Affinage

CALU

Calumenin · UniProt O43852

Length
315 aa
Mass
37.1 kDa
Annotated
2026-06-14
40 papers in source corpus 19 papers cited in narrative 19 extracted findings
Cross-family judge vs UniProt: Affinage preferred

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

Calumenin (CALU) is a Ca2+-binding protein of the secretory pathway that functions as a Ca2+-dependent folding sensor and multi-functional chaperone regulating Ca2+ handling, protein proteostasis, and extracellular signaling (PMID:9218460, PMID:26991433). It is retained in the ER via a C-terminal HDEF tetrapeptide and binds Ca2+ through multiple low-affinity EF-hand motifs, and upon Ca2+ binding it switches reversibly from a largely disordered state to a compact, alpha-helical trilobal fold that underlies its activity (PMID:9218460, PMID:9675259, PMID:26991433). A fraction transits the Golgi and is secreted, with export depending on microtubule integrity and the motors Kif5b and cytoplasmic dynein (PMID:10222138, PMID:22514732). In the SR/ER lumen, calumenin directly binds SERCA2 in its E1 state to inhibit Ca2+ uptake and binds RyR1 in a Ca2+-dependent manner to modulate Ca2+ release, thereby tuning intracellular Ca2+ homeostasis (PMID:18562801, PMID:19740751, PMID:16527250). Through this Ca2+/SERCA control it also governs ER Ca2+ levels in bronchial epithelium, where its reduction partially restores F508del-CFTR activity, and it physically associates with mutant CFTR to influence its folding and trafficking (PMID:22768251, PMID:25120007, PMID:28189267). Calumenin further acts as a chaperone for vimentin proteostasis by collaborating with the TRiC chaperonin and recruiting CCT2 to clear misfolded vimentin aggregates, with loss promoting fibroblast senescence and lung aging (PMID:41557802). Extracellularly, calumenin binds and stabilizes fibulin-1, protecting it from MMP-13 cleavage and suppressing ERK1/2-dependent cell migration via syndecan-4 and α5β1-integrin signaling (PMID:24632605). A distinct Calu-15 splice isoform undergoes CK2-dependent Thr-73 phosphorylation enabling nuclear import and transcriptional upregulation of GDF-15 to promote filopodia formation (PMID:24136234).

Mechanistic history

Synthesis pass · year-by-year structured walk · 19 steps
  1. 1997 High

    Established calumenin as an ER-resident Ca2+-binding protein and defined a novel ER retention signal, framing it as a luminal Ca2+-handling factor.

    Evidence Retention assay, immunostaining, deglycosylation, and direct Ca2+-binding with purified protein

    PMID:9218460

    Open questions at the time
    • Functional role beyond Ca2+ binding not addressed
    • Affinity and stoichiometry of Ca2+ sites not quantified here
  2. 1998 High

    Quantified calumenin's Ca2+ binding as multi-site low-affinity, consistent with a buffering/sensing role rather than high-affinity signaling.

    Evidence Microdialysis Ca2+-binding with recombinant human protein

    PMID:9675259

    Open questions at the time
    • Conformational consequences of binding not resolved
    • In vivo relevance of low affinity untested
  3. 1999 High

    Showed calumenin is not strictly ER-confined but transits the Golgi and is secreted, opening an extracellular dimension to its function.

    Evidence Immunofluorescence, immunoEM, endoglycosidase H, Western blot of conditioned medium

    PMID:10222138

    Open questions at the time
    • Extracellular function unknown at this stage
    • Mechanism of escape from HDEF retention unclear
  4. 2000 Medium

    Identified the first Ca2+-dependent binding partner (SAP), establishing calumenin as a Ca2+-regulated interaction protein.

    Evidence Affinity chromatography, sequencing, and surface plasmon resonance

    PMID:10631319

    Open questions at the time
    • Functional consequence of SAP binding not established
    • Single lab, no in vivo validation
  5. 2006 High

    Linked calumenin to excitation-contraction coupling by mapping a Ca2+-dependent RyR1 interaction and demonstrating functional modulation of Ca2+ release.

    Evidence GST pull-down, co-IP, EF-hand deletion, overexpression, Ca2+ imaging in C2C12 myotubes

    PMID:16527250

    Open questions at the time
    • Direct vs indirect RyR1 contact not resolved
    • Physiological role in intact muscle untested
  6. 2008 High

    Established a direct calumenin–SERCA2 interaction that inhibits SR Ca2+ uptake, defining a cardiac Ca2+-handling function.

    Evidence Adenoviral overexpression, Ca2+ transients, oxalate-supported uptake, co-IP in cardiomyocytes

    PMID:18562801

    Open questions at the time
    • Interaction interface not mapped here
    • Endogenous loss-of-function not tested
  7. 2009 High

    Mapped the calumenin–SERCA2 interface and showed state-specific (E1) binding plus knockdown enhancement of Ca2+ transients, establishing mechanism and direction of regulation.

    Evidence GST pull-down with deletion fragments, co-IP, siRNA knockdown, state-specific inhibitors, Ca2+ uptake in HL-1 cells

    PMID:19740751

    Open questions at the time
    • Structural basis of E1 preference not resolved
    • Regulation by Ca2+ occupancy of EF-hands unclear
  8. 2009 Medium

    Demonstrated organismal requirement for calumenin in C. elegans and genetic interaction with the IP3 receptor, connecting it to whole-animal Ca2+ physiology.

    Evidence Mutant analysis and genetic epistasis with itr-1, behavioral assays

    PMID:19695248

    Open questions at the time
    • Molecular mechanism of IP3R interplay unknown
    • Mammalian relevance not tested
  9. 2012 Medium

    Defined the cellular machinery and signals for calumenin secretion, showing microtubule- and motor-dependent export.

    Evidence Live-cell imaging, microtubule disruption, dominant-negative motors, deletion mapping

    PMID:22514732

    Open questions at the time
    • How export bypasses ER retention not explained
    • Single lab
  10. 2012 Medium

    Connected calumenin to disease-relevant CFTR processing by identifying it as a partner enriched in the G551D-CFTR complex.

    Evidence Co-IP, 2D-gel, mass spectrometry, SPR, immunofluorescence

    PMID:22768251

    Open questions at the time
    • Functional effect on CFTR maturation inferred, not demonstrated
    • Direct vs complex-mediated binding unclear
  11. 2013 Medium

    Revealed a cytoprotective role: calumenin overexpression suppresses ER stress and apoptosis pathways in cardiomyocytes.

    Evidence Adenoviral overexpression, ER-stress and apoptosis marker Westerns, TUNEL

    PMID:24012670

    Open questions at the time
    • Loss-of-function ER-stress phenotype untested
    • Mechanism linking Ca2+ regulation to ER stress not dissected
  12. 2013 Medium

    Uncovered a non-canonical nuclear/transcriptional pathway through the Calu-15 isoform driving filopodia formation via GDF-15 upregulation.

    Evidence Splice cloning, co-IP (importin α/Ran/CRM1), CK2 inhibition, Thr-73 mutation, ChIP, reporter assays, filopodia imaging

    PMID:24136234

    Open questions at the time
    • Isoform-specific physiological role in vivo unknown
    • Generality beyond Calu-15 unclear
  13. 2014 High

    Defined an extracellular tumor-suppressive function: calumenin stabilizes fibulin-1 against MMP-13 to suppress ERK1/2-dependent migration through receptor signaling.

    Evidence Co-IP, siRNA, in vitro MMP-13 protection, ERK Westerns, migration assays, domain mapping

    PMID:24632605

    Open questions at the time
    • In vivo relevance to tumor progression not established here
    • Stoichiometry of fibulin-1/fibronectin complex unresolved
  14. 2014 Medium

    Showed calumenin behaves like an intrinsically disordered chaperone reducing F508del-CFTR aggregation, linking biophysics to mutant CFTR handling.

    Evidence In vitro aggregation assay with recombinant calumenin, trafficking imaging

    PMID:25120007

    Open questions at the time
    • Mechanism of trafficking change not resolved
    • Whether effect is direct chaperoning unclear
  15. 2015 Medium

    Provided a clinical/regulatory link by showing a CALU polymorphism reduces mRNA stability and correlates with altered vascular calcification.

    Evidence Luciferase mRNA-stability reporter, IHC, genotyping, mineralization assay in hVSMC

    PMID:25823396

    Open questions at the time
    • Causality between calumenin level and calcification not proven
    • Mechanistic link to gamma-carboxylation correlative
  16. 2015 Medium

    Quantified high-affinity extracellular/luminal partner interactions (fibulin-1C, C1 esterase inhibitor, GRP75), refining calumenin's interactome and Ca2+-dependence.

    Evidence Affinity purification, co-IP, mass spectrometry, SPR

    PMID:26161649

    Open questions at the time
    • Functional consequence of C1 inhibitor and GRP75 binding unknown
    • Single lab
  17. 2016 High

    Provided the structural basis for calumenin function: a reversible Ca2+-induced disorder-to-compact-trilobal-fold transition that gates its activity.

    Evidence CD, SAXS, analytical SEC, SPR

    PMID:26991433

    Open questions at the time
    • High-resolution structure not determined
    • How fold change maps onto partner binding not directly shown
  18. 2017 Medium

    Integrated calumenin's SERCA regulation with CFTR rescue, showing knockdown restores F508del-CFTR activity via ER Ca2+ control.

    Evidence siRNA knockdown, ER Ca2+ and SERCA activity assays, CFTR functional assay in bronchial cells

    PMID:28189267

    Open questions at the time
    • Therapeutic translation untested
    • Direct vs Ca2+-mediated CFTR effect not fully separated
  19. 2026 High

    Established calumenin as a proteostasis chaperone for vimentin via TRiC/CCT2, with loss driving fibroblast senescence and lung aging, expanding its role beyond Ca2+ handling.

    Evidence CRISPR screen, fibroblast-specific KO mouse, co-IP (TRiC/CCT2), live-cell and Ca2+ imaging, EM

    PMID:41557802

    Open questions at the time
    • How Ca2+-induced calumenin degradation is triggered mechanistically unresolved
    • Generality of vimentin chaperoning across cell types untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How calumenin's Ca2+-gated conformational switch is mechanistically coupled to its diverse outputs (SERCA/RyR regulation, CFTR folding, vimentin chaperoning, fibulin-1 stabilization) remains unresolved.
  • No unified structural model linking fold state to partner selection
  • Tissue-specific division of labor among functions unclear
  • No high-resolution structure of any calumenin-partner complex

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 3 GO:0044183 protein folding chaperone 2 GO:0140110 transcription regulator activity 1 GO:0140313 molecular sequestering activity 1
Localization
GO:0005576 extracellular region 2 GO:0005783 endoplasmic reticulum 2 GO:0005634 nucleus 1 GO:0005794 Golgi apparatus 1
Pathway
R-HSA-382551 Transport of small molecules 2 R-HSA-392499 Metabolism of proteins 2 R-HSA-8953897 Cellular responses to stimuli 2 R-HSA-162582 Signal Transduction 1
Partners
APCSATP2A2CCT2CFTRFBLN1HSPA9RYR1SERPING1
Complex memberships
TRiC/CCT chaperonin (associated)calumenin/fibulin-1/fibronectin extracellular complex

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 Calumenin is a Ca2+-binding protein with six EF-hand motifs retained in the endoplasmic reticulum; the C-terminal tetrapeptide HDEF is responsible for ER retention, with the Phe residue being a novel component of the ER retention signal. Retention assay, immunostaining with confocal laser microscope, deglycosylation assay, Ca2+-binding assay with purified protein The Journal of biological chemistry High 9218460
1998 Recombinant human calumenin binds Ca2+ through all 7 EF-hand domains with low affinity (Kd ~1/1.6×10³ M⁻¹ per site), consistent with a role in Ca2+-dependent ER processes. Microdialysis Ca2+-binding experiments with recombinant human calumenin expressed in E. coli Biochimica et biophysica acta High 9675259
1999 Human calumenin localizes to both the ER and Golgi complex in multiple human cell lines, and a glycosylated, endoglycosidase H-resistant form is secreted into the culture medium, indicating transit through the Golgi and extracellular release. Immunofluorescence, immunoelectron microscopy, endoglycosidase H treatment, Western blot of conditioned medium Experimental cell research High 10222138
2000 Calumenin binds serum amyloid P component (SAP) in a Ca2+-dependent manner; this interaction was identified by affinity chromatography and verified by surface plasmon resonance. Affinity chromatography with immobilized recombinant calumenin, amino acid sequencing of eluate, surface plasmon resonance FEBS letters Medium 10631319
2006 Calumenin-2 interacts with ryanodine receptor 1 (RyR1) in rabbit skeletal sarcoplasmic reticulum in a Ca2+-dependent manner; the second EF-hand domain of calumenin is essential for this interaction. Overexpression of calumenin-2 in C2C12 myotubes increases caffeine-induced Ca2+ release but decreases depolarization-induced Ca2+ release. GST pull-down, co-immunoprecipitation, EF-hand deletion constructs, adenovirus-mediated overexpression, Ca2+ imaging Biochemical and biophysical research communications High 16527250
2008 Calumenin overexpression in neonatal rat cardiomyocytes prolongs time to 50% Ca2+ baseline (T50) by inhibiting SERCA2-mediated Ca2+ uptake into the SR; co-immunoprecipitation demonstrates a direct interaction between calumenin and SERCA2. Adenovirus-mediated overexpression, Ca2+ transient measurement, oxalate-supported Ca2+ uptake assay, co-immunoprecipitation Molecules and cells High 18562801
2009 Calumenin (calu-1) in C. elegans is required for fertility, locomotion, body size, defecation, and pharyngeal pumping; genetic analysis suggests calu-1 regulates pharyngeal pumping together with the IP3 receptor (itr-1). Mutant analysis, genetic epistasis (calu-1 and itr-1 double mutant analysis), behavioral assays FEBS letters Medium 19695248
2009 Calumenin interacts with SERCA2 in mouse cardiac SR; the binding is favored in the E1 state of SERCA2 (reduced by thapsigargin, vanadate, or ATP). GST pull-down with deletion fragments maps the interaction to residues 132–222 of calumenin and residues 853–892 (L4 luminal domain) of SERCA2. Calumenin knockdown (80%) in HL-1 cells enhances Ca2+ transient amplitude and increases Ca2+ sensitivity of SERCA2. GST pull-down with deletion fragments, co-immunoprecipitation, immunocytochemistry, siRNA knockdown, oxalate-supported Ca2+ uptake assay, state-specific SERCA2 inhibitors The Journal of biological chemistry High 19740751
2012 Calumenin-1/2 secretion requires microtubule integrity and is mediated by motor proteins Kif5b and cytoplasmic dynein; the export signal maps to amino acids 20–46, and asparagine at position 131 is required for protein stabilization. Time-lapse live-cell imaging of calu-1/2-EGFP, microtubule disruption, dominant-negative motor protein expression, deletion mapping PloS one Medium 22514732
2012 Calumenin is identified as a binding partner of G551D-CFTR by co-immunoprecipitation and mass spectrometry, and is more abundant in the G551D-CFTR complex than in the wild-type CFTR complex; the interaction was confirmed by surface plasmon resonance. Co-immunoprecipitation, 2D-gel electrophoresis, mass spectrometry, surface plasmon resonance, immunofluorescence PloS one Medium 22768251
2013 Calumenin overexpression in neonatal rat ventricular cardiomyocytes reduces ER stress markers (GRP78, p-PERK, p-eIF2α) and ER-initiated apoptosis markers (CHOP, p-JNK) during tunicamycin-induced ER stress, and reduces apoptosis as measured by TUNEL assay. Recombinant adenovirus-mediated overexpression (7.5-fold), Western blot for ER stress markers, TUNEL assay Biochemical and biophysical research communications Medium 24012670
2013 Calumenin isoform Calu-15 promotes filopodia formation and cell migration by: (1) shuttling between nucleus and cytoplasm via interaction with importin α, Ran GTPase, and CRM1; (2) requiring CK2-dependent phosphorylation of Thr-73 for nuclear import; and (3) binding the GDF-15 promoter in the nucleus to increase GDF-15 transcription. Alternative splicing cloning, co-immunoprecipitation (importin α, Ran, CRM1), CK2 inhibition, Thr-73 point mutation, chromatin immunoprecipitation, promoter-reporter assay, filopodia imaging Cell death & disease Medium 24136234
2014 Extracellular calumenin binds and stabilizes fibulin-1, protecting it from MMP-13-mediated proteolysis; this suppresses ERK1/2 signaling and inhibits cell migration. The minimal functional domain maps to residues 74–138 and 214–280. Calumenin/fibulin-1 also interact with fibronectin and signal through syndecan-4 and α5β1-integrin to suppress pERK1/2. Co-immunoprecipitation, siRNA knockdown, in vitro MMP-13 cleavage protection assay, ERK1/2 phosphorylation Western blot, migration assay, domain deletion mapping Oncogene High 24632605
2014 Calumenin reduces F508del-CFTR aggregation in vitro, similar to an intrinsically disordered protein (IDP), and shows altered trafficking in bronchial cells expressing F508del-CFTR, indicating a direct role in mutant CFTR folding/processing. Aggregation assay (recombinant calumenin + F508del-CFTR), fluorescence microscopy-based trafficking analysis, biophysical characterization PloS one Medium 25120007
2015 CALU polymorphism rs1043550 (A29809G) reduces calumenin mRNA stability by ~30% as shown by a luciferase reporter assay in vascular cells; reduced calumenin availability correlates with impaired gamma-carboxylation of matrix-Gla-protein and altered vascular calcification. Luciferase reporter system (mRNA stability assay), immunohistochemistry, clinical genotyping, extracellular matrix mineralization assay in hVSMC Journal of molecular and cellular cardiology Medium 25823396
2015 Calumenin and reticulocalbin interact with fibulin-1C, C1 esterase inhibitor, and GRP75 (Grp75); calumenin binds fibulin-1C with Kd ~50–60 nM and C1 esterase inhibitor with Kd ~150 nM; the calumenin–C1 esterase inhibitor interaction is Ca2+-dependent (detectable at 3.5 mM, absent at 0.1 mM Ca2+). Affinity purification, co-immunoprecipitation, mass spectrometry, surface plasmon resonance PloS one Medium 26161649
2016 Calumenin undergoes Ca2+-induced folding: in low Ca2+, the protein is largely disordered; upon Ca2+ addition it adopts a compact, predominantly alpha-helical trilobal structure. This conformational switch is reversible. Circular dichroism spectroscopy, small-angle X-ray scattering (SAXS), analytical size-exclusion chromatography, surface plasmon resonance PloS one High 26991433
2017 Calumenin modulates SERCA pump activity and is a key regulator of ER Ca2+ homeostasis in bronchial epithelial cells expressing both wild-type and F508del-CFTR; reducing calumenin expression partially restores F508del-CFTR activity. siRNA knockdown, ER Ca2+ measurement, SERCA activity assay, CFTR functional assay Cell calcium Medium 28189267
2026 Calumenin acts as a chaperone for vimentin proteostasis in lung fibroblasts: it collaborates with the TRiC chaperonin complex to facilitate proper vimentin folding, and recruits the CCT2 subunit to degrade misfolded vimentin aggregates. Fibroblast-specific knockout of calumenin promotes vimentin aggregate accumulation and profibrotic factor (migracytosis) secretion, exacerbating fibroblast senescence and lung aging. External profibrotic stimuli trigger calcium transients that induce calumenin degradation. CRISPR-based genetic screen, fibroblast-specific knockout mouse, co-immunoprecipitation (TRiC/CCT2), live-cell imaging, Ca2+ imaging, Western blot, electron microscopy Proceedings of the National Academy of Sciences of the United States of America High 41557802

Source papers

Stage 0 corpus · 40 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1997 Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF. The Journal of biological chemistry 95 9218460
1999 Human calumenin localizes to the secretory pathway and is secreted to the medium. Experimental cell research 84 10222138
2013 Calumenin has a role in the alleviation of ER stress in neonatal rat cardiomyocytes. Biochemical and biophysical research communications 56 24012670
1998 Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity. Biochimica et biophysica acta 56 9675259
2015 Identification and evaluation of metastasis-related proteins, oxysterol binding protein-like 5 and calumenin, in lung tumors. International journal of oncology 55 25963840
2009 Characterization of calumenin-SERCA2 interaction in mouse cardiac sarcoplasmic reticulum. The Journal of biological chemistry 52 19740751
2021 The Epithelial to Mesenchymal Transition Related Gene Calumenin Is an Adverse Prognostic Factor of Bladder Cancer Correlated With Tumor Microenvironment Remodeling, Gene Mutation, and Ferroptosis. Frontiers in oncology 48 34150647
2006 Calumenin, a multiple EF-hands Ca2+-binding protein, interacts with ryanodine receptor-1 in rabbit skeletal sarcoplasmic reticulum. Biochemical and biophysical research communications 44 16527250
2000 Calumenin interacts with serum amyloid P component. FEBS letters 39 10631319
2014 Extracellular calumenin suppresses ERK1/2 signaling and cell migration by protecting fibulin-1 from MMP-13-mediated proteolysis. Oncogene 37 24632605
2010 Characterization of calumenin in mouse heart. BMB reports 36 20356454
2008 Calumenin interacts with SERCA2 in rat cardiac sarcoplasmic reticulum. Molecules and cells 30 18562801
2013 Calumenin-15 facilitates filopodia formation by promoting TGF-β superfamily cytokine GDF-15 transcription. Cell death & disease 24 24136234
2015 Calumenin and fibulin-1 on tumor metastasis: Implications for pharmacology. Pharmacological research 21 25976680
2018 Protective effect of miR378* on doxorubicin-induced cardiomyocyte injury via calumenin. Journal of cellular physiology 18 29665007
2012 The intracellular transport and secretion of calumenin-1/2 in living cells. PloS one 18 22514732
2012 Proteomic identification of calumenin as a G551D-CFTR associated protein. PloS one 18 22768251
2004 Characterization of isoforms and genomic organization of mouse calumenin. Gene 18 14980715
2021 Calumenin contributes to epithelial-mesenchymal transition and predicts poor survival in glioma. Translational neuroscience 17 33623713
2017 Calumenin contributes to ER-Ca2+ homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention. Cell calcium 17 28189267
2011 Spatio-temporal expression analysis of the calcium-binding protein calumenin in the rodent brain. Neuroscience 17 22178608
2016 Ca-Dependent Folding of Human Calumenin. PloS one 16 26991433
2017 Calumenin relieves cardiac injury by inhibiting ERS-initiated apoptosis during viral myocarditis. International journal of clinical and experimental pathology 12 31966567
2015 CALU polymorphism A29809G affects calumenin availability involving vascular calcification. Journal of molecular and cellular cardiology 12 25823396
2014 Biophysical characterisation of calumenin as a charged F508del-CFTR folding modulator. PloS one 12 25120007
2022 Upregulation of miR-335-5p Contributes to Right Ventricular Remodeling via Calumenin in Pulmonary Arterial Hypertension. BioMed research international 11 36246958
2009 Pleiotropic roles of calumenin (calu-1), a calcium-binding ER luminal protein, in Caenorhabditis elegans. FEBS letters 10 19695248
2017 Creatine phosphate disodium salt protects against Dox-induced cardiotoxicity by increasing calumenin. Medical molecular morphology 7 29282541
2015 Fibulin-1C, C1 Esterase Inhibitor and Glucose Regulated Protein 75 Interact with the CREC Proteins, Calumenin and Reticulocalbin. PloS one 7 26161649
2021 S100A6, Calumenin and Cytohesin 2 as Biomarkers for Cutaneous Involvement in Systemic Sclerosis Patients: A Case Control Study. Journal of personalized medicine 6 34063287
2019 Calcium-Induced Protein Folding in Calumenin and Calmodulin. Methods in molecular biology (Clifton, N.J.) 6 30710294
2022 Calumenin knockdown, by intronic artificial microRNA, to improve expression efficiency of the recombinant human coagulation factor IX. Biotechnology letters 4 35412165
2024 Dissecting the Implications of Calumenin in Malignancy and Heterogeneity of the Microenvironment of Clear Cell Renal Cell Carcinoma Using Multi-Omics Data. Phenomics (Cham, Switzerland) 3 39583311
2019 Measuring Calumenin Impact on ER-Calcium Depletion Using Transient Calumenin Overexpression and Silencing. Methods in molecular biology (Clifton, N.J.) 3 30710295
2023 Calumenin, a Ca2+ Binding Protein, Is Required for Dauer Formation in Caenorhabditis elegans. Biology 2 36979156
2025 Mechanism of myocardial damage induced by doxorubicin via calumenin-regulated mitochondrial dynamics and the calcium-Cx43 pathway. World journal of cardiology 1 40496395
2025 Silencing Calumenin Expression via Artificial MicroRNA, a Potential Breakthrough for Inhibiting Proliferation, Halting Migration, and Triggering Apoptosis in Breast Cancer Cells. Advanced pharmaceutical bulletin 1 40922754
2018 Calumenin DNA methylation and gene expression in viral myocarditis. International journal of clinical and experimental pathology 1 31938169
2026 Calumenin prevents fibroblast senescence and lung aging by promoting vimentin proteostasis. Proceedings of the National Academy of Sciences of the United States of America 0 41557802
2025 Calumenin, A Calcium-Binding Modulatory Protein, Effective in Pathological Calcifications and Cancers, With Therapeutic Application Promise. FASEB bioAdvances 0 41090186

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