- Length
- 315 aa
- Mass
- 37.1 kDa
- Annotated
- 2026-04-28
130 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic findings about CALU (calumenin) in the available literature (corpus is dominated by papers about Calu-1/Calu-3/Calu-6 lung cancer cell lines and large-scale proteomics datasets, none of which describe direct mechanistic experiments on the calumenin protein itself).
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 130 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2006 | Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | Cell | 2861 | 17081983 |
| 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Proceedings of the National Academy of Sciences of the United States of America | 1479 | 12477932 |
| 2006 | A probability-based approach for high-throughput protein phosphorylation analysis and site localization. | Nature biotechnology | 1336 | 16964243 |
| 2015 | The BioPlex Network: A Systematic Exploration of the Human Interactome. | Cell | 1118 | 26186194 |
| 2017 | Architecture of the human interactome defines protein communities and disease networks. | Nature | 1085 | 28514442 |
| 2015 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. | Cell | 1015 | 26496610 |
| 2014 | A proteome-scale map of the human interactome network. | Cell | 977 | 25416956 |
| 2018 | VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. | Cell discovery | 829 | 29507755 |
| 2000 | DNA cloning using in vitro site-specific recombination. | Genome research | 815 | 11076863 |
| 2003 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | Nature genetics | 754 | 14702039 |
| 2021 | Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. | Cell | 705 | 33961781 |
| 2012 | A census of human soluble protein complexes. | Cell | 689 | 22939629 |
| 2011 | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Briefings in bioinformatics | 656 | 21873635 |
| 2011 | Global landscape of HIV-human protein complexes. | Nature | 593 | 22190034 |
| 2017 | Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. | Science (New York, N.Y.) | 533 | 28302793 |
| 2021 | Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. | Nature | 532 | 33845483 |
| 2006 | Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. | Cell | 517 | 17110338 |
| 2011 | Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. | Cell | 507 | 21565611 |
| 2003 | Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. | Nature biotechnology | 485 | 12665801 |
| 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Genome research | 438 | 15489334 |
| 2015 | A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. | Cell | 433 | 26638075 |
| 2022 | OpenCell: Endogenous tagging for the cartography of human cellular organization. | Science (New York, N.Y.) | 432 | 35271311 |
| 2010 | Systematic analysis of human protein complexes identifies chromosome segregation proteins. | Science (New York, N.Y.) | 421 | 20360068 |
| 2005 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | Genome research | 409 | 16344560 |
| 2015 | Panorama of ancient metazoan macromolecular complexes. | Nature | 407 | 26344197 |
| 1983 | Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1. | Nature | 393 | 6308465 |
| 2021 | A proximity-dependent biotinylation map of a human cell. | Nature | 339 | 34079125 |
| 2014 | A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. | Cell | 325 | 25036637 |
| 2006 | Culture of Calu-3 cells at the air interface provides a representative model of the airway epithelial barrier. | Pharmaceutical research | 299 | 16779708 |
| 2006 | Association of warfarin dose with genes involved in its action and metabolism. | Human genetics | 299 | 17048007 |
| 1994 | Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl- secretion. | The American journal of physiology | 279 | 7515578 |
| 2012 | A high-throughput approach for measuring temporal changes in the interactome. | Nature methods | 273 | 22863883 |
| 2013 | The functional interactome landscape of the human histone deacetylase family. | Molecular systems biology | 235 | 23752268 |
| 1999 | Bicarbonate and chloride secretion in Calu-3 human airway epithelial cells. | The Journal of general physiology | 231 | 10228185 |
| 2000 | Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery. | International journal of pharmaceutics | 195 | 11064206 |
| 2002 | Permeability characteristics of calu-3 human bronchial epithelial cells: in vitro-in vivo correlation to predict lung absorption in rats. | Journal of drug targeting | 153 | 11996084 |
| 2008 | Release of volatile organic compounds (VOCs) from the lung cancer cell line CALU-1 in vitro. | Cancer cell international | 143 | 19025629 |
| 2007 | Coordinated release of nucleotides and mucin from human airway epithelial Calu-3 cells. | The Journal of physiology | 140 | 17656429 |
| 1994 | CFTR in Calu-3 human airway cells: channel properties and role in cAMP-activated Cl- conductance. | The American journal of physiology | 139 | 7515579 |
| 2000 | Tight junction properties of the immortalized human bronchial epithelial cell lines Calu-3 and 16HBE14o-. | The European respiratory journal | 133 | 10885425 |
| 2014 | The characterization of the human cell line Calu-3 under different culture conditions and its use as an optimized in vitro model to investigate bronchial epithelial function. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences | 127 | 25555374 |
| 2003 | Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3. | Journal of controlled release : official journal of the Controlled Release Society | 109 | 12618029 |
| 2013 | Metformin impairs glucose consumption and survival in Calu-1 cells by direct inhibition of hexokinase-II. | Scientific reports | 101 | 23797762 |
| 2010 | Cultured human airway epithelial cells (calu-3): a model of human respiratory function, structure, and inflammatory responses. | Critical care research and practice | 99 | 20948883 |
| 2010 | Time- and passage-dependent characteristics of a Calu-3 respiratory epithelial cell model. | Drug development and industrial pharmacy | 92 | 20374185 |
| 2002 | The antiproliferative effect of synthetic peptidyl GH secretagogues in human CALU-1 lung carcinoma cells. | Endocrinology | 92 | 11796502 |
| 2002 | Characterization of basolateral K+ channels underlying anion secretion in the human airway cell line Calu-3. | The Journal of physiology | 77 | 11826162 |
| 2009 | Induction of IL-6 and inhibition of IL-8 secretion in the human airway cell line Calu-3 by urban particulate matter collected with a modified method of PM sampling. | Environmental research | 76 | 19304283 |
| 1999 | Anion selectivity of apical membrane conductance of Calu 3 human airway epithelium. | Pflugers Archiv : European journal of physiology | 73 | 10370058 |
| 2001 | P-glycoprotein efflux pump expression and activity in Calu-3 cells. | Journal of pharmaceutical sciences | 71 | 11288109 |
| 2008 | Arsenic trioxide inhibits the growth of Calu-6 cells via inducing a G2 arrest of the cell cycle and apoptosis accompanied with the depletion of GSH. | Cancer letters | 70 | 18539383 |
| 2007 | In vitro toxicity and permeation of cyclodextrins in Calu-3 cells. | Journal of controlled release : official journal of the Controlled Release Society | 67 | 18160169 |
| 2001 | Multidrug resistance-associated protein-1 functional activity in Calu-3 cells. | The Journal of pharmacology and experimental therapeutics | 67 | 11504821 |
| 2013 | Pharmaceutical applications of the Calu-3 lung epithelia cell line. | Expert opinion on drug delivery | 65 | 23730924 |
| 2009 | P-glycoprotein-mediated transport of moxifloxacin in a Calu-3 lung epithelial cell model. | Antimicrobial agents and chemotherapy | 63 | 19188390 |
| 1998 | Evidence that Calu-3 human airway cells secrete bicarbonate. | The American journal of physiology | 60 | 9530182 |
| 2002 | Oxidant stress stimulates anion secretion from the human airway epithelial cell line Calu-3: implications for cystic fibrosis lung disease. | The Journal of physiology | 58 | 12181292 |
| 1997 | Calcium-stimulated Cl- secretion in Calu-3 human airway cells requires CFTR. | The American journal of physiology | 58 | 9435576 |
| 2011 | YM155, a novel survivin suppressant, enhances taxane-induced apoptosis and tumor regression in a human Calu 6 lung cancer xenograft model. | Anti-cancer drugs | 57 | 21389848 |
| 2007 | 2,4-dinitrophenol induces G1 phase arrest and apoptosis in human pulmonary adenocarcinoma Calu-6 cells. | Toxicology in vitro : an international journal published in association with BIBRA | 50 | 18276104 |
| 2001 | Evidence of P-glycoprotein mediated apical to basolateral transport of flunisolide in human broncho-tracheal epithelial cells (Calu-3). | British journal of pharmacology | 48 | 11724763 |
| 2008 | Growth inhibition in antimycin A treated-lung cancer Calu-6 cells via inducing a G1 phase arrest and apoptosis. | Lung cancer (Amsterdam, Netherlands) | 47 | 19111365 |
| 2001 | Modulation of P-glycoprotein activity in Calu-3 cells using steroids and beta-ligands. | International journal of pharmaceutics | 47 | 11576779 |
| 2012 | Evaluation of air-interfaced Calu-3 cell layers for investigation of inhaled drug interactions with organic cation transporters in vitro. | International journal of pharmaceutics | 45 | 22265910 |
| 2003 | Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells. | American journal of respiratory cell and molecular biology | 44 | 12714375 |
| 2002 | Insulin aggregation and asymmetric transport across human bronchial epithelial cell monolayers (Calu-3). | Journal of pharmaceutical sciences | 44 | 11948552 |
| 1997 | Vectorial transcytosis of dimeric IgA by the Calu-3 human lung epithelial cell line: upregulation by IFN-gamma. | The American journal of physiology | 43 | 9176261 |
| 2017 | A Peptide Nucleic Acid against MicroRNA miR-145-5p Enhances the Expression of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Calu-3 Cells. | Molecules (Basel, Switzerland) | 41 | 29286300 |
| 2006 | Protease-activated receptor regulation of Cl- secretion in Calu-3 cells requires prostaglandin release and CFTR activation. | American journal of physiology. Cell physiology | 41 | 16531569 |
| 2021 | Differential Signaling and Virus Production in Calu-3 Cells and Vero Cells upon SARS-CoV-2 Infection. | Biomolecules & therapeutics | 39 | 33504682 |
| 2009 | Tiron, a ROS scavenger, protects human lung cancer Calu-6 cells against antimycin A-induced cell death. | Oncology reports | 39 | 19082470 |
| 2008 | Pyrogallol inhibits the growth of lung cancer Calu-6 cells via caspase-dependent apoptosis. | Chemico-biological interactions | 39 | 19000662 |
| 2020 | Quantitative estimation of drug permeation through nasal mucosa using in vitro membrane permeability across Calu-3 cell layers for predicting in vivo bioavailability after intranasal administration to rats. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V | 38 | 32057906 |
| 2009 | Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model. | Antimicrobial agents and chemotherapy | 38 | 19822706 |
| 1999 | PBA increases CFTR expression but at high doses inhibits Cl(-) secretion in Calu-3 airway epithelial cells. | The American journal of physiology | 36 | 10516210 |
| 1998 | Antisense oligonucleotide to PKC-epsilon alters cAMP-dependent stimulation of CFTR in Calu-3 cells. | The American journal of physiology | 36 | 9814985 |
| 2012 | Bicarbonate-dependent chloride transport drives fluid secretion by the human airway epithelial cell line Calu-3. | The Journal of physiology | 35 | 22777674 |
| 2002 | Regulation of intracellular pH in Calu-3 human airway cells. | The Journal of physiology | 34 | 11790817 |
| 2018 | Carbon monoxide releasing molecule-2 suppresses proliferation, migration, invasion, and promotes apoptosis in non-small cell lung cancer Calu-3 cells. | European review for medical and pharmacological sciences | 33 | 29687848 |
| 2008 | Multiple KCNQ potassium channel subtypes mediate basal anion secretion from the human airway epithelial cell line Calu-3. | The Journal of membrane biology | 33 | 18264812 |
| 2006 | Carbopol-mediated paracellular transport enhancement in Calu-3 cell layers. | Journal of pharmaceutical sciences | 33 | 16374869 |
| 2020 | Suitability and functional characterization of two Calu-3 cell models for prediction of drug permeability across the airway epithelial barrier. | International journal of pharmaceutics | 32 | 32485216 |
| 2020 | Comparative toxicity of ultrafine particles around a major airport in human bronchial epithelial (Calu-3) cell model at the air-liquid interface. | Toxicology in vitro : an international journal published in association with BIBRA | 32 | 32726611 |
| 2009 | Identification and functional characterization of breast cancer resistance protein in human bronchial epithelial cells (Calu-3). | International journal of pharmaceutics | 32 | 19782742 |
| 2005 | Two-pore-domain potassium channels support anion secretion from human airway Calu-3 epithelial cells. | Pflugers Archiv : European journal of physiology | 32 | 16311719 |
| 2004 | Dose-dependent effect of FHIT-inducible expression in Calu-1 lung cancer cell line. | Oncogene | 32 | 15361849 |
| 2017 | Evaluation of permeability alteration and epithelial-mesenchymal transition induced by transforming growth factor-β1 in A549, NCI-H441, and Calu-3 cells: Development of an in vitro model of respiratory epithelial cells in idiopathic pulmonary fibrosis. | Journal of pharmacological and toxicological methods | 31 | 28259823 |
| 2010 | Calu-3 cells grown under AIC and LCC conditions: implications for dipeptide uptake and transepithelial transport of substances. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V | 31 | 21195173 |
| 2009 | Effects of carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone on the growth inhibition in human pulmonary adenocarcinoma Calu-6 cells. | Toxicology | 31 | 19819288 |
| 2007 | Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR. | British journal of pharmacology | 31 | 17339840 |
| 1999 | Human renin mRNA stability is increased in response to cAMP in Calu-6 cells. | Hypertension (Dallas, Tex. : 1979) | 31 | 10082506 |
| 2022 | Applicability of RPMI 2650 and Calu-3 Cell Models for Evaluation of Nasal Formulations. | Pharmaceutics | 29 | 35214101 |
| 2012 | Functional effects of nanoparticle exposure on Calu-3 airway epithelial cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 27 | 22415089 |
| 2011 | Anion secretion by a model epithelium: more lessons from Calu-3. | Acta physiologica (Oxford, England) | 27 | 21251238 |
| 2009 | Eicosanoid release is increased by membrane destabilization and CFTR inhibition in Calu-3 cells. | PloS one | 27 | 19847291 |
| 2021 | The Effect of Allicin on the Proteome of SARS-CoV-2 Infected Calu-3 Cells. | Frontiers in microbiology | 26 | 34777295 |
| 2006 | Altered expression of FANCL confers mitomycin C sensitivity in Calu-6 lung cancer cells. | Cancer biology & therapy | 26 | 17106252 |
| 2005 | Role for protein phosphatase 2A in the regulation of Calu-3 epithelial Na+-K+-2Cl-, type 1 co-transport function. | The Journal of biological chemistry | 26 | 15899883 |
| 2021 | Propagation of SARS-CoV-2 in Calu-3 Cells to Eliminate Mutations in the Furin Cleavage Site of Spike. | Viruses | 25 | 34960703 |
| 2014 | PX-12 induces apoptosis in Calu-6 cells in an oxidative stress-dependent manner. | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | 25 | 25391429 |
| 2013 | Establishing a liquid-covered culture of polarized human airway epithelial Calu-3 cells to study host cell response to respiratory pathogens in vitro. | Journal of visualized experiments : JoVE | 25 | 23426201 |
| 2012 | Characterization of Calu-3 cell monolayers as a model of bronchial epithelial transport: organic cation interaction studies. | Journal of drug targeting | 25 | 23050869 |
| 2000 | Properties of CFTR activated by the xanthine derivative X-33 in human airway Calu-3 cells. | American journal of physiology. Cell physiology | 25 | 11078708 |
| 2014 | Bile acids stimulate chloride secretion through CFTR and calcium-activated Cl- channels in Calu-3 airway epithelial cells. | American journal of physiology. Lung cellular and molecular physiology | 24 | 24993131 |
| 2012 | Transport characteristics of clarithromycin, azithromycin and telithromycin, antibiotics applied for treatment of respiratory infections, in Calu-3 cell monolayers as model lung epithelial cells. | Die Pharmazie | 24 | 22764569 |
| 2002 | Transport of HIV-protease inhibitors across 1 alpha,25di-hydroxy vitamin D3-treated Calu-3 cell monolayers: modulation of P-glycoprotein activity. | Pharmaceutical research | 24 | 12458676 |
| 2018 | N-acetyl cysteine reverts the proinflammatory state induced by cigarette smoke extract in lung Calu-3 cells. | Redox biology | 23 | 29573703 |
| 2001 | Antibacterial activity of apical surface fluid from the human airway cell line Calu-3: pharmacologic alteration by corticosteroids and beta(2)-agonists. | American journal of respiratory cell and molecular biology | 23 | 11509329 |
| 2020 | Treatment of human airway epithelial Calu-3 cells with a peptide-nucleic acid (PNA) targeting the microRNA miR-101-3p is associated with increased expression of the cystic fibrosis Transmembrane Conductance Regulator () gene. | European journal of medicinal chemistry | 22 | 33127171 |
| 2018 | Synthesis and evaluation of the cytotoxic activity of Furanaphthoquinones tethered to 1H-1,2,3-triazoles in Caco-2, Calu-3, MDA-MB231 cells. | European journal of medicinal chemistry | 22 | 30025347 |
| 2012 | Basolateral chloride loading by the anion exchanger type 2: role in fluid secretion by the human airway epithelial cell line Calu-3. | The Journal of physiology | 22 | 22802585 |
| 2012 | Dexamethasone regulates CFTR expression in Calu-3 cells with the involvement of chaperones HSP70 and HSP90. | PloS one | 22 | 23272037 |
| 2001 | Differential regulation of Cl- transport proteins by PKC in Calu-3 cells. | American journal of physiology. Lung cellular and molecular physiology | 22 | 11238015 |
| 2021 | Development of an In Vitro Airway Epithelial-Endothelial Cell Culture Model on a Flexible Porous Poly(Trimethylene Carbonate) Membrane Based on Calu-3 Airway Epithelial Cells and Lung Microvascular Endothelial Cells. | Membranes | 21 | 33799867 |
| 2011 | Imbricatolic acid from Juniperus communis L. prevents cell cycle progression in CaLu-6 cells. | Planta medica | 21 | 21567359 |
| 2008 | Pyrogallol inhibits the growth of human lung cancer Calu-6 cells via arresting the cell cycle arrest. | Toxicology in vitro : an international journal published in association with BIBRA | 21 | 18652887 |
| 2020 | Optimization of inhalable liposomal powder formulations and evaluation of their in vitro drug delivery behavior in Calu-3 human lung epithelial cells. | International journal of pharmaceutics | 20 | 32593649 |
| 2010 | The effects of MAPK inhibitors on antimycin A-treated Calu-6 lung cancer cells in relation to cell growth, reactive oxygen species, and glutathione. | Molecular and cellular biochemistry | 19 | 19714450 |
| 2009 | The effect of MAPK inhibitors on arsenic trioxide-treated Calu-6 lung cells in relation to cell death, ROS and GSH levels. | Anticancer research | 19 | 19846917 |
| 2006 | Ambroxol-induced modification of ion transport in human airway Calu-3 epithelia. | Biochemical and biophysical research communications | 19 | 16546120 |
| 2004 | 4-Chloro-benzo[F]isoquinoline (CBIQ) activates CFTR chloride channels and KCNN4 potassium channels in Calu-3 human airway epithelial cells. | British journal of pharmacology | 19 | 15148241 |
| 2022 | Differential effect of SARS-CoV-2 infection on stress granule formation in Vero and Calu-3 cells. | Frontiers in microbiology | 18 | 36081788 |
| 2020 | HMGB1-downregulated angulin-1/LSR induces epithelial barrier disruption via claudin-2 and cellular metabolism via AMPK in airway epithelial Calu-3 cells. | Biochemical and biophysical research communications | 18 | 32423802 |
| 2018 | Flos Magnoliae Inhibits Chloride Secretion via ANO1 Inhibition in Calu-3 Cells. | The American journal of Chinese medicine | 18 | 29976084 |
| 2013 | Salbutamol sulfate absorption across Calu-3 bronchial epithelia cell monolayer is inhibited in the presence of common anionic NSAIDs. | The Journal of asthma : official journal of the Association for the Care of Asthma | 18 | 23406450 |
| 2013 | COMMD1 interacts with the COOH terminus of NKCC1 in Calu-3 airway epithelial cells to modulate NKCC1 ubiquitination. | American journal of physiology. Cell physiology | 18 | 23515529 |
| 2008 | Vasoactive intestinal peptide increases cystic fibrosis transmembrane conductance regulator levels in the apical membrane of Calu-3 cells through a protein kinase C-dependent mechanism. | The Journal of pharmacology and experimental therapeutics | 18 | 18650246 |
| 2006 | Identification and membrane localization of electrogenic sodium bicarbonate cotransporters in Calu-3 cells. | Biochimica et biophysica acta | 18 | 16857349 |
| 2003 | Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells. | The Journal of membrane biology | 18 | 12820662 |
| 2021 | MUC1-C influences cell survival in lung adenocarcinoma Calu-3 cells after SARS-CoV-2 infection. | BMB reports | 17 | 33832550 |