pharmacology 62 33967799
2012 Cold-inducible RNA-binding protein (CIRP) regulates target mRNA stabilization in the mouse testis. FEBS letters 62 22819822
2016 Temperature regulates splicing efficiency of the cold-inducible RNA-binding protein gene Cirbp. Genes & development 58 27633015
2022 Extracellular CIRP Promotes GPX4-Mediated Ferroptosis in Sepsis. Frontiers in immunology 57 35844517
2020 Extracellular CIRP and TREM-1 axis promotes ICAM-1-Rho-mediated NETosis in sepsis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 57 32506691
2020 Nonclassical nuclear localization signals mediate nuclear import of CIRBP. Proceedings of the National Academy of Sciences of the United States of America 55 32234784
2024 Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway. Military Medical Research 54 39465383
2018 A cold-inducible RNA-binding protein (CIRP)-derived peptide attenuates inflammation and organ injury in septic mice. Scientific reports 54 29434211
1998 Diurnal change of the cold-inducible RNA-binding protein (Cirp) expression in mouse brain. Biochemical and biophysical research communications 54 9571190
2020 Extracellular CIRP induces macrophage endotoxin tolerance through IL-6R-mediated STAT3 activation. JCI insight 51 32027619
2018 CIRBP is a novel oncogene in human bladder cancer inducing expression of HIF-1α. Cell death & disease 51 30315244
2015 Cold-inducible RNA-binding protein CIRP/hnRNP A18 regulates telomerase activity in a temperature-dependent manner. Nucleic acids research 46 26673712
2022 Extracellular CIRP dysregulates macrophage bacterial phagocytosis in sepsis. Cellular & molecular immunology 39 36471113
2019 CIRP Induces Neutrophil Reverse Transendothelial Migration in Sepsis. Shock (Augusta, Ga.) 37 30148763
2019 Chronic hypoxia-induced Cirbp hypermethylation attenuates hypothermic cardioprotection via down-regulation of ubiquinone biosynthesis. Science translational medicine 37 31019028
2015 Cold-inducible RNA-binding protein, CIRP, inhibits DNA damage-induced apoptosis by regulating p53. Biochemical and biophysical research communications 37 26188505
2020 Cold-inducible RNA-binding protein (CIRP) in inflammatory diseases: Molecular insights of its associated signalling pathways. Scandinavian journal of immunology 36 32738154
2020 Inhibition of Efferocytosis by Extracellular CIRP-Induced Neutrophil Extracellular Traps. Journal of immunology (Baltimore, Md. : 1950) 36 33380498
2012 Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells. BMC biotechnology 34 23046908
2021 CIRP promotes the progression of non-small cell lung cancer through activation of Wnt/β-catenin signaling via CTNNB1. Journal of experimental & clinical cancer research : CR 33 34465343
2021 Extracellular CIRP activates STING to exacerbate hemorrhagic shock. JCI insight 32 34291735
2023 Exosome-derived CIRP: An amplifier of inflammatory diseases. Frontiers in immunology 31 36865547
2018 Cold-inducible RNA-binding protein (CIRP) induces translation of the cell-cycle inhibitor p27Kip1. Nucleic acids research 31 29361038
2004 Osmotic stress of salmon stimulates upregulation of a cold inducible RNA binding protein (CIRP) similar to that of mammals and amphibians. Biochimie 31 15308334
2021 Normothermic machine perfusion attenuates hepatic ischaemia-reperfusion injury by inhibiting CIRP-mediated oxidative stress and mitochondrial fission. Journal of cellular and molecular medicine 29 34786826
2021 Extracellular CIRP Induces Macrophage Extracellular Trap Formation Via Gasdermin D Activation. Frontiers in immunology 29 35003095
2023 Regulation of cold-inducible RNA-binding protein (CIRBP) in response to cellular stresses. Biochimie 28 37037339
2021 Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation. Frontiers in molecular biosciences 28 34738012
2020 Extracellular CIRP Induces Inflammation in Alveolar Type II Cells via TREM-1. Frontiers in cell and developmental biology 28 32984356
2014 Protein overexpression of CIRP and TLR4 in oral squamous cell carcinoma: an immunohistochemical and clinical correlation analysis. Medical oncology (Northwood, London, England) 27 25027624
2013 Tumor necrosis factor and transforming growth factor β regulate clock genes by controlling the expression of the cold inducible RNA-binding protein (CIRBP). The Journal of biological chemistry 27 24337574
2022 ETS-1 facilitates Th1 cell-mediated mucosal inflammation in inflammatory bowel diseases through upregulating CIRBP. Journal of autoimmunity 26 35926374
2018 Exogenous hydrogen sulfide ameliorates high glucose-induced myocardial injury & inflammation via the CIRP-MAPK signaling pathway in H9c2 cardiac cells. Life sciences 25 29857073
2009 Overexpression of CIRP may reduce testicular damage induced by cryptorchidism. Clinical and investigative medicine. Medecine clinique et experimentale 25 19331798
2021 Hypoxia causes mitochondrial dysfunction and brain memory disorder in a manner mediated by the reduction of Cirbp. The Science of the total environment 24 34715218
2018 Posttranscriptional Regulation of 14q32 MicroRNAs by the CIRBP and HADHB during Vascular Regeneration after Ischemia. Molecular therapy. Nucleic acids 24 30665182
2021 Cirbp-PSD95 axis protects against hypobaric hypoxia-induced aberrant morphology of hippocampal dendritic spines and cognitive deficits. Molecular brain 23 34419133
2019 Effects of Cold-inducible RNA-binding Protein (CIRP) on Liver Glycolysis during Acute Cold Exposure in C57BL/6 Mice. International journal of molecular sciences 23 30909542
2017 TRPV4-dependent induction of a novel mammalian cold-inducible protein SRSF5 as well as CIRP and RBM3. Scientific reports 23 28536481
2020 CIRBP Ameliorates Neuronal Amyloid Toxicity via Antioxidative and Antiapoptotic Pathways in Primary Cortical Neurons. Oxidative medicine and cellular longevity 22 32184914
2020 Frontline Science: Extracellular CIRP generates a proinflammatory Ly6G+ CD11bhi subset of low-density neutrophils in sepsis. Journal of leukocyte biology 22 33070370
2024 Blocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells. Cell death discovery 21 38538578
2021 Extracellular CIRP Activates the IL-6Rα/STAT3/Cdk5 Pathway in Neurons. Molecular neurobiology 21 33783711
2021 Extracellular CIRP-Impaired Rab26 Restrains EPOR-Mediated Macrophage Polarization in Acute Lung Injury. Frontiers in immunology 21 34925338
2019 CIRP downregulation renders cardiac cells prone to apoptosis in heart failure. Biochemical and biophysical research communications 21 31405566
2021 Extracellular CIRP Induces an Inflammatory Phenotype in Pulmonary Fibroblasts via TLR4. Frontiers in immunology 20 34367191
2017 Expression of RNA-binding Motif Protein 3 (RBM3) and Cold-inducible RNA-binding protein (CIRP) Is Associated with Improved Clinical Outcome in Patients with Colon Cancer. Anticancer research 20 28373441
2023 CIRP attenuates acute kidney injury after hypothermic cardiovascular surgery by inhibiting PHD3/HIF-1α-mediated ROS-TGF-β1/p38 MAPK activation and mitochondrial apoptotic pathways. Molecular medicine (Cambridge, Mass.) 19 37127576
2022 Extracellular CIRP induces acute kidney injury via endothelial TREM-1. Frontiers in physiology 19 36246143
2020 Potential Role of Extracellular CIRP in Alcohol-Induced Alzheimer's Disease. Molecular neurobiology 19 32827106
2017 The mechanism of CIRP in inhibition of keratinocytes growth arrest and apoptosis following low dose UVB radiation. Molecular carcinogenesis 19 27864909
2015 Expression of cold-inducible RNA-binding protein (CIRP) in pituitary adenoma and its relationships with tumor recurrence. Medical science monitor : international medical journal of experimental and clinical research 19 25934796
2008 Cold stress and light signals induce the expression of cold-inducible RNA binding protein (cirp) in the brain and eye of the Japanese treefrog (Hyla japonica). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 19 18722545
2024 Cirbp suppression compromises DHODH-mediated ferroptosis defense and attenuates hypothermic cardioprotection in an aged donor transplantation model. The Journal of clinical investigation 18 38690728
2022 CIRBP Regulates Pancreatic Cancer Cell Ferroptosis and Growth by Directly Binding to p53. Journal of immunology research 18 36061308
2015 Developmental competence of mature yak vitrified-warmed oocytes is enhanced by IGF-I via modulation of CIRP during in vitro maturation. Cryobiology 18 26519204
2022 Dihydroartemisinin Reduces Irradiation-Induced Mitophagy and Radioresistance in Lung Cancer A549 Cells via CIRBP Inhibition. Life (Basel, Switzerland) 16 36013308
2021 Absence of Cold-Inducible RNA-Binding Protein (CIRP) Promotes Angiogenesis and Regeneration of Ischemic Tissue by Inducing M2-Like Macrophage Polarization. Biomedicines 15 33916904
2019 Therapeutic hypothermia protects photoreceptors through activating Cirbp pathway. Neurochemistry international 14 30878570
2013 The protective effect of Cold-inducible RNA-binding protein (CIRP) on testicular torsion/detorsion: an experimental study in mice. Journal of pediatric surgery 14 24094970
2008 Cold-inducible RNA binding protein (CIRP), a novel XTcf-3 specific target gene regulates neural development in Xenopus. BMC developmental biology 14 18687117
2024 Extracellular CIRP promotes Kupffer cell inflammatory polarization in sepsis. Frontiers in immunology 13 38881891
2021 Human antigen R (HuR) and Cold inducible RNA-binding protein (CIRP) influence intestinal mucosal barrier function in ulcerative colitis by competitive regulation on Claudin1. BioFactors (Oxford, England) 13 33638934
2020 Cold-inducible RNA-binding protein (CIRBP) promotes porcine reproductive and respiratory syndrome virus (PRRSV)-induced inflammatory response. International immunopharmacology 13 32593159
2017 CIRBP protects H9C2 cells against myocardial ischemia through inhibition of NF-κB pathway. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 13 28355355
2024 ThermomiR-377-3p-induced suppression of Cirbp expression is required for effective elimination of cancer cells and cancer stem-like cells by hyperthermia. Journal of experimental & clinical cancer research : CR 12 38419081
2023 A Synthetic Poly(A) Tail Targeting Extracellular CIRP Inhibits Sepsis. Journal of immunology (Baltimore, Md. : 1950) 12 37585248
2022 MiR-383-5p promotes apoptosis of ovarian granulosa cells by targeting CIRP through the PI3K/AKT signaling pathway. Archives of gynecology and obstetrics 12 35226160
2021 CIRBP Knockdown Attenuates Tumourigenesis and Improves the Chemosensitivity of Pancreatic Cancer via the Downregulation of DYRK1B. Frontiers in cell and developmental biology 12 34490236
2021 Identification of CIRBP and TRPV4 as Immune-Related Diagnostic Biomarkers in Osteoarthritis. International journal of general medicine 12 35002293
2024 Extracellular CIRP induces abnormal activation of fibroblast-like synoviocytes from patients with RA via the TLR4-mediated HDAC3 pathways. International immunopharmacology 11 38218010
2023 Targeting extracellular CIRP with an X-aptamer shows therapeutic potential in acute pancreatitis. iScience 11 37360693
2022 CIRBP-OGFR axis safeguards against cardiomyocyte apoptosis and cardiotoxicity induced by chemotherapy. International journal of biological sciences 11 35541895
2021 Extracellular CIRP decreases Siglec-G expression on B-1a cells skewing them towards a pro-inflammatory phenotype in sepsis. Molecular medicine (Cambridge, Mass.) 11 34058975
2019 RBM3 and CIRP expressions in targeted temperature management treated cardiac arrest patients-A prospective single center study. PloS one 11 31821351
2021 Cold-inducible RNA-binding protein (CIRP) potentiates uric acid-induced IL-1β production. Arthritis research & therapy 10 33902703
2020 Co-Clinical Imaging Resource Program (CIRP): Bridging the Translational Divide to Advance Precision Medicine. Tomography (Ann Arbor, Mich.) 10 32879897
2024 A NOVEL OPSONIC EXTRACELLULAR CIRP INHIBITOR MOP3 ALLEVIATES GUT ISCHEMIA/REPERFUSION INJURY. Shock (Augusta, Ga.) 9 39178245
2024 Decreased cold-inducible RNA-binding protein (CIRP) binding to GluRl on neuronal membranes mediates memory impairment resulting from prolonged hypobaric hypoxia exposure. CNS neuroscience & therapeutics 9 39315498
2023 Extracellular CIRP Induces Calpain Activation in Neurons via PLC-IP3-Dependent Calcium Pathway. Molecular neurobiology 9 36853429
2022 Regulation of CIRP by genetic factors of SP1 related to cold sensitivity. Frontiers in immunology 9 36189232
2021 Clinical relevance for circulating cold-inducible RNA-binding protein (CIRP) in patients with adult-onset Still's disease. PloS one 9 34351954
2018 The regulation of CIRBP by transforming growth factor beta during heat shock-induced testicular injury. Andrology 9 30461215