Affinage

CACNG6

Voltage-dependent calcium channel gamma-6 subunit · UniProt Q9BXT2

Length
260 aa
Mass
28.1 kDa
Annotated
2026-04-28
11 papers in source corpus 2 papers cited in narrative 2 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CACNG6 encodes a voltage-dependent calcium channel gamma subunit that stabilizes the channel complex and participates in regulating calcium ion influx (PMID:20860846). Downregulation of CACNG6 reduces calcium influx and has been linked to indirect modulation of the MAPK pathway in an in vivo mouse pneumonia model (PMID:41819427). Direct mechanistic characterization of CACNG6 through reconstitution, mutagenesis, or structural studies is largely uncharacterized.

Mechanistic history

Synthesis pass · year-by-year structured walk · 2 steps
  1. 2010 Low

    CACNG6 was annotated as a stabilizing subunit of voltage-dependent calcium channels, linking it to calcium ion regulation in the context of airway physiology — but this claim derived from functional annotation rather than direct experimentation on CACNG6.

    Evidence Genetic association study with functional annotation of CACNG6

    PMID:20860846

    Open questions at the time
    • No direct experimental demonstration of CACNG6 stabilizing the calcium channel complex was performed in this study
    • No mutagenesis or reconstitution evidence for CACNG6 function
    • Relationship to specific calcium channel alpha subunits not characterized
  2. 2026 Low

    Pharmacological downregulation of CACNG6 was shown to reduce calcium influx and indirectly modulate the MAPK pathway, providing the first functional perturbation data linking CACNG6 to calcium signaling in an in vivo disease model.

    Evidence In vivo mouse pneumonia model with nanoparticle drug delivery system and pathway analysis

    PMID:41819427

    Open questions at the time
    • Single study with indirect inference; no genetic knockout, rescue, or direct CACNG6-specific perturbation was performed
    • MAPK modulation is inferred indirectly and could reflect secondary effects of reduced calcium influx rather than a direct CACNG6 function
    • No in vitro electrophysiology or biochemical reconstitution to confirm CACNG6's contribution to channel activity

Open questions

Synthesis pass · forward-looking unresolved questions
  • The direct molecular function of CACNG6 — including which calcium channel complexes it incorporates into, its biophysical effects on channel gating or trafficking, and whether it modulates AMPA receptor trafficking like related family members — remains uncharacterized by direct experimentation.
  • No electrophysiological reconstitution of CACNG6 with defined calcium channel subunits
  • No structural data for CACNG6 in a channel complex
  • No comparison of CACNG6 function to other TARP/gamma subunit family members

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.

Evidence

Reading pass · 2 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2026 CACNG6 downregulation inhibits calcium ion influx, which indirectly modulates the MAPK pathway, as demonstrated in a mouse pneumonia model using a nanoparticle drug delivery system (PT@M2). In vivo mouse model with pharmacological intervention and pathway analysis Journal of controlled release Low 41819427
2010 CACNG6 encodes a protein described as stabilizing the voltage-dependent calcium channel, implicated in calcium ion regulation relevant to airway inflammation and bronchodilation. Genetic association study with functional annotation of CACNG6 role BMC medical genetics Low 20860846

Source papers

Stage 0 corpus · 11 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 Genomic Regions Associated with Feed Efficiency Indicator Traits in an Experimental Nellore Cattle Population. PloS one 58 27760167
2016 Evaluation of voltage-dependent calcium channel γ gene families identified several novel potential susceptible genes to schizophrenia. Scientific reports 54 27102562
2010 Association of CACNG6 polymorphisms with aspirin-intolerance asthmatics in a Korean population. BMC medical genetics 21 20860846
2019 Proestrus Differentially Regulates Expression of Ion Channel and Calcium Homeostasis Genes in GnRH Neurons of Mice. Frontiers in molecular neuroscience 20 31213979
2016 Identification of Transcription Factor-Gene Regulatory Network in Acute Myocardial Infarction. Heart, lung & circulation 16 27746059
2024 Bioinformatics-based screening and analysis of the key genes involved in the influence of antiangiogenesis on myeloid-derived suppressor cells and their effects on the immune microenvironment. Medical oncology (Northwood, London, England) 8 38526604
2025 Identifying therapeutic target genes for diabetic retinopathy using systematic druggable genome-wide Mendelian randomization. Diabetology & metabolic syndrome 4 40301928
2023 Detection of genomic variations and selection signatures in Wagyu using whole-genome sequencing data. Animal genetics 4 37792466
2021 Web-based transcriptome analysis determines a sixteen-gene signature and associated drugs on hearing loss patients: A bioinformatics approach. Journal of clinical laboratory analysis 4 34758154
2025 Systematic druggable genome-wide mendelian randomization identifies therapeutic targets for childhood asthma. Medicine 1 41398767
2026 M2 macrophage-mediated tigecycline nanoparticles for combating CRKP pneumonia via antibacterial and immunomodulatory therapy. Journal of controlled release : official journal of the Controlled Release Society 0 41819427