- Length
- 752 aa
- Mass
- 83.3 kDa
- Annotated
- 2026-04-28
130 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
Parse failed
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 130 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Proceedings of the National Academy of Sciences of the United States of America | 1479 | 12477932 |
| 2017 | Architecture of the human interactome defines protein communities and disease networks. | Nature | 1085 | 28514442 |
| 2006 | Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. | Nature genetics | 872 | 16518403 |
| 2020 | A reference map of the human binary protein interactome. | Nature | 849 | 32296183 |
| 2003 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | Nature genetics | 754 | 14702039 |
| 1996 | The C2 domain calcium-binding motif: structural and functional diversity. | Protein science : a publication of the Protein Society | 709 | 8976547 |
| 2021 | Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. | Cell | 705 | 33961781 |
| 2011 | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Briefings in bioinformatics | 656 | 21873635 |
| 2013 | Seven new loci associated with age-related macular degeneration. | Nature genetics | 649 | 23455636 |
| 1994 | Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | Gene | 492 | 8125298 |
| 2013 | Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. | Nature genetics | 463 | 23535732 |
| 2015 | Widespread macromolecular interaction perturbations in human genetic disorders. | Cell | 454 | 25910212 |
| 2004 | The lectin-complement pathway--its role in innate immunity and evolution. | Immunological reviews | 443 | 15199963 |
| 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Genome research | 438 | 15489334 |
| 2010 | Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. | Proceedings of the National Academy of Sciences of the United States of America | 433 | 20385819 |
| 2010 | Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). | Proceedings of the National Academy of Sciences of the United States of America | 376 | 20385826 |
| 2005 | Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. | Journal of proteome research | 350 | 16335952 |
| 2009 | Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. | Investigative ophthalmology & visual science | 255 | 19661236 |
| 1976 | Inherited structural polymorphism in human C2: evidence for genetic linkage between C2 and Bf. | The Journal of experimental medicine | 249 | 978135 |
| 1967 | Formation and functional significance of a molecular complex derived from the second and the fourth component of human complement. | The Journal of experimental medicine | 245 | 6019133 |
| 2008 | Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. | Investigative ophthalmology & visual science | 238 | 19117936 |
| 2000 | Proteolytic activities of two types of mannose-binding lectin-associated serine protease. | Journal of immunology (Baltimore, Md. : 1950) | 232 | 10946292 |
| 2007 | Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. | Cell | 231 | 17719543 |
| 2011 | Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. | Human molecular genetics | 208 | 21665990 |
| 1985 | Rat medulla oblongata. III. Adrenergic (C1 and C2) neurons, nerve fibers and presumptive terminal processes. | The Journal of comparative neurology | 194 | 2858498 |
| 1980 | Purification and characterization of two components of botulinum C2 toxin. | Infection and immunity | 190 | 6785232 |
| 2009 | Interpretation of genetic association studies: markers with replicated highly significant odds ratios may be poor classifiers. | PLoS genetics | 188 | 19197355 |
| 2014 | Signaling through C2 domains: more than one lipid target. | Biochimica et biophysica acta | 179 | 24440424 |
| 2002 | Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains. | The Journal of biological chemistry | 168 | 11959863 |
| 2012 | Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2. | Proceedings of the National Academy of Sciences of the United States of America | 164 | 22691502 |
| 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | American journal of human genetics | 164 | 19913121 |
| 2009 | Niemann-Pick C2 (NPC2) and intracellular cholesterol trafficking. | Biochimica et biophysica acta | 162 | 19232397 |
| 2007 | Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration. | Human molecular genetics | 153 | 17576744 |
| 2000 | Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor. | Cancer research | 151 | 11156408 |
| 1986 | Primary structure of human complement component C2. Homology to two unrelated protein families. | The Biochemical journal | 150 | 2949737 |
| 2006 | Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2. | The Journal of clinical investigation | 146 | 16670774 |
| 2013 | In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. | Proteomics | 138 | 23533145 |
| 2009 | Paths reunited: Initiation of the classical and lectin pathways of complement activation. | Immunobiology | 122 | 19783065 |
| 2019 | Multiple C2 domains and transmembrane region proteins (MCTPs) tether membranes at plasmodesmata. | EMBO reports | 118 | 31286648 |
| 2012 | Otoferlin: a multi-C2 domain protein essential for hearing. | Trends in neurosciences | 114 | 22959777 |
| 1997 | Ca2+-signaling cycle of a membrane-docking C2 domain. | Biochemistry | 108 | 9340010 |
| 2006 | Structure and action of the binary C2 toxin from Clostridium botulinum. | Journal of molecular biology | 102 | 17027031 |
| 1975 | Hereditary complement (C2) deficiency with dermatomyositis. | The American journal of medicine | 101 | 1090155 |
| 2006 | A role for hnRNP C1/C2 and Unr in internal initiation of translation during mitosis. | The EMBO journal | 88 | 17159903 |
| 1996 | Growth and differentiation of C2 myogenic cells are dependent on serum response factor. | Molecular and cellular biology | 87 | 8887636 |
| 1986 | Effects of chlorpromazine and phencyclidine on mouse C2 acetylcholine receptor kinetics. | The Journal of physiology | 87 | 2432254 |
| 2001 | Membrane targeting of C2 domains of phospholipase C-delta isoforms. | The Journal of biological chemistry | 81 | 11706040 |
| 2006 | The C2 domain protein BAP1 negatively regulates defense responses in Arabidopsis. | The Plant journal : for cell and molecular biology | 79 | 17018034 |
| 1997 | Regulation of protein kinase C betaII by its C2 domain. | Biochemistry | 79 | 9398289 |
| 1981 | On the significance of C2, C4, and factor B polymorphisms in disease. | Human genetics | 79 | 7016719 |
| 2002 | Dissimilation of the C2 sulfonates. | Archives of microbiology | 69 | 12471498 |
| 1984 | The factor B and C2 genes. | Philosophical transactions of the Royal Society of London. Series B, Biological sciences | 69 | 6149579 |
| 1989 | Expression of the Rhodobacter sphaeroides cytochrome c2 structural gene. | Journal of bacteriology | 68 | 2536660 |
| 1981 | Primary structure of the phage P22 repressor and its gene c2. | Biochemistry | 66 | 7260059 |
| 2014 | pRMH760, a precursor of A/C₂ plasmids carrying blaCMY and blaNDM genes. | Microbial drug resistance (Larchmont, N.Y.) | 64 | 24841670 |
| 2018 | Niemann-Pick C2 Proteins: A New Function for an Old Family. | Frontiers in physiology | 61 | 29472868 |
| 1991 | A membrane protein is required for bacteriophage c2 infection of Lactococcus lactis subsp. lactis C2. | Journal of bacteriology | 58 | 1917843 |
| 2001 | Roles of calcium ions in the membrane binding of C2 domains. | The Biochemical journal | 57 | 11672443 |
| 1994 | Prevalence of a mutation causing C2 deficiency in systemic lupus erythematosus. | The Journal of rheumatology | 55 | 7932427 |
| 2015 | Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program). | Oncotarget | 54 | 26177051 |
| 2010 | The hypersensitive response induced by the V2 protein of a monopartite begomovirus is countered by the C2 protein. | Molecular plant pathology | 53 | 20447273 |
| 1989 | cDNA cloning and expression of human complement component C2. | Journal of immunology (Baltimore, Md. : 1950) | 53 | 2493504 |
| 1976 | Hereditary C2 deficiency: diagnosis and HLA gene complex associations. | Journal of immunology (Baltimore, Md. : 1950) | 53 | 1082903 |
| 2015 | Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII. | Cell reports | 52 | 26279568 |
| 2012 | The role of C2 domains in PKC signaling. | Advances in experimental medicine and biology | 52 | 22453964 |
| 2017 | Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human PI3KC3-C1 and -C2. | Cell research | 51 | 28731030 |
| 2016 | Overexpression of Rice Glutaredoxin OsGrx_C7 and OsGrx_C2.1 Reduces Intracellular Arsenic Accumulation and Increases Tolerance in Arabidopsis thaliana. | Frontiers in plant science | 51 | 27313586 |
| 2016 | Ring-like oligomers of Synaptotagmins and related C2 domain proteins. | eLife | 51 | 27434670 |
| 2005 | The origin of C1A-C2 interdomain interactions in protein kinase Calpha. | The Journal of biological chemistry | 51 | 16079140 |
| 1983 | P22 c2 repressor. Domain structure and function. | The Journal of biological chemistry | 51 | 6554278 |
| 2003 | Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity. | Biochemical pharmacology | 49 | 12754099 |
| 1986 | Sensory function and gating of histaminergic neuron C2 in Aplysia. | The Journal of neuroscience : the official journal of the Society for Neuroscience | 49 | 3746415 |
| 2011 | Clostridial binary toxins: iota and C2 family portraits. | Frontiers in cellular and infection microbiology | 46 | 22919577 |
| 1997 | Interleukin-15 stimulates C2 skeletal myoblast differentiation. | Biochemical and biophysical research communications | 45 | 9345260 |
| 2007 | Crystal structure of the bovine lactadherin C2 domain, a membrane binding motif, shows similarity to the C2 domains of factor V and factor VIII. | Journal of molecular biology | 43 | 17583728 |
| 2020 | ARGX-117, a therapeutic complement inhibiting antibody targeting C2. | The Journal of allergy and clinical immunology | 42 | 32926878 |
| 2015 | Identification of a Chemoreceptor for C2 and C3 Carboxylic Acids. | Applied and environmental microbiology | 41 | 26048936 |
| 1992 | Occupancy of a C2-C2 type 'zinc-finger' protein domain by copper. Direct observation by electrospray ionization mass spectrometry. | FEBS letters | 41 | 1505681 |
| 2010 | Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. | The Journal of biological chemistry | 40 | 20089867 |
| 1993 | Antineoplastic agent doxorubicin inhibits myogenic differentiation of C2 myoblasts. | The Journal of biological chemistry | 40 | 8449915 |
| 1981 | Linkage of total deficiency of the second component (C2) of the complement system and of genetic C2-polymorphism to the major histocompatibility complex of the guinea pig. | Journal of immunology (Baltimore, Md. : 1950) | 37 | 7252150 |
| 2017 | Visible-Light-Induced C2 Alkylation of Pyridine N-Oxides. | The Journal of organic chemistry | 36 | 28102664 |
| 1990 | Production of staphylococcal enterotoxins C1 and C2 and thermonuclease throughout the growth cycle. | Applied and environmental microbiology | 36 | 2306093 |
| 1982 | Prostatic steroid binding protein: organisation of C1 and C2 genes. | Nucleic acids research | 36 | 6292830 |
| 2013 | Ubiquitin interacts with the Tollip C2 and CUE domains and inhibits binding of Tollip to phosphoinositides. | The Journal of biological chemistry | 35 | 23880770 |
| 2000 | Double C2 protein. A review. | Biochimie | 35 | 10865129 |
| 1985 | The structure and genetics of the C2 and factor B genes. | Immunological reviews | 35 | 3902623 |
| 2017 | Visible-light-mediated C2-amination of thiophenes by using DDQ as an organophotocatalyst. | Chemical communications (Cambridge, England) | 34 | 28294249 |
| 2021 | Nickel-Catalyzed Dearomative Arylboration of Indoles: Regioselective Synthesis of C2- and C3-Borylated Indolines. | Journal of the American Chemical Society | 31 | 34582691 |
| 2020 | Apolipoprotein C2 - CD36 Promotes Leukemia Growth and Presents a Targetable Axis in Acute Myeloid Leukemia. | Blood cancer discovery | 31 | 32944714 |
| 2009 | Binding and internalization of Clostridium botulinum C2 toxin. | Infection and immunity | 30 | 19720757 |
| 2000 | A Schistosoma protein, Sh-TOR, is a novel inhibitor of complement which binds human C2. | FEBS letters | 29 | 10734221 |
| 2018 | Phosphatidylinositol-specific phospholipase C2 functions in auxin-modulated root development. | Plant, cell & environment | 28 | 30496625 |
| 2012 | Association of C2 and CFB polymorphisms with anterior uveitis. | Investigative ophthalmology & visual science | 28 | 22714898 |
| 2003 | Immunoglobulin deficiencies and susceptibility to infection among homozygotes and heterozygotes for C2 deficiency. | Journal of clinical immunology | 28 | 12959222 |
| 1999 | Modular PH and C2 domains in membrane attachment and other functions. | FEBS letters | 28 | 10376674 |
| 2010 | DOC2B, C2 domains, and calcium: A tale of intricate interactions. | Molecular neurobiology | 27 | 20052564 |
| 2003 | Apoptotic activities of C2-ceramide and C2-dihydroceramide homologues against HL-60 cells. | Bioorganic & medicinal chemistry | 27 | 12788346 |
| 2012 | Cigarette smoke and muscle catabolism in C2 myotubes. | Mechanisms of ageing and development | 26 | 23262287 |
| 2011 | PKCgamma in Vc and C1/C2 is involved in trigeminal neuropathic pain. | Journal of dental research | 26 | 21393551 |
| 2015 | Biosynthesis of Epimers C2 and C2a in the Gentamicin C Complex. | Chembiochem : a European journal of chemical biology | 25 | 26083124 |
| 2015 | Introduction of Methyl Groups at C2 and C6 Positions Enhances the Antiangiogenesis Activity of Curcumin. | Scientific reports | 25 | 26391485 |
| 2008 | PD98059 enhances C2 myoblast differentiation through p38 MAPK activation: a novel role for PD98059. | The Journal of endocrinology | 25 | 18467380 |
| 2012 | Protein kinase Cθ C2 domain is a phosphotyrosine binding module that plays a key role in its activation. | The Journal of biological chemistry | 24 | 22787157 |
| 2011 | Geminivirus C2 protein might be the key player for geminiviral co- option of SCF-mediated ubiquitination. | Plant signaling & behavior | 23 | 21691154 |
| 2003 | Efficient C2'alpha-hydroxylation of deoxyribose in protein-induced Z-form DNA. | Journal of the American Chemical Society | 23 | 12568612 |
| 2021 | Improving the Thermostability of a Fungal GH11 Xylanase via Fusion of a Submodule (C2) from Hyperthermophilic CBM9_1-2. | International journal of molecular sciences | 22 | 35008888 |
| 2015 | Transcriptome modulations due to A/C2 plasmid acquisition. | Plasmid | 22 | 26079188 |
| 2012 | Modular dispensability of dysferlin C2 domains reveals rational design for mini-dysferlin molecules. | The Journal of biological chemistry | 22 | 22736764 |
| 2016 | Staphylococcal enterotoxin C2 expedites bone consolidation in distraction osteogenesis. | Journal of orthopaedic research : official publication of the Orthopaedic Research Society | 21 | 27431811 |
| 2016 | A generalized stoichiometric model of C3, C2, C2+C4, and C4 photosynthetic metabolism. | Journal of experimental botany | 21 | 27535993 |
| 2021 | A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming. | Proceedings of the National Academy of Sciences of the United States of America | 20 | 33836576 |
| 2010 | The C2 domains of classical and novel PKCs as versatile decoders of membrane signals. | BioFactors (Oxford, England) | 20 | 20049899 |
| 1985 | Expression of complement proteins C2 and factor B in transfected L cells. | The Journal of clinical investigation | 19 | 3850903 |
| 2017 | Integration of C₁ and C₂ Metabolism in Trees. | International journal of molecular sciences | 18 | 28946627 |
| 2002 | Effects of C2-ceramide on the Malme-3M melanoma cell line. | Journal of dermatological science | 18 | 12354415 |
| 1993 | Temporally Regulated Transcriptional Expression of the Genomes of Lactococcal Bacteriophages c2 and sk1. | Applied and environmental microbiology | 18 | 16349085 |
| 2005 | Complement C2 receptor inhibitor trispanning: from man to schistosome. | Springer seminars in immunopathology | 17 | 16235057 |
| 2000 | Sialic acid inhibits agrin signaling in C2 myotubes. | Cell and tissue research | 17 | 10741468 |
| 1994 | SRD1, a S. cerevisiae gene affecting pre-rRNA processing contains a C2/C2 zinc finger motif. | Nucleic acids research | 17 | 8165142 |
| 1990 | Molecular cloning, sequencing and expression of cytochrome c2 from Rhodospirillum rubrum. | The Biochemical journal | 17 | 2154194 |
| 1978 | Purification and properties of phage P22 c2 repressor. | European journal of biochemistry | 17 | 340229 |
| 2023 | Chemoselective Late-Stage Functionalization of Peptides via Photocatalytic C2-Alkylation of Tryptophan. | Organic letters | 16 | 37462428 |
| 2020 | Phosphatidylinositol-phospholipase C2 regulates pattern-triggered immunity in Nicotiana benthamiana. | Journal of experimental botany | 16 | 32412590 |
| 2015 | Voltage-sensing phosphatase modulation by a C2 domain. | Frontiers in pharmacology | 16 | 25904865 |
| 1986 | C2 and factor B: structure and genetics. | Biochemical Society symposium | 16 | 3101701 |
| 1984 | Structure and activation of complement components C2 and factor B. | Philosophical transactions of the Royal Society of London. Series B, Biological sciences | 16 | 6149575 |
| 2017 | The eΠg3 state of C2: A pathway to dissociation. | The Journal of chemical physics | 14 | 28711036 |
| 2013 | SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. | Journal of dermatological science | 14 | 23999003 |
| 1993 | Structure of the human C2 gene. | Journal of immunology (Baltimore, Md. : 1950) | 14 | 8326124 |