Affinage

CIB2

Calcium and integrin-binding family member 2 · UniProt O75838

Length
187 aa
Mass
21.6 kDa
Annotated
2026-06-09
31 papers in source corpus 23 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/7 claims corpus-supported (86%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CIB2 is an EF-hand divalent-cation-binding protein that serves as an obligate auxiliary subunit of the hair-cell mechanoelectrical transduction (MET) channel, where it is required for sensory transduction underlying hearing and balance (PMID:28663585, PMID:34089643). It binds directly to the pore-forming subunits TMC1 and TMC2, and loss of CIB2 abolishes MET currents in cochlear hair cells while causing post-natal stereocilia regression and hair-cell death; deafness-causing mutations disrupt these interactions (PMID:28663585, PMID:29084757). Structural work establishes that CIB2 (with its paralog CIB3) engages TMC1/2 through at least two cytoplasmic interfaces, including a conserved hydrophobic groove flanked by transmembrane domains and a vertebrate-specific TMC1 site, and that cation-bound CIB2 presents a negatively charged surface that contacts the positively charged TMC1 N-terminus to structurally stabilize the channel (PMID:34089643, PMID:39773557, PMID:40000792). Beyond a scaffolding role, CIB2 acts as a Ca2+ sensor: Ca2+ binding drives a conformational change in the TMC1-CIB2 complex that modulates channel conductivity, and disruption of the CIB2 Ca2+-binding site or pathogenic variants with diminished cation affinity perturb MET function (PMID:39889697, PMID:40000792). Biophysically, CIB2 preferentially binds Mg2+ over Ca2+ and is likely Mg2+-loaded under physiological conditions, with distinct EF3 (Mg2+) and EF4 (Ca2+) metal sites (PMID:30174586, PMID:39586446). CIB2 and CIB3 act redundantly in vestibular hair cells, where double knockout abolishes MET currents and causes balance deficits (PMID:37001993). Outside the inner ear, CIB2 interacts with integrin α7Bβ1D at muscle junctions (PMID:18611855), negatively regulates mTORC1 by preferentially binding GDP-Rheb to promote autophagy (PMID:34162842), inhibits sphingosine kinase 1 membrane translocation (PMID:28729416), and competes with CIB1 to restrain calcineurin activation in atrial cardiomyocytes (PMID:37128899).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2012 High

    Establishing that CIB2 localizes to stereocilia and modulates calcium responses placed an uncharacterized deafness gene into the inner-ear sensory and Usher interactome context.

    Evidence Mouse immunolocalization, heterologous calcium-response assays, and zebrafish/Drosophila functional studies

    PMID:23023331

    Open questions at the time
    • Did not identify the direct molecular partner mediating MET
    • Mechanism of calcium-response modulation in heterologous cells unresolved
  2. 2008 Medium

    Identification of CIB2 as a calcium-binding integrin α7Bβ1D partner at muscle junctions defined an early biochemical activity and binding partner before its inner-ear role was known.

    Evidence Co-immunoprecipitation, calcium-binding assay, and immunolocalization in mouse skeletal muscle

    PMID:18611855

    Open questions at the time
    • Functional consequence of the integrin interaction in muscle not defined
    • Single lab
  3. 2009 Medium

    Characterizing CIB2 as a myristoylated, membrane-associated Ca2+-conformational-switch protein induced by NMDA receptor signaling broadened its biochemical profile beyond muscle.

    Evidence Calcium binding, subcellular fractionation, immunocytochemistry, and pharmacological inhibitors in hippocampal neurons

    PMID:19433056

    Open questions at the time
    • No defined neuronal physiological role
    • Functional target of the Ca2+ switch not identified
  4. 2017 High

    Demonstrating direct CIB2-TMC1/TMC2 binding and loss of MET currents in CIB2-null hair cells identified CIB2 as an essential component of the cochlear mechanotransduction machinery.

    Evidence Reciprocal Co-IP, electrophysiology, and multiple knockout/knock-in mouse lines across labs

    PMID:28663585 PMID:29084757 PMID:29255404

    Open questions at the time
    • Structural basis of the interaction not yet resolved
    • Did not explain cochlea-vs-vestibule specificity
  5. 2021 High

    Crystallographic capture of CIB binding to a TMC1 cytoplasmic domain via a conserved hydrophobic groove established CIB2/3 as KChIP-like auxiliary subunits that govern channel localization and function.

    Evidence X-ray co-crystal structure (CIB3-TMC1 domain) with mutagenesis, knockouts, and MET recordings

    PMID:34089643

    Open questions at the time
    • Full-length channel architecture and second interface not resolved
    • How cation binding feeds into channel gating untested in this study
  6. 2021 High

    Discovery that CIB2 preferentially binds GDP-Rheb to suppress mTORC1 and promote autophagy revealed a signaling function distinct from its channel role, with relevance to LAM.

    Evidence Cib2 knockout mouse, GDP-vs-GTP-Rheb Co-IP, mTORC1/autophagy assays, and patient fibroblast rescue

    PMID:34162842

    Open questions at the time
    • Relationship between mTORC1 role and MET-channel role unclear
    • Tissue specificity of Rheb regulation not defined
  7. 2018 Medium

    Biophysical metal-binding measurements showed CIB2 favors Mg2+ over Ca2+ physiologically and mapped how the E64D deafness mutation allosterically impairs the Mg2+-bound state.

    Evidence Binding assays, NMR, and analytical ultracentrifugation with mutagenesis

    PMID:30174586

    Open questions at the time
    • Oligomeric state disputed by later study
    • Physiological metal occupancy in hair cells not directly measured
  8. 2019 Medium

    Refined biophysics established CIB2 as monomeric and defined a 1:1 Mg2+-favored interaction with the α7B integrin cytosolic region, correcting the earlier dimer model.

    Evidence Native MS, cross-linking/MS, gel filtration, DLS, SPR, and MD simulations

    PMID:31636333

    Open questions at the time
    • Contradicts prior dimer report; reconciliation incomplete
    • Single lab
  9. 2023 High

    Genetic dissection showed CIB2 and CIB3 act redundantly for vestibular MET yet have non-redundant roles in regional stereocilia maintenance, explaining the cochlea-specific severity of CIB2 loss.

    Evidence Cib2/Cib3 double-knockout mice, MET electrophysiology, balance tests, in situ hybridization

    PMID:37001993

    Open questions at the time
    • Molecular basis of region-specific roles unresolved
    • Compensation mechanism not defined
  10. 2023 Medium

    CIB2 was shown to restrain calcineurin signaling by competing with CIB1 in atrial cardiomyocytes, linking it to atrial fibrillation and fibrosis under stress.

    Evidence Cardiomyocyte-specific knockout/overexpression mice, in vivo electrophysiology, and CIB2-vs-CIB1 competition assays

    PMID:37128899

    Open questions at the time
    • Structural basis of competition not defined
    • Single lab
  11. 2025 High

    High-resolution structures of the mammalian CIB2-TMC1 complex defined the dual cytoplasmic binding interfaces and showed Ca2+ binding drives a conformational change that tunes channel conductivity, establishing CIB2 as the MET channel's cation sensor.

    Evidence X-ray crystallography, NMR, MD simulations, ex vivo MET recordings, and multi-species knockouts with calcium-site mutagenesis

    PMID:39773557 PMID:39889697 PMID:40000792

    Open questions at the time
    • How CIB2 conformational change is mechanically coupled to gating not fully resolved
    • In vivo cation occupancy during transduction not directly measured

Open questions

Synthesis pass · forward-looking unresolved questions
  • How CIB2's multiple roles (MET auxiliary subunit, integrin partner, mTORC1/Rheb regulator, SK1 inhibitor, calcineurin competitor) are integrated within a single protein and partitioned across tissues remains unresolved.
  • No unifying model linking channel and signaling roles
  • Tissue-specific partner selection mechanism unknown
  • Stereocilia development functions distinct from whirlin remain mechanistically undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 5 GO:0098772 molecular function regulator activity 4 GO:0005198 structural molecule activity 2 GO:0140299 molecular sensor activity 2
Localization
GO:0005856 cytoskeleton 3 GO:0005886 plasma membrane 2 GO:0005929 cilium 2 GO:0005794 Golgi apparatus 1
Pathway
R-HSA-112316 Neuronal System 3 R-HSA-9709957 Sensory Perception 3 R-HSA-162582 Signal Transduction 2 R-HSA-9612973 Autophagy 1
Partners
CIB3ITGA7PPP3 (CALCINEURIN)RHEBSPHK1TMC1TMC2WHRN
Complex memberships
TMC1/TMC2 MET channel complex

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2012 CIB2 localizes to mechanosensory stereocilia of inner ear hair cells and to retinal photoreceptor and pigmented epithelium cells. CIB2 significantly decreased ATP-induced calcium responses in heterologous cells, and deafness-causing mutations altered this effect. CIB2 is a member of the vertebrate Usher interactome. Mouse immunolocalization, heterologous cell calcium response assays, zebrafish and Drosophila functional studies Nature genetics High 23023331
2017 CIB2 binds directly to TMC1 and TMC2 (pore-forming subunits of the hair cell mechanotransducer channel). Loss of CIB2 abolishes mechanoelectrical transduction (MET) currents in auditory hair cells. Deafness-causing CIB2 mutations disrupt these interactions. CIB2 is required for normal operation of mechanotransducer channels and limits growth of transducing stereocilia. Co-immunoprecipitation (CIB2 with TMC1/2), electrophysiology (MET current recording), two mutant mouse lines (knockout and knock-in) Nature communications High 28663585
2017 Loss of CIB2 (but not CIB1) abolishes mechanoelectrical transduction currents in auditory hair cells and causes profound hearing loss; CIB2 knockout also affects stereocilia development. CRISPR/Cas9 knockout mice, electrophysiology (MET current recording), auditory brainstem response Frontiers in molecular neuroscience High 29255404
2017 MET currents are totally abolished in auditory hair cells of CIB2-/- mice but remain unchanged in vestibular hair cells. CIB2 deficiency leads to stereocilia regression and hair-cell death specifically in the cochlea after birth. CIB2 knockout mouse, electrophysiology (MET currents in cochlear and vestibular hair cells), histology EMBO molecular medicine High 29084757
2021 CIB2 and CIB3 are structurally similar to KChIP proteins (auxiliary subunits of voltage-gated Kv4 channels). CIB2/3 bind to TMC1/2 through a domain flanked by transmembrane domains 2 and 3, mediated through a conserved CIB hydrophobic groove. CIB2 regulates TMC1/2 localization and function in hair cells. CIB2 and CIB3 function as auxiliary subunits of the MET channel. X-ray crystallography (co-crystal structure of CIB3 with TMC1 CIB-binding domain), mouse knockouts, functional MET recordings Neuron High 34089643
2021 CIB2 negatively regulates mTORC1 signaling by preferentially binding to GDP-loaded (inactive) Rheb, thereby promoting autophagy. CIB2 deficiency leads to reduced lysosomal capacity, impaired autophagic clearance, and increased mTORC1 signaling. Overexpressing CIB2 in LAM patient-derived fibroblasts downregulates hyperactive mTORC1 signaling. Cib2 knockout mouse (retinal phenotype), co-immunoprecipitation (CIB2 with GDP-Rheb vs GTP-Rheb), biochemical assays for mTORC1 activity, autophagy assays Nature communications High 34162842
2023 CIB2 and CIB3 act redundantly to regulate MET in vestibular hair cells; double knockout of Cib2 and Cib3 completely abolishes MET currents in vestibular hair cells and causes severe balance deficits. CIB2 and CIB3 play distinct, non-redundant roles in stereocilia maintenance in vestibular striolar vs. extrastriolar regions. Cib2/Cib3 double knockout mice, electrophysiology (MET current recording), balance behavioral tests, in situ hybridization The Journal of neuroscience High 37001993
2008 CIB2 is a calcium-binding protein that interacts with integrin α7Bβ1D in skeletal muscle. CIB2 colocalizes with the integrin α7B subunit at the sarcolemma, neuromuscular junctions, and myotendinous junctions. Co-immunoprecipitation (CIB2 with integrin α7Bβ1D), calcium binding assay, immunolocalization in mouse skeletal muscle The Journal of biological chemistry Medium 18611855
2009 CIB2 (calmyrin2) binds Ca2+ and undergoes a Ca2+/conformational switch; it undergoes N-myristoylation (without Ca2+/myristoyl switch), is membrane-associated, and localizes with Golgi apparatus and dendrite markers in neurons. CIB2 protein and mRNA are induced ~7-fold and ~2-fold, respectively, upon NMDA receptor stimulation via Ca2+, ERK1/2, and PKC pathways. Calcium binding assays, subcellular fractionation, immunocytochemistry, pharmacological inhibitors (NMDAR antagonists, BAPTA, ERK/PKC inhibitors) in cultured hippocampal neurons Archives of biochemistry and biophysics Medium 19433056
2017 CIB2 binds sphingosine kinase 1 (SK1) at the same site as CIB1, but lacks the Ca2+-myristoyl switch function. CIB2 blocks SK1 translocation to the plasma membrane and inhibits its oncogenic signaling, sensitizing cells to TNFα-induced apoptosis and inhibiting Ras-induced neoplastic transformation. Co-immunoprecipitation, SK1 membrane localization assays, apoptosis assays, transformation assays, tumor xenograft models Cancer research Medium 28729416
2018 CIB2 preferentially binds Mg2+ (Kd ~290 μM) over Ca2+ (Kd ~0.5 mM) under physiological conditions, likely existing as Mg2+-bound under physiological conditions. CIB2 forms a non-covalent dimer and interacts with α7B integrin in this state. The USH1J-linked E64D mutation disrupts long-range allosteric communication between the N-terminal E64 residue and the EF3 metal-binding site, impairing Mg2+-bound conformation without substantially affecting integrin binding. Biochemical binding assays, NMR spectroscopy, analytical ultracentrifugation Frontiers in molecular neuroscience Medium 30174586
2016 CIB2 knockdown strongly impairs HIV-1 replication in Jurkat cells and primary CD4+ T lymphocytes specifically at the viral entry step. CIB2 knockdown reduces surface expression of CXCR4, CCR5, and integrin α4β7, suggesting a mechanism for reduced viral entry. siRNA knockdown, viral entry assays, flow cytometry for surface receptor expression Scientific reports Medium 27489023
2019 CIB2 is monomeric under all tested conditions (contrary to prior dimer report), with uncommon hydrodynamic properties due to high hydrophobic solvent accessible surface. CIB2 interacts with the α7B integrin cytosolic region proximal to the membrane in a 1:1 stoichiometry, with kinetically favored binding in the presence of Mg2+ and absence of Ca2+. Native mass spectrometry, chemical cross-linking/MS, analytical gel filtration, dynamic light scattering, surface plasmon resonance, molecular dynamics simulations Scientific reports Medium 31636333
2023 CIB2 competes with CIB1 for calcineurin binding, inhibiting CIB1-mediated calcineurin activation in atrial cardiomyocytes. Cardiomyocyte-specific Cib2 knockout enhances atrial fibrillation occurrence and atrial fibrosis under stress, while Cib2 overexpression mitigates these effects. Cardiomyocyte-specific Cib2 knockout and overexpression mouse models, in vivo electrophysiology, biochemical competition assays (CIB2 vs CIB1 for calcineurin) Circulation Medium 37128899
2025 CIB2 and CIB3 form heteromeric complexes with TMC1 and TMC2 through at least two cytoplasmic domains; NMR spectroscopy validated CIB2/3 interaction with TMC1 fragments. Molecular dynamics simulations predict TMCs are structurally stabilized by CIB proteins to form cation channels. Intact CIB2/3-TMC1/2 complexes are required for MET function in mouse cochlea, vestibular organs, and zebrafish inner ear and lateral line. AlphaFold2 modeling, NMR spectroscopy (TMC1 fragment interactions), molecular dynamics simulations, mouse/zebrafish knockout functional MET recordings eLife High 39773557
2025 CIB2 acts as a Ca2+ sensor for MET: the TMC1-CIB2 complex undergoes a Ca2+-induced conformational change. A vertebrate-specific binding site on TMC1 (CR3 region) interacts with apo-CIB2. Disruption of CIB2 calcium-binding site perturbs MET channel conductivity ex vivo. Dominant deafness mutations in TMC1 cluster around the putative ion pore or at CIB2-binding interfaces. X-ray crystallography (CIB2-TMC1 complex structure), ex vivo cochlea MET recordings, mutagenesis of CIB2 calcium-binding site Developmental cell High 39889697
2025 Crystal structure of the mammalian CIB2-TMC1 complex at high resolution reveals that cation-bound CIB2 forms a negatively charged surface interacting with a positively charged TMC1 N-terminus. Ca2+ modulates CIB2 interaction with both the N-terminal domain and the loop 1 region of TMC1, with Ca2+-bound CIB2 capable of simultaneously binding both regions. Pathogenic CIB2 variants show diminished calcium-binding affinities and differential effects on dual TMC1 binding sites. X-ray crystallography, mutagenesis, calcium binding assays Communications biology High 40000792
2024 CIB2 mechanically constrains TMC1/2 conformations to ensure proper force sensitivity and dynamic range of MET channels. The deafness-causing R186W CIB2 mutation increases resting open probability of MET channels, steepens MET I-X curve, abolishes fast adaptation, and increases leftward I-X curve shifts upon depolarization. R186W also disrupts electron-dense material at stereocilia tips and causes loss of BAIAP2L2 from the same location. New mouse knock-in model (R186W), electrophysiology (MET current recording with fast piezo probe), AlphaFold2 structural prediction, electron microscopy bioRxivpreprint Medium 37461484
2024 CIB2 interacts with whirlin through the CIB2 EF2 domain and the whirlin HHD2 domain. Overexpression of whirlin in Cib2-/- mice does not rescue stereocilia morphology, and double heterozygous Cib2/Whrn mice have normal hearing, indicating CIB2 has independent functions in stereocilia staircase development distinct from whirlin. Deletion constructs and nanoscale pulldown (NanoSPD) assays, AlphaFold2 multimer modeling, double mutant mouse genetics, auditory testing bioRxivpreprint Medium 39131343
2023 CIB2 interacts with ADGRV1 (USH2C protein) and both share a common interactome including TRiC/CCT chaperonin complex and BBS chaperonin-like proteins. CIB2 and ADGRV1 co-localize at photoreceptor cilia. Tandem affinity purification/mass spectrometry, co-immunoprecipitation validation, immunohistochemistry Frontiers in cell and developmental biology Medium 37427378
2024 CIB2 EF3 motif preferentially binds Mg2+ and EF4 binds Ca2+, with high mobility in EF4 regardless of bound metal. The Mg2+/Ca2+-bound state of CIB2 is structurally flexible, with pico-nanosecond motions induced in a region involved in target (α7B integrin) recognition. Solution NMR (amide nitrogen relaxation), molecular dynamics simulations, ITC, DSC International journal of biological macromolecules Medium 39586446
2015 The CIB2 p.Arg186Trp mutation disrupts inhibition of ATP-induced Ca2+ responses in heterologous cells but does not alter interactions with whirlin or targeting to hair cell stereocilia tips. Heterologous cell calcium response assay, co-immunoprecipitation (CIB2 with whirlin), ex vivo hair cell expression PloS one Low 26426422
2024 CIB2 knockdown inhibits myoblast proliferation (S-phase arrest, downregulation of CDK4/Cyclin D/E) and promotes differentiation in goat myogenic satellite cells via the integrin α7β1-PI3K/AKT axis. CTCF acts as a transcriptional repressor of CIB2 by binding an intragenic region. siRNA knockdown, cell cycle analysis, RT-qPCR, RNA-seq, ChIP assay Cells Low 40801631

Source papers

Stage 0 corpus · 31 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. Nature genetics 203 23023331
2017 CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells. Nature communications 149 28663585
2017 Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice. Frontiers in molecular neuroscience 106 29255404
2017 CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival. EMBO molecular medicine 70 29084757
2021 CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells. Neuron 66 34089643
2018 Variants in CIB2 cause DFNB48 and not USH1J. Clinical genetics 50 29112224
2021 CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function. Nature communications 40 34162842
2008 Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2 chain-deficient muscular dystrophy. The Journal of biological chemistry 40 18611855
2009 Biochemical characterization and expression analysis of a novel EF-hand Ca2+ binding protein calmyrin2 (Cib2) in brain indicates its function in NMDA receptor mediated Ca2+ signaling. Archives of biochemistry and biophysics 34 19433056
2015 Novel and recurrent CIB2 variants, associated with nonsyndromic deafness, do not affect calcium buffering and localization in hair cells. European journal of human genetics : EJHG 28 26173970
2015 A Novel C-Terminal CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family. PloS one 28 26426422
2017 CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1. Cancer research 27 28729416
2018 Preferential Binding of Mg2+ Over Ca2+ to CIB2 Triggers an Allosteric Switch Impaired in Usher Syndrome Type 1J. Frontiers in molecular neuroscience 26 30174586
2025 Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels. eLife 23 39773557
2023 CIB2 and CIB3 Regulate Stereocilia Maintenance and Mechanoelectrical Transduction in Mouse Vestibular Hair Cells. The Journal of neuroscience : the official journal of the Society for Neuroscience 18 37001993
2023 CIB2 Is a Novel Endogenous Repressor of Atrial Remodeling. Circulation 17 37128899
2005 DFNB48, a new nonsyndromic recessive deafness locus, maps to chromosome 15q23-q25.1. Human genetics 13 15711797
2023 Usher syndrome proteins ADGRV1 (USH2C) and CIB2 (USH1J) interact and share a common interactome containing TRiC/CCT-BBS chaperonins. Frontiers in cell and developmental biology 11 37427378
2019 Oligomeric state, hydrodynamic properties and target recognition of human Calcium and Integrin Binding protein 2 (CIB2). Scientific reports 11 31636333
2022 Calcium- and Integrin-Binding Protein 2 (CIB2) in Physiology and Disease: Bright and Dark Sides. International journal of molecular sciences 10 35408910
2016 CIB1 and CIB2 are HIV-1 helper factors involved in viral entry. Scientific reports 10 27489023
2016 Advances in genetic hearing loss: CIB2 gene. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 10 27771768
2024 Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels. bioRxiv : the preprint server for biology 9 37398045
2025 Mechano-electrical transduction components TMC1-CIB2 undergo a Ca2+-induced conformational change linked to hearing loss. Developmental cell 7 39889697
2017 Genetic Testing of Non-familial Deaf Patients for CIB2 and GJB2 Mutations: Phenotype and Genetic Counselling. Biochemical genetics 7 29086887
2023 Calcium and Integrin-binding protein 2 (CIB2) controls force sensitivity of the mechanotransducer channels in cochlear outer hair cells. bioRxiv : the preprint server for biology 4 37461484
2025 Structural insights into calcium-dependent CIB2-TMC1 interaction in hair cell mechanotransduction. Communications biology 3 40000792
2024 Structural dynamics of calcium and integrin-binding protein 2 (CIB2) reveal uncommon flexibility and heterogeneous calcium and magnesium loading. International journal of biological macromolecules 3 39586446
2024 CIB2 mediates acquired gefitinib resistance by inducing ZEB1 expression and epithelial-mesenchymal transition. Aging 2 39264588
2025 CTCF Represses CIB2 to Balance Proliferation and Differentiation of Goat Myogenic Satellite Cells via Integrin α7β1-PI3K/AKT Axis. Cells 1 40801631
2024 CIB2 function is distinct from Whirlin in the development of cochlear stereocilia staircase pattern. bioRxiv : the preprint server for biology 1 39131343

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