Affinage

CIRBP

Cold-inducible RNA-binding protein · UniProt Q14011

Length
172 aa
Mass
18.6 kDa
Annotated
2026-06-09
100 papers in source corpus 42 papers cited in narrative 42 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CIRBP (CIRP) is a cold- and stress-inducible RNA-binding protein with a dual identity: intracellularly it acts as a post-transcriptional regulator that binds target mRNA UTRs to control their stability and translation, while extracellularly it functions as a damage-associated molecular pattern (DAMP) that drives inflammation (PMID:24097189, PMID:29361038). As an RNA chaperone, CIRP binds defined mRNAs through a (U/A)-rich core motif and tunes the levels of cell-cycle, hypoxia, mitochondrial, neuronal, and oncogenic effectors: it enhances translation of the p27Kip1 5'UTR (PMID:29361038), stabilizes HIF-1α, CTNNB1, Atp5g3, and PSD95/GluR1 mRNAs to support proliferation, mitochondrial respiration, and synaptic integrity (PMID:30315244, PMID:34465343, PMID:34715218, PMID:34419133, PMID:39315498), and represses OGFR and Claudin1, the latter in competition with HuR (PMID:35541895, PMID:33638934). Through direct binding to the telomerase RNA TERC it sustains telomerase activity and Cajal-body localization (PMID:26673712), and through binding Dyrk1b it modulates p27/cyclin D1 to promote G1/S progression (PMID:22711815). CIRP nuclear import is governed by two nonclassical NLS–importin interactions—an RG/RGG region read by TNPO1 and an RSY region read by TNPO3—with SRPK1-mediated phosphorylation and arginine methylation of the RG/RGG region reciprocally gating phase separation, TNPO1 binding, and stress-granule recruitment (PMID:32234784, PMID:34738012). Once released, extracellular CIRP binds the TLR4-MD2 complex, TREM-1, and IL-6R to trigger NF-κB/MAPK/STAT3 inflammatory programs in macrophages, neutrophils, endothelial, and alveolar epithelial cells, driving cytokine release, ER stress, ICAM-1–Rho–dependent NETosis, GSDMD-dependent MET formation, GPX4-suppressing ferroptosis, ZBP1-stabilized PANoptosis, and STING-driven type I interferon production (PMID:24097189, PMID:32027618, PMID:32027619, PMID:28128330, PMID:32506691, PMID:35003095, PMID:35844517, PMID:39465383, PMID:34291735). Its own induction is controlled transcriptionally by Sp1 binding to a mild-cold responsive element and by temperature-dependent splicing efficiency and alternative 5'UTR/IRES usage (PMID:23046908, PMID:27633015, PMID:19398494).

Mechanistic history

Synthesis pass · year-by-year structured walk · 21 steps
  1. 1998 Medium

    Established CIRP as a constitutively expressed brain protein with light-dependent circadian oscillation, framing it as a stress/environment-responsive factor rather than a constitutive housekeeping protein.

    Evidence Northern blot and IHC across brain regions with constant-darkness and developmental controls in mice

    PMID:9571190

    Open questions at the time
    • No molecular mechanism for the oscillation
    • No RNA targets or partners identified at this stage
  2. 2004 Medium

    Resolved how hypoxia induces CIRP, showing transcriptional upregulation independent of HIF-1 and mitochondria and thereby separating CIRP induction from the canonical hypoxia axis.

    Evidence Nuclear run-on, HIF-1α/HIF-1β-deficient cell lines, and mitochondria-depleted cells

    PMID:15075239

    Open questions at the time
    • Transcription factor mediating hypoxic induction not identified
    • Did not address cold induction mechanism
  3. 2006 Medium

    First mechanistic intracellular function: CIRP cytoprotects against TNF-α apoptosis via ERK activation, linking the protein to cell-survival signaling.

    Evidence Cirp transduction into Cirp-deficient fibroblasts with ERK inhibitor and caspase-8 readout

    PMID:16569452

    Open questions at the time
    • Mechanism connecting CIRP to ERK not defined
    • No RNA-binding link established for this effect
  4. 2009 Medium

    Explained cold-induced CIRP protein upregulation through alternative transcription start sites generating an IRES-bearing 5'UTR transcript enriched at 32°C.

    Evidence 5'UTR transcript characterization and IRES reporter/stability assays in NIH-3T3 cells

    PMID:19398494

    Open questions at the time
    • Trans-acting factors controlling start-site choice unknown
    • IRES-mediated translation mechanism not dissected
  5. 2012 High

    Defined two distinct intracellular roles: direct binding to Dyrk1b to control p27/cyclin D1 and cell-cycle progression, and sequence-specific mRNA binding/stabilization via a (U/A)-rich motif.

    Evidence Cirp KO mice with cell-cycle analysis and binding assays; RIP-Chip and biotin pull-down in testis

    PMID:22711815 PMID:22819822

    Open questions at the time
    • Generality of the binding motif beyond testis transcripts not tested
    • How Dyrk1b binding integrates with RNA-binding function unclear
  6. 2012 Medium

    Identified the transcriptional basis of mild-cold induction: Sp1 binding to a defined MCRE element drives CIRP expression at 32°C.

    Evidence CAT reporter, ChIP, MCRE mutagenesis, and Sp1 gain/loss in multiple cell lines

    PMID:23046908

    Open questions at the time
    • How temperature controls Sp1 nuclear translocation not mechanistically resolved
  7. 2013 High

    Discovered the extracellular DAMP function of CIRP, showing peptide-mapped binding to the TLR4-MD2 complex that drives TNF-α/HMGB1 release and tissue injury — a paradigm shift defining a second, inflammatory life of the protein.

    Evidence SPR binding with peptide mapping, CIRP-deficient mice, recombinant CIRP injection, and antisera blockade

    PMID:24097189

    Open questions at the time
    • Mechanism of CIRP release from cells not defined here
    • Downstream signaling beyond cytokine release not detailed
  8. 2013 Medium

    Connected CIRP to circadian amplitude control downstream of cytokine signaling, showing TNF/TGFβ suppress CIRBP and that CIRBP loss sensitizes clock genes to TNF.

    Evidence Cirp depletion with cytokine specificity panel and clock-gene readouts in fibroblasts and neuronal cells

    PMID:24337574

    Open questions at the time
    • Molecular target of CIRBP in clock-gene regulation not identified
  9. 2015 High

    Extended intracellular RNA chaperone activity to telomere maintenance via direct binding to telomerase RNA TERC and regulation of Cajal-body localization.

    Evidence IP-MS, CRISPR/siRNA knockdown, telomerase activity and telomere length assays

    PMID:26673712

    Open questions at the time
    • Structural basis of TERC binding unknown
    • Whether telomere effect requires CIRP RGG/phase behavior untested
  10. 2016 High

    Identified temperature-dependent splicing efficiency, not transcription rate, as a primary driver of cold-induced Cirbp mRNA accumulation, refining the induction model.

    Evidence Genome-wide approach-to-steady-state kinetics in temperature-cycled NIH3T3 cells

    PMID:27633015

    Open questions at the time
    • Splicing factors mediating the temperature response not identified
  11. 2018 High

    Demonstrated a specific cold-stress effector axis: CIRP binds the p27Kip1 5'UTR to enhance translation, linking cold induction to cell-cycle slowing.

    Evidence RNA binding, reporter translation, shRNA knockdown, and p27Kip1 KO MEF rescue under hypothermia

    PMID:29361038

    Open questions at the time
    • Translation-enhancement mechanism (e.g., IRES vs. cap) not fully defined
  12. 2018 Medium

    Generalized 3'UTR-mediated mRNA stabilization to oncogenic targets (HIF-1α) and showed an upstream cytokine suppressor of CIRBP (TGF-β in germ cells).

    Evidence RIP and 3'UTR binding/stability assays in bladder cancer; TGF-β isoform treatment and in vivo antagonist in testis

    PMID:30315244 PMID:30461215

    Open questions at the time
    • How CIRP discriminates stabilizing vs. destabilizing targets unclear
  13. 2020 High

    Expanded eCIRP receptor repertoire to TREM-1 and IL-6R, defining distinct inflammatory outputs (pro-inflammatory activation vs. STAT3-driven endotoxin tolerance/M2 polarization).

    Evidence SPR/Biacore, FRET, colocalization, TREM-1-/- mice, peptide inhibitors, and IL-6R neutralization with functional rescue

    PMID:32027618 PMID:32027619

    Open questions at the time
    • How a single ligand engages multiple receptors to opposite ends not resolved
    • Stoichiometry/competition among TLR4, TREM-1, IL-6R unknown
  14. 2020 High

    Defined the nuclear-import logic of CIRBP: two nonclassical NLS regions read by TNPO1 (RG/RGG) and TNPO3 (RSY) that couple localization to phase separation and stress-granule recruitment.

    Evidence Biophysical binding, NLS mutagenesis, and cell-based localization/phase-separation assays

    PMID:32234784

    Open questions at the time
    • In vivo relevance of dual-importin control not established
  15. 2021 High

    Established PTM gating of CIRBP behavior: SRPK1 phosphorylation of the RG/RGG region impairs LLPS, TNPO1 binding, and SG association, reciprocally regulated by arginine methylation.

    Evidence In vitro SRPK1 kinase assay, LLPS reconstitution, TNPO1 binding, and cellular SG recruitment with new phosphosite mapping

    PMID:34738012

    Open questions at the time
    • Methyltransferase responsible not identified
    • Upstream signals controlling the PTM switch unknown
  16. 2021 Medium

    Broadened intracellular target set to mitochondrial (Atp5g3), neuronal (PSD95), oncogenic (CTNNB1), and cardiac (OGFR) mRNAs, mostly via UTR binding with stability/translation control and in vivo functional rescue.

    Evidence 3'/5'UTR binding, RIP, mRNA decay and IRES reporter assays, KO/overexpression, AAV/stereotaxic delivery across tissue models

    PMID:34419133 PMID:34465343 PMID:34715218 PMID:35541895

    Open questions at the time
    • Whether these targets share a common recognition motif untested
    • Tissue-specific selectivity of CIRP targeting unexplained
  17. 2021 Medium

    Linked CIRBP to ferroptosis through interaction with ELAVL1/HuR-driven ferritinophagy, and identified HuR competition on Claudin1 mRNA, positioning CIRP within an antagonistic RBP network.

    Evidence Co-IP and colocalization for CIRBP-ELAVL1; RIP and dual-luciferase competition for Claudin1; loss-of-function in IR and DSS-colitis models

    PMID:33638934 PMID:34114349

    Open questions at the time
    • Direct vs. indirect nature of CIRBP-ELAVL1 cooperation not fully dissected
    • Generality of CIRP-HuR competition beyond these targets unknown
  18. 2021 Medium

    Mapped multiple eCIRP-driven cell-death and effector programs: TLR4-dependent ER stress, TREM-1/ICAM-1/Rho NETosis, Rab26-EPOR M2 impairment, and STING/TLR4-MyD88-TRIF type I IFN production.

    Evidence Multiple KO models (TLR4, TREM-1, ICAM-1, Rab26, EPOR, STING, MyD88, TRIF), peptide inhibitors, and rmCIRP challenge in sepsis/hemorrhage models

    PMID:28128330 PMID:32506691 PMID:34291735 PMID:34925338

    Open questions at the time
    • How eCIRP triggers such divergent downstream programs from shared receptors unclear
    • Single-lab pathway dissections
  19. 2022 Medium

    Defined eCIRP-induced ferroptosis and macrophage extracellular trap formation as TLR4/GPX4 and caspase-1/GSDMD-dependent death modalities.

    Evidence TLR4-/- macrophages, ferrostatin-1 rescue, GSDMD/caspase-1 inhibitors and imaging in macrophage models

    PMID:35003095 PMID:35844517

    Open questions at the time
    • Link between TLR4 signaling and GPX4 suppression not mechanistically traced
    • Single-lab findings
  20. 2024 Medium

    Defined the release trigger and a novel intracellular-extracellular death axis: lactate-driven lactylation promotes CIRP release, and internalized eCIRP stabilizes ZBP1 by blocking TRIM32-mediated degradation to drive ZBP1-RIPK3 PANoptosis.

    Evidence Lactylation measurement, TLR4-endocytosis tracking, eCIRP-ZBP1 and ZBP1-TRIM32 Co-IP, and Casp8/Ripk3/Zbp1 KO mice in CLP sepsis

    PMID:39465383

    Open questions at the time
    • Lactyltransferase responsible not identified
    • Single-lab; structural basis of ZBP1 competition unknown
  21. 2024 High

    Connected CIRBP to hypothermic organ protection mechanistically, showing it sustains DHODH-mediated ubiquinone reduction and CoQ-dependent antioxidant capacity to prevent ferroptosis in cold-preserved hearts.

    Evidence Cirbp-KO/transgenic rats, promoter methylation analysis, proteomics, DHODH/CoQ measurement, and lipid peroxidation assays in CPB/transplant models

    PMID:31019028 PMID:38690728

    Open questions at the time
    • Whether the CoQ/DHODH effect is RNA-binding-dependent not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how a single protein partitions between its nuclear/cytoplasmic RNA-regulatory roles and its extracellular DAMP function, how target/receptor selectivity is achieved, and what physiological signals govern the release switch in vivo.
  • No unified model linking PTM/phase state to release
  • No structural model of CIRP–receptor or CIRP–RNA complexes
  • Selectivity rules for mRNA targets vs. receptors undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 9 GO:0048018 receptor ligand activity 3 GO:0045182 translation regulator activity 2 GO:0098772 molecular function regulator activity 2
Localization
GO:0005576 extracellular region 3 GO:0005634 nucleus 3 GO:0005829 cytosol 3 GO:0005730 nucleolus 1
Pathway
R-HSA-168256 Immune System 5 R-HSA-5357801 Programmed Cell Death 4 R-HSA-8953854 Metabolism of RNA 4 R-HSA-1640170 Cell Cycle 2 R-HSA-9612973 Autophagy 1
Partners
DYRK1BELAVL1IL6RLY96TLR4TNPO1TNPO3TREM1
Complex memberships
telomerase complex

Evidence

Reading pass · 42 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 Extracellular CIRP acts as a damage-associated molecular pattern (DAMP) that binds the TLR4-MD2 complex (as well as TLR4 and MD2 individually), stimulating TNF-α and HMGB1 release from macrophages and causing inflammatory tissue injury in vivo. Human CIRP amino acids 106–125 bind MD2 with high affinity as determined by surface plasmon resonance. Surface plasmon resonance binding assay; recombinant CIRP injection in vivo; CIRP-deficient mouse model; anti-CIRP antisera blockade Nature medicine High 24097189
2020 eCIRP is a biologically active endogenous ligand of TREM-1 on macrophages. Surface plasmon resonance revealed strong binding between eCIRP and TREM-1, confirmed by FRET in macrophages. TREM-1 siRNA, decoy peptide LP17, and TREM-1-/- mice dramatically reduced eCIRP-induced inflammation. Surface plasmon resonance; FRET assay; TREM-1-/- mice; siRNA knockdown; inhibitory peptide M3 derived from eCIRP sequence JCI insight High 32027618
2020 eCIRP binds IL-6 receptor (IL-6R) on macrophages, activating STAT3 phosphorylation and promoting macrophage endotoxin tolerance and M2 polarization. Blockade of IL-6R with neutralizing Ab inhibited eCIRP-induced p-STAT3 and restored LPS-stimulated TNF-α release. Biacore binding assay; FRET; immunostaining colocalization; STAT3 inhibitor (Stattic); anti-IL-6R neutralizing antibody; rmCIRP stimulation of macrophages JCI insight High 32027619
2020 CIRBP nuclear import is mediated by two nonclassical nuclear localization signals: an RG/RGG-rich region recognized by Transportin-1 (TNPO1) and an RSY-rich region recognized by Transportin-3 (TNPO3). These interactions regulate nuclear localization, phase separation, and stress granule recruitment of CIRBP. Biophysical binding assays; cell-based localization experiments; mutagenesis of NLS regions; phase separation assays Proceedings of the National Academy of Sciences of the United States of America High 32234784
2021 Phosphorylation of the CIRBP RG/RGG region by SRPK1 impairs liquid-liquid phase separation (LLPS), binding to TNPO1, and stress granule association in cells. Arginine methylation of the same region reciprocally regulates SRPK1-mediated phosphorylation, revealing interplay between these two PTMs. In vitro phosphorylation assay with SRPK1; LLPS assay; TNPO1 binding assay; cell-based SG recruitment; identification of two novel phosphorylation sites Frontiers in molecular biosciences High 34738012
2012 Cirp directly binds Dyrk1b/Mirk kinase in the nucleus of undifferentiated spermatogonia, inhibiting Dyrk1b's binding to p27 (reducing p27 phosphorylation and destabilizing it) and inhibiting Dyrk1b-mediated phosphorylation of cyclin D1 (stabilizing cyclin D1), thereby promoting cell-cycle progression from G0/G1 to S phase. Cirp knockout mice; direct protein binding assays; co-immunoprecipitation; cell-cycle analysis; spermatogonial cell line knockdown; cyclin D1 and p27 protein level measurements Proceedings of the National Academy of Sciences of the United States of America High 22711815
2015 CIRP associates with the active telomerase complex through direct binding to the RNA component TERC, regulates Cajal body localization of telomerase, and modulates TERT mRNA levels. CIRP inhibition by CRISPR-Cas9 or siRNA leads to reduced telomerase activity and shortened telomere length. Co-immunoprecipitation coupled with mass spectrometry; CRISPR-Cas9 and siRNA knockdown; telomerase activity assay; telomere length measurement; Cajal body localization assay Nucleic acids research High 26673712
2016 Temperature-dependent accumulation of Cirbp mRNA is controlled primarily by regulation of splicing efficiency (fraction of pre-mRNA processed into mature mRNA), not transcription rate, and this post-transcriptional mechanism is widespread in temperature-dependent gene expression control. NIH3T3 fibroblasts exposed to simulated temperature cycles; genome-wide 'approach to steady-state' kinetics; mRNA/pre-mRNA quantification Genes & development High 27633015
2018 CIRP selectively binds the 5' UTR of p27Kip1 mRNA and enhances its translation. In cells exposed to mild hypothermia, induced CIRP correlated with increased p27Kip1 5'UTR reporter translation and p27Kip1 protein accumulation; shRNA-mediated CIRP knockdown prevented this induction. p27Kip1 KO MEFs showed no increase in doubling time under cold stress, unlike WT cells. RNA binding assay; reporter translation assay; shRNA knockdown; p27Kip1 KO MEFs; mild hypothermia induction Nucleic acids research High 29361038
2006 Cirp protects cells from TNF-α-induced apoptosis by activating the ERK pathway: Cirp transduction into Cirp-deficient fibroblasts increased phosphorylated ERK and suppressed TNF-α-induced caspase-8 activation. The ERK-specific inhibitor PD98059 abrogated Cirp's cytoprotective effect. Cirp transduction into Cirp-deficient mouse fibroblasts; ERK inhibitor (PD98059); caspase-8 activation assay; apoptosis assay at 37°C and 32°C Biochimica et biophysica acta Medium 16569452
2012 CIRP binds specific mRNAs in testis (identified by RIP-Chip and biotin pull-down), predominantly through a (Un)(n≥2) core recognition sequence, and stabilizes the bound mRNAs. Target mRNAs are associated with translation regulation, antioxidant activity, and reproduction. RIP-Chip (RNA-binding protein immunoprecipitation-microarray); biotin pull-down assay; mRNA stability assays FEBS letters Medium 22819822
2017 Extracellular CIRP induces ER stress in lung tissue via TLR4 activation. In CIRP-/- septic mice, ER stress markers (BiP, pIRE1α, sXBP1, CHOP, cleaved caspase-12) were not elevated, whereas TLR4 KO mice showed no ER stress induction after recombinant CIRP injection. CIRP-/- and TLR4-/- mouse models; cecal ligation and puncture sepsis; recombinant CIRP injection; Western blot for ER stress markers Scientific reports Medium 28128330
2020 eCIRP-induced ICAM-1+ neutrophil generation is mediated by TREM-1, and ICAM-1 on neutrophils activates Rho GTPase to promote NETosis. Blockade of ICAM-1 decreased Rho activation, and Rho inhibition decreased rmCIRP-induced NET formation. TREM-1-/- mice; TREM-1 inhibitor LP17; ICAM-1-/- neutrophils; Rho activation assay; rmCIRP stimulation; flow cytometry FASEB journal Medium 32506691
2021 eCIRP impairs macrophage bacterial phagocytosis by activating STAT3 phosphorylation, which promotes STAT3-βPIX complex formation, preventing βPIX from activating Rac1 and thereby reducing ARP2 and p-cofilin expression needed for actin remodeling. STAT3 inhibition rescued phagocytic dysfunction. CIRP-/- mice; rmCIRP stimulation of macrophages; co-immunoprecipitation of STAT3-βPIX complex; STAT3 inhibitor stattic; actin remodeling assays; in vivo bacterial load measurement Cellular & molecular immunology Medium 36471113
2021 eCIRP activates STING through TLR4/MyD88/TRIF pathways, leading to pTBK1 and pIRF3 activation and type I IFN production, exacerbating hemorrhagic shock. STING-/- mice showed reduced lung inflammation and mortality; TLR4-/-, MyD88-/-, and TRIF-/- macrophages failed to activate STING downstream of eCIRP. STING-/-, TLR4-/-, MyD88-/-, TRIF-/- mouse models; rmCIRP injection; Western blot for pTBK1 and pIRF3; cytokine measurement; controlled hemorrhage model JCI insight Medium 34291735
2024 Lactate accumulation during sepsis promotes lactylation of CIRP in macrophages, causing its release. Internalized eCIRP (via TLR4-mediated endocytosis by pulmonary vascular endothelial cells) competitively binds ZBP1, blocking TRIM32-mediated proteasomal degradation of ZBP1, stabilizing ZBP1 and enhancing ZBP1-RIPK3-dependent PANoptosis. CLP sepsis model; Casp8-/-, Ripk3-/-, Zbp1-/- mice; measurement of CIRP lactylation; co-immunoprecipitation of eCIRP-ZBP1 and ZBP1-TRIM32; TLR4-mediated endocytosis tracking Military Medical Research Medium 39465383
2019 Chronic hypoxia induces hypermethylation of the Cirbp promoter, suppressing CIRP expression and preventing cold-stress induction. CIRP deficiency attenuates hypothermic cardioprotection by downregulating the cardiac ubiquinone biosynthesis pathway, reducing CoQ10, increasing oxidative stress, and impairing ATP production. Rat CPB model; Cirbp-KO and Cirbp-transgenic rats; methylation analysis of Cirbp promoter in neonatal cardiomyocytes and human specimens; cardiac proteomics; CoQ10 measurement Science translational medicine High 31019028
2024 CIRBP suppression in aged donor hearts attenuates hypothermic cardioprotection by decreasing DHODH expression, compromising DHODH-mediated ubiquinone (CoQ) reduction, leading to cardiac lipid peroxidation and ferroptosis after transplantation. Rat heart transplantation model; Cirbp-KO rats; RNA-Seq; cardiac proteomics; DHODH expression measurement; lipid peroxidation assay The Journal of clinical investigation Medium 38690728
2018 CIRBP binds the 3'-UTR of HIF-1α mRNA to increase its mRNA stability in bladder cancer cells, thereby inducing HIF-1α expression and promoting cancer cell proliferation and migration. RNA immunoprecipitation; 3'UTR binding assay; CIRBP overexpression/knockdown; mRNA stability assay Cell death & disease Medium 30315244
2021 CIRP directly binds the 3'UTR of Atp5g3 mRNA to regulate mitochondrial homeostasis and ATP biogenesis under hypoxic stress, and sustains protein levels of respiratory chain complexes II (SDHB) and IV (MT-CO1). 3'UTR binding assay; Cirbp KO and overexpression; respiratory complex protein level measurement; ATP measurement; hypoxia model The Science of the total environment Medium 34715218
2021 CIRBP promotes ferroptosis in renal ischemia-reperfusion injury by interacting with ELAVL1 (HuR), which activates ferritinophagy. CIRBP-ELAVL1 interaction was confirmed by co-immunoprecipitation and fluorescence colocalization. Silencing CIRBP inhibited ferritinophagy and ferroptosis. Co-immunoprecipitation; fluorescence colocalization; siCIRBP; autophagy inhibitor; si-ELAVL1; anti-CIRP antibody mouse model of IR injury Journal of cellular and molecular medicine Medium 34114349
2021 CIRP binds to p53 mRNA (RIP assay) and regulates ferroptosis in pancreatic cancer cells through the p53/GPX4 pathway: cold-induced CIRBP expression was associated with decreased GPX4 and increased DPP4, NOX1, FTH1, Fe2+ accumulation, and ROS. RNA immunoprecipitation (RIP); CIRBP overexpression/knockdown; cold induction; ferroptosis marker measurement; ferroptosis inhibitor rescue Journal of immunology research Low 36061308
2021 CIRP directly binds the 3'UTR of PSD95 mRNA to post-transcriptionally regulate PSD95 protein levels; overexpression of Cirbp in hippocampus rescues hypobaric hypoxia-induced reduction of PSD95 and attenuates dendritic spine injury and cognitive deficits. 3'UTR binding assay; Cirbp overexpression via stereotaxic injection; PSD95 protein quantification; dendritic spine morphology analysis; behavioral memory tests Molecular brain Medium 34419133
2021 eCIRP induces macrophage extracellular trap (MET) formation through sequential activation of caspase-1 and gasdermin D (GSDMD). Caspase-1 and GSDMD inhibitors (z-VAD-fmk and disulfiram) significantly decreased rmCIRP-induced MET formation in THP-1 macrophages. Time-lapse fluorescence microscopy; SYTOX Orange staining; Western blot for cleaved caspase-1 and GSDMD; pharmacological inhibitors; primary peritoneal macrophages Frontiers in immunology Medium 35003095
2022 eCIRP induces ferroptosis in macrophages and lung tissue during sepsis by decreasing GPX4 expression and increasing lipid ROS in a TLR4-dependent manner. TLR4-/- macrophages showed attenuated GPX4 depression and lipid ROS increase after rmCIRP treatment. RAW 264.7 cells and TLR4-/- peritoneal macrophages; GPX4 expression; lipid ROS measurement; ferroptosis inhibitor ferrostatin-1; CIRP-/- mice CLP model; eCIRP inhibitor C23 Frontiers in immunology Medium 35844517
2012 A mild-cold responsive element (MCRE, octanucleotide 5'-TCCCCGCC-3') in the cirp 5' flanking region is bound by the transcription factor Sp1, which translocates more to the nucleus at 32°C than 37°C. Sp1 overexpression increased endogenous Cirp and reporter expression; Sp1 downregulation had the opposite effect. MCRE mutation abolished these effects. Reporter gene assay (CAT); chromatin immunoprecipitation; immunohistochemistry; Sp1 overexpression/downregulation; MCRE mutagenesis; multiple cell lines BMC biotechnology Medium 23046908
2004 Upregulation of CIRP by hypoxia is independent of HIF-1α and HIF-1β and does not require mitochondria. Nuclear run-on assays demonstrated that hypoxia-induced CIRP expression occurs at the level of gene transcription. Respiratory chain inhibitors (NaN3 and cyanide) blocked this response, but cells depleted of mitochondria still upregulated CIRP during hypoxia. HIF-1α-deficient (Z-33) and HIF-1β-deficient (Hepa-1 c4) cell lines; actinomycin-D; in vitro nuclear run-on assay; mitochondria-depleted cells; respiratory chain inhibitors Journal of cell science Medium 15075239
2009 CIRP expression is modulated by alternative transcription start sites generating three major 5'-UTR transcripts with different translational properties. The longest 32°C-enriched transcript exhibits IRES-like activity, and its levels and stability are increased at mild hypothermia, contributing to CIRP protein upregulation. 5'-UTR transcript characterization; IRES reporter assay; transcript stability measurement at different temperatures; NIH-3T3 cells RNA (New York, N.Y.) Medium 19398494
2013 TNF and TGFβ (but not IL-1β, IL-6, IFNα, or IFNγ) impair CIRBP expression in fibroblasts and neuronal cells; CIRBP depletion increases susceptibility of cells to TNF-mediated inhibition of clock gene (period genes, PAR-bZip) expression, revealing CIRBP as a regulator of circadian clock gene amplitude downstream of cytokine signaling. Cirp depletion; cytokine stimulation; clock gene expression measurement in fibroblasts and neuronal cells The Journal of biological chemistry Medium 24337574
2021 CIRP directly binds to OGFR mRNA and represses OGFR expression by reducing mRNA stability. CIRBP deficiency enables OGF-OGFR signaling to promote chemotherapy-induced cardiomyocyte apoptosis; exogenous CIRBP delivery to mouse myocardium mitigated doxorubicin-induced cardiac apoptosis. mRNA stability assay; RNA immunoprecipitation; CIRBP/OGFR overexpression/knockdown; AAV-mediated myocardial CIRBP delivery; cardiac apoptosis measurement International journal of biological sciences Medium 35541895
2015 CIRP inhibits DNA damage-induced apoptosis by regulating p53: CIRP knockdown increased p53 levels and pro-apoptotic gene expression, while CIRP overexpression decreased p53 levels and upregulated anti-apoptotic genes. Effect placed CIRP upstream of p53 in DNA damage apoptosis pathway. CIRP overexpression and siRNA knockdown; etoposide-induced DNA damage; p53 and apoptosis gene expression measurement; Western blot Biochemical and biophysical research communications Low 26188505
2021 CIRP directly binds CTNNB1 mRNA at its 3'- and 5'-UTRs (confirmed by RNA immunoprecipitation and biotin pull-down), enhancing CTNNB1 mRNA stability and promoting IRES-mediated CTNNB1 protein synthesis, leading to activation of Wnt/β-catenin signaling and downstream targets in NSCLC. RNA immunoprecipitation; biotin pull-down; mRNA decay assay; luciferase reporter (IRES); CIRBP overexpression/knockdown in multiple cell lines; in vivo xenograft Journal of experimental & clinical cancer research Medium 34465343
2021 eCIRP induces TREM-1 expression in alveolar type II (ATII) cells and triggers IL-6 and CXCL2 production via TREM-1. TREM-1-/- ATII cells showed reduced cytokine release after rmCIRP treatment, and TREM-1 antagonist peptides (M3, LP17) significantly decreased this response. Primary ATII cell isolation; TREM-1-/- mice; rmCIRP stimulation; TREM-1 antagonist peptides; flow cytometry; ELISA Frontiers in cell and developmental biology Medium 32984356
2022 eCIRP induces acute kidney injury via TREM-1 on renal endothelial cells. TREM-1-/- mice injected with rmCIRP showed attenuated AKI markers (BUN, creatinine, NGAL) and reduced renal ICAM-1 expression. M3 peptide blocked eCIRP activation of human renal glomerular endothelial cells. TREM-1-/- mice; rmCIRP IV injection; renal function markers; primary human renal glomerular endothelial cells; M3 inhibitory peptide Frontiers in physiology Medium 36246143
1998 Cirp is constitutively and diurnally expressed in the brain; Cirp mRNA levels oscillate in the suprachiasmatic nucleus and cerebral cortex (rising during daytime, falling at night), are absent in constant darkness, and are not present in 3-day-old mice, suggesting light-dependent regulation of Cirp in circadian rhythm circuits. Northern blot; immunohistochemistry; constant darkness control; developmental stage comparison Biochemical and biophysical research communications Medium 9571190
2018 CIRBP specifically binds pre-miR-329 (but not pri-miR-329) in RBP immunoprecipitation experiments after hindlimb ischemia, suggesting a role in posttranscriptional regulation of 14q32 microRNA processing. RNA pull-down SILAC mass spectrometry; RBP immunoprecipitation; hindlimb ischemia mouse model; CRISPR/Cas9 HADHB-/- cells Molecular therapy. Nucleic acids Low 30665182
2020 Under PRRSV infection, CIRBP translocates from the nucleus to the cytoplasm and is present in cytoplasmic stress granules. Overexpression of CIRBP promoted inflammatory cytokine expression and oxidative stress (iNOS, ROS) via the NF-κB pathway in infected macrophages. Immunofluorescence for CIRBP localization; stress granule colocalization; CIRBP overexpression; NF-κB pathway inhibitor; cytokine and ROS measurement International immunopharmacology Low 32593159
2021 CIRP and HuR competitively bind Claudin1 mRNA; CIRP binding suppresses Claudin1 expression while HuR binding enhances it. This competition regulates intestinal mucosal barrier function in ulcerative colitis. Validated by RNA immunoprecipitation and dual-luciferase reporter assay. RNA immunoprecipitation; dual-luciferase reporter assay; CIRP and HuR overexpression/knockdown; transepithelial electrical resistance; in vivo DSS colitis model BioFactors Medium 33638934
2023 A synthetic poly(A) tail mimic (A12) selectively and strongly binds the RNA-binding motif of eCIRP, preventing eCIRP binding to TLR4. A12 attenuated eCIRP-induced macrophage MAPK and NF-κB activation and inflammatory cytokine production in vitro and in vivo. Direct binding assay (A12-eCIRP RBM interaction); macrophage stimulation; NF-κB and MAPK activation assays; CLP sepsis model; bacterial load measurement Journal of immunology Medium 37585248
2021 eCIRP impairs Rab26 in macrophages, reducing Rab26-mediated surface transport of EPOR, resulting in decreased macrophage EPOR surface expression and impaired M2 polarization. EPO treatment failed to promote M2 polarization in Rab26 KO macrophages, confirming the Rab26-EPOR axis. Rab26 KO macrophages; myeloid-specific EPOR-deficient mice; anti-CIRP antibody treatment; EPOR surface expression assay; macrophage polarization measurement Frontiers in immunology Medium 34925338
2018 TGF-β2 and TGF-β3 directly downregulate CIRBP mRNA and protein expression in germ cells (GC2-spd). In vivo, heat-induced CIRBP downregulation in mouse testes is mediated by TGF-β upregulation; local TGF-β antagonist injection attenuated heat-induced CIRBP downregulation. In vitro TGF-β isoform treatment of GC2-spd cells; in vivo local testicular injection of TGF-β antagonist; CIRBP mRNA and protein quantification Andrology Medium 30461215
2024 CIRP maintains GluR1 (AMPA receptor subunit) stability on neuronal cell membranes by binding GluR1 mRNA; hypobaric hypoxia reduces CIRP expression and the CIRP-GluR1 interaction, causing GluR1 redistribution to cytoplasm, synaptic loss, and memory impairment. Cirp KO mice phenocopied this deficit. Cirp KO mice; hypobaric hypoxia model; mRNA binding assay; GluR1 surface vs. cytoplasmic protein distribution; dendritic spine and synapse counting; behavioral memory tests; Tat-C16 peptide rescue CNS neuroscience & therapeutics Medium 39315498

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis. Nature medicine 377 24097189
2004 Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism. Journal of cell science 217 15075239
2019 Extracellular CIRP (eCIRP) and inflammation. Journal of leukocyte biology 182 30645013
2016 Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold. Cellular and molecular life sciences : CMLS 175 27147467
1997 Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene. Gene 139 9434172
2020 Extracellular CIRP as an endogenous TREM-1 ligand to fuel inflammation in sepsis. JCI insight 123 32027618
2006 Cirp protects against tumor necrosis factor-alpha-induced apoptosis via activation of extracellular signal-regulated kinase. Biochimica et biophysica acta 104 16569452
1998 Decreased expression of cold-inducible RNA-binding protein (CIRP) in male germ cells at elevated temperature. The American journal of pathology 99 9422546
2018 CIRP increases ICAM-1+ phenotype of neutrophils exhibiting elevated iNOS and NETs in sepsis. Journal of leukocyte biology 98 29345380
2017 Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress. Scientific reports 83 28128330
2015 The Cold-Inducible RNA-Binding Protein (CIRP) Level in Peripheral Blood Predicts Sepsis Outcome. PloS one 76 26361390
2012 Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice. Proceedings of the National Academy of Sciences of the United States of America 72 22711815
1999 Effects of ischemia and H2O2 on the cold stress protein CIRP expression in rat neuronal cells. Free radical biology & medicine 72 10641716
2013 Effects of moderate and deep hypothermia on RNA-binding proteins RBM3 and CIRP expressions in murine hippocampal brain slices. Brain research 71 23415676
2021 CIRBP promotes ferroptosis by interacting with ELAVL1 and activating ferritinophagy during renal ischaemia-reperfusion injury. Journal of cellular and molecular medicine 66 34114349
2024 Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway. Military Medical Research 65 39465383
2014 Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer. Cancer research 64 25187386
2009 Cold-inducible RNA binding protein (CIRP) expression is modulated by alternative mRNAs. RNA (New York, N.Y.) 64 19398494
2021 Emodin Alleviates Severe Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting the Cold-Inducible RNA-Binding Protein (CIRP)-Mediated Activation of the NLRP3/IL-1β/CXCL1 Signaling. Frontiers in pharmacology 63 33967799
2012 Cold-inducible RNA-binding protein (CIRP) regulates target mRNA stabilization in the mouse testis. FEBS letters 63 22819822
2022 Extracellular CIRP Promotes GPX4-Mediated Ferroptosis in Sepsis. Frontiers in immunology 58 35844517
2020 Nonclassical nuclear localization signals mediate nuclear import of CIRBP. Proceedings of the National Academy of Sciences of the United States of America 58 32234784
2016 Temperature regulates splicing efficiency of the cold-inducible RNA-binding protein gene Cirbp. Genes & development 58 27633015
2020 Extracellular CIRP and TREM-1 axis promotes ICAM-1-Rho-mediated NETosis in sepsis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 57 32506691
2020 Extracellular CIRP induces macrophage endotoxin tolerance through IL-6R-mediated STAT3 activation. JCI insight 54 32027619
2018 A cold-inducible RNA-binding protein (CIRP)-derived peptide attenuates inflammation and organ injury in septic mice. Scientific reports 54 29434211
1998 Diurnal change of the cold-inducible RNA-binding protein (Cirp) expression in mouse brain. Biochemical and biophysical research communications 54 9571190
2018 CIRBP is a novel oncogene in human bladder cancer inducing expression of HIF-1α. Cell death & disease 52 30315244
2015 Cold-inducible RNA-binding protein CIRP/hnRNP A18 regulates telomerase activity in a temperature-dependent manner. Nucleic acids research 46 26673712
2022 Extracellular CIRP dysregulates macrophage bacterial phagocytosis in sepsis. Cellular & molecular immunology 42 36471113
2020 Inhibition of Efferocytosis by Extracellular CIRP-Induced Neutrophil Extracellular Traps. Journal of immunology (Baltimore, Md. : 1950) 38 33380498
2020 Cold-inducible RNA-binding protein (CIRP) in inflammatory diseases: Molecular insights of its associated signalling pathways. Scandinavian journal of immunology 37 32738154
2019 CIRP Induces Neutrophil Reverse Transendothelial Migration in Sepsis. Shock (Augusta, Ga.) 37 30148763
2019 Chronic hypoxia-induced Cirbp hypermethylation attenuates hypothermic cardioprotection via down-regulation of ubiquinone biosynthesis. Science translational medicine 37 31019028
2015 Cold-inducible RNA-binding protein, CIRP, inhibits DNA damage-induced apoptosis by regulating p53. Biochemical and biophysical research communications 37 26188505
2012 Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells. BMC biotechnology 35 23046908
2021 Extracellular CIRP activates STING to exacerbate hemorrhagic shock. JCI insight 33 34291735
2021 CIRP promotes the progression of non-small cell lung cancer through activation of Wnt/β-catenin signaling via CTNNB1. Journal of experimental & clinical cancer research : CR 33 34465343
2018 Cold-inducible RNA-binding protein (CIRP) induces translation of the cell-cycle inhibitor p27Kip1. Nucleic acids research 33 29361038
2021 Extracellular CIRP Induces Macrophage Extracellular Trap Formation Via Gasdermin D Activation. Frontiers in immunology 32 35003095
2023 Exosome-derived CIRP: An amplifier of inflammatory diseases. Frontiers in immunology 31 36865547
2021 Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation. Frontiers in molecular biosciences 31 34738012
2004 Osmotic stress of salmon stimulates upregulation of a cold inducible RNA binding protein (CIRP) similar to that of mammals and amphibians. Biochimie 31 15308334
2023 Regulation of cold-inducible RNA-binding protein (CIRBP) in response to cellular stresses. Biochimie 30 37037339
2021 Normothermic machine perfusion attenuates hepatic ischaemia-reperfusion injury by inhibiting CIRP-mediated oxidative stress and mitochondrial fission. Journal of cellular and molecular medicine 30 34786826
2022 ETS-1 facilitates Th1 cell-mediated mucosal inflammation in inflammatory bowel diseases through upregulating CIRBP. Journal of autoimmunity 28 35926374
2020 Extracellular CIRP Induces Inflammation in Alveolar Type II Cells via TREM-1. Frontiers in cell and developmental biology 28 32984356
2021 Hypoxia causes mitochondrial dysfunction and brain memory disorder in a manner mediated by the reduction of Cirbp. The Science of the total environment 27 34715218
2014 Protein overexpression of CIRP and TLR4 in oral squamous cell carcinoma: an immunohistochemical and clinical correlation analysis. Medical oncology (Northwood, London, England) 27 25027624
2013 Tumor necrosis factor and transforming growth factor β regulate clock genes by controlling the expression of the cold inducible RNA-binding protein (CIRBP). The Journal of biological chemistry 27 24337574
2024 Blocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells. Cell death discovery 26 38538578
2018 Exogenous hydrogen sulfide ameliorates high glucose-induced myocardial injury & inflammation via the CIRP-MAPK signaling pathway in H9c2 cardiac cells. Life sciences 25 29857073
2009 Overexpression of CIRP may reduce testicular damage induced by cryptorchidism. Clinical and investigative medicine. Medecine clinique et experimentale 25 19331798
2021 Extracellular CIRP Activates the IL-6Rα/STAT3/Cdk5 Pathway in Neurons. Molecular neurobiology 24 33783711
2021 Cirbp-PSD95 axis protects against hypobaric hypoxia-induced aberrant morphology of hippocampal dendritic spines and cognitive deficits. Molecular brain 24 34419133
2018 Posttranscriptional Regulation of 14q32 MicroRNAs by the CIRBP and HADHB during Vascular Regeneration after Ischemia. Molecular therapy. Nucleic acids 24 30665182
2021 Extracellular CIRP-Impaired Rab26 Restrains EPOR-Mediated Macrophage Polarization in Acute Lung Injury. Frontiers in immunology 23 34925338
2020 CIRBP Ameliorates Neuronal Amyloid Toxicity via Antioxidative and Antiapoptotic Pathways in Primary Cortical Neurons. Oxidative medicine and cellular longevity 23 32184914
2020 Frontline Science: Extracellular CIRP generates a proinflammatory Ly6G+ CD11bhi subset of low-density neutrophils in sepsis. Journal of leukocyte biology 23 33070370
2019 Effects of Cold-inducible RNA-binding Protein (CIRP) on Liver Glycolysis during Acute Cold Exposure in C57BL/6 Mice. International journal of molecular sciences 23 30909542
2017 TRPV4-dependent induction of a novel mammalian cold-inducible protein SRSF5 as well as CIRP and RBM3. Scientific reports 23 28536481
2019 CIRP downregulation renders cardiac cells prone to apoptosis in heart failure. Biochemical and biophysical research communications 22 31405566
2020 Potential Role of Extracellular CIRP in Alcohol-Induced Alzheimer's Disease. Molecular neurobiology 21 32827106
2017 Expression of RNA-binding Motif Protein 3 (RBM3) and Cold-inducible RNA-binding protein (CIRP) Is Associated with Improved Clinical Outcome in Patients with Colon Cancer. Anticancer research 21 28373441
2023 CIRP attenuates acute kidney injury after hypothermic cardiovascular surgery by inhibiting PHD3/HIF-1α-mediated ROS-TGF-β1/p38 MAPK activation and mitochondrial apoptotic pathways. Molecular medicine (Cambridge, Mass.) 20 37127576
2022 Extracellular CIRP induces acute kidney injury via endothelial TREM-1. Frontiers in physiology 20 36246143
2021 Extracellular CIRP Induces an Inflammatory Phenotype in Pulmonary Fibroblasts via TLR4. Frontiers in immunology 20 34367191
2017 The mechanism of CIRP in inhibition of keratinocytes growth arrest and apoptosis following low dose UVB radiation. Molecular carcinogenesis 20 27864909
2024 Cirbp suppression compromises DHODH-mediated ferroptosis defense and attenuates hypothermic cardioprotection in an aged donor transplantation model. The Journal of clinical investigation 19 38690728
2015 Expression of cold-inducible RNA-binding protein (CIRP) in pituitary adenoma and its relationships with tumor recurrence. Medical science monitor : international medical journal of experimental and clinical research 19 25934796
2008 Cold stress and light signals induce the expression of cold-inducible RNA binding protein (cirp) in the brain and eye of the Japanese treefrog (Hyla japonica). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 19 18722545
2022 Dihydroartemisinin Reduces Irradiation-Induced Mitophagy and Radioresistance in Lung Cancer A549 Cells via CIRBP Inhibition. Life (Basel, Switzerland) 18 36013308
2022 CIRBP Regulates Pancreatic Cancer Cell Ferroptosis and Growth by Directly Binding to p53. Journal of immunology research 18 36061308
2015 Developmental competence of mature yak vitrified-warmed oocytes is enhanced by IGF-I via modulation of CIRP during in vitro maturation. Cryobiology 18 26519204
2021 Absence of Cold-Inducible RNA-Binding Protein (CIRP) Promotes Angiogenesis and Regeneration of Ischemic Tissue by Inducing M2-Like Macrophage Polarization. Biomedicines 15 33916904
2024 Extracellular CIRP promotes Kupffer cell inflammatory polarization in sepsis. Frontiers in immunology 14 38881891
2019 Therapeutic hypothermia protects photoreceptors through activating Cirbp pathway. Neurochemistry international 14 30878570
2013 The protective effect of Cold-inducible RNA-binding protein (CIRP) on testicular torsion/detorsion: an experimental study in mice. Journal of pediatric surgery 14 24094970
2008 Cold-inducible RNA binding protein (CIRP), a novel XTcf-3 specific target gene regulates neural development in Xenopus. BMC developmental biology 14 18687117
2024 Extracellular CIRP induces abnormal activation of fibroblast-like synoviocytes from patients with RA via the TLR4-mediated HDAC3 pathways. International immunopharmacology 13 38218010
2024 ThermomiR-377-3p-induced suppression of Cirbp expression is required for effective elimination of cancer cells and cancer stem-like cells by hyperthermia. Journal of experimental & clinical cancer research : CR 13 38419081
2021 Human antigen R (HuR) and Cold inducible RNA-binding protein (CIRP) influence intestinal mucosal barrier function in ulcerative colitis by competitive regulation on Claudin1. BioFactors (Oxford, England) 13 33638934
2021 Identification of CIRBP and TRPV4 as Immune-Related Diagnostic Biomarkers in Osteoarthritis. International journal of general medicine 13 35002293
2020 Cold-inducible RNA-binding protein (CIRBP) promotes porcine reproductive and respiratory syndrome virus (PRRSV)-induced inflammatory response. International immunopharmacology 13 32593159
2017 CIRBP protects H9C2 cells against myocardial ischemia through inhibition of NF-κB pathway. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 13 28355355
2023 Targeting extracellular CIRP with an X-aptamer shows therapeutic potential in acute pancreatitis. iScience 12 37360693
2023 A Synthetic Poly(A) Tail Targeting Extracellular CIRP Inhibits Sepsis. Journal of immunology (Baltimore, Md. : 1950) 12 37585248
2022 MiR-383-5p promotes apoptosis of ovarian granulosa cells by targeting CIRP through the PI3K/AKT signaling pathway. Archives of gynecology and obstetrics 12 35226160
2022 CIRBP-OGFR axis safeguards against cardiomyocyte apoptosis and cardiotoxicity induced by chemotherapy. International journal of biological sciences 12 35541895
2021 CIRBP Knockdown Attenuates Tumourigenesis and Improves the Chemosensitivity of Pancreatic Cancer via the Downregulation of DYRK1B. Frontiers in cell and developmental biology 12 34490236
2024 A NOVEL OPSONIC EXTRACELLULAR CIRP INHIBITOR MOP3 ALLEVIATES GUT ISCHEMIA/REPERFUSION INJURY. Shock (Augusta, Ga.) 11 39178245
2024 Decreased cold-inducible RNA-binding protein (CIRP) binding to GluRl on neuronal membranes mediates memory impairment resulting from prolonged hypobaric hypoxia exposure. CNS neuroscience & therapeutics 11 39315498
2021 Extracellular CIRP decreases Siglec-G expression on B-1a cells skewing them towards a pro-inflammatory phenotype in sepsis. Molecular medicine (Cambridge, Mass.) 11 34058975
2019 RBM3 and CIRP expressions in targeted temperature management treated cardiac arrest patients-A prospective single center study. PloS one 11 31821351
2024 Extracellular CIRP induces CD4CD8αα intraepithelial lymphocyte cytotoxicity in sepsis. Molecular medicine (Cambridge, Mass.) 10 38302880
2022 Regulation of CIRP by genetic factors of SP1 related to cold sensitivity. Frontiers in immunology 10 36189232
2021 Cold-inducible RNA-binding protein (CIRP) potentiates uric acid-induced IL-1β production. Arthritis research & therapy 10 33902703
2020 Cold-inducible RNA-binding protein Cirp, but not Rbm3, may regulate transcript processing and protection in tissues of the hibernating ground squirrel. Cell stress & chaperones 10 32307648
2020 Co-Clinical Imaging Resource Program (CIRP): Bridging the Translational Divide to Advance Precision Medicine. Tomography (Ann Arbor, Mich.) 10 32879897
2018 The regulation of CIRBP by transforming growth factor beta during heat shock-induced testicular injury. Andrology 9 30461215

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