Affinage

CCDC146

Coiled-coil domain-containing protein 146 · UniProt Q8IYE0

Length
955 aa
Mass
112.8 kDa
Annotated
2026-06-09
83 papers in source corpus 11 papers cited in narrative 11 extracted findings
Cross-family judge faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CCDC146 (MBO2) is a conserved coiled-coil protein that functions as an axonemal component of motile cilia and flagella, where it is tightly associated with doublet microtubules and governs ciliary waveform (PMID:11977094, PMID:6725408). Genetic analysis in Chlamydomonas first established that loss of MBO2 locks flagella into a symmetric "move-backward-only" waveform, eliminates the asymmetric beat required for forward motility, and removes a defined set of axonemal polypeptides together with beak-like B-tubule projections of specific outer doublets (PMID:6725408). Cryo-electron tomography places CCDC146 and FAP58/CCDC147 within a conserved L-shaped structure that interconnects inner dynein arms with regulatory complexes including radial spokes and central-pair projections, providing a structural basis for its control of beat coordination (PMID:38568782). In mammals, CCDC146 is a microtubule-associated protein that localizes to the centrosome and microtubule-related organelles during mitosis in somatic cells, and to the axonemal microtubule doublets as a probable microtubule inner protein in spermatozoa (PMID:38441556). It is essential for sperm flagellum biogenesis: it physically interacts with CCDC38, CCDC42, and the intraflagellar transport proteins IFT88 and IFT20, and its loss destabilizes IFT20, IFT88, ODF2, and axonemal dyneins (DNAH17, DNAH1, SPAG6), disrupting the manchette, head-tail coupling apparatus, and axoneme (PMID:38038747, PMID:39245651). Bi-allelic pathogenic CCDC146 mutations cause multiple morphological abnormalities of the flagellum (MMAF) and oligoasthenoteratozoospermia with male infertility, recapitulated in knockout and knock-in mice that show severe sperm nuclear and chromatin defects (PMID:38441556, PMID:39245651, PMID:40070084). Beyond its motility role, CCDC146 is directly bound by the Chlamydia trachomatis inclusion membrane protein CT288 and recruited to the chlamydial inclusion periphery (PMID:30094225).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1984 High

    Established that the MBO2 locus controls ciliary waveform asymmetry, the first mechanistic link between this gene and flagellar motility.

    Evidence Genetic analysis with reactivated isolated axonemes, 2D-PAGE of labeled axonemes, and EM ultrastructure in Chlamydomonas mbo2 mutants

    PMID:6725408

    Open questions at the time
    • Did not identify the molecular product of the locus
    • Mechanism by which loss converts asymmetric to symmetric beat unresolved
  2. 2002 High

    Identified the MBO2 gene product as a coiled-coil axonemal protein distributed along the flagellar length and tightly bound to doublet microtubules, with a C-terminal domain regulating force generation.

    Evidence Molecular cloning, antibody immunolocalization, epitope-tag swimming assay, and axonemal fractionation in Chlamydomonas

    PMID:11977094

    Open questions at the time
    • Did not define the protein complex partners
    • No structural placement within the axoneme
  3. 2014 Medium

    Extended CCDC146 to mammals as a centrosome-associated protein, linking the axonemal protein to centriole biology.

    Evidence Mass spectrometry of isolated sperm centrioles with immunofluorescence in cultured cells

    PMID:25074808

    Open questions at the time
    • No functional consequence tested for CCDC146
    • Centrosomal versus axonemal role not distinguished
  4. 2018 High

    Revealed a non-motility interaction in which a pathogen protein hijacks CCDC146, identifying its first direct binding partner in human cells.

    Evidence Yeast two-hybrid, reciprocal co-IP, and live-cell imaging with cytoskeleton/Golgi perturbation in Chlamydia-infected mammalian cells

    PMID:30094225

    Open questions at the time
    • Functional significance of CT288 binding for infection unknown
    • Relationship to centrosomal pool of CCDC146 unresolved
  5. 2019 Medium

    Confirmed conservation of MBO2 function in directional flagellar motility in a trypanosomatid, generalizing its role across motile-cilium-bearing eukaryotes.

    Evidence CRISPR-Cas9 knockout, in vivo barcode fitness assay, and motility analysis in Leishmania mexicana

    PMID:31242261

    Open questions at the time
    • No molecular partners or structural placement defined in this system
    • Ortholog study outside mammals
  6. 2023 High

    Defined CCDC146 as essential for mouse sperm flagellum biogenesis and identified its physical partners linking it to IFT machinery and other coiled-coil proteins.

    Evidence Ccdc146 knockout mouse phenotyping, co-IP with CCDC38/CCDC42/IFT88/IFT20, western blotting, and structural interaction modeling

    PMID:38038747

    Open questions at the time
    • Direct versus indirect nature of protein-level destabilization unresolved
    • Atomic interaction models not experimentally validated
  7. 2024 High

    Pinpointed the molecular site of CCDC146 action via cryo-EM, placing it in an L-shaped complex that bridges inner dynein arms to regulatory structures controlling waveform.

    Evidence Cryo-electron tomography, epitope tagging, and comparative proteomics of Chlamydomonas mbo mutants

    PMID:38568782

    Open questions at the time
    • Precise stoichiometry with FAP58/CCDC147 not defined
    • How the structure mechanically alters dynein activity unresolved
  8. 2024 High

    Established CCDC146 as a human MMAF/infertility disease gene and resolved its dual localization as a somatic microtubule-associated protein and a sperm axonemal microtubule inner protein.

    Evidence Patient cohort sequencing, KO mouse, expansion microscopy, sarkosyl fractionation, and immunofluorescence

    PMID:38441556

    Open questions at the time
    • MIP assignment based on solubilization inference, not direct structure
    • Mechanism coupling loss to multi-organelle (manchette, HTCA) failure unresolved
  9. 2024 High

    Showed that a truncating mutation abolishes the CCDC146-IFT20 interaction, mechanistically tying CCDC146 loss to IFT20 degradation and axonemal dynein depletion.

    Evidence Patient sequencing, knock-in mouse, co-IP of wild-type versus mutant CCDC146 with IFT20, and western blotting of axonemal proteins

    PMID:39245651

    Open questions at the time
    • Whether IFT20 loss alone accounts for the full phenotype unknown
    • Domain mapping of the IFT20-binding region incomplete
  10. 2025 Medium

    Quantified the severity of sperm nuclear and chromatin defects upon CCDC146 loss relative to other MMAF genes, linking it to post-fertilization embryo failure.

    Evidence Comparative KO mouse study with nuclear morphology, DNA compaction/ploidy assays, and ICSI embryo development tracking

    PMID:40070084

    Open questions at the time
    • Causal pathway from axonemal/manchette defect to nuclear/chromatin defect not established
    • Single comparative study
  11. 2025 Medium

    Proposed a primary-cilium-based role for CCDC146 in motor neurons relevant to ALS, where its overexpression impairs cilia and depletion rescues neuronal and TDP-43 pathology.

    Evidence iPSC-derived motor neurons, ASO knockdown, cilia assays, TDP-43 immunofluorescence, and ALS mouse survival (preprint)

    PMID:38633814

    Open questions at the time
    • Preprint, not yet peer-reviewed
    • Mechanism linking CCDC146 dosage to TDP-43 mislocalization unresolved
    • Relationship to its axonemal MIP function unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • How CCDC146 mechanically couples the L-shaped axonemal complex to dynein regulation, and how its loss propagates from microtubule organelles to sperm nuclear architecture, remain unresolved.
  • No experimental validation of atomic interaction models
  • Causal chain from MIP loss to chromatin/nuclear defects undefined
  • ALS-related cilia role awaits peer-reviewed confirmation

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 2 GO:0008092 cytoskeletal protein binding 2
Localization
GO:0005929 cilium 4 GO:0005815 microtubule organizing center 3 GO:0005856 cytoskeleton 2
Pathway
R-HSA-1474165 Reproduction 3 R-HSA-1852241 Organelle biogenesis and maintenance 3
Partners
CCDC147CCDC38CCDC42CT288IFT20IFT88
Complex memberships
axonemal L-shaped MBO2/FAP58 complex

Evidence

Reading pass · 11 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 The Chlamydomonas MBO2 gene encodes a novel ~110 kDa axonemal protein with extensive alpha-helical coiled-coils and two leucine zippers. Antibodies to MBO2p localized it along the entire length of flagella (not just proximally), and it was present in paralyzed flagellar mutants lacking different axonemal structures, indicating it is a component of a previously uncharacterized flagellar protein complex tightly associated with doublet microtubules. Insertion of an HA epitope in the conserved C-terminal domain reduced swimming velocity, implicating this domain in regulation of force-generation during ciliary beat. Molecular cloning, antibody localization, epitope tagging with functional swimming assay, axonemal fractionation Cell motility and the cytoskeleton High 11977094
2018 Human CCDC146 localizes to the centrosome in uninfected mammalian cells (ectopic expression). Upon Chlamydia trachomatis infection, CCDC146 centrosomal localization diminishes and the protein accumulates at the periphery of the chlamydial inclusion. The C. trachomatis inclusion membrane protein CT288 directly binds CCDC146 (identified by yeast two-hybrid and confirmed by co-immunoprecipitation in mammalian cells). Recruitment of CCDC146 to the inclusion periphery did not require host Golgi, microtubules, or microfilaments but required chlamydial protein synthesis. A C-terminal fragment (residues 692–955) showed CT288-dependent differences in inclusion-periphery localization. Yeast two-hybrid, co-immunoprecipitation, live-cell imaging/immunofluorescence, pharmacological disruption of cytoskeleton and Golgi Frontiers in cellular and infection microbiology High 30094225
2014 CCDC146 was identified as a centrosome-associated protein in cultured mammalian cells by mass spectrometry of sperm centrioles followed by localization assessment of candidate proteins. Mass spectrometry of isolated sperm centrioles; immunofluorescence localization in cultured cells Journal of cell science Medium 25074808
2023 CCDC146 is essential for sperm flagellum biogenesis and male fertility in mice. Knockout of Ccdc146 in male mice causes complete infertility with MMAF-like phenotype (flagellum and manchette organization defects) but does not affect female fertility. CCDC146 physically interacts with CCDC38 and CCDC42 (validated interactions; atomic-level interaction models built). CCDC146 also interacts with IFT complex proteins IFT88 and IFT20. Knockout leads to decreased protein levels of ODF2, IFT88, and IFT20 but not CCDC38, CCDC42, or ODF1. Ccdc146 knockout mouse, male infertility phenotyping, co-immunoprecipitation with CCDC38/CCDC42/IFT88/IFT20, western blotting, structural interaction modeling Cellular and molecular life sciences : CMLS High 38038747
2024 CCDC146 (MBO2 ortholog) and FAP58/CCDC147 form part of a conserved L-shaped structure in the axoneme that varies between outer doublet microtubules. This L-shaped complex interconnects inner dynein arms with multiple regulatory complexes (including radial spokes and central pair projections). Loss of MBO2 in Chlamydomonas mbo mutants alters the ciliary waveform. Comparative proteomics of mbo mutants identified additional missing proteins overlapping with other motility mutants, revealing interconnected protein defects. Cryo-electron tomography, epitope tagging, comparative proteomics of mbo mutants Molecular biology of the cell High 38568782
2024 Bi-allelic pathogenic mutations in human CCDC146 cause MMAF (multiple morphological abnormalities of the flagellum) and male infertility. In somatic cells, CCDC146 localizes to the centrosome and to multiple microtubule-related organelles during mitosis, consistent with it being a microtubule-associated protein (MAP). In spermatozoa, CCDC146 localizes to the axoneme at the level of microtubule doublets (not centrioles). Expansion microscopy with sarkosyl solubilization of microtubule doublets suggests CCDC146 may be a microtubule inner protein (MIP). Ccdc146 KO mice are infertile with identical sperm phenotype; absence of CCDC146 impairs all microtubule-based organelles including manchette, HTCA, and axoneme. Patient cohort sequencing, Ccdc146 KO mouse generation, expansion microscopy, sarkosyl fractionation, immunofluorescence localization in somatic cells and spermatozoa eLife High 38441556
2024 A homozygous nonsense mutation (c.916C>T, p.Arg306*) in CCDC146 causes oligoasthenoteratozoospermia (OAT) in a human male patient. The truncated protein retains only 2 of 5 coiled-coil domains. A knock-in mouse model recapitulates infertility with reduced sperm counts, diminished motility, and multiple sperm head/flagella defects. Both human and mouse CCDC146 interact with IFT20; this interaction is lost in the mutant, leading to IFT20 degradation. Axonemal proteins DNAH17, DNAH1, and SPAG6 are significantly reduced in sperm of mutant mice. Patient sequencing, knock-in mouse model, co-immunoprecipitation of wild-type and mutant CCDC146 with IFT20, western blotting of axonemal proteins Zoological research High 39245651
2025 CCDC146 is located within the basal body of primary cilia in human motor neurons (iPSC-derived). Overexpression of CCDC146 impairs cilia structure and function. Depletion of CCDC146 using antisense oligonucleotides (ASO) rescues cilia defects caused by overexpression, rescues ALS-specific neuronal survival defects in iPSC-derived motor neurons from sporadic and familial ALS patients, and extends survival while reversing TDP-43 pathology in an ALS mouse model. A rare noncoding variant (chr7:76,009,472:C>T) in ALS patients increases CCDC146 expression and exacerbates TDP-43 mislocalization. iPSC-derived motor neurons, genetic editing of ALS variant, ASO knockdown, cilia structure/function assays, TDP-43 localization immunofluorescence, ALS mouse model survival medRxivpreprint Medium 38633814
2019 In Leishmania mexicana promastigotes, loss of the MBO2 (CCDC146 ortholog) axonemal protein results in uncoordinated swimming and prevents parasites from reaching anterior regions of the sand fly alimentary tract, demonstrating that MBO2 is required for directional flagellar motility essential for sand fly colonization. CRISPR-Cas9 knockout in Leishmania, barcode sequencing fitness assay in vivo (sand fly infections), motility analysis PLoS pathogens Medium 31242261
1984 Mutations at the Chlamydomonas MBO2 locus (move backward only) result in cells that exclusively display the symmetric flagellar waveform (moving backward only), with loss of the asymmetric ciliary waveform required for forward motility. mbo2 axonemes are deficient in eight axonemal polypeptides compared to wild type (six shared with mbo1/mbo3, and two unique to mbo2), and mbo2 axonemes specifically lack the beak-like projections within B-tubules of outer doublets 5 and 6. Genetic analysis, reactivated isolated axonemes (ATP-driven motility), 2D-SDS-PAGE of 35S/32P-labeled axonemes, electron microscopy ultrastructural analysis The Journal of cell biology High 6725408
2025 Ccdc146 knockout mouse spermatozoa exhibit the most severe nuclear defects (morphology, DNA compaction, chromosomal architecture, ploidy) among MMAF mouse models tested (Ccdc146-/- > Cfap43-/- > Armc2-/- ≈ Cfap44-/-). Sperm from Ccdc146-/- mice show the highest rate of failure to support embryo development to blastocyst stage after ICSI, correlating with severity of nuclear defects. Comparative KO mouse study, nuclear morphology analysis, DNA compaction/chromosomal architecture assays, ploidy determination, ICSI with embryo development tracking Molecular human reproduction Medium 40070084

Source papers

Stage 0 corpus · 83 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1996 Mechanism of NO-induced oxidation of myoglobin and hemoglobin. Biochemistry 504 8679521
1991 Ligand binding to heme proteins: connection between dynamics and function. Biochemistry 271 2018767
1993 Cloning of flagellar genes in Chlamydomonas reinhardtii by DNA insertional mutagenesis. Genetics 191 8244002
1992 A novel site-directed mutant of myoglobin with an unusually high O2 affinity and low autooxidation rate. The Journal of biological chemistry 175 1629229
2006 Hemoglobins dioxygenate nitric oxide with high fidelity. Journal of inorganic biochemistry 102 16439024
2019 Genetic dissection of a Leishmania flagellar proteome demonstrates requirement for directional motility in sand fly infections. PLoS pathogens 97 31242261
2014 Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. Journal of cell science 93 25074808
2002 Myoglobin as a model system for designing heme protein based blood substitutes. Biophysical chemistry 93 12128195
1997 Identification of conformational substates involved in nitric oxide binding to ferric and ferrous myoglobin through difference Fourier transform infrared spectroscopy (FTIR). Biochemistry 87 9315857
1994 Ligand binding to heme proteins: the effect of light on ligand binding in myoglobin. Biochemistry 86 7947750
1999 Reactions of sperm whale myoglobin with hydrogen peroxide. Effects of distal pocket mutations on the formation and stability of the ferryl intermediate. The Journal of biological chemistry 73 9890961
2000 Metabolic modulation of sympathetic vasoconstriction in human skeletal muscle: role of tissue hypoxia. The Journal of physiology 70 10970439
1977 Molecular description of dioxygen bonding in hemoglobin. Proceedings of the National Academy of Sciences of the United States of America 61 266173
1984 Mutant strains of Chlamydomonas reinhardtii that move backwards only. The Journal of cell biology 54 6725408
2004 Competition with xenon elicits ligand migration and escape pathways in myoglobin. Biophysical journal 52 14695286
1996 Reactions of oxymyoglobin with NO, NO2, and NO2- under argon and in air. Chemical research in toxicology 51 8951244
2003 NO enhances presynaptic currents during cerebellar mossy fiber-granule cell LTP. Journal of neurophysiology 49 14534272
2005 Quantum chemical evaluation of protein control over heme ligation: CO/O2 discrimination in myoglobin. The journal of physical chemistry. B 37 16851321
2004 In vitro nonenzymatic glycation enhances the role of myoglobin as a source of oxidative stress. Free radical research 31 15104207
2002 The Chlamydomonas MBO2 locus encodes a conserved coiled-coil protein important for flagellar waveform conversion. Cell motility and the cytoskeleton 31 11977094
2005 Nitric oxide, cytochrome c oxidase and myoglobin: competition and reaction pathways. FEBS letters 29 15848199
2004 Conformational substates of the oxyheme centers in alpha and beta subunits of hemoglobin as disclosed by EPR and ENDOR studies of cryoreduced protein. Biochemistry 29 15147217
1998 African elephant myoglobin with an unusual autoxidation behavior: comparison with the H64Q mutant of sperm whale myoglobin. Biochimica et biophysica acta 29 9748556
2019 Low mutation and neoantigen burden and fewer effector tumor infiltrating lymphocytes correlate with breast cancer metastasization to lymph nodes. Scientific reports 28 30670769
1998 Carbon monoxide inhibition of regulatory pathways in myocardium. The American journal of physiology 28 9841541
2012 Mechanism and kinetics of inducible nitric oxide synthase auto-S-nitrosation and inactivation. Biochemistry 27 22242685
2000 Dual nature of the distal histidine residue in the autoxidation reaction of myoglobin and hemoglobin comparison of the H64 mutants. European journal of biochemistry 27 11012669
2010 Fructose-induced modifications of myoglobin: Change of structure from met (Fe3+) to oxy (Fe2+) form. International journal of biological macromolecules 26 21087622
1998 Stabilizing bound O2 in myoglobin by valine68 (E11) to asparagine substitution. Biochemistry 26 9843395
1981 One-electron reduction in oxyform of hemoproteins. The Journal of biological chemistry 26 7298661
1995 Role of globin moiety in the autoxidation reaction of oxymyoglobin: effect of 8 M urea. Biophysical journal 24 8527673
2018 The Human Centrosomal Protein CCDC146 Binds Chlamydia trachomatis Inclusion Membrane Protein CT288 and Is Recruited to the Periphery of the Chlamydia-Containing Vacuole. Frontiers in cellular and infection microbiology 21 30094225
2009 Myoglobin and mitochondria: oxymyoglobin interacts with mitochondrial membrane during deoxygenation. Biochemistry. Biokhimiia 21 19916935
2003 Hemichrome formation observed in human haemoglobin A under various buffer conditions. Acta physiologica Scandinavica 19 12940938
2003 Gravitaxis in Chlamydomonas reinhardtii studied with novel mutants. Plant & cell physiology 19 14581636
2002 Yeast flavohemoglobin from Candida norvegensis. Its structural, spectral, and stability properties. The Journal of biological chemistry 19 12192008
2023 CCDC146 is required for sperm flagellum biogenesis and male fertility in mice. Cellular and molecular life sciences : CMLS 18 38038747
2021 Myoglobin, expressed in brown adipose tissue of mice, regulates the content and activity of mitochondria and lipid droplets. Biochimica et biophysica acta. Molecular and cell biology of lipids 18 34384891
2011 Bridging the gap between chemistry, physiology, and evolution: quantifying the functionality of sperm whale myoglobin mutants. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 18 21903173
1995 Resonance Raman studies of the heme active site of the homodimeric myoglobin from Nassa mutabilis: a peculiar case. Biochemistry 18 7779795
2014 Metmyoglobin reduction by polyphenols and mechanism of the conversion of metmyoglobin to oxymyoglobin by quercetin. Journal of agricultural and food chemistry 17 24401086
1999 Regulation of respiration in myocardium in the transient and steady state. The American journal of physiology 17 10516176
2018 Myoglobin: Oxygen Depot or Oxygen Transporter to Mitochondria? A Novel Mechanism of Myoglobin Deoxygenation in Cells (review). Biochemistry. Biokhimiia 16 29618303
2016 Hemoglobin and Myoglobin as Reducing Agents in Biological Systems. Redox Reactions of Globins with Copper and Iron Salts and Complexes. Biochemistry. Biokhimiia 16 28260494
2024 Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse. eLife 14 38441556
2000 Noninvasive assessment of cardiac ischemic injury using (87)Rb and (23)Na MR imaging, (31)P MR, and optical spectroscopy. Magnetic resonance in medicine 14 11108627
1993 Application of molecular dynamics and free energy perturbation methods to metalloporphyrin-ligand systems II: CO and dioxygen binding to myoglobin. Protein science : a publication of the Protein Society 14 8268807
2015 Interactions of hemoglobin and myoglobin with their ligands CN(-), CO, and O2 monitored by electrospray ionization-mass spectrometry. Analytical chemistry 13 26327529
2021 Genome-wide association study identified INSC gene associated with Trail Making Test Part A and Alzheimer's disease related cognitive phenotypes. Progress in neuro-psychopharmacology & biological psychiatry 11 34224794
2014 Using THz time-scale infrared spectroscopy to examine the role of collective, thermal fluctuations in the formation of myoglobin allosteric communication pathways and ligand specificity. Soft matter 11 24801988
2022 Myoglobin Interaction with Lactate Rapidly Releases Oxygen: Studies on Binding Thermodynamics, Spectroscopy, and Oxygen Kinetics. International journal of molecular sciences 10 35563138
2000 A primitive myoglobin from Tetrahymena pyriformis: its heme environment, autoxidizability, and genomic DNA structure. Biochimica et biophysica acta 10 11087949
2012 Fluorescence studies on the interaction of myoglobin with mitochondria. Biochemistry. Biokhimiia 9 22803945
1991 Use of dual wavelength spectrophotometry and continuous enzymatic depletion of oxygen for determination of the oxygen binding constants of hemoglobin. Analytical biochemistry 9 1952070
2013 Effect of artificial and natural phospholipid membranes on rate of sperm whale oxymyoglobin autooxidation. Biochemistry. Biokhimiia 8 23586720
2005 [Myoglobin and mitochondria: kinetics of oxymyoglobin deoxygenation in mitochondria suspension]. Biofizika 8 15856988
2022 Discovery and characterization of tumor antigens in hepatocellular carcinoma for mRNA vaccine development. Journal of cancer research and clinical oncology 7 36038676
1992 Stability properties of Aplysia oxymyoglobin: effect of esterification of the heme propionates. Biochimica et biophysica acta 7 1730027
2024 The MBO2/FAP58 heterodimer stabilizes assembly of inner arm dynein b and reveals axoneme asymmetries involved in ciliary waveform. Molecular biology of the cell 6 38568782
2024 Homozygous CCDC146 mutation causes oligoasthenoteratozoospermia in humans and mice. Zoological research 6 39245651
2020 Effect of the exposure to oxidation and malondialdehyde on turkey and rabbit meat protein oxidative stability. Journal of food science 6 32857873
1979 Dioxygen replacement reaction in myoglobin. Biochemistry 6 572704
2022 Technological properties, chemical composition, texture profile, and sensory evaluation of goose muscles from Polish native breeds. Poultry science 5 36571876
2007 Ferrocyanide - a novel catalyst for oxymyoglobin oxidation by molecular oxygen. The FEBS journal 4 17892484
1996 Identification of new genes expressed in a human erythroleukemia cell line. Blood cells, molecules & diseases 4 8807082
1997 Metabolic response in Arenicola marina to limiting oxygen as reflected in the 1H-NMR oxymyoglobin signal. European journal of biochemistry 3 9030744
1986 [Mechanism of electron transfer between myoglobin derivatives and ferricytochrome C]. Biofizika 3 3006793
2025 Antisense oligonucleotide depletion of CCDC146 is a broad-spectrum therapeutic strategy for ALS. medRxiv : the preprint server for health sciences 2 38633814
2010 The main role of inner histidines in the molecular mechanism of myoglobin oxidation catalyzed by copper compounds. Inorganic chemistry 2 20088488
2003 Role of myoglobin in regulating respiration. Advances in experimental medicine and biology 2 14562765
2025 Early Progression Prediction in Korean Crohn's Disease Using a Korean-Specific PrediXcan Model. International journal of molecular sciences 1 40243508
2025 Mapping the brain cell-specific regulatory architecture of migraine: a single-cell causal framework nominating inhibitory-neuronal BTBD16 and astrocytic RIMS1 as therapeutic targets. The journal of headache and pain 1 41345547
2019 Comparison of 2° and 10° standard observers used with C and D65 illuminants in measurements of colour in raw minced pork loin. Acta scientiarum polonorum. Technologia alimentaria 1 31930791
2017 A comparison of two methods of determining colour change in the assessment of the quality of pork. Acta scientiarum polonorum. Technologia alimentaria 1 29055980
2012 [Study of the interaction of myoglobin with lipid bilayer membranes by potentiodynamic method]. Biofizika 1 22567910
2008 [The mechanism of oxymyoglobin oxidation by copper ions and complexes: myoglobins carboxymethylated and carboxyamidated at histidine residues]. Biofizika 1 18819271
2005 [The oxidation of sperm whale, horse, and pig oxymyoglobins, catalyzed by ferrocyanide ions: kinetics and mechanism]. Biofizika 1 15759501
2005 [The mechanism of oxymyoglobin oxidation catalyzed by ferrocyanide ions: chemically modified and mutant sperm whale myoglobins]. Biofizika 1 16212053
1982 [Electron transfer in hemoproteins. VIII. Influence of ionic strength on the rate of reduction of ferricytochrome c by oxymyoglobin derivatives, chemically modified at histidine residues]. Molekuliarnaia biologiia 1 6280031
2025 Exploring the therapeutic effect of melatonin targeting common biomarkers in testicular germ cell tumor, prostate adenocarcinoma, and male infertility: an integrated biology approach. Mammalian genome : official journal of the International Mammalian Genome Society 0 40056207
2025 A comprehensive study of the sperm head defects in MMAF condition and their impact on embryo development in mice. Molecular human reproduction 0 40070084
2025 Genome-wide genetic characterization and selection signatures in Anatolian Merino sheep. Archives animal breeding 0 42256732
2021 Comparison of D65/10° and A/10° illuminant/observer systems for colour measurement of raw pork. Acta scientiarum polonorum. Technologia alimentaria 0 34724372

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