Affinage

CASP1

Caspase-1 · UniProt P29466

Length
404 aa
Mass
45.2 kDa
Annotated
2026-06-09
60 papers in source corpus 15 papers cited in narrative 15 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CASP1 (interleukin-1β converting enzyme/ICE) is a cysteine protease that drives inflammatory and cell-death programs by proteolytically maturing inflammatory cytokines and executing pyroptosis (PMID:8034320, PMID:34531375). Within reconstituted inflammasome systems CASP1 is recruited into a complex with NLRP3 and ASC, where ASC induction promotes its autocatalytic activation (PMID:35221708); activated CASP1 then processes pro-IL-1β and pro-IL-18 and cleaves gasdermin D, with re-expression of CASP1 restoring N-GSDMD, IL-1β and IL-18 generation (PMID:8034320, PMID:34531375). Inflammasome engagement is triggered by upstream danger inputs including manganese-induced lysosomal damage and cathepsin B release (PMID:28318352) and intracellular chloride sensing through SGK1, which feeds an autocrine IL-1β amplification loop (PMID:33835494). CASP1 expression is set by epigenetic and transcriptional regulators: the histone methyltransferases G9A/EHMT2 and PRMT5 silence the gene via H3K9me2 and H4R3me2s respectively (PMID:28383547, PMID:34531375), while PRDM1 and IFNγ/STAT1 signaling directly activate its transcription (PMID:36822457, PMID:39432156). Beyond canonical cytokine substrates, CASP1 cleaves the glucocorticoid receptor to reduce GR levels and confer glucocorticoid resistance (PMID:25938942), and small metabolites such as kynurenine bind CASP1 directly to suppress its cleavage activity and dampen pyroptosis (PMID:41079603). CASP1 also acts non-catalytically as a scaffold: through its CARD domain it interacts with RPTOR/mTORC1 to constrain NF-κB signaling, and loss or CARD disruption triggers excessive NF-κB activity (PMID:41500224). Consistent with these dual roles, gain-of-function CASP1 variants drive both inflammasome hyperactivation and RIP2-dependent NF-κB activation in autoinflammatory disease, while other disease variants reveal scaffolding and subcellular-localization functions independent of catalysis (PMID:31252176, PMID:32556329).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1994 High

    Established the molecular identity of CASP1 as the protease responsible for converting inactive pro-IL-1β into active IL-1β, defining its founding biochemical function.

    Evidence Genomic cloning, transcription start site mapping, and FISH localization of the human gene

    PMID:8034320

    Open questions at the time
    • Did not resolve how the enzyme is activated in cells
    • No structural mechanism of substrate cleavage defined
  2. 1999 Medium

    Distinguished CASP1's IL-1β-processing inflammatory role from a separate capacity to directly induce cell death in vivo, hinting at functions beyond cytokine maturation.

    Evidence Intradermal plasmid transfer in mouse skin with TUNEL staining and anti-IL-1β neutralization

    PMID:10468192

    Open questions at the time
    • Molecular pathway of the IL-1β-independent death was not defined
    • Single-lab in vivo gain-of-function
  3. 2015 High

    Identified the glucocorticoid receptor as a non-canonical CASP1 substrate, explaining how inflammasome activation can drive glucocorticoid resistance.

    Evidence CASP1 overexpression/knockdown and inhibition in ALL cells with GR cleavage and transcriptional readouts

    PMID:25938942

    Open questions at the time
    • Cleavage site on GR not mapped
    • Generality beyond leukemia models untested
  4. 2017 Medium

    Showed CASP1 expression is epigenetically repressed by G9A-mediated H3K9me2 and that this repression supports tumor invasion, placing CASP1 under chromatin-level control.

    Evidence shRNA knockdown, ChIP, luciferase promoter assay, and invasion/migration rescue in NSCLC

    PMID:28383547

    Open questions at the time
    • Whether de-repressed CASP1 acts catalytically or as scaffold here is unclear
    • Single-lab finding
  5. 2017 Medium

    Connected an environmental trigger to inflammasome activation by showing manganese activates NLRP3-CASP1 via lysosomal damage and cathepsin B release rather than autophagosome accumulation.

    Evidence In vivo Mn exposure plus BV2 microglia, CTSB inhibition, and CASP1 activity/cytokine assays

    PMID:28318352

    Open questions at the time
    • Direct link between CTSB and CASP1 activation step not biochemically resolved
    • Single-lab study
  6. 2019 Medium

    Revealed that disease-associated CASP1 variants alter pyroptosome formation, nuclear localization, and cell mechanics, exposing scaffolding/localization roles independent of catalysis.

    Evidence Variant transduction in THP-1 monocytes with immunofluorescence, pyroptosome and deformability assays

    PMID:31252176

    Open questions at the time
    • Mechanism linking nuclear localization to function unknown
    • Single-lab variant panel
  7. 2020 Medium

    Showed a gain-of-function CASP1 variant simultaneously hyperactivates the inflammasome and RIP2-dependent NF-κB signaling, tying CASP1 to autoinflammatory disease through two pathways.

    Evidence Whole exome sequencing, patient PBMC caspase-1 activity and cytokine assays, NF-κB reporter assays

    PMID:32556329

    Open questions at the time
    • Single patient case
    • Direct mechanism of RIP2 engagement by CASP1 not defined
  8. 2021 Medium

    Extended epigenetic control of CASP1 to PRMT5-mediated H4R3me2s and demonstrated that relieving this silencing promotes pyroptosis, linking CASP1 re-expression to gasdermin/cytokine output.

    Evidence PRMT5 knockdown/inhibition with CASP1 rescue and pyroptosis marker Western blots in myeloma, with in vivo validation

    PMID:34531375

    Open questions at the time
    • Whether PRMT5 acts solely at the CASP1 promoter not established
    • Single-lab finding
  9. 2021 Medium

    Identified intracellular chloride and SGK1 as upstream modulators of NLRP3-CASP1, defining an autocrine IL-1β amplification loop that reinforces inflammasome activity.

    Evidence Ionophore Cl- modulation in epithelial cells with VX-765, MCC950, SGK1 knockdown, and IL-1β/ROS measurements

    PMID:33835494

    Open questions at the time
    • Direct chloride sensor for CASP1 not identified
    • Single-lab study
  10. 2022 Medium

    Provided reciprocal co-IP evidence that CASP1 physically associates with NLRP3 and is activated upon ASC nucleation in a reconstituted system, anchoring CASP1 within the inflammasome complex.

    Evidence Co-IP in HEK293-iASC-NLRP3/CASP1 cells with inducible ASC, activity biosensor, and inhibitor panel

    PMID:35221708

    Open questions at the time
    • Stoichiometry and structure of the assembled complex not resolved
    • Reconstituted overexpression system
  11. 2023 Medium

    Placed CASP1 downstream of IFNγ/STAT1 signaling in ATRA-induced pyroptosis and differentiation of APL cells, defining a transcriptional activation route for CASP1.

    Evidence CASP1 overexpression and ATRA treatment in APL cells with pathway and pyroptosis/differentiation assays

    PMID:36822457

    Open questions at the time
    • Direct STAT1 binding to CASP1 promoter not shown
    • Single-lab study
  12. 2024 Medium

    Demonstrated direct transcriptional activation of CASP1 by PRDM1 driving nucleus pulposus pyroptosis, completing a transcription-factor-level control node.

    Evidence mRNA-seq, ChIP, dual-luciferase reporter, and CASP1 knockdown epistasis with in vivo models

    PMID:39432156

    Open questions at the time
    • Tissue-specificity of PRDM1-CASP1 regulation not explored
    • Single-lab finding
  13. 2025 Medium

    Showed kynurenine directly binds CASP1 to inhibit its cleavage activity, identifying a metabolite-level brake on pyroptosis that shapes the tumor microenvironment.

    Evidence Surface plasmon resonance binding, CASP1 overexpression rescue, and VX-765 inhibition in M2 macrophages/RCC co-culture

    PMID:41079603

    Open questions at the time
    • Binding site on CASP1 not mapped
    • Single-lab study
  14. 2026 Medium

    Defined a protease-independent scaffolding role for CASP1, where its CARD domain interacts with RPTOR/mTORC1 to restrain NF-κB and support leukemic growth.

    Evidence CASP1 deletion/CARD disruption, CASP1-RPTOR co-IP, NF-κB assays, and a pro-CASP1 PROTAC degrader with in vivo leukemia models

    PMID:41500224

    Open questions at the time
    • Structural basis of CASP1-RPTOR interaction unresolved
    • How scaffolding suppresses NF-κB mechanistically not detailed

Open questions

Synthesis pass · forward-looking unresolved questions
  • How CASP1's catalytic, pro-death, and scaffolding/RPTOR functions are partitioned and coordinated within a single cell remains unresolved.
  • No structural model integrating CARD-scaffolding and protease states
  • Switch between cytokine maturation, GR cleavage, and NF-κB control not defined
  • Physiological substrate repertoire beyond IL-1β/IL-18/GSDMD/GR incompletely mapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 4 GO:0016787 hydrolase activity 2 GO:0060090 molecular adaptor activity 2
Localization
GO:0005634 nucleus 1 GO:0005829 cytosol 1
Pathway
R-HSA-168256 Immune System 3 R-HSA-162582 Signal Transduction 2 R-HSA-5357801 Programmed Cell Death 2
Partners
ASCNLRP3RPTOR
Complex memberships
NLRP3 inflammasome

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1994 The human CASP1 gene (IL1BC) encodes the IL-1β converting enzyme (ICE), a protease that proteolytically cleaves the inactive pro-form of IL-1β into biologically active IL-1β. The gene consists of 10 exons spanning at least 10.6 kb, maps to chromosome 11q22.2-q22.3, and has a single transcription start site ~33 bp upstream of the initiator Met codon. Genomic cloning, PCR-based transcription start site mapping, fluorescence in situ hybridization (FISH) Genomics High 8034320
1999 In vivo intradermal transfer of CASP1 DNA into mouse skin demonstrates dual roles: CASP1 drives IL-1β-associated granulomatous inflammatory infiltration (suppressed by anti-IL-1β antibody) AND independently induces apoptotic cell death (TUNEL-positive cells persist after IL-1β neutralization), establishing CASP1 as both an IL-1β processor and a direct apoptosis inducer in vivo. Intradermal plasmid DNA transfer, TUNEL staining, neutralizing antibody treatment, plasma IL-1β measurement Journal of dermatological science Medium 10468192
2015 CASP1 cleaves the glucocorticoid receptor (GR), reducing GR protein levels and diminishing the glucocorticoid-induced transcriptional response. NLRP3 activates CASP1 in leukemia cells, and knockdown or pharmacological inhibition of CASP1 restores GR levels and reverses glucocorticoid resistance, establishing GR as a direct CASP1 substrate. CASP1 overexpression/knockdown in ALL cells, Western blot for GR cleavage, glucocorticoid transcriptional response assays, pharmacological CASP1 inhibition Nature genetics High 25938942
2017 G9A (EHMT2) histone methyltransferase silences CASP1 expression by increasing H3K9me2 at the CASP1 promoter. Knockdown of G9A de-represses CASP1, and re-knockdown of CASP1 in G9A-deficient cells restores tumor invasion/migration capacity, placing CASP1 downstream of G9A-mediated epigenetic repression in NSCLC. shRNA knockdown, chromatin immunoprecipitation (ChIP) for H3K9me2, luciferase promoter assay, invasion/migration rescue experiments Cell death & disease Medium 28383547
2017 Manganese (Mn) activates the NLRP3-CASP1 inflammasome in hippocampal microglia by inducing lysosomal damage and autophagy-lysosomal dysfunction; released lysosomal cathepsin B (CTSB) plays a key role in NLRP3-CASP1 activation. Increased autophagosomes were NOT the main cause of inflammasome activation. In vivo Mn exposure in mice, BV2 cell culture, CTSB inhibition, autophagy modulation, CASP1 activity assays, IL-1β/IL-18 ELISA Autophagy Medium 28318352
2019 CASP1 variants (p.L265S, p.R240Q, and catalytic-site p.C285A) cause mutation-specific molecular alterations in macrophages including abnormal pyroptosome formation, impaired nuclear localization of pro-caspase-1 (for p.L265S), reduced pro-inflammatory cell death (for p.C285A), and changes in macrophage deformability, revealing scaffolding/localization roles of CASP1 beyond its catalytic activity. shRNA knockdown + viral transduction of CASP1 variants in THP-1 monocytes, immunofluorescence for subcellular localization, pyroptosome formation assay, deformability measurements Clinical immunology Medium 31252176
2020 A CASP1 missense variant (p.R161H) is gain-of-function for both inflammasome activation and NF-κB signaling: patient PBMCs show increased caspase-1 activity, elevated IL-1β and IL-18 production upon NLRP3 stimulation, elevated IL-18 and IFNγ in whole blood, and the variant induces increased NF-κB activation in a RIP2-dependent manner in reporter assays. Whole exome sequencing, caspase-1 activity assay in patient PBMCs, cytokine ELISA, NF-κB luciferase reporter assay with CASP1 variant expression Rheumatology (Oxford, England) Medium 32556329
2021 PRMT5 (protein arginine methyltransferase 5) epigenetically silences CASP1 expression via H4R3me2s symmetric dimethylation; PRMT5 inhibition increases CASP1 expression and promotes pyroptosis in multiple myeloma cells, with CASP1 re-expression rescuing pyroptosis markers (N-GSDMD, IL-1β, IL-18) upon PRMT5 knockdown. PRMT5 knockdown/inhibition, rescue CASP1 expression, Western blot for pyroptosis markers, in vitro and in vivo phenotypic assays Cell death & disease Medium 34531375
2021 NLRP3 and CASP1 expression and activity are modulated by intracellular Cl- concentration, with maximal expression and activity at 75 mM Cl-; this effect is mediated upstream by SGK1 kinase, which stimulates mature IL-1β secretion, which in turn autocrinally upregulates ROS, CASP1, NLRP3, and IL-1β itself. CASP1 inhibitor VX-765 and NLRP3 inhibitor MCC950 completely block Cl--stimulated IL-1β mRNA expression. Ionophore-induced Cl- modulation in epithelial cells, CASP1 inhibitor (VX-765), NLRP3 inhibitor (MCC950), SGK1 shRNA/inhibitor, ROS measurement, ELISA for IL-1β Immunology Medium 33835494
2023 ATRA (all-trans-retinoic acid) activates CASP1 expression via the IFNγ/STAT1 signaling pathway in APL cells; activated CASP1 triggers pyroptosis and differentiation of APL cells, demonstrating CASP1 as a downstream effector of IFNγ/STAT1 in ATRA-induced APL cell death. CASP1 overexpression in APL cells, ATRA treatment, IFNγ/STAT1 pathway analysis, pyroptosis and differentiation assays European journal of pharmacology Medium 36822457
2024 PRDM1 transcription factor directly activates CASP1 transcription (confirmed by ChIP and dual-luciferase reporter assay), promoting nucleus pulposus cell pyroptosis. CASP1 silencing reverses the effects of PRDM1 overexpression on pyroptosis, placing CASP1 directly downstream of PRDM1 transcriptional control. mRNA sequencing, chromatin immunoprecipitation (ChIP), dual-luciferase reporter assay, CASP1 knockdown epistasis rescue, in vitro and in vivo models Cell biology and toxicology Medium 39432156
2025 Kynurenine directly binds CASP1 (confirmed by surface plasmon resonance) and reduces CASP1 cleavage, thereby suppressing pyroptosis in M2 macrophages. CASP1 overexpression reverses kynurenine-induced suppression of pyroptosis, establishing a direct inhibitory kynurenine-CASP1 interaction that promotes a tumor-supportive microenvironment in renal cell carcinoma. Surface plasmon resonance (direct binding), CASP1 overexpression rescue, VX-765 pharmacological inhibition, Transwell co-culture, pyroptosis assays Open life sciences Medium 41079603
2026 CASP1 functions as a scaffolding hub controlling NF-κB signaling in leukemia via interaction with raptor (RPTOR), a component of mTORC1, independent of its protease activity. Loss of CASP1 or disruption of its CARD domain induces excessive NF-κB activity and impairs leukemic cell growth; a PROTAC degrader of pro-CASP1 suppresses leukemic cells. CASP1 deletion/CARD domain disruption, co-IP of CASP1 with RPTOR, NF-κB activity assays, PROTAC degrader, in vivo leukemia burden assessment Cell chemical biology Medium 41500224
2022 Co-immunoprecipitation confirmed that CASP1 is pulled down with NLRP3 in a reconstituted HEK293 inflammasome system (HEK293-iASC-NLRP3/CASP1), and ASC induction leads to increased cleaved/active CASP1; this complex formation is inhibited by MCC950, Glyburide, VX-765, and VRT-043198. Co-immunoprecipitation, doxycycline-inducible ASC expression system, fluorescence biosensor for CASP1 activity, flow cytometry, Western blot Journal of inflammation research Medium 35221708
1998 The rat Il1bc (CASP1 ortholog) gene was mapped to the centromeric region of rat chromosome 8, a region homologous to mouse chromosome 9, using linkage analysis in HXB and BXH recombinant inbred strains. Linkage analysis in recombinant inbred strains Folia biologica Low 10730851

Source papers

Stage 0 corpus · 60 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2017 The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability. Autophagy 191 28318352
2015 NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells. Nature genetics 140 25938942
2017 G9A promotes tumor cell growth and invasion by silencing CASP1 in non-small-cell lung cancer cells. Cell death & disease 66 28383547
2020 Long noncoding RNA MIAT regulates primary human retinal pericyte pyroptosis by modulating miR-342-3p targeting of CASP1 in diabetic retinopathy. Experimental eye research 55 33065089
2011 The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles. Retrovirology 52 22151792
1994 Molecular characterization of the gene for human interleukin-1 beta converting enzyme (IL1BC). Genomics 44 8034320
2018 The long non-coding RNA SNHG5 regulates gefitinib resistance in lung adenocarcinoma cells by targetting miR-377/CASP1 axis. Bioscience reports 35 29592872
2018 Impact of steroid hormones E2 and P on the NLRP3/ASC/Casp1 axis in primary mouse astroglia and BV-2 cells after in vitro hypoxia. The Journal of steroid biochemistry and molecular biology 34 29772377
2019 Benzene metabolites trigger pyroptosis and contribute to haematotoxicity via TET2 directly regulating the Aim2/Casp1 pathway. EBioMedicine 32 31474553
2015 Identification of an HIV-1 Mutation in Spacer Peptide 1 That Stabilizes the Immature CA-SP1 Lattice. Journal of virology 30 26537676
2016 Helical Conformation in the CA-SP1 Junction of the Immature HIV-1 Lattice Determined from Solid-State NMR of Virus-like Particles. Journal of the American Chemical Society 29 27593947
2020 Propofol Attenuates Inflammatory Damage via Inhibiting NLRP1-Casp1-Casp6 Signaling in Ischemic Brain Injury. Biological & pharmaceutical bulletin 28 32999158
2021 PRMT5 regulates cell pyroptosis by silencing CASP1 in multiple myeloma. Cell death & disease 27 34531375
2024 Study of kaempferol in the treatment of rheumatoid arthritis through modulation of the NLRP3/CASP1/GSDMD axis and T-cell activation: Based on network pharmacology, single-cell analysis, and experimental validation. International immunopharmacology 25 39388897
2022 The A20/TNFAIP3-CDC20-CASP1 Axis Promotes Inflammation-mediated Metastatic Disease in Triple-negative Breast Cancer. Anticancer research 22 35093867
1999 An attempt to analyse progress in fold recognition from CASP1 to CASP3. Proteins 22 10526373
2022 MicroRNA-22 suppresses NLRP3/CASP1 inflammasome pathway-mediated proinflammatory cytokine production by targeting the HIF-1α and NLRP3 in human dental pulp fibroblasts. International endodontic journal 20 35979583
2020 Effects of an HIV-1 maturation inhibitor on the structure and dynamics of CA-SP1 junction helices in virus-like particles. Proceedings of the National Academy of Sciences of the United States of America 20 32341150
2021 NLR family pyrin domain containing 3 (NLRP3) and caspase 1 (CASP1) modulation by intracellular Cl- concentration. Immunology 19 33835494
2020 Systemic juvenile idiopathic arthritis and recurrent macrophage activation syndrome due to a CASP1 variant causing inflammasome hyperactivation. Rheumatology (Oxford, England) 17 32556329
2020 Sodium P-aminosalicylic Acid Inhibits Manganese-Induced Neuroinflammation in BV2 Microglial Cells via NLRP3-CASP1 Inflammasome Pathway. Biological trace element research 17 33156491
2019 Mice lacking Casp1, Ifngr and Nos2 genes exhibit altered depressive- and anxiety-like behaviour, and gut microbiome composition. Scientific reports 16 31015500
2009 Mutational analysis of CASP1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 14 genes in gastrointestinal stromal tumors. Human pathology 16 19269008
2018 Genetic association study of NLRP1, CARD, and CASP1 inflammasome genes with chronic Chagas cardiomyopathy among Trypanosoma cruzi seropositive patients in Bolivia. PloS one 15 29438387
2025 HERV-W Env Induces Neuron Pyroptosis via the NLRP3-CASP1-GSDMD Pathway in Recent-Onset Schizophrenia. International journal of molecular sciences 14 39859234
2023 CASP1 is a target for combination therapy in pancreatic cancer. European journal of pharmacology 13 37949157
2017 The NLRP3 and CASP1 gene polymorphisms are associated with developing of acute coronary syndrome: a case-control study. Immunologic research 13 28456882
2024 PRDM1 promotes nucleus pulposus cell pyroptosis leading to intervertebral disc degeneration via activating CASP1 transcription. Cell biology and toxicology 12 39432156
2024 Alloferon Mitigates LPS-Induced Endometritis by Attenuating the NLRP3/CASP1/IL-1β/IL-18 Signaling Cascade. Inflammation 11 38913143
2004 Mapping and transcription profiling of CASP1, 3, 6, 7 and 8 in relation to caspase activity in the bovine cumulus-oocyte complex. Animal genetics 11 15147397
2023 Overexpression of CASP1 triggers acute promyelocytic leukemia cell pyroptosis and differentiation. European journal of pharmacology 10 36822457
2023 Testis cell pyroptosis mediated by CASP1 and CASP4: possible sertoli cell-only syndrome pathogenesis. Reproductive biology and endocrinology : RB&E 9 37296437
2021 Puerarin protects against human retinal endothelial cells injury induced by high glucose via regulating miR-16-5p/CASP1 axis. General physiology and biophysics 9 34100379
2019 CASP1 variants influence subcellular caspase-1 localization, pyroptosome formation, pro-inflammatory cell death and macrophage deformability. Clinical immunology (Orlando, Fla.) 9 31252176
2012 A molecular and computational diagnostic approach identifies FOXP3, ICOS, CD52 and CASP1 as the most informative biomarkers in acute graft-versus-host disease. Haematologica 8 22491736
2021 Association between Polymorphisms in the IL-1β, TNFRSF11B, CASP1, and IL-6 Genes and Orthodontic-Induced External Apical Root Resorption. Journal of clinical medicine 6 34575287
2013 CASP-1, -2 and -5 gene polymorphisms and cancer risk: A review and meta-analysis. Biomedical reports 6 24648977
2024 Tsg101 UEV Interaction with Nedd4 HECT Relieves E3 Ligase Auto-Inhibition, Promoting HIV-1 Assembly and CA-SP1 Maturation Cleavage. Viruses 5 39459900
2023 Menstrual blood-derived endometrial stem cells inhibit neuroinflammation by regulating microglia through the TLR4/MyD88/NLRP3/Casp1 pathway. The international journal of biochemistry & cell biology 5 36754162
1999 Intradermal transfer of caspase-1 (CASP1) DNA into mouse dissects: role of CASP1 in interleukin-1beta associated skin inflammation and apoptotic cell death. Journal of dermatological science 5 10468192
2025 Correlation Analysis of Pyroptosis-Related Genes CASP1, NLRP3, AIM2, and NLRP1 With Lung Adenocarcinoma. International journal of genomics 4 40026444
2022 Dynamic disequilibrium-based pathogenicity model in mutated pyrin's B30.2 domain-Casp1/p20 complex. Journal, genetic engineering & biotechnology 4 35190906
2025 Elevated levels of IRF1 and CASP1 as pyroptosis-related biomarkers for intestinal epithelial cells in Crohn's disease. Frontiers in immunology 3 40018047
2026 Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia. Cell chemical biology 2 41500224
2022 CASPorter: A Novel Inducible Human CASP1/NALP3/ASC Inflammasome Biosensor. Journal of inflammation research 2 35221708
2022 CASP1 Gene Polymorphisms and BAT1-NFKBIL-LTA-CASP1 Gene-Gene Interactions Are Associated with Restenosis after Coronary Stenting. Biomolecules 2 35740890
2026 Integrative transcriptomic and structural modeling reveal CASP1, TLR3, PYCARD, and CD274 as immune-modulatory drivers in breast cancer. Naunyn-Schmiedeberg's archives of pharmacology 1 41549178
2026 Berberine alleviates early brain injury after subarachnoid hemorrhage by inhibiting GSK3β-mediated CASP1-dependent pyroptosis. International immunopharmacology 1 41650890
2025 Activation of the NALP3-CASP1-IL-1 β Inflammatory Pathway by Pesticide Exposure in Human Umbilical Vein Endothelial Cells. International journal of molecular sciences 1 40430087
2024 High expression of CASP1 induces atherosclerosis. Medicine 1 38640260
2024 Correlation Between Blood Levels of Cysteine Protease Caspase-1 (Casp1) and Pain Scores (NRS) Post-surgery: A Prospective Randomized Study of Patients With Cholelithiasis. Anticancer research 1 38925829
2026 Cabozantinib induces NLRP3-CASP1-GSDMD-dependent pyroptosis in hepatocellular carcinoma. Life sciences 0 41534776
2026 The NLRP3-CASP1 Axis Contributes to Pyroptosis in Bovine Mammary Epithelial Cells During Clinical Mastitis. Antioxidants (Basel, Switzerland) 0 41897529
2026 Mechanistic Topology of Notopterygium incisum Essential Oil against Rheumatoid Arthritis: Machine Learning-Guided CASP1 Screening and Nanoemulsion Evaluation. Chinese journal of integrative medicine 0 41920256
2025 CircTHADA regulates endothelial cell pyroptosis in diabetic retinopathy through miR-494-3p/CASP1/GSDMD-N/IL-1β pathway. Experimental cell research 0 40090540
2025 Comprehensive analysis of pyroptosis-related genes in psoriasis and targeted gene editing of CASP1 and CASP5 using lipid nanoparticles to alleviate skin inflammation. Frontiers in bioengineering and biotechnology 0 40771724
2025 Interrogating ABCC1 and CASP1 as key players in epigallocatechin gallate's action against radiotherapy-resistant nasopharyngeal carcinoma. Scientific reports 0 41022935
2025 Kynurenine facilitates renal cell carcinoma progression by suppressing M2 macrophage pyroptosis through inhibition of CASP1 cleavage. Open life sciences 0 41079603
2025 CASP1 as a potential target of Dendrobium in Sjögren's syndrome: Multi-omics analysis and preliminary experimental evidence. International immunopharmacology 0 41101222
1998 Linkage mapping of the interleukin 1beta converting enzyme (Il1bc) and the glutamate receptor subunit KA1 (Grik4) genes to rat chromosome 8. Folia biologica 0 10730851

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