Affinage

CERS3

Ceramide synthase 3 · UniProt Q8IU89

Length
383 aa
Mass
46.3 kDa
Annotated
2026-06-09
75 papers in source corpus 17 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CERS3 (CerS3/LASS3) is a (dihydro)ceramide synthase that catalyzes amide-bond formation between a sphingoid long-chain base and a fatty acyl-CoA, with a distinctive preference for very-long- and ultra-long-chain (≥C26, up to C32–C36) acyl chains (PMID:16753040, PMID:23549421, PMID:28966260). Through this activity it is the principal source of very-long-chain ceramides in two specialized tissues: the differentiating epidermis, where it is the predominant CerS isoform and is induced upon keratinocyte differentiation (PMID:18541923), and the male germ line, where it is restricted to germ cells and sharply upregulated during testicular maturation (PMID:18308723). In skin, CERS3 operates within the acylceramide pathway, acting downstream of the ELOVL1/ELOVL4 elongation machinery and CYP4F22-mediated ω-hydroxylation to generate ω-hydroxyceramides that are subsequently transacylated by PNPLA1 (PMID:23826266, PMID:23689133, PMID:28966260); it is co-regulated with ELOVL4 by PPARβ/δ during differentiation and itself positively feeds back on ultra-long-chain fatty acid synthesis (PMID:23826266). In spermatogenesis, CerS3-derived ultra-long polyunsaturated ceramide anchors are required for intercellular bridge stability, and its loss causes apoptosis, multinuclear giant cell formation, and meiotic arrest (PMID:26045466). Its catalytic activity is tuned by C-terminal CK2-site phosphorylation, which increases Vmax (PMID:26887952), and is stimulated several-fold by physical interaction with acyl-CoA-binding protein (ACBP), which delivers very-long-chain acyl-CoA substrates (PMID:28320857). Enzymatic inactivation of CERS3 by recessive mutations causes autosomal recessive congenital ichthyosis through loss of very-long-chain stratum corneum ceramides, with reduction of acylceramide alone being sufficient for the phenotype (PMID:23549421, PMID:23754960, PMID:33492757). CERS3 activity is directly inhibited by riboflavin and by aclidinium bromide, linking its C26 ceramide product to EGFR activation in colorectal cancer (PMID:40609532).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2006 High

    Established that CERS3 is a catalytically active (dihydro)ceramide synthase, defining its core biochemical activity before any tissue role was known.

    Evidence In vivo [3H]dihydrosphingosine labelling, ESI-MS, and in vitro CerS assay with overexpressed protein

    PMID:16753040

    Open questions at the time
    • Initial broad substrate report did not resolve the very-long-chain preference later defined
    • No physiological tissue context established
  2. 2008 High

    Identified the two specialized tissues where CERS3 dominates — germ cells and keratinocytes — and linked it to very-long-chain/polyunsaturated sphingolipid production.

    Evidence qRT-PCR across postnatal testis development and keratinocyte differentiation, lipidomics of cell fractions, comparison with spermatogenic mutants

    PMID:18308723 PMID:18541923

    Open questions at the time
    • Did not establish whether VLC ceramide loss is causal for any phenotype
    • Mechanism of acyl-chain-length selectivity unresolved
  3. 2013 High

    Demonstrated that loss-of-function CERS3 mutations cause autosomal recessive congenital ichthyosis through specific depletion of very-long-chain ceramides, connecting enzyme activity to human barrier disease.

    Evidence Autozygosity mapping/exome sequencing, N-acylation enzymatic assays in patient keratinocytes and recombinant mutants, lipidomics, reconstructed skin across families

    PMID:23549421 PMID:23754960

    Open questions at the time
    • Which downstream lipid species (acylceramide vs protein-bound) is most critical not yet resolved
    • Did not place CERS3 within the full enzymatic pathway
  4. 2013 High

    Placed CERS3 in a cooperative epidermal chain-elongation pathway with ELOVL1/ELOVL4 under PPARβ/δ control, showing it both consumes and promotes ultra-long-chain acyl-CoA synthesis.

    Evidence Elovl1-KO mouse epidermal lipidomics, CERS3 siRNA knockdown with elongase activity readout, PPARβ/δ pathway analysis

    PMID:23689133 PMID:23826266

    Open questions at the time
    • Molecular basis of CERS3-elongase co-regulation not defined
    • Direct PPARβ/δ binding to the CERS3 locus not shown
  5. 2015 High

    Defined the germ-cell function of CerS3: its ultra-long polyunsaturated ceramides stabilize intercellular bridges required for male meiotic cytokinesis.

    Evidence CerS3-KO mice with apoptosis/multinuclear giant cell/meiotic-arrest phenotype, in situ MS imaging, genetic epistasis with glucosylceramide synthase KO

    PMID:26045466

    Open questions at the time
    • Molecular mechanism by which ceramide anchors stabilize bridges not detailed
    • Lipid-protein interactions at the bridge undefined
  6. 2017 High

    Identified two regulatory inputs to CERS3 activity — CK2-site phosphorylation and ACBP-mediated substrate delivery — explaining how very-long-chain acyl-CoA usage is enabled and tuned.

    Evidence Phospho-mapping with CK2 inhibitor and dephosphorylation assays; in vitro reconstitution, reciprocal Co-IP, and ACBP-KO testis lipidomics

    PMID:26887952 PMID:28320857

    Open questions at the time
    • Physiological conditions controlling CK2 phosphorylation of CERS3 unknown
    • Structural basis of ACBP–CerS3 interaction not resolved
  7. 2017 Medium

    Positioned CERS3 within the sequential acylceramide pathway as the amide-bond-forming step between CYP4F22-derived ω-hydroxy ULCFA and PNPLA1 transacylation.

    Evidence Pathway summary integrating CYP4F22 and PNPLA1 mutant analyses

    PMID:28966260

    Open questions at the time
    • Review-level synthesis rather than single reconstituted assay
    • Order/coupling of ω-hydroxylation and N-acylation not biochemically isolated
  8. 2021 High

    Refined the disease mechanism by showing that reduction of acylceramide alone, with near-normal protein-bound ceramide, is sufficient to cause ichthyosis.

    Evidence Recombinant mutant CERS3 activity assays plus comprehensive stratum corneum ceramide profiling by LC-MS/MS in a compound-heterozygous patient

    PMID:33492757

    Open questions at the time
    • Genotype–residual-activity–severity relationship across more patients not mapped
    • Single patient lipidomic comparison
  9. 2022 Medium

    Extended CERS3 biology beyond barrier/germline into context-dependent transcriptional regulation and roles in cancer and host–pathogen interactions.

    Evidence S1PR1/CerS6 nuclear-translocation studies in endothelial cells; CERS3 knockdown/overexpression in HCC cells with RNA-seq; CERS3 siRNA in P. berghei liver-stage hepatocyte model

    PMID:35753729 PMID:36068200 PMID:40689642

    Open questions at the time
    • CerS6-mediated transcriptional repression of CERS3 not biochemically reconstituted
    • SMAD6 link is RNA-seq inference without mechanistic validation
    • Parasite phenotype from single method/lab
  10. 2025 High

    Identified small-molecule and microbial inhibitors of CERS3 and linked its C26 ceramide product to oncogenic EGFR signaling.

    Evidence CERS3 activity assays with riboflavin and aclidinium bromide, EGFR binding assays, CRC patient/mouse lipidomics, bacterial supplementation

    PMID:40609532

    Open questions at the time
    • Structural basis of riboflavin/aclidinium inhibition of CERS3 not defined
    • Generality of C26-ceramide/EGFR axis beyond CRC unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How CERS3 acyl-chain selectivity, phosphoregulation, and ACBP-mediated substrate channeling are structurally integrated, and how its product ceramides are sensed by downstream effectors, remain unresolved.
  • No structural model of CERS3 or its substrate-binding pocket in the corpus
  • Mechanism coupling phosphorylation, ACBP binding, and catalysis undefined
  • Direct chromatin-level transcriptional regulators not biochemically established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 4 GO:0140096 catalytic activity, acting on a protein 2
Localization
GO:0005783 endoplasmic reticulum 1
Pathway
R-HSA-1430728 Metabolism 3 R-HSA-1266738 Developmental Biology 2
Partners
ACBPCK2CYP4F22ELOVL1ELOVL4PNPLA1

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 CERS3 (LASS3) encodes a (dihydro)ceramide synthase with relatively broad substrate specificity, preferring middle- to long-chain fatty acyl-CoAs; overproduction in vivo increases several ceramide species, confirmed by [3H]dihydrosphingosine labelling, ESI-MS, and an in vitro ceramide synthase assay. In vivo [3H]dihydrosphingosine labelling, electrospray-ionization MS, in vitro (dihydro)ceramide synthase assay with overexpressed protein The Biochemical journal High 16753040
2008 CerS3 is the ceramide synthase responsible for synthesis of very long-chain polyunsaturated fatty acid (VLC-PUFA, C26–C32) sphingolipids in male germ cells; Cers3 mRNA is up-regulated >700-fold during postnatal testicular maturation and is restricted to germ cells among the six CERS family members. Quantitative RT-PCR during postnatal development, lipid analysis of testicular cell fractions, comparison with male sterile mouse mutants arrested at different spermatogenic stages The Journal of biological chemistry High 18308723
2008 All six CerS family members, including CerS3, can synthesize 2-hydroxy-ceramide when overproduced in HEK 293T cells, and produce 2-hydroxy-CER with acyl-chain length matching the respective non-hydroxy-CER produced; CerS3 mRNA is the most predominantly expressed in keratinocytes and is upregulated upon differentiation. Overexpression in HEK 293T cells, lipid analysis (in vivo and in vitro CerS assay), siRNA knockdown, quantitative RT-PCR in keratinocytes Journal of lipid research High 18541923
2013 A homozygous missense mutation in CERS3 inactivates ceramide synthase 3 activity (demonstrated by N-acylation assay with C26-CoA) in patient keratinocytes and recombinant mutant proteins, causing a specific loss of very long-chain ceramides (C26–C34) in terminally differentiating keratinocytes and impairing epidermal barrier function. Autozygosity mapping, exome sequencing, ceramide synthase activity assay (N-acylation with C26-CoA) in patient keratinocytes and recombinant proteins, lipidomics, reconstructed patient skin The Journal of investigative dermatology High 23549421
2013 Splice site and deletion mutations in CERS3 cause disturbed sphingolipid profiles with reduced very long-chain ceramides, interfering with epidermal differentiation and demonstrating that CERS3 is essential for human epidermal lipid homeostasis. Genome-wide SNP genotyping, exome sequencing, functional analysis of patient skin and in vitro differentiated keratinocytes (sphingolipid profiling) PLoS genetics High 23754960
2013 CERS3 and ELOVL4 are co-regulated at both transcriptional and enzymatic levels during keratinocyte differentiation; knockdown of CERS3 reduces elongase activities toward ULC acyl-CoAs, indicating CERS3 positively regulates ultra-long-chain fatty acid (ULCFA) synthesis. PPARβ/δ is involved in transcriptional up-regulation of both genes. siRNA knockdown of CERS3 in keratinocytes with measurement of elongase activity, qRT-PCR, in vivo and in vitro expression analyses, PPARβ/δ pathway analysis PloS one High 23826266
2013 Two ceramide synthases, CerS2 and CerS3, expressed in an epidermal-layer-specific manner, regulate ELOVL1 to produce acyl-CoAs with different chain lengths; loss of Elovl1 in mice decreases ceramides with ≥C26 fatty acids (CerS3 substrates) while increasing those with ≤C24, establishing a cooperative pathway for epidermal ceramide chain-length determination. Elovl1 knockout mice, lipid mass spectrometry of epidermis, layer-specific expression analysis Molecular and cellular biology High 23689133
2015 CerS3 localizes in pachytene spermatocytes until completion of meiosis and in elongating spermatids; CerS3-KO mice display enhanced apoptosis during meiosis, formation of multinuclear giant cells, and spermatogenic arrest, establishing that CerS3-derived ceramides with ultra-long polyunsaturated anchors are required for stability of intercellular bridges during male meiotic cytokinesis. High-resolution mass spectrometric imaging (in situ), CerS3 knockout mice, glucosylceramide synthase KO mice (genetic epistasis), immunolocalization of CerS3 Human molecular genetics High 26045466
2016 CERS3 (along with CERS2, 4, 5, 6) is phosphorylated at the cytoplasmic C-terminal region, predominantly at CK2 consensus motifs; phosphorylation modestly increases CerS3 catalytic activity (Vmax), as shown by dephosphorylation experiments reducing activity. Phosphorylation mapping by MS, CK2 inhibitor (CX-4945) treatment, in vitro ceramide synthase activity assays before and after dephosphorylation The Journal of biological chemistry High 26887952
2017 Acyl-CoA-binding protein (ACBP) stimulates CerS3 activity approximately 7-fold in vitro, physically interacts with CerS3 (Co-IP), and requires binding of very-long-chain acyl-CoA esters for this stimulatory effect; CerS3 activity and very-long-chain ceramide levels are significantly reduced in testes of ACBP-knockout mice. In vitro ceramide synthase activity assay with ACBP, Co-immunoprecipitation of ACBP with CerS3, ACBP-KO mouse testes lipidomics, cytosol complementation assay The Journal of biological chemistry High 28320857
2017 In the acylceramide biosynthetic pathway, CerS3 performs amide-bond formation between a sphingoid long-chain base and an ultra-long-chain fatty acid (ULCFA, 28–36 carbons) that has been ω-hydroxylated by CYP4F22, and the resulting ω-hydroxyceramide is then transacylated by PNPLA1 to generate acylceramide. Pathway reconstitution and mutant analysis using CYP4F22 and PNPLA1 mutants demonstrating placement of CerS3 in the sequential pathway Yakugaku zasshi Medium 28966260
2021 In a patient with compound heterozygous CERS3 mutations (p.Arg75* and p.Arg229His), ceramide synthase activity was reduced to 4% and 56% of wild-type respectively; stratum corneum ceramide profiling showed greatly reduced acylceramide levels but nearly unchanged protein-bound ceramide levels, indicating acylceramide reduction alone is sufficient to cause ichthyosis. In vitro ceramide synthase activity assay with recombinant mutant CERS3 proteins, comprehensive stratum corneum ceramide profiling by LC-MS/MS The Journal of dermatology High 33492757
2022 S1PR1 downregulates CERS3 transcription in endothelial cells by inducing CerS6 nuclear translocation, which inhibits CERS3 at the transcriptional level, thereby decreasing ceramide levels and promoting angiogenesis in hepatocellular carcinoma. S1PR1 overexpression/knockdown in endothelial cells, CerS6 nuclear translocation imaging, qRT-PCR of CERS3, ceramide quantification, in vitro and in vivo angiogenesis assays Cell death & disease Medium 36068200
2022 CerS3 knockdown in an in vitro Plasmodium berghei liver stage model reduced parasitophorous vacuole size and infection rate (but not invasion), establishing that host CerS3-derived ceramides support parasite development within hepatocytes. siRNA-mediated knockdown of CERS3 in hepatocytes, P. berghei liver stage infection assay with measurement of PV size and infection rate mBio Medium 40689642
2022 CERS3 knockdown in Hep3B hepatocellular carcinoma cells (and overexpression in HCCLM3 cells) alters cell proliferation, migration, and invasion; RNA sequencing identified SMAD6 as a downstream effector of CerS3 in HCC cells. Retroviral/lentiviral overexpression and shRNA knockdown, MTT, EdU, Transwell, scratch assays, RNA sequencing Zhong nan da xue xue bao Low 35753729
2025 Riboflavin produced by Bacteroides cellulosilyticus directly inhibits CERS3 enzymatic activity, reducing d18:1/26:0 ceramide (C26) levels in colorectal cancer; C26 ceramide activates EGFR by binding its extracellular region, promoting cancer cell proliferation; aclidinium bromide also inhibits CERS3 activity. CERS3 activity assays with riboflavin and aclidinium bromide, ceramide profiling in CRC patients and mouse models, EGFR binding assays, bacterial supplementation experiments Cell metabolism High 40609532
2025 siRNA-mediated knockdown of CERS3 in sheep embryos resulted in a 9.5% decrease in blastocyst formation rate, indicating a functional role for CERS3 in early embryonic development. siRNA knockdown in sheep embryos, blastocyst formation rate assessment Epigenetics Low 41024457
2025 In a human skin equivalent model, doxycycline-inducible shRNA knockdown of CerS3 reduces polar lipid staining (Nile Red) and causes a significant reduction in specific ceramide classes and ceramide chain length, without affecting stratification or terminal differentiation; the knockdown is reversible upon doxycycline removal. Inducible shRNA in 3D human skin equivalents (HSEs), Nile Red staining, mass spectrometry-based lipidomics bioRxivpreprint Medium

Source papers

Stage 0 corpus · 75 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity. The Biochemical journal 158 16753040
2013 Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production. Molecular and cellular biology 145 23689133
2013 Impaired epidermal ceramide synthesis causes autosomal recessive congenital ichthyosis and reveals the importance of ceramide acyl chain length. The Journal of investigative dermatology 135 23549421
2013 Mutations in CERS3 cause autosomal recessive congenital ichthyosis in humans. PLoS genetics 132 23754960
2017 Altered expression of epidermal lipid bio-synthesis enzymes in atopic dermatitis skin is accompanied by changes in stratum corneum lipid composition. Journal of dermatological science 107 28571749
2010 A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. The journals of gerontology. Series A, Biological sciences and medical sciences 103 20304771
2009 Very long chain sphingolipids: tissue expression, function and synthesis. FEBS letters 100 20035755
2008 Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. The Journal of biological chemistry 98 18308723
2008 2-Hydroxy-ceramide synthesis by ceramide synthase family: enzymatic basis for the preference of FA chain length. Journal of lipid research 89 18541923
2016 Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region. The Journal of biological chemistry 73 26887952
2014 Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia. The Biochemical journal 67 24738593
2019 Genotype-phenotype correlation in a large English cohort of patients with autosomal recessive ichthyosis. The British journal of dermatology 56 31168818
2015 Male meiotic cytokinesis requires ceramide synthase 3-dependent sphingolipids with unique membrane anchors. Human molecular genetics 51 26045466
2009 Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism. Molecular cancer research : MCR 49 19609004
2020 A specific gut microbiota and metabolomic profiles shifts related to antidiabetic action: The similar and complementary antidiabetic properties of type 3 resistant starch from Canna edulis and metformin. Pharmacological research 47 32504839
2019 IFN-γ Reduces Epidermal Barrier Function by Affecting Fatty Acid Composition of Ceramide in a Mouse Atopic Dermatitis Model. Journal of immunology research 47 30838224
2015 Brain-specific epigenetic markers of schizophrenia. Translational psychiatry 43 26575221
2013 Cooperative Synthesis of Ultra Long-Chain Fatty Acid and Ceramide during Keratinocyte Differentiation. PloS one 43 23826266
2019 Autosomal recessive congenital ichthyosis: Genomic landscape and phenotypic spectrum in a cohort of 125 consanguineous families. Human mutation 42 30578701
2017 Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein. The Journal of biological chemistry 39 28320857
2022 S1PR1 induces metabolic reprogramming of ceramide in vascular endothelial cells, affecting hepatocellular carcinoma angiogenesis and progression. Cell death & disease 38 36068200
2015 Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner. The Journal of biological chemistry 35 25839235
2022 Deficiency of CFB attenuates renal tubulointerstitial damage by inhibiting ceramide synthesis in diabetic kidney disease. JCI insight 32 36546481
2017 Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome. Clinical epigenetics 32 28861129
2021 Decrease of ceramides with long-chain fatty acids in psoriasis: Possible inhibitory effect of interferon gamma on chain elongation. Experimental dermatology 29 34270128
2021 Meta-Analysis of Mutations in ALOX12B or ALOXE3 Identified in a Large Cohort of 224 Patients. Genes 28 33435499
2009 Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies. Journal of lipid research 28 19786568
2021 Type 3 resistant starch from Canna edulis modulates obesity and obesity-related low-grade systemic inflammation in mice by regulating gut microbiota composition and metabolism. Food & function 26 34784410
2018 Mutation update for CYP4F22 variants associated with autosomal recessive congenital ichthyosis. Human mutation 24 30011118
2018 Strawberry seed extract and its major component, tiliroside, promote ceramide synthesis in the stratum corneum of human epidermal equivalents. PloS one 21 30300355
2017 Autosomal recessive congenital ichthyosis: CERS3 mutations identified by a next generation sequencing panel targeting ichthyosis genes. European journal of human genetics : EJHG 21 28875980
2023 Mutational Spectrum of the ABCA12 Gene and Genotype-Phenotype Correlation in a Cohort of 64 Patients with Autosomal Recessive Congenital Ichthyosis. Genes 18 36980989
2025 Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression. Cell metabolism 17 40609532
2013 Expression of a tumor-associated gene, LASS2, in the human bladder carcinoma cell lines BIU-87, T24, EJ and EJ-M3. Experimental and therapeutic medicine 17 23407876
2021 Comprehensive stratum corneum ceramide profiling reveals reduced acylceramides in ichthyosis patient with CERS3 mutations. The Journal of dermatology 15 33492757
2017 [Elucidation of the Synthetic Mechanism of Acylceramide, an Essential Lipid for Skin Barrier Function]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 11 28966260
2022 Sulfonated (1 → 6)-β-d-Glucan (Lasiodiplodan): A Promising Candidate against the Acyclovir-Resistant Herpes Simplex Virus Type 1 (HSV-1) Strain. Biomacromolecules 10 36173245
2020 Gentiana lutea Extract Modulates Ceramide Synthesis in Primary and Psoriasis-Like Keratinocytes. Molecules (Basel, Switzerland) 10 32316273
2021 β-Sitosterol 3-O-D-glucoside increases ceramide levels in the stratum corneum via the up-regulated expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructed human epidermal keratinization model. PloS one 9 33684145
2024 Genomic characterization of dryland adaptation in endangered Anxi cattle in China. Animal genetics 8 38436096
2023 Expression of Ceramide-Metabolizing Enzymes in the Heart Adipose Tissue of Cardiovascular Disease Patients. International journal of molecular sciences 8 37298446
2022 Weill-Marchesani syndrome 4 caused by compound heterozygosity of a maternal submicroscopic deletion and a paternal nonsense variant in the ADAMTS17 gene: A case report. American journal of ophthalmology case reports 8 35496767
2021 Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 8 33844153
2020 Congenital ichthyosis in Prader-Willi syndrome associated with maternal chromosome 15 uniparental disomy: Case report and review of autosomal recessive conditions unmasked by UPD. American journal of medical genetics. Part A 8 32815268
2017 Effect of glycation focusing on the process of epidermal lipid synthesis in a reconstructed skin model and membrane fluidity of stratum corneum lipids. Dermato-endocrinology 7 29484088
2023 Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis. Biomedicines 6 36831084
2022 The Sphingolipid Asset Is Altered in the Nigrostriatal System of Mice Models of Parkinson's Disease. Biomolecules 6 35053241
2022 Epidermal 1-O-acylceramides appear with the establishment of the water permeability barrier in mice and are produced by maturating keratinocytes. Lipids 6 35318678
2022 Genotype of autosomal recessive congenital ichthyosis from a tertiary care center in India. Pediatric dermatology 6 35412663
2018 Phytosphingosine Increases Biosynthesis of Phytoceramide by Uniquely Stimulating the Expression of Dihydroceramide C4-desaturase (DES2) in Cultured Human Keratinocytes. Lipids 6 30460697
2025 Effects of Th1/Th17 and Th2 cytokines on lipid metabolism in differentiated keratinocytes. Frontiers in physiology 5 40046180
2022 Alteration to the Skin Ceramide Profile Following Broad-Spectrum UV Exposure. Journal of drugs in dermatology : JDD 5 35005872
2021 Generation of Stilbene Glycoside with Promising Cell Rejuvenation Activity through Biotransformation by the Entomopathogenic Fungus Beauveria bassiana. Biomedicines 5 34067529
2020 Congenital ichthyosiform erythroderma with a novel variant in ABCA12 in a Chinese patient. Pediatric investigation 5 32851342
2025 Polysaccharide from Prinsepia utilis Royle maintains the skin barrier by mediating differentiation, lipid metabolism and tight junction of keratinocyte. Scientific reports 3 40595762
2023 A Novel Eight-Gene Signature for Lipid Metabolism Predicts the Progression of Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma. Reproductive sciences (Thousand Oaks, Calif.) 3 37749448
2021 Electrolytic-reduction ion water induces ceramide synthesis in human skin keratinocytes. Drug discoveries & therapeutics 3 34707072
2025 Effects of natural killer cell‑conditioned medium on UVB‑induced photoaging in human keratinocytes and a human reconstructed skin model. Molecular medicine reports 2 40084708
2025 Metabolome and transcriptome analyses reveal the mechanism underlying the differences in skin development between the two duck breeds during embryonic stage. Poultry science 2 40499236
2025 Epigenetic remodeling of sheep oocytes and embryos induced by maternal methionine supplementation. Epigenetics 2 41024457
2024 DNA Methylation Patterns Associated with Tinnitus in Young Adults-A Pilot Study. Journal of the Association for Research in Otolaryngology : JARO 2 39147981
2022 Clinical and genetic investigation of ichthyosis in familial and sporadic cases in south of Tunisia: genotype-phenotype correlation. BMC medical genomics 2 34983512
2022 Ceramide synthase 3 affects invasion and metastasis of hepatocellular carcinoma via the SMAD6 gene. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2 35753729
2025 Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations. Epigenetics 1 40143670
2025 Host sphingolipids support Plasmodium berghei liver stage development. mBio 1 40689642
2025 GBA3 as a regulator of sphingolipid metabolism in the progression of hepatocellular carcinoma. Journal of gastrointestinal oncology 1 40950347
2025 Type 3 resistant starch from Canna edulis improves Parkinson's symptoms, including behavioral function and nerve damage, in Parkinson's model rats by regulating the gut-brain axis. The Journal of nutritional biochemistry 1 41338420
2024 Hair Growth-Promoting Effect of Hydrangea serrata (Thunb.) Ser. Extract and Its Active Component Hydrangenol: In Vitro and In Vivo Study. International journal of molecular sciences 1 39408700
2024 Molecular analysis of inherited disorders of cornification in polish patients show novel variants and functional data and provokes questions on the significance of secondary findings. Orphanet journal of rare diseases 1 39501396
2023 Differentiation-linked changes in the biosynthesis and turnover of sphingomyelins in rat male germ cells: Genes involved and effects of testosterone. The Journal of biological chemistry 1 36841478
2026 Sirtuin 1 mediated ceramide metabolism regulates intestinal mechanical barrier function in turbot (Scophthalmus maximus L.). International journal of biological macromolecules 0 41856194
2026 Response surface methodology optimization of cell-free supernatant from P. pentosaceus BJQ fermentation of CeRS3 and its in vitro lipid-lowering effects. Journal of microbiological methods 0 41936882
2026 Tape strips capture immune and epidermal hyperplasia markers in the major orphan ichthyoses. The Journal of investigative dermatology 0 41966446
2026 Dysregulation of fatty acid and sphingolipid metabolism is involved in abnormal nasal epithelial differentiation. International archives of allergy and immunology 0 42044130
2026 Uncoupling of nutrient sensing and cell size control by specific defects in ceramide structure. Biology open 0 42093330

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