Affinage

CERS3

Ceramide synthase 3 · UniProt Q8IU89

Length
383 aa
Mass
46.3 kDa
Annotated
2026-04-28
74 papers in source corpus 18 papers cited in narrative 18 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CERS3 is a ceramide synthase that catalyzes amide-bond formation between long-chain sphingoid bases and very-long-chain to ultra-long-chain fatty acyl-CoAs (C24–C36), generating the very-long-chain ceramides and acylceramide precursors essential for epidermal permeability barrier formation and male germ cell meiosis (PMID:16753040, PMID:23549421, PMID:26045466, PMID:28966260). In the epidermis, CERS3 operates downstream of ELOVL1/ELOVL4-mediated fatty acid elongation and upstream of PNPLA1-catalyzed acylceramide completion; its transcription is induced by PPARβ/δ during keratinocyte differentiation, and its enzymatic activity is stimulated ~7-fold by acyl-CoA-binding protein (ACBP) and modestly regulated by CK2-mediated C-terminal phosphorylation (PMID:23826266, PMID:23689133, PMID:28320857, PMID:26887952). Loss-of-function mutations in CERS3 cause autosomal recessive congenital ichthyosis (ARCI) through specific depletion of ultra-long-chain and acylceramides in the stratum corneum (PMID:23549421, PMID:23754960, PMID:33492757). CERS3-produced C26 ceramide can also activate EGFR signaling to promote colorectal cancer cell proliferation, a pathway inhibitable by bacterial riboflavin or aclidinium bromide (PMID:40609532).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 2006 High

    Establishing CERS3 as a bona fide ceramide synthase with relatively broad acyl-CoA specificity (C16–C26) resolved the question of whether this uncharacterized LASS family member possessed intrinsic (dihydro)ceramide synthase activity.

    Evidence In vivo [³H]dihydrosphingosine labeling and in vitro ceramide synthase assay upon overexpression

    PMID:16753040

    Open questions at the time
    • Preferred substrates in native tissues not yet defined
    • No structural basis for substrate recognition
  2. 2008 High

    Identification of CERS3 as the dominant ceramide synthase in both testicular germ cells and differentiating keratinocytes established its tissue-specific roles in generating VLC-PUFA sphingolipids for spermatogenesis and 2-hydroxy-ceramides for epidermis.

    Evidence qRT-PCR expression profiling in testis and keratinocytes; lipidomic analysis of spermatogenic mutants; in vitro assays with 2-hydroxy-fatty acyl-CoA substrates

    PMID:18308723 PMID:18541923

    Open questions at the time
    • Direct genetic proof of CERS3 requirement in each tissue not yet available
    • Mechanism by which CERS3 accommodates 2-hydroxy substrates unknown
  3. 2013 High

    Discovery that homozygous loss-of-function CERS3 mutations cause autosomal recessive congenital ichthyosis (ARCI) through depletion of C26–C34 ceramides proved CERS3 is essential for epidermal barrier function and positioned it in a defined biosynthetic pathway with ELOVL1 and PPARβ/δ.

    Evidence Exome sequencing of ARCI families, in vitro enzymatic assays of patient and recombinant mutant proteins, lipidomic profiling of patient keratinocytes, ELOVL1-KO mouse epistasis, PPARβ/δ regulation by siRNA and expression analysis

    PMID:23549421 PMID:23689133 PMID:23754960 PMID:23826266

    Open questions at the time
    • Direct promoter binding by PPARβ/δ not demonstrated
    • Contribution of individual ultra-long-chain species to barrier function not resolved
  4. 2015 High

    CerS3-knockout mice revealed that CerS3 is required for meiotic progression and intercellular bridge stability in spermatocytes, confirming a cell-autonomous role in male fertility through production of sphingolipids with ultra-long polyunsaturated anchors.

    Evidence CerS3-KO mice with in situ mass spectrometric imaging and immunolocalization in pachytene spermatocytes and elongating spermatids

    PMID:26045466

    Open questions at the time
    • Specific sphingolipid species mediating intercellular bridge stability not identified
    • Whether human male infertility results from CERS3 mutations is untested
  5. 2016 High

    Demonstration that CK2-mediated phosphorylation of the CERS3 C-terminal region modulates catalytic activity established a post-translational regulatory mechanism for this enzyme.

    Evidence CK2 inhibitor (CX-4945) treatment followed by in vitro ceramide synthase activity assay and phospho-mapping

    PMID:26887952

    Open questions at the time
    • Magnitude of regulation is modest; physiological contexts where this matters are unclear
    • Individual phospho-site contributions not dissected by mutagenesis
  6. 2017 High

    Identification of ACBP as a physical interactor that delivers very-long-chain acyl-CoA to CerS3 and stimulates its activity ~7-fold resolved how substrate supply is coupled to ceramide synthesis, and placement of CERS3 within the complete acylceramide biosynthetic pathway (ELOVL1/4→CYP4F22→CERS3→PNPLA1) defined its precise enzymatic step.

    Evidence Co-immunoprecipitation of ACBP with CerS3, in vitro assays in ACBP-KO liver cytosol and testes lipidomics; biochemical pathway reconstitution

    PMID:28320857 PMID:28966260

    Open questions at the time
    • Structural basis of ACBP–CerS3 interaction unknown
    • Whether ACBP regulation is tissue-specific (skin vs. testis) not compared
  7. 2021 High

    Quantitative enzymatic analysis of compound heterozygous CERS3 mutations demonstrated that reduction in acylceramide—not protein-bound ceramide—is sufficient to cause ichthyosis, refining the genotype-phenotype relationship.

    Evidence In vitro ceramide synthase assay of recombinant R75* and R229H mutant proteins with stratum corneum ceramide profiling by mass spectrometry

    PMID:33492757

    Open questions at the time
    • Threshold of residual activity needed to prevent disease not defined
    • Whether modifier genes modulate phenotypic severity is unknown
  8. 2022 Medium

    Transcriptional repression of CERS3 by nuclear CerS6 downstream of S1PR1 signaling in endothelial cells revealed an inter-CerS regulatory circuit linking sphingolipid metabolism to angiogenesis.

    Evidence siRNA knockdown and overexpression with nuclear fractionation in endothelial cells; in vitro and in vivo angiogenesis assays

    PMID:36068200

    Open questions at the time
    • Direct CerS6 binding to CERS3 promoter not shown
    • Not independently replicated
    • Relevance to in vivo vascular biology beyond tumor angiogenesis untested
  9. 2025 High

    Discovery that CERS3-produced C26 ceramide directly binds and activates EGFR to promote colorectal cancer cell proliferation, inhibitable by bacterial riboflavin or aclidinium bromide, extended CERS3 function to oncogenic signaling and identified the first pharmacological inhibitors of this enzyme.

    Evidence CERS3 overexpression/knockdown in CRC cells, EGFR extracellular domain binding assay, ceramide MS, riboflavin and aclidinium bromide inhibition assays, mouse CRC models

    PMID:40609532

    Open questions at the time
    • Selectivity of CERS3 inhibitors over other CerS family members not characterized
    • Whether C26 ceramide–EGFR binding occurs under physiological lipid concentrations is uncertain
    • Structural mechanism of EGFR activation by C26 ceramide unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the three-dimensional structure of CERS3, the molecular basis of its ultra-long-chain acyl-CoA selectivity, the full scope of post-translational regulatory mechanisms, and whether CERS3 inhibition is therapeutically viable in cancer without compromising skin or testicular barrier function.
  • No crystal or cryo-EM structure available
  • Mechanism of acyl-chain length selectivity unresolved
  • Therapeutic window for CERS3 inhibition not defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 7
Localization
GO:0005783 endoplasmic reticulum 2
Pathway
R-HSA-1430728 Metabolism 7 R-HSA-1643685 Disease 3
Partners
ACBPCERS6CYP4F22ELOVL1ELOVL4PNPLA1

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 CERS3 (LASS3) encodes a (dihydro)ceramide synthase with relatively broad substrate specificity, preferring middle- to long-chain fatty acyl-CoAs (C16–C26 range). Overexpression in vivo increased several ceramide species, confirmed by in vitro ceramide synthase assay. In vivo [3H]dihydrosphingosine labeling, electrospray-ionization MS, in vitro (dihydro)ceramide synthase assay The Biochemical journal High 16753040
2008 CERS3 mRNA expression is restricted to germ cells in the testis and is upregulated >700-fold during postnatal testicular maturation; CERS3 drives synthesis of very long-chain polyunsaturated fatty acid (VLC-PUFA, C26–C32) sphingolipids required for male meiosis and spermatogenesis. Quantitative RT-PCR, lipidomic analysis of male sterile mutants with spermatogenic arrest at defined stages, correlation with sphingolipid profiles The Journal of biological chemistry High 18308723
2008 CerS3/LASS3 mRNA is the most predominantly expressed ceramide synthase in keratinocytes, its expression increases upon differentiation, and all CerS members including CerS3 can produce 2-hydroxy-ceramide with chain-length specificity matching their respective non-hydroxy ceramide products. Quantitative RT-PCR, overexpression in HEK 293T cells, in vitro CerS assay with 2-hydroxy-fatty acyl-CoA substrates Journal of lipid research High 18541923
2013 Loss-of-function mutations in CERS3 cause autosomal recessive congenital ichthyosis by abolishing ceramide synthase activity toward C26-CoA, resulting in specific loss of very long chain ceramides (C26–C34) in terminally differentiating keratinocytes and disruption of epidermal barrier function. Autozygosity mapping, exome sequencing, in vitro N-acylation assay with C26-CoA in patient keratinocytes and recombinant mutant proteins, lipidomic profiling of patient keratinocytes, reconstructed patient skin analysis The Journal of investigative dermatology High 23549421
2013 CERS3 mutations (homozygous deletion and splice site mutation) cause ARCI by disrupting sphingolipid metabolism with reduced levels of epidermis-specific very long-chain ceramides, interfering with epidermal differentiation and lipid homeostasis. Genome-wide SNP-genotyping, exome sequencing, sphingolipid profiling in patient skin and in vitro differentiated keratinocytes PLoS genetics High 23754960
2013 CERS3 and ELOVL4 are coordinately upregulated during keratinocyte differentiation via PPARβ/δ; CERS3 knockdown reduces elongase activity toward ultra-long-chain acyl-CoAs, indicating CERS3 positively regulates ULCFA synthesis. In vivo and in vitro mRNA expression analysis, siRNA knockdown of CERS3, elongase activity assay PLoS one High 23826266
2013 ELOVL1 is required for producing C26+ fatty acids used by CerS2 and CerS3 in the epidermis; layer-specific expression of CerS2 and CerS3 regulates acyl-CoA chain-length inputs for ceramide production, establishing ELOVL1 as upstream of CerS3 in the epidermal ceramide biosynthetic pathway. Elovl1 knockout mouse generation, lipidomic analysis of epidermis, immunohistochemistry for CerS2 and CerS3 expression Molecular and cellular biology High 23689133
2015 CerS3 localizes to pachytene spermatocytes until completion of meiosis and to elongating spermatids; loss of CerS3 in mice causes spermatogenic arrest with enhanced apoptosis during meiosis and formation of multinuclear giant cells, linked to loss of sphingolipids with ultra-long polyunsaturated anchors required for intercellular bridge stability. High-resolution mass spectrometric imaging (in situ), CerS3-KO mice, glucosylceramide synthase-KO mice, immunolocalization of CerS3 Human molecular genetics High 26045466
2016 CERS3 enzyme activity is regulated by phosphorylation at its cytoplasmic C-terminal region; dephosphorylation (via CK2 inhibitor CX-4945) modestly reduces CERS3 catalytic activity, with most phosphorylated residues conforming to a CK2 consensus motif. Phosphorylation analysis, CK2 inhibitor treatment (CX-4945), in vitro ceramide synthase activity assay The Journal of biological chemistry High 26887952
2017 Acyl-CoA-binding protein (ACBP) binds very-long-chain acyl-CoA esters and stimulates CerS3 activity by ~7-fold; ACBP physically interacts with CerS3, and CerS3 activity is significantly reduced in testes of ACBP-knockout mice along with reduced long- and very-long-chain ceramide levels. In vitro ceramide synthase assay with liver cytosol from WT and ACBP-KO mice, Co-immunoprecipitation (ACBP with CerS3), lipid mass spectrometry in ACBP-KO testes The Journal of biological chemistry High 28320857
2017 The complete biosynthetic pathway for acylceramide in epidermis was established: ELOVL1 and ELOVL4 synthesize ultra-long-chain fatty acids (ULCFA), CYP4F22 ω-hydroxylates ULCFA, CERS3 forms the amide bond with a long-chain base, and PNPLA1 transacylates linoleic acid to produce acylceramide. Genetic pathway analysis, in vitro reconstitution of enzymatic steps, mutant protein analysis Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan High 28966260
2021 Compound heterozygous CERS3 mutations (nonsense p.Arg75* and missense p.Arg229His) reduce ceramide synthase activity to 4% and 56% of wild-type, respectively; patient stratum corneum shows greatly reduced acylceramide levels while protein-bound ceramide levels remain nearly unchanged, demonstrating that acylceramide reduction alone is sufficient to cause ichthyosis. In vitro ceramide synthase activity assay of recombinant mutant CERS3 proteins, comprehensive stratum corneum ceramide profiling by mass spectrometry The Journal of dermatology High 33492757
2022 S1PR1 promotes angiogenesis by decreasing ceramide levels via CerS3 downregulation; mechanistically, S1PR1 induces CerS6 nuclear translocation which transcriptionally inhibits CerS3 in endothelial cells. siRNA knockdown, overexpression experiments, nuclear fractionation, in vitro and in vivo angiogenesis assays Cell death & disease Medium 36068200
2022 In diabetic kidney disease, CFB deficiency reduces NF-κB p65 activation, which normally drives transcription of CERS3; inhibiting this pathway reduces ceramide biosynthesis and attenuates tubulointerstitial injury. siRNA knockdown of CFB in HK-2 cells, Cfb-knockout diabetic mice, ceramide synthase inhibitor (fumonisin B1), NF-κB signaling analysis JCI insight Medium 36546481
2025 CERS3 produces C26 ceramide (d18:1/26:0) which activates epidermal growth factor receptor (EGFR) by binding its extracellular region to promote cancer cell proliferation; bacterial riboflavin from Bacteroides cellulosilyticus inhibits CERS3 activity, reducing C26 ceramide and delaying colorectal cancer progression; aclidinium bromide also inhibits CERS3 activity. CERS3 overexpression/knockdown in CRC cells, EGFR binding assay, ceramide mass spectrometry, riboflavin-CERS3 activity inhibition assay, aclidinium bromide CERS3 activity assay, mouse CRC models Cell metabolism High 40609532
2025 CerS3 (mammalian) expressed in yeast supports near-normal nutrient-dependent cell size modulation through production of C24–C26 ceramides, demonstrating that CERS3 substrate specificity for very-long-chain ceramides determines downstream TORC2 signaling and cell size control. Expression of mammalian CerS3 in yeast elongation mutants (elo3Δ), TORC2 signaling readout (Ypk1/2 pT662), cell size measurement under nutrient deprivation bioRxivpreprint Medium bio_10.1101_2025.11.28.691118
2025 Inducible knockdown of CerS3 in 3D human skin equivalents reduces polar lipid staining and causes a specific reduction in ultra-long-chain ceramide classes and chain lengths without disrupting stratification or terminal differentiation, confirming CerS3's specific role in ultra-long-chain ceramide synthesis for epidermal barrier lipid composition. Doxycycline-inducible shRNA knockdown of CerS3 in N/TERT keratinocytes in 3D HSEs, mass spectrometry lipidomics, Nile Red staining bioRxivpreprint Medium bio_10.1101_2025.01.20.633956
2022 CerS3 overexpression promotes HCC cell proliferation, migration, and invasion via activation of the SMAD6 gene, as determined by RNA sequencing of downstream targets. Retroviral overexpression and lentiviral shRNA knockdown of CerS3 in HCC cell lines (Hep3B, HCCLM3), MTT/EdU proliferation assays, Transwell invasion assay, RNA sequencing Zhong nan da xue xue bao. Yi xue ban Low 35753729

Source papers

Stage 0 corpus · 74 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity. The Biochemical journal 157 16753040
2013 Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production. Molecular and cellular biology 144 23689133
2013 Impaired epidermal ceramide synthesis causes autosomal recessive congenital ichthyosis and reveals the importance of ceramide acyl chain length. The Journal of investigative dermatology 133 23549421
2013 Mutations in CERS3 cause autosomal recessive congenital ichthyosis in humans. PLoS genetics 131 23754960
2017 Altered expression of epidermal lipid bio-synthesis enzymes in atopic dermatitis skin is accompanied by changes in stratum corneum lipid composition. Journal of dermatological science 107 28571749
2010 A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. The journals of gerontology. Series A, Biological sciences and medical sciences 103 20304771
2009 Very long chain sphingolipids: tissue expression, function and synthesis. FEBS letters 100 20035755
2008 Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. The Journal of biological chemistry 98 18308723
2008 2-Hydroxy-ceramide synthesis by ceramide synthase family: enzymatic basis for the preference of FA chain length. Journal of lipid research 89 18541923
2016 Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region. The Journal of biological chemistry 73 26887952
2014 Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia. The Biochemical journal 66 24738593
2019 Genotype-phenotype correlation in a large English cohort of patients with autosomal recessive ichthyosis. The British journal of dermatology 55 31168818
2015 Male meiotic cytokinesis requires ceramide synthase 3-dependent sphingolipids with unique membrane anchors. Human molecular genetics 51 26045466
2009 Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism. Molecular cancer research : MCR 49 19609004
2020 A specific gut microbiota and metabolomic profiles shifts related to antidiabetic action: The similar and complementary antidiabetic properties of type 3 resistant starch from Canna edulis and metformin. Pharmacological research 47 32504839
2019 IFN-γ Reduces Epidermal Barrier Function by Affecting Fatty Acid Composition of Ceramide in a Mouse Atopic Dermatitis Model. Journal of immunology research 47 30838224
2015 Brain-specific epigenetic markers of schizophrenia. Translational psychiatry 43 26575221
2013 Cooperative Synthesis of Ultra Long-Chain Fatty Acid and Ceramide during Keratinocyte Differentiation. PloS one 43 23826266
2019 Autosomal recessive congenital ichthyosis: Genomic landscape and phenotypic spectrum in a cohort of 125 consanguineous families. Human mutation 42 30578701
2017 Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein. The Journal of biological chemistry 39 28320857
2022 S1PR1 induces metabolic reprogramming of ceramide in vascular endothelial cells, affecting hepatocellular carcinoma angiogenesis and progression. Cell death & disease 36 36068200
2015 Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner. The Journal of biological chemistry 34 25839235
2017 Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome. Clinical epigenetics 32 28861129
2022 Deficiency of CFB attenuates renal tubulointerstitial damage by inhibiting ceramide synthesis in diabetic kidney disease. JCI insight 29 36546481
2021 Decrease of ceramides with long-chain fatty acids in psoriasis: Possible inhibitory effect of interferon gamma on chain elongation. Experimental dermatology 28 34270128
2009 Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies. Journal of lipid research 28 19786568
2021 Meta-Analysis of Mutations in ALOX12B or ALOXE3 Identified in a Large Cohort of 224 Patients. Genes 27 33435499
2018 Mutation update for CYP4F22 variants associated with autosomal recessive congenital ichthyosis. Human mutation 24 30011118
2021 Type 3 resistant starch from Canna edulis modulates obesity and obesity-related low-grade systemic inflammation in mice by regulating gut microbiota composition and metabolism. Food & function 23 34784410
2018 Strawberry seed extract and its major component, tiliroside, promote ceramide synthesis in the stratum corneum of human epidermal equivalents. PloS one 21 30300355
2017 Autosomal recessive congenital ichthyosis: CERS3 mutations identified by a next generation sequencing panel targeting ichthyosis genes. European journal of human genetics : EJHG 21 28875980
2023 Mutational Spectrum of the ABCA12 Gene and Genotype-Phenotype Correlation in a Cohort of 64 Patients with Autosomal Recessive Congenital Ichthyosis. Genes 18 36980989
2013 Expression of a tumor-associated gene, LASS2, in the human bladder carcinoma cell lines BIU-87, T24, EJ and EJ-M3. Experimental and therapeutic medicine 17 23407876
2021 Comprehensive stratum corneum ceramide profiling reveals reduced acylceramides in ichthyosis patient with CERS3 mutations. The Journal of dermatology 15 33492757
2025 Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression. Cell metabolism 13 40609532
2017 [Elucidation of the Synthetic Mechanism of Acylceramide, an Essential Lipid for Skin Barrier Function]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 11 28966260
2020 Gentiana lutea Extract Modulates Ceramide Synthesis in Primary and Psoriasis-Like Keratinocytes. Molecules (Basel, Switzerland) 10 32316273
2022 Sulfonated (1 → 6)-β-d-Glucan (Lasiodiplodan): A Promising Candidate against the Acyclovir-Resistant Herpes Simplex Virus Type 1 (HSV-1) Strain. Biomacromolecules 9 36173245
2021 β-Sitosterol 3-O-D-glucoside increases ceramide levels in the stratum corneum via the up-regulated expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructed human epidermal keratinization model. PloS one 9 33684145
2024 Genomic characterization of dryland adaptation in endangered Anxi cattle in China. Animal genetics 8 38436096
2022 Weill-Marchesani syndrome 4 caused by compound heterozygosity of a maternal submicroscopic deletion and a paternal nonsense variant in the ADAMTS17 gene: A case report. American journal of ophthalmology case reports 8 35496767
2021 Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 8 33844153
2020 Congenital ichthyosis in Prader-Willi syndrome associated with maternal chromosome 15 uniparental disomy: Case report and review of autosomal recessive conditions unmasked by UPD. American journal of medical genetics. Part A 8 32815268
2023 Expression of Ceramide-Metabolizing Enzymes in the Heart Adipose Tissue of Cardiovascular Disease Patients. International journal of molecular sciences 7 37298446
2017 Effect of glycation focusing on the process of epidermal lipid synthesis in a reconstructed skin model and membrane fluidity of stratum corneum lipids. Dermato-endocrinology 7 29484088
2022 Epidermal 1-O-acylceramides appear with the establishment of the water permeability barrier in mice and are produced by maturating keratinocytes. Lipids 6 35318678
2022 Genotype of autosomal recessive congenital ichthyosis from a tertiary care center in India. Pediatric dermatology 6 35412663
2018 Phytosphingosine Increases Biosynthesis of Phytoceramide by Uniquely Stimulating the Expression of Dihydroceramide C4-desaturase (DES2) in Cultured Human Keratinocytes. Lipids 6 30460697
2025 Effects of Th1/Th17 and Th2 cytokines on lipid metabolism in differentiated keratinocytes. Frontiers in physiology 5 40046180
2022 Alteration to the Skin Ceramide Profile Following Broad-Spectrum UV Exposure. Journal of drugs in dermatology : JDD 5 35005872
2022 The Sphingolipid Asset Is Altered in the Nigrostriatal System of Mice Models of Parkinson's Disease. Biomolecules 5 35053241
2021 Generation of Stilbene Glycoside with Promising Cell Rejuvenation Activity through Biotransformation by the Entomopathogenic Fungus Beauveria bassiana. Biomedicines 5 34067529
2020 Congenital ichthyosiform erythroderma with a novel variant in ABCA12 in a Chinese patient. Pediatric investigation 5 32851342
2023 Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis. Biomedicines 3 36831084
2023 A Novel Eight-Gene Signature for Lipid Metabolism Predicts the Progression of Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma. Reproductive sciences (Thousand Oaks, Calif.) 3 37749448
2021 Electrolytic-reduction ion water induces ceramide synthesis in human skin keratinocytes. Drug discoveries & therapeutics 3 34707072
2025 Metabolome and transcriptome analyses reveal the mechanism underlying the differences in skin development between the two duck breeds during embryonic stage. Poultry science 2 40499236
2025 Polysaccharide from Prinsepia utilis Royle maintains the skin barrier by mediating differentiation, lipid metabolism and tight junction of keratinocyte. Scientific reports 2 40595762
2024 DNA Methylation Patterns Associated with Tinnitus in Young Adults-A Pilot Study. Journal of the Association for Research in Otolaryngology : JARO 2 39147981
2022 Clinical and genetic investigation of ichthyosis in familial and sporadic cases in south of Tunisia: genotype-phenotype correlation. BMC medical genomics 2 34983512
2022 Ceramide synthase 3 affects invasion and metastasis of hepatocellular carcinoma via the SMAD6 gene. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2 35753729
2025 Effects of natural killer cell‑conditioned medium on UVB‑induced photoaging in human keratinocytes and a human reconstructed skin model. Molecular medicine reports 1 40084708
2025 Host sphingolipids support Plasmodium berghei liver stage development. mBio 1 40689642
2025 GBA3 as a regulator of sphingolipid metabolism in the progression of hepatocellular carcinoma. Journal of gastrointestinal oncology 1 40950347
2025 Epigenetic remodeling of sheep oocytes and embryos induced by maternal methionine supplementation. Epigenetics 1 41024457
2024 Hair Growth-Promoting Effect of Hydrangea serrata (Thunb.) Ser. Extract and Its Active Component Hydrangenol: In Vitro and In Vivo Study. International journal of molecular sciences 1 39408700
2024 Molecular analysis of inherited disorders of cornification in polish patients show novel variants and functional data and provokes questions on the significance of secondary findings. Orphanet journal of rare diseases 1 39501396
2023 Differentiation-linked changes in the biosynthesis and turnover of sphingomyelins in rat male germ cells: Genes involved and effects of testosterone. The Journal of biological chemistry 1 36841478
2026 Sirtuin 1 mediated ceramide metabolism regulates intestinal mechanical barrier function in turbot (Scophthalmus maximus L.). International journal of biological macromolecules 0 41856194
2026 Response surface methodology optimization of cell-free supernatant from P. pentosaceus BJQ fermentation of CeRS3 and its in vitro lipid-lowering effects. Journal of microbiological methods 0 41936882
2026 Tape strips capture immune and epidermal hyperplasia markers in the major orphan ichthyoses. The Journal of investigative dermatology 0 41966446
2026 Dysregulation of fatty acid and sphingolipid metabolism is involved in abnormal nasal epithelial differentiation. International archives of allergy and immunology 0 42044130
2025 Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations. Epigenetics 0 40143670
2025 Type 3 resistant starch from Canna edulis improves Parkinson's symptoms, including behavioral function and nerve damage, in Parkinson's model rats by regulating the gut-brain axis. The Journal of nutritional biochemistry 0 41338420