Affinage

CA14

Carbonic anhydrase 14 · UniProt Q9ULX7

Round 2 corrected
Length
337 aa
Mass
37.7 kDa
Annotated
2026-04-28
111 papers in source corpus 10 papers cited in narrative 10 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CA14 encodes a type I transmembrane carbonic anhydrase that catalyzes extracellular CO₂ hydration with low specific activity and is expressed predominantly in brain, kidney, skeletal muscle, and liver (PMID:10512682). On neuronal membranes, CA14 facilitates AE3-mediated Cl⁻/HCO₃⁻ exchange to regulate intracellular pH in hippocampal neurons, functioning in a cell-surface complex with the anion exchanger (PMID:19279262). In the kidney, CA14 localizes to luminal membranes of proximal tubule S1/S2 segments, where it contributes to bicarbonate reabsorption alongside CA IV (PMID:12028451). During melanocyte differentiation, MITF-driven CA14 translocates to the nucleus, where its pH-raising activity activates p300/CBP histone acetyltransferase to promote H3K27 acetylation at differentiation gene loci, and CRISPR loss-of-function in zebrafish produces hypopigmented, immature melanocytes (PMID:31709752).

Mechanistic history

Synthesis pass · year-by-year structured walk · 7 steps
  1. 1999 High

    Cloning of CA14 established a new transmembrane carbonic anhydrase isoform with low catalytic activity, acetazolamide sensitivity, and broad tissue expression, filling a gap in the membrane-bound CA family.

    Evidence cDNA cloning, Northern blot, enzymatic activity assays on recombinant human CA14

    PMID:10512682

    Open questions at the time
    • No direct protein localization at this stage
    • Physiological substrate context unknown
    • Selectivity profile versus other membrane CAs not resolved
  2. 2001 High

    Immunolocalization of CA14 to neuronal membranes and axons across multiple brain regions identified it as the candidate extracellular CA modulating synaptic pH, resolving which membrane CA isoform is present on neurons.

    Evidence Immunostaining with two independent antibodies in mouse and human brain tissue

    PMID:11172051

    Open questions at the time
    • Functional consequence of neuronal CA14 activity on synaptic transmission not yet tested
    • Relationship to other neuronal CAs (e.g., CA IV) unclear
  3. 2002 High

    Demonstration that CA14 is abundantly expressed on luminal membranes of proximal tubule segments revised the model attributing all membrane-bound CA activity in renal bicarbonate reabsorption to CA IV alone.

    Evidence Immunofluorescence and Western blot on rat and mouse kidney sections

    PMID:12028451

    Open questions at the time
    • Relative quantitative contribution of CA14 versus CA IV to bicarbonate reabsorption not measured
    • No CA14-knockout kidney phenotype reported
  4. 2009 High

    Functional coupling of CA14 to the AE3 anion exchanger in hippocampal neurons was demonstrated, establishing the first direct physiological role for CA14 — regulation of intracellular pH via facilitation of Cl⁻/HCO₃⁻ exchange.

    Evidence Intracellular pH measurements with isoform-specific inhibitory antibodies, benzolamide, and AE3-knockout mouse neurons

    PMID:19279262

    Open questions at the time
    • Physical interaction between CA14 and AE3 not shown biochemically
    • Whether CA14 similarly couples to other bicarbonate transporters in non-neuronal tissues is unknown
  5. 2014 High

    Determination of the crystal structure of the CA14 extracellular domain revealed the canonical α-CA fold and identified region 127–136 as a key structural difference from other membrane CAs, providing a basis for isoform-selective inhibitor design.

    Evidence X-ray crystallography of recombinant human CA14 extracellular domain with structural comparison to CA IV, IX, XII

    PMID:24374484

    Open questions at the time
    • No full-length structure including transmembrane and cytoplasmic domains
    • Selective inhibitors validated against CA14 in vivo not yet reported
  6. 2019 High

    An unexpected nuclear role for CA14 was uncovered: during melanocyte differentiation, MITF-driven CA14 translocates to the nucleus where its pH-raising activity activates p300/CBP, enhancing H3K27 acetylation at differentiation loci — establishing CA14 as an epigenetic amplifier of melanocyte maturation.

    Evidence Overexpression/knockdown, intracellular pH measurement, ChIP for H3K27ac and p300/CBP, CRISPR/Cas9 ca14 missense mutation in zebrafish producing hypopigmentation

    PMID:31709752

    Open questions at the time
    • Mechanism of CA14 nuclear translocation (signal, transport machinery) uncharacterized
    • Whether nuclear CA14 activity is relevant outside melanocytes is unknown
    • Direct physical interaction between CA14 and p300/CBP not demonstrated
  7. 2022 Medium

    Independent morpholino knockdown in zebrafish confirmed that CA14 loss reduces melanin content per melanocyte without affecting melanocyte number, corroborating its role specifically in differentiation/maturation rather than specification.

    Evidence Morpholino knockdown in zebrafish with FACS-based melanocyte quantification using mitfa::GFP and tyrp1::GFP transgenic lines

    PMID:35312674

    Open questions at the time
    • Morpholino approach has known off-target risks; stable genetic knockout confirmation in zebrafish would strengthen the conclusion
    • Downstream gene expression changes upon CA14 loss in vivo not profiled

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the mechanism of CA14 nuclear translocation, whether nuclear CA14 epigenetic activity extends beyond melanocytes, the relative in vivo contribution of CA14 versus CA IV to renal bicarbonate handling, and whether CA14–AE3 coupling involves direct physical interaction.
  • No CA14-knockout mouse phenotype reported for brain or kidney
  • Nuclear translocation mechanism unknown
  • Isoform-selective CA14 inhibitors not validated in vivo

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016787 hydrolase activity 4 GO:0016829 lyase activity 3
Localization
GO:0005886 plasma membrane 4 GO:0005634 nucleus 1
Pathway
R-HSA-1266738 Developmental Biology 2 R-HSA-382551 Transport of small molecules 2 R-HSA-4839726 Chromatin organization 1
Partners
AE3MITFP300/CBP

Evidence

Reading pass · 10 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 Human CA14 encodes a 337-amino-acid transmembrane carbonic anhydrase with hydrophobic signal sequence and transmembrane domain, showing 29–46% similarity to other active CA isozymes (highest to CA XII); the protein displays low catalytic activity and is sensitive to acetazolamide but not to sulfonamide; mRNA (~1.7 kb) is expressed in heart, brain, liver, skeletal muscle, and spinal cord but not in salivary gland or pancreas; the gene maps to chromosome 1q21. cDNA cloning, sequencing, Northern blot, RT-PCR, RNA dot-blot, enzymatic activity assay Genomics High 10512682
2001 CA XIV protein is localized on neuronal membranes and axons in both mouse and human brain; highest expression is on large neuronal bodies and axons in the anterolateral pons and medulla oblongata, with additional expression in hippocampus, corpus callosum, cerebellar white matter and peduncles, pyramidal tract, and choroid plexus, identifying CA XIV as a candidate extracellular carbonic anhydrase modulating synaptic transmission. Immunostaining with two antibodies (anti-recombinant mouse CA XIV and anti-human C-terminal peptide) on mouse and human brain tissue; immunolocalization Proceedings of the National Academy of Sciences of the United States of America High 11172051
2002 CA XIV protein is abundantly expressed on the apical (luminal) plasma membranes of S1 and S2 segments of proximal tubules in rodent kidney, with weaker basolateral staining and strong staining in the initial thin descending limb of Henle; co-expression with CA IV but also unique regions, suggesting CA XIV accounts for a substantial fraction of bicarbonate reabsorption previously attributed to CA IV. RT-PCR, Western blot, immunofluorescence with polyclonal anti-mouse CA XIV antibodies on rat and mouse kidney sections Kidney international High 12028451
2003 In human skeletal muscle during chronic hypoxia (altitude exposure), membrane-bound CA XIV protein expression decreases by 23–47%, whereas CA IV increases by 39%, indicating that CA XIV and CA IV are differentially regulated during hypoxic adaptation affecting acid-base control capacity in muscle. Immunoblotting of skeletal muscle membrane fractions from lowlanders at sea level vs. 2 and 8 weeks at 4100 m altitude, compared to Bolivian natives The Journal of physiology Medium 12611920
2009 CA14 (along with CA4) enhances AE3-mediated Cl⁻/HCO₃⁻ exchange in hippocampal neurons to regulate intracellular pH; inhibition of extracellular CA activity by the poorly permeant blocker benzolamide or by inhibitory antibodies specific for CA4 or CA14 augmented NH₄⁺-induced cytosolic alkalinization, an effect absent when anion exchange was blocked or Cl⁻ removed; AE3-null neurons lacked this CA-dependent pH modulation, placing CA14 in a functional complex with the AE3 anion exchanger. Intracellular pH measurements (NH₄⁺-induced alkalinization assay), selective CA inhibition with benzolamide and isoform-specific inhibitory antibodies, DIDS anion exchange blockade, AE3-knockout mouse neurons, quantitative PCR, single-cell PCR The Journal of neuroscience High 19279262
2010 3,4-Dihydroisoquinoline-2(1H)-sulfonamide derivatives inhibit human CA XIV (transmembrane isoform) at nanomolar concentrations; the X-ray crystal structure of one compound bound to hCA II confirmed sulfonamide–zinc coordination, and docking predicted analogous interactions at hCA XIV and hCA IX active sites, supporting the zinc-binding sulfonamide mechanism for hCA XIV inhibition. Enzymatic inhibition assays against hCA I, II, IX, XIV; X-ray crystallography of inhibitor–hCA II complex; molecular docking to hCA IX and hCA XIV Journal of medicinal chemistry Medium 20170095
2014 The crystal structure of the entire extracellular domain of human CA XIV was determined, revealing the typical α-CA fold with a 10-stranded β-sheet core; structural comparison with membrane-associated hCA IV, IX, and XII identified the region 127–136 and differing oligomeric arrangements as key structural differences, providing a framework for designing selective inhibitors of each membrane-associated CA isoform. Recombinant protein expression, purification, and X-ray crystallography of the hCA XIV extracellular domain; structural comparison with hCA IV, IX, XII crystal structures Biopolymers High 24374484
2019 During melanocyte differentiation, MITF directly activates CA14 transcription; CA14 protein translocates to the nucleus where its carbonic anhydrase activity raises intracellular pH, activating the histone acetyltransferase p300/CBP; this leads to enhanced H3K27 acetylation at selected differentiation gene loci, amplifying their MITF-driven expression. CRISPR-mediated targeted missense mutation of ca14 in zebrafish produces immature, acidic melanocytes with decreased pigmentation, establishing CA14 as a required epigenetic amplifier of the melanocyte maturation program. Cell-based reporter assays, CA14 overexpression and knockdown, intracellular pH measurement, ChIP for H3K27ac and p300/CBP, CRISPR/Cas9 missense mutation in zebrafish with pigmentation phenotyping EMBO reports High 31709752
2022 Morpholino-based silencing of ca14 in zebrafish larvae causes a decrease in melanin content per melanocyte (differentiator phenotype) without altering melanocyte numbers, consistent with CA14 acting at the melanocyte differentiation/maturation step rather than specification; this functional dissection placed CA14 among genes that selectively alter melanin production. Morpholino knockdown in zebrafish, larval pigmentation imaging, FACS-based quantification of melanocyte numbers and melanin content using mitfa::GFP and tyrp1::GFP transgenic lines Journal of visualized experiments : JoVE Medium 35312674
2014 CA14 mRNA expression in rat retina decreases after 2–4 weeks of dietary zinc deficiency and partially recovers upon return to normal zinc diet, co-regulated with CA2 and inversely with ZnT-3, indicating that zinc availability regulates retinal CA14 expression. RT-PCR quantification of CA14 (and CA2, ZnT-3) mRNA in rat retina under low-zinc diet conditions with dietary rescue Genetics and molecular research : GMR Low 24634117

Source papers

Stage 0 corpus · 111 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 Biological insights from 108 schizophrenia-associated genetic loci. Nature 5878 25056061
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
1988 Distribution of the mineralocorticoid and the glucocorticoid receptor mRNAs in the rat hippocampus. Journal of neuroscience research 308 2851057
2011 Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders. Journal of psychiatry & neuroscience : JPN 292 21223646
2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome research 285 12975309
2011 Toward an understanding of the protein interaction network of the human liver. Molecular systems biology 207 21988832
2005 Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease. Journal of pineal research 164 15617532
2017 Hippocampal subfield volumes in mood disorders. Molecular psychiatry 146 28115740
2006 The DNA sequence and biological annotation of human chromosome 1. Nature 144 16710414
1998 Chronic administration of imipramine and citalopram alters the expression of NMDA receptor subunit mRNAs in mouse brain. A quantitative in situ hybridization study. Journal of molecular neuroscience : MN 125 9770644
2002 Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients. Journal of pineal research 110 11841602
2001 Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain. Proceedings of the National Academy of Sciences of the United States of America 109 11172051
2010 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Molecular medicine (Cambridge, Mass.) 108 20379614
1999 Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1. Genomics 104 10512682
1993 5'-Heterogeneity of the mineralocorticoid receptor messenger ribonucleic acid: differential expression and regulation of splice variants within the rat hippocampus. Endocrinology 98 8404687
2003 Human skeletal muscle and erythrocyte proteins involved in acid-base homeostasis: adaptations to chronic hypoxia. The Journal of physiology 94 12611920
1998 Distribution of glutamate decarboxylase65 immunoreactive puncta on pyramidal and nonpyramidal neurons in hippocampus of schizophrenic brain. Synapse (New York, N.Y.) 82 9661250
2001 Hippocampal estrogen beta-receptor immunoreactivity is increased in Alzheimer's disease. Brain research 81 11454321
1997 Distribution of parvalbumin-immunoreactive neurons in brain correlates with hippocampal and temporal cortical pathology in Creutzfeldt-Jakob disease. Journal of neuropathology and experimental neurology 71 9329455
2013 Aspergillus flavus VelB acts distinctly from VeA in conidiation and may coordinate with FluG to modulate sclerotial production. Fungal genetics and biology : FG & B 66 23994319
2009 Carbonic anhydrases CA4 and CA14 both enhance AE3-mediated Cl--HCO3- exchange in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 61 19279262
2011 Effects of laeA deletion on Aspergillus flavus conidial development and hydrophobicity may contribute to loss of aflatoxin production. Fungal biology 59 22289775
2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Genome research 57 15342556
2002 Carbonic anhydrase XIV: luminal expression suggests key role in renal acidification. Kidney international 55 12028451
1997 Role of proofreading and mismatch repair in maintaining the stability of nucleotide repeats in DNA. Nucleic acids research 54 9064658
1999 Limbic P300s in temporal lobe epilepsy with and without Ammon's horn sclerosis. The European journal of neuroscience 50 10336658
1993 Substance P and substance P receptor histochemistry in human neurodegenerative diseases. Regulatory peptides 50 7692486
2014 Quantification of subfield pathology in hippocampal sclerosis: a systematic review and meta-analysis. Epilepsy research 46 25107686
1999 Genetic variations on the Y chromosome in the Japanese population and implications for modern human Y chromosome lineage. Journal of human genetics 44 10429363
2010 Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies. Journal of medicinal chemistry 41 20170095
2004 Identification of a novel type 1 diabetes susceptibility gene, T-bet. Human genetics 41 15241679
2014 The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors. Biopolymers 39 24374484
1997 Developmental changes of glutamate receptors in the rat cerebral cortex and hippocampus. Anatomy and embryology 37 9006716
2004 Differences in the cellular distribution of D1 receptor mRNA in the hippocampus of bipolars and schizophrenics. Synapse (New York, N.Y.) 36 15452863
1992 Autoradiographic distribution of [3H]nicotine binding in human cortex: relative abundance in subicular complex. Journal of chemical neuroanatomy 36 1418753
2017 The Aspergillus flavus Homeobox Gene, hbx1, is Required for Development and Aflatoxin Production. Toxins 34 29023405
1998 Time-dependent and regional expression of GABA transporter mRNAs following amygdala-kindled seizures in rats. Brain research. Molecular brain research 34 9526043
1999 Stabilization of the intermediate in frameshift mutation. Mutation research 31 10029680
1994 Distribution of immediate early gene zif-268, c-fos, c-jun and jun-D mRNAs in the adult cat with special references to brain region related to vision. Neuroscience letters 29 7830935
2004 Neuronal expression of cyclooxygenase-2, a pro-inflammatory protein, in the hippocampus of patients with schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry 28 15276698
2017 Seven-Tesla MRI of Hippocampal Sclerosis: An In Vivo Feasibility Study With Histological Correlations. Investigative radiology 27 28538339
2015 Relevance of hippocampal integrity for memory outcome after surgical treatment of mesial temporal lobe epilepsy. Journal of neurology 27 26138541
2007 Interferon-gamma and interleukin-4 gene polymorphisms in Caucasian idiopathic inflammatory myopathy patients in UK. Annals of the rheumatic diseases 27 17405833
2007 Familial pure proximal renal tubular acidosis--a clinical and genetic study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 27 17881426
2021 The effect of age and sex on the expression of GABA signaling components in the human hippocampus and entorhinal cortex. Scientific reports 26 34728681
2003 Gene expression for carbonic anhydrase isoenzymes in human nasal mucosa. Chemical senses 26 14578124
2019 pH-controlled histone acetylation amplifies melanocyte differentiation downstream of MITF. EMBO reports 25 31709752
2004 Subregional analysis of GABA(A) receptor subunit mRNAs in the hippocampus of older persons with and without cognitive impairment. Journal of chemical neuroanatomy 24 15363487
1996 Expression of c-fos and fos-B proteins following transient forebrain ischemia: effect of hypothermia. Brain research. Molecular brain research 24 9013791
2018 Hippocampal Subfield Volumetry: Differential Pattern of Atrophy in Different Forms of Genetic Frontotemporal Dementia. Journal of Alzheimer's disease : JAD 23 29889066
1991 Structure and sequence analysis of the human activin beta A subunit gene. DNA sequence : the journal of DNA sequencing and mapping 23 1777673
2020 Mesoscale diffusion magnetic resonance imaging of the ex vivo human hippocampus. Human brain mapping 22 32621364
1993 Ischemia-induced changes in alpha-tubulin and beta-actin mRNA in the gerbil brain and effects of bifemelane hydrochloride. Brain research 22 8435749
1992 Intrahippocampal colchicine alters hypothalamic corticotropin-releasing hormone and hippocampal steroid receptor mRNA in rat brain. Neuroendocrinology 22 1320216
1997 Expression and distribution of the dentatorubral-pallidoluysian atrophy gene product (atrophin-1/drplap) in neuronal and non-neuronal tissues. Journal of the neurological sciences 20 9077491
2023 Effects of Fisetin Treatment on Cellular Senescence of Various Tissues and Organs of Old Sheep. Antioxidants (Basel, Switzerland) 19 37627641
2022 Identification of novel prostate cancer genes in patients stratified by Gleason classification: Role of antitumoral genes. International journal of cancer 18 35234293
2020 Induction of core symptoms of autism spectrum disorder by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys. Science bulletin 18 36654241
2025 Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia. Nature human behaviour 17 39753749
2017 Different mossy fiber sprouting patterns in ILAE hippocampal sclerosis types. Epilepsy research 17 28822872
2004 Increased expression of neuronal cyclooxygenase-2 in the hippocampus in amyotrophic lateral sclerosis both with and without dementia. Acta neuropathologica 17 14991384
2018 Increased TLR4 and TREM-1 expression on monocytes and neutrophils in preterm birth: further evidence of a proinflammatory state. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 16 29534643
1999 Immunogenicity of malaria transmission-blocking vaccine candidate, y230.CA14 following crosslinking in the presence of tetanus toxoid. Parasite immunology 16 10583858
2022 Predicting biochemical-recurrence-free survival using a three-metabolic-gene risk score model in prostate cancer patients. BMC cancer 15 35246070
2019 Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment. Neural plasticity 15 31827497
2018 Strain-specific differential expression of astrocytes and microglia in the mouse hippocampus. Brain and behavior 15 29761014
2000 Effect of thyroid hormone deficiency on developmental expression of goalpha gene in the brain of neonatal rats by competitive RT-PCR and in situ hybridization histochemistry. Brain research 15 10802026
1998 In vivo biodistribution of a radiotracer for imaging serotonin-1A receptor sites with PET:[11C]LY274601. Life sciences 15 9808064
2004 Study on the haplotypes of MICA and MICB microsatellite and HLA-B locus in the Guangzhou Han population. Tissue antigens 13 15304009
1994 Postmortem stability of mRNA for glucocorticoid and mineralocorticoid receptor in rodent brain. Brain research 13 7953622
2020 A Bioinformatics Research on Novel Mechanism of Compound Kushen Injection for Treating Breast Cancer by Network Pharmacology and Molecular Docking Verification. Evidence-based complementary and alternative medicine : eCAM 12 32849897
2020 Crystal Structure of Isoform CBd of the Basic Phospholipase A2 Subunit of Crotoxin: Description of the Structural Framework of CB for Interaction with Protein Targets. Molecules (Basel, Switzerland) 11 33202772
2003 Activation of metabotropic glutamate receptor 5 is associated with effect of amphetamine on brain neurons. Synapse (New York, N.Y.) 11 14556238
2005 Intact hippocampal gray matter in schizophrenia as revealed by automatized image analysis postmortem. Anatomy and embryology 10 16187139
2011 Comprehensive neuropathologic analysis of genetic prion disease associated with the E196K mutation in PRNP reveals phenotypic heterogeneity. Journal of neuropathology and experimental neurology 8 21293298
2000 Identification of a new CA dinucleotide repeat in the human factor VIII gene. British journal of haematology 8 11167772
1994 Hexokinase I messenger RNA in the rat central nervous system. Molecular and cellular neurosciences 8 7704441
2022 Nanomolar affinity of EF-hands in neuronal calcium sensor 1 for bivalent cations Pb2+, Mn2+, and Hg2. Metallomics : integrated biometal science 7 35657675
2021 Ca14-3-3 Interacts With CaWRKY58 to Positively Modulate Pepper Response to Low-Phosphorus Starvation. Frontiers in plant science 7 33519860
2006 Equilibrium shift by target DNA substrates for determination of DNA binding ligands. Bioorganic & medicinal chemistry letters 7 17046249
2006 The human calcium-sensing receptor and interleukin-6 genes are associated with bone mineral density in Chinese. Yi chuan xue bao = Acta genetica Sinica 6 17046587
2024 Co-pathologies modify hippocampal protein accumulation patterns in neurodegenerative diseases. Alzheimer's & dementia : the journal of the Alzheimer's Association 5 39711489
2021 Study of the co-expression gene modules of non-small cell lung cancer metastases. Cancer biomarkers : section A of Disease markers 4 33337349
2025 Proteomic signature of dementia risk in type 2 diabetes. Journal of advanced research 3 40829688
2020 Deletions of the Idh1, Eco1, Rom2, and Taf10 Genes Differently Control the Hyphal Growth, Drug Tolerance, and Virulence of Candida albicans. Folia biologica 3 33069188
2019 Genome Sequence of an Aspergillus flavus CA14 Strain That Is Widely Used in Gene Function Studies. Microbiology resource announcements 3 31416879
2004 [The study on the haplotype of MICA and MICB microsatellite locus in Guangzhou Han population]. Yi chuan = Hereditas 3 15640005
2026 Plasma Proteomic Signatures of Physical Activity Provide Insights into Biological Impacts and Its Protective Role Against Dementia. Medicine and science in sports and exercise 2 41582318
2025 Targeted plasma proteomics reveals organ damage signatures of AIDS- and noncommunicable disease-related deaths in people with HIV. Nature communications 2 40274826
2024 Exploring novel drug targets for atopic dermatitis through plasma proteome with genome. Archives of dermatological research 2 39136778
2021 Chromosome-Level Aspergillus flavus Strain CA14 Genome Assembly. Microbiology resource announcements 2 33414302
2014 Regulation of zinc transporter 3 and carbonic anhydrases 2 and 14 mRNA expression in the retina of rats affected by low dietary zinc. Genetics and molecular research : GMR 2 24634117
2014 Anterior-posterior cerebral blood volume gradient in human subiculum. Hippocampus 2 24677295
2014 IFNG+874A/T polymorphisms and IFNG CA repeat polymorphism associated with asthma in Asian--a meta-analysis. The Journal of asthma : official journal of the Association for the Care of Asthma 2 24995662
2005 Immunohistochemical Localization of Fas-associated phosphatase-1 (FAP-1) in Alzheimer disease hippocampus. Applied immunohistochemistry & molecular morphology : AIMM 2 15894934
2002 [Inhibitory effect of all-trans-retinoid and polyphenon-100 on microsatellite instability in a colon cancer line]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2 12048675
2025 Unraveling diethyl phthalate-induced prostate carcinogenesis: core targets revealed by integrated network toxicology, machine learning, and structural validation. Human genomics 1 41444679
2007 [Long-term effects of recurrent seizures in neonate period on gamma-aminobutyric acid A receptor alpha1 and beta2 subunits expression in adult brain: experiment with rats]. Zhonghua yi xue za zhi 1 17425879
2003 [Detection of point mutation in p53 gene by capillary electrophoresis-PCR-SSCP analysis]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 1 12910694
2001 [Effect of NOS positive neurons in rats with learning-remembering barrier]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 1 12536726
2025 A multimodal caffeic acid-derived alkyl-amide antidiabetic agent: targeting α-glucosidase, α-amylase, oxidative stress, and protein glycation. RSC advances 0 41181007
2022 Reverse Genetic Approach to Identify Regulators of Pigmentation using Zebrafish. Journal of visualized experiments : JoVE 0 35312674
2015 Molecular analysis of dinucleotide microsatellite in growth hormone gene of Asian seabass (Lates calcarifer) from Mumbal, India. Journal of environmental biology 0 26536806
2004 [The polymorphism distributions of MICA and MICB microsatellite in Guangdong Han population]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 0 15192843
1998 [Investigation of the genetic instability of tumor cells by transfection of RER+ cell lines with exogenous microsatellite sequence]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 0 9691137