Affinage

CD8B

T-cell surface glycoprotein CD8 beta chain · UniProt P10966

Length
210 aa
Mass
23.7 kDa
Annotated
2026-06-09
59 papers in source corpus 16 papers cited in narrative 14 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CD8B encodes the β subunit of the CD8αβ coreceptor that endows cytotoxic T cells with sensitive recognition of peptide–MHC class I antigen (PMID:9973530). Its extracellular Ig-like domain directly engages MHC class I/β2-microglobulin and raises the avidity of CD8 binding, while also coupling efficiently to the TCR/CD3 complex; both ectodomain and cytoplasmic functions contribute to CD8+ T cell development in vivo (PMID:10795739, PMID:9574520, PMID:9973530). The cytoplasmic tail of CD8β is palmitoylated, which partitions the coreceptor into lipid rafts where it associates constitutively with p56(lck) and with TCR/CD3, so that MHC-peptide engagement activates raft-localized Lck to phosphorylate CD3 and initiate signaling (PMID:11714755, PMID:10795739). Surface display of CD8β is strictly dependent on co-expression of CD8α, with which it forms disulfide-bonded heterodimers and higher-order oligomers (PMID:3258885, PMID:3145196, PMID:2452747, PMID:6166718). CD8β function is further tuned by post-translational and developmental controls: ST3Gal-1–mediated sialylation of stalk O-glycans acts as a thymic maturation switch modulating MHC I binding avidity (PMID:12459555), ART2.2-catalyzed ADP-ribosylation of extracellular arginines impairs MHC-I tetramer binding and in vivo cytotoxicity (PMID:23575529), and CD8β onset during human thymopoiesis coincides with pre-TCR signaling and β-selection (PMID:10552959). Human CD8B produces alternatively spliced isoforms with distinct cytoplasmic tails (M-1 to M-4) that differ in T cell subset distribution, ubiquitination-driven trafficking, internalization, and functional output (PMID:18490743, PMID:23533620).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1981 Medium

    Established that CD8 is a multi-subunit cell surface molecule in which CD8β (Lyt-3) is a distinct disulfide-bonded chain that modulates, but is not strictly required for, cytolytic activity.

    Evidence mAb precipitation, 2D gel electrophoresis, protease stripping, and cytotoxicity blocking on murine effector cells

    PMID:6166718

    Open questions at the time
    • Did not define the molecular basis of CD8β's contribution to MHC binding or signaling
    • Subunit stoichiometry of dimers/tetramers/hexamers not functionally dissected
  2. 1988 High

    Answered why CD8β does not appear alone by showing its surface expression requires CD8α, defining an obligate assembly dependency.

    Evidence Transfection of Ly-3 alone versus Ly-2/Ly-3 co-transfection into mouse L cells with flow cytometry

    PMID:2452747 PMID:3145196 PMID:3258885

    Open questions at the time
    • Trafficking/folding step at which CD8α is required was not identified
    • Did not address functional role of the heterodimer
  3. 1998 Medium

    Distinguished the ectodomain contribution of CD8β, showing it independently binds MHC I/β2m and uniquely couples to TCR/CD3.

    Evidence Chimeric CD8β/α molecules and binding assays with T hybridoma alloantigen responses

    PMID:9574520

    Open questions at the time
    • Affinities and binding geometry not quantified
    • Single-lab functional readout without structural data
  4. 1999 Medium

    Quantified the coreceptor advantage of CD8αβ over CD8αα, showing the CD8β ectodomain confers ~100-fold greater antigen sensitivity independent of cytoplasmic tails.

    Evidence Transfection of CD8α with/without CD8β and cytoplasmic deletion mutants in N15wt hybridoma, IL-2 readout

    PMID:9973530

    Open questions at the time
    • Mechanism by which ectodomain enhances avidity not resolved at molecular level
    • Single cell-line system
  5. 1999 Medium

    Placed CD8β acquisition in developmental context, showing its onset coincides with pre-TCR signaling and β-selection during human thymopoiesis.

    Evidence Multicolor flow cytometry of primary human thymocyte subsets correlated with intracellular TCRβ and pre-TCRα

    PMID:10552959

    Open questions at the time
    • Correlative; causal link between CD8β onset and β-selection not tested
    • Transcriptional regulators of timing not identified
  6. 2000 High

    Dissected in vivo the division of labor between CD8β domains, showing the ectodomain raises MHC I avidity while the cytoplasmic tail enhances Lck and LAT association, with both contributing to CD8+ T cell development.

    Evidence Reconstitution of CD8β-deficient mice with chimeric transgenes, avidity assays, co-IP for Lck/LAT

    PMID:10795739

    Open questions at the time
    • Did not resolve the biochemical step linking cytoplasmic tail to Lck/LAT recruitment
    • Relative quantitative contributions in mature effector function not separated
  7. 2001 High

    Defined the signaling mechanism: palmitoylation of the CD8β cytoplasmic tail drives raft partitioning, constitutive p56(lck) and TCR/CD3 association, and Lck activation upon MHC-peptide engagement.

    Evidence TCR photoaffinity labeling, CD8β cytoplasmic mutants in T1.4 hybridomas, raft fractionation, co-IP

    PMID:11714755

    Open questions at the time
    • Palmitoyl-transferase responsible not identified
    • Dynamics of raft entry/exit during signaling not measured
  8. 2002 High

    Identified a glycan-based developmental switch: ST3Gal-1 sialylation of CD8β stalk O-glycans during thymic maturation alters MHC I binding avidity.

    Evidence ES-MS and MS/MS of CD8β glycopeptides from immature versus mature thymocytes

    PMID:12459555

    Open questions at the time
    • Functional consequence on selection thresholds not directly tested
    • Whether sialylation is reversed in peripheral effector cells unknown
  9. 2008 Medium

    Revealed isoform diversity, showing human CD8β splice variants are differentially distributed across T cell subsets, with M-2 trafficked to a lysosomal compartment via cytoplasmic ubiquitination at K215.

    Evidence qRT-PCR in primary human T cells, confocal localization of chimeras, ubiquitination assay

    PMID:18490743

    Open questions at the time
    • Functional impact of isoform-specific trafficking on signaling not established
    • Ubiquitin ligase not identified
  10. 2008 Medium

    Showed CD8β is not strictly essential, as CD8β-knockout mice mount normal antiviral responses by preferentially selecting CD8-independent TCRs.

    Evidence CD8β KO mice, tetramer staining, cytotoxicity, TCR repertoire analysis in LCMV infection

    PMID:19088062

    Open questions at the time
    • Compensatory repertoire shift mechanism not molecularly defined
    • May not generalize to CD8-dependent or chronic antigens
  11. 2013 Medium

    Defined isoform-specific trafficking control and effector tuning, showing the M-4 cytoplasmic tail uses a leucine-based internalization motif and mono-ubiquitination to regulate surface expression and enhance antigen-induced cytokine secretion.

    Evidence Mutagenesis of leucine and NPW motifs, ubiquitination assays in 293T and human T cells, MIP-1β secretion assay

    PMID:23533620

    Open questions at the time
    • EH-domain partner of the NPW motif not identified
    • Mechanistic link from trafficking to enhanced cytokine output unresolved
  12. 2013 High

    Identified ADP-ribosylation as a post-translational off-switch, showing ART2.2 modifies extracellular arginines of CD8β to impair MHC-I tetramer binding and in vivo cytotoxicity.

    Evidence NAD+ treatment of murine CD8+ T cells, ART2-deficient mice, inhibitory anti-ART2.2 nanobodies, tetramer binding and in vivo cytotoxicity assays

    PMID:23575529

    Open questions at the time
    • Specific modified arginine residues not mapped
    • Physiological contexts of extracellular NAD+ exposure not defined
  13. 2024 Medium

    Linked cytokine environment to coreceptor remodeling, showing IL-15 drives cell-cycle-dependent CD8β down-modulation and isoform mRNA shifts, generating CD8αβlow/CD8αα cells with elevated Lck.

    Evidence CFSE labeling, flow cytometry, qPCR for CD8α/CD8β isoforms, intracellular Lck staining across IL-2/IL-7/IL-15

    PMID:38903513

    Open questions at the time
    • Functional consequence of IL-15-driven CD8β loss on T cell function not established
    • Signaling pathway from IL-15 to isoform switch unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the multiple post-translational and isoform-level controls on CD8β (palmitoylation, sialylation, ADP-ribosylation, ubiquitination, splicing) are integrated to set coreceptor avidity and signaling thresholds across development and effector states remains unresolved.
  • No structural model integrating glycan/ADP-ribosylation effects on MHC binding
  • Enzymes for palmitoylation and isoform ubiquitination unidentified
  • Interplay between cytokine-driven down-modulation and antigen sensitivity untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 3 GO:0098631 cell adhesion mediator activity 2
Localization
GO:0005886 plasma membrane 3 GO:0005764 lysosome 1
Pathway
R-HSA-168256 Immune System 3 R-HSA-1266738 Developmental Biology 2 R-HSA-162582 Signal Transduction 2
Partners
ART2.2CD8ALATLCKST3GAL1
Complex memberships
CD8αβ coreceptorTCR/CD3 complex

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 The cytoplasmic portion of CD8β, primarily due to its palmitoylation, mediates partitioning of CD8 into lipid rafts, where it efficiently associates with p56(lck). The cytoplasmic portion of CD8β also mediates constitutive association of CD8 with TCR/CD3, and because CD8αβ partitions in rafts, its interaction with TCR/CD3 promotes raft association of TCR/CD3. Engagement of these TCR/CD3-CD8/lck adducts by multimeric MHC-peptide induces activation of p56(lck) in rafts, which phosphorylates CD3 and initiates T cell activation. TCR photoaffinity labeling, transfection of CD8β cytoplasmic mutants into T1.4 hybridomas, lipid raft fractionation, co-immunoprecipitation The Journal of experimental medicine High 11714755
2000 The CD8β extracellular domain increases the avidity of CD8 binding to MHC class I, and the intracellular domain of CD8β enhances association with Lck and LAT, two intracellular signaling molecules required for TCR signal transduction. Both the intracellular and extracellular domains of CD8β can contribute independently to CD8+ T cell development in vivo, but together are most efficient. In vivo reconstitution of CD8β-deficient mice with transgenic CD8β chimeric molecules, MHC I binding avidity assays, co-immunoprecipitation for Lck and LAT association Immunity High 10795739
2002 CD8β core type-1 O-glycans on threonine residues proximal to the CD8β Ig headpiece are sialylated by ST3Gal-1 sialyltransferase during thymic maturation. Non-sialylated glycoforms are present in immature thymocytes but absent in mature thymocytes, and this sialylation creates a molecular developmental switch that affects MHC class I ligand binding avidity. Electrospray mass spectrometry (ES-MS) and tandem MS/MS analysis of CD8β glycopeptides from immature and mature thymocytes The Journal of biological chemistry High 12459555
1998 The extracellular portion of CD8β is capable of independent interaction with MHC class I/β2-microglobulin dimers in the absence of CD8α, and CD8β may further enhance interaction with MHC class I/β2m when associated with CD8α. Additionally, the extracellular portion of CD8β is uniquely capable of efficient interaction with the TCR/CD3 complex, coupling it to surface components that enhance TCR-mediated signals. T hybridoma responses to alloantigen, chimeric CD8β-α molecules (extracellular CD8β, transmembrane/cytoplasmic CD8α), binding assays Journal of immunology Medium 9574520
1999 The ectodomain of CD8β greatly enhances the coreceptor function of CD8αβ relative to CD8αα homodimers, conferring ~100-fold greater sensitivity to peptide antigen-induced IL-2 production; this enhancement is independent of both CD8α and CD8β cytoplasmic tails, as demonstrated by cytoplasmic deletion mutants. Transfection of CD8α alone or with CD8β cDNA into mouse T cell hybridoma N15wt; analysis of IL-2 production with cytoplasmic deletion mutants Cellular immunology Medium 9973530
1988 CD8β (Ly-3) requires CD8α (Ly-2) for cell surface expression; transfection of the Ly-3 gene alone does not result in detectable surface expression of Ly-3 antigenic determinants, whereas co-transfection with Ly-2 results in surface expression. Conversely, Ly-2 surface expression is not dependent on Ly-3. Gene transfection into mouse L cells, flow cytometry with monoclonal antibodies Journal of immunology High 2452747 3145196 3258885
2013 ART2.2 (ADP-ribosyl transferase 2.2) uses extracellular NAD+ to ADP-ribosylate CD8β on arginine residues of its extracellular domain on murine CD8+ T cells. This modification prevents binding of anti-CD8β mAb YTS156.7.7, interferes with MHC-I tetramer binding, and reduces CD8+ T-cell-mediated cytotoxicity in vivo. In vitro and in vivo NAD+ treatment of murine CD8+ T cells, ART2-deficient mice, inhibitory anti-ART2.2 single-domain antibodies, OVA:MHC-I tetramer binding assay, in vivo cytotoxicity assay European journal of immunology High 23575529
2008 Human CD8β splice variants (M-1, M-2, M-3, M-4) differ in expression patterns across T cell subsets: M-1 is predominant in naïve T cells, M-4 is predominant in effector memory T cells, and M-2 mRNA is elevated 10–20-fold upon T cell stimulation. The M-2 isoform is targeted to a lysosomal compartment via ubiquitination of lysine K215 in its cytoplasmic tail; upon short-term stimulation, M-2 localizes to the cell surface with the TCR complex. Quantitative RT-PCR in primary human T cells; fluorescent chimera localization by confocal microscopy in transfected cell lines; ubiquitination assay Journal of immunology Medium 18490743
2013 The CD8β M-4 isoform contains a dihydrophobic leucine-based receptor internalization motif in its cytoplasmic tail that regulates cell surface expression and downregulation after activation. The M-4 cytoplasmic tail associates with ubiquitinated targets, is itself mono-ubiquitinated on a lysine residue, and contains an NPW motif (potential EH domain binding site) that modulates ubiquitinated target interaction. T cells expressing CD8αβ M-4 showed twofold higher frequency of MIP-1β secreting cells responding to antigen compared to M-1 expressing T cells. Mutagenesis of leucine-based motif and NPW motif, ubiquitination assays in 293T cells and human T cell line, functional cytokine secretion assay with primary peripheral blood T cells PloS one Medium 23533620
1981 Lyt-2 (CD8α) and Lyt-3 (CD8β) antigens are carried on separate disulfide-bonded subunits of the same cell surface macromolecule, present as dimers, tetramers, and hexamers on thymocytes. Selective tryptic removal of Lyt-3 (CD8β) from cytotoxic effector cells does not abolish cytotoxic activity, but reduces blocking by anti-Lyt-3 while increasing blocking by anti-Lyt-2, suggesting CD8β modulates but is not essential for cytolytic activity. Monoclonal antibody precipitation, SDS-PAGE, 2D gel electrophoresis, protease treatment of effector cells, cytotoxicity blocking assay The Journal of experimental medicine Medium 6166718
1999 During human intrathymic development, CD8β expression is acquired after CD8α and coincides with expression of cytoplasmic TCRβ chain (TCRβic) and surface CD3 and pre-TCRα. CD8β onset marks the transition associated with pre-TCR-mediated beta-selection, and CD8αβ heterodimers are selectively found on DP thymocytes that have undergone pre-TCR signaling. In vivo analysis of human thymocyte subsets; multicolor flow cytometry; correlation of CD8β with TCRβic and proliferative status Blood Medium 10552959
2024 IL-15 induces cell-cycle-dependent down-modulation of CD8β from the surface of human naïve CD8+ T cells, generating CD8αβlow and CD8αα T cells. This is associated with a decrease in mRNA of the CD8β M-4 isoform while M-1/M-2 isoform and CD8α mRNA levels increase. CD8+ T cell blasts generated by IL-15 show increased Lck levels, distinct from cells cultured with IL-2 or IL-7. CFSE labeling, flow cytometry, qPCR for CD8α and CD8β isoforms, intracellular Lck staining, cytokine comparison (IL-2, IL-7, IL-15) Frontiers in immunology Medium 38903513
2008 In CD8β knockout mice, CD8+ T cells mount normal primary, secondary, and memory responses to acute LCMV infection because CD8-independent TCRs are preferentially selected in the absence of CD8β, effectively compensating for reduced coreceptor function of CD8αα. The TCR repertoire, particularly the TCRα chain, differs between CD8β KO and wild-type mice. CD8β knockout mice, tetramer staining, cytotoxicity assays, TCR repertoire analysis, LCMV infection model International immunology Medium 19088062
1998 Cross-linking of macrophage CD8β (in addition to CD8α) stimulates nitric oxide production and upregulation of inducible NO synthase. This signaling through CD8β is inhibited by broad-spectrum protein tyrosine kinase inhibitors (genistein), src-family kinase inhibitor (PP1), and PKC inhibitors, indicating involvement of src-family tyrosine kinases and PKC downstream of CD8β. Antibody cross-linking of rat macrophage CD8β, NO production assay, iNOS Western blot, pharmacological inhibitors of kinase pathways Journal of immunology Medium 9637515

Source papers

Stage 0 corpus · 59 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2001 CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes. The Journal of experimental medicine 173 11714755
1981 Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity. The Journal of experimental medicine 170 6166718
2005 Characterisation of salmon and trout CD8alpha and CD8beta. Molecular immunology 134 15829311
1988 Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expression. Journal of immunology (Baltimore, Md. : 1950) 104 3258885
2014 Elevated T cell receptor signaling identifies a thymic precursor to the TCRαβ(+)CD4(-)CD8β(-) intraepithelial lymphocyte lineage. Immunity 85 25131532
2000 Role of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus. Immunity 84 10795739
1988 The human Lyt-3 molecule requires CD8 for cell surface expression. The EMBO journal 72 3145196
2012 CD4 and CD8 homologues in Japanese flounder, Paralichthys olivaceus: Differences in the expressions and localizations of CD4-1, CD4-2, CD8α and CD8β. Developmental and comparative immunology 63 23089138
2002 Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction. The Journal of biological chemistry 61 12459555
2017 Characterizations of CD4-1, CD4-2 and CD8β T cell subpopulations in peripheral blood leucocytes, spleen and head kidney of Japanese flounder (Paralichthys olivaceus). Molecular immunology 56 28260650
1988 Gene transfer of the Ly-3 chain gene of the mouse CD8 molecular complex: co-transfer with the Ly-2 polypeptide gene results in detectable cell surface expression of the Ly-3 antigenic determinants. European journal of immunology 49 2452747
1987 A human homolog of the mouse CD8 molecule, Lyt-3: genomic sequence and expression. Immunogenetics 43 3114136
2015 Magnitude and kinetics of multifunctional CD4+ and CD8β+ T cells in pigs infected with swine influenza A virus. Veterinary research 42 25971313
2007 Molecular cloning and characterization of carp (Cyprinus carpio L.) CD8beta and CD4-like genes. Fish & shellfish immunology 38 17977746
2007 Genomic organization and expression of CD8alpha and CD8beta genes in fugu Takifugu rubripes. Fish & shellfish immunology 37 17629710
1998 Mechanisms of macrophage stimulation through CD8: macrophage CD8alpha and CD8beta induce nitric oxide production and associated killing of the parasite Leishmania major. Journal of immunology (Baltimore, Md. : 1950) 37 9637515
1987 Molecular cloning of Lyt-3, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to immunoglobulin and T-cell receptor variable and joining regions. Proceedings of the National Academy of Sciences of the United States of America 37 3035575
1999 Beta-selection is associated with the onset of CD8beta chain expression on CD4(+)CD8alphaalpha(+) pre-T cells during human intrathymic development. Blood 36 10552959
1999 The CD8beta ectodomain contributes to the augmented coreceptor function of CD8alphabeta heterodimers relative to CD8alphaalpha homodimers. Cellular immunology 32 9973530
1997 The Bop gene adjacent to the mouse CD8b gene encodes distinct zinc-finger proteins expressed in CTLs and in muscle. Journal of immunology (Baltimore, Md. : 1950) 30 9013956
1979 Ef2: a new LY-3-linked light-chain marker expressed in normal mouse serum immunoglobulin. The Journal of experimental medicine 29 109570
1983 Recombination between kappa chain genetic markers and the Lyt-3 locus. Immunogenetics 27 6411613
2011 Identification of CD3ε, CD4, CD8β splice variants of Atlantic salmon. Fish & shellfish immunology 25 21821134
2018 Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β+ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules. Frontiers in immunology 23 29930558
1987 Molecular characterization of the murine cytotoxic T-cell membrane glycoprotein Ly-3 (CD8). Proceedings of the National Academy of Sciences of the United States of America 23 3498943
2013 CD8-β ADP-ribosylation affects CD8(+) T-cell function. European journal of immunology 22 23575529
1997 Polymorphism of chicken CD8-alpha, but not CD8-beta. Immunogenetics 21 9271629
1989 Isolation and characterization of the mouse CD8 beta-chain (Ly-3) genes. Absence of an intervening sequence between V- and J-like gene segments. Journal of immunology (Baltimore, Md. : 1950) 21 2784466
1995 Bop: a new T-cell-restricted gene located upstream of and opposite to mouse CD8b. Immunogenetics 19 7590968
2010 Molecular cloning and expression of orange-spotted grouper (Epinephelus coioides) CD8α and CD8β genes. Fish & shellfish immunology 17 21193050
2008 Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. Journal of immunology (Baltimore, Md. : 1950) 17 18490743
2003 CD8beta/CD28 expression defines functionally distinct populations of peripheral blood T lymphocytes. Clinical and experimental immunology 16 12930358
1997 Identification of an enriched CD4+ CD8alpha++ CD8beta+ T-cell subset among tumor-infiltrating lymphocytes in human renal cell carcinoma. International journal of cancer 15 9139839
2011 Channel catfish CD8α and CD8β co-receptors: characterization, expression and polymorphism. Fish & shellfish immunology 14 21272650
1998 Mechanisms of CD8beta-mediated T cell response enhancement: interaction with MHC class I/beta2-microglobulin and functional coupling to TCR/CD3. Journal of immunology (Baltimore, Md. : 1950) 14 9574520
2024 Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β. European journal of nuclear medicine and molecular imaging 13 39218831
2007 Inhibitory effect of dietary n-3 polyunsaturated fatty acids to intestinal IL-15 expression is associated with reduction of TCRalphabeta+CD8alpha+CD8beta-intestinal intraepithelial lymphocytes. The Journal of nutritional biochemistry 12 17855067
2004 Molecular characterization of guinea - pig (Cavia porcellus) CD8alpha and CD8beta cDNA. Tissue antigens 12 14705990
2000 CD8+ thymic lymphocytes express reduced levels of CD8beta and increased interferon gamma in cats perinatally infected with the JSY3 molecular clone of feline immunodeficiency virus. AIDS research and human retroviruses 11 11054269
2019 CD8β Depletion Does Not Prevent Control of Viral Replication or Protection from Challenge in Macaques Chronically Infected with a Live Attenuated Simian Immunodeficiency Virus. Journal of virology 9 31092584
1993 Differential susceptibility of mouse Lyt-2 and Lyt-3 genes to negative regulation. Immunogenetics 9 8423051
2020 CD45RA, CD8β, and IFNγ Are Potential Immune Biomarkers of Human Cognitive Function. Frontiers in immunology 7 33324408
2008 CD8beta knockout mice mount normal anti-viral CD8+ T cell responses--but why? International immunology 7 19088062
1982 The lateral mobility and surface distribution of Lyt-1, Lyt-2 and Lyt-3 on mouse thymocytes. Molecular immunology 7 6191201
2021 Expression and polymorphisms of CD8B gene and its associations with body weight and size traits in sheep. Animal biotechnology 6 34928779
2017 CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin. Journal of leukocyte biology 6 28637895
2016 Monitoring of local CD8β-expressing cell populations during Eimeria tenella infection of naïve and immune chickens. Parasite immunology 6 27138684
2020 An engineered anti-idiotypic antibody-derived killer peptide (KP) early activates swine inflammatory monocytes, CD3+CD16+ natural killer T cells and CD4+CD8α+ double positive CD8β+ cytotoxic T lymphocytes associated with TNF-α and IFN-γ secretion. Comparative immunology, microbiology and infectious diseases 5 32758800
2013 The human CD8β M-4 isoform dominant in effector memory T cells has distinct cytoplasmic motifs that confer unique properties. PloS one 5 23533620
2001 Differential modulation of CD8beta by rat gammadelta and alphabeta T cells after activation. Immunology 5 11722639
1997 Expression of CD8beta and alteration of cell surface phenotype in adult T-cell leukaemia cells. British journal of haematology 3 9233579
1996 Autoimmune diabetes-prone NOD mice express the Lyt2 alpha (Lyt2.1) and Lyt3 alpha (Lyt3.1) alleles of CD8. Immunogenetics 3 8537123
1985 Functional relationships of Lyt-2 and Lyt-3 expression and T-cell cytotoxicity: a new model system. Advances in experimental medicine and biology 3 3875974
2024 In vitro IL-15-activated human naïve CD8+ T cells down-modulate the CD8β chain and become CD8αα T cells. Frontiers in immunology 1 38903513
1986 [Characteristics of the T-lymphocytes interacting with hematopoietic stem cells: the expression of Lyt-3 antigen]. Tsitologiia 1 3087041
2026 Development of anti-CD4-1/CD8β monoclonal antibodies and spatiotemporal immune profiling of response to live attenuated IHNV in rainbow trout (Oncorhynchus mykiss). Fish & shellfish immunology 0 41796695
2026 Divergent transcriptomic trajectories in CD4/CD8β/TcR1 bead-enriched peripheral lymphocyte fraction following experimental infection with low- and high-virulence strains of noncytopathic bovine viral diarrhea virus type 2. Virus research 0 42034289
2025 Phenotypes of porcine blood CD8β T cells and their capacity for IFN gamma production in the context of PRV vaccination. Developmental and comparative immunology 0 39988100
2024 Characterization of a novel functional porcine CD3+CD4lowCD8α+CD8β+ T-helper/memory lymphocyte subset in the respiratory tract lymphoid tissues of swine influenza A virus vaccinated pigs. Veterinary immunology and immunopathology 0 38861830

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