Affinage

C1QL3

Complement C1q-like protein 3 · UniProt Q5VWW1

Length
255 aa
Mass
26.7 kDa
Annotated
2026-06-09
31 papers in source corpus 19 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

C1QL3 (CTRP13) is a secreted, disulfide-linked oligomeric gC1q-domain protein with two distinct functional arenas: a synaptic organizer in the CNS and a metabolic/vascular regulator in peripheral tissues (PMID:21378161, PMID:27478018). In neurons, C1QL3 is secreted and binds the adhesion-class GPCR BAI3/ADGRB3, and acts in an activity-dependent manner to support excitatory synapse density; its loss reduces synapse number and produces fear-memory and other behavioral deficits (PMID:27478018). C1QL3 additionally forms a trans-synaptic adhesion complex with the neuronal pentraxins NPTX1 and NPTXR in co-expressing excitatory neurons, and localizes between pre- and postsynaptic markers at hippocampal mossy fiber synapses (PMID:33337553, PMID:41959109). This synaptic function extends across circuits, maintaining excitatory synapses in the suprachiasmatic nucleus to support circadian behavior and in the basolateral amygdala, where C1QL3 controls morphine-withdrawal aversion memories through ubiquitination-mediated turnover of PSD95 (PMID:28553739, PMID:38772224). In peripheral tissues, recombinant CTRP13 promotes glucose uptake in adipocytes, myotubes, and hepatocytes by activating AMPK signaling and ameliorates lipid-induced insulin resistance by suppressing JNK stress signaling and repressing gluconeogenic gene expression (PMID:21378161). CTRP13 confers broad vasoprotection through several effector axes: activation of CaMKKβ/AMPK, AMPK/Nrf2/ARE, and PKA–PPARα–GCH1/BH4–eNOS signaling, protein-level stabilization of NAMPT1 and autophagy-lysosomal degradation of CD36, and suppression of ferroptosis via GCH1/BH4 and AMPK/KLF4 pathways (PMID:32554851, PMID:34338573, PMID:31676569, PMID:32966772, PMID:30222079, PMID:39541845). Paradoxically, constitutive loss of CTRP13 in mice improves systemic metabolism, identifying it as a context-dependent negative metabolic regulator (PMID:37844630).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2011 High

    Established that C1QL3/CTRP13 is a secreted oligomeric protein and a functional metabolic effector, answering whether this gC1q-domain protein has hormone-like activity on glucose handling.

    Evidence Heterologous expression and biochemical characterization of secreted protein; in vitro glucose uptake and AMPK assays with purified recombinant protein across adipocytes, myotubes, and hepatocytes

    PMID:21378161

    Open questions at the time
    • No receptor identified for the metabolic effects
    • Mechanism linking C1QL3 binding to AMPK activation not resolved
  2. 2013 Medium

    Showed C1QL3 acts centrally as an anorexigenic factor embedded in a hypothalamic feedback loop, extending its biology from peripheral metabolism to CNS energy balance control.

    Evidence Intracerebroventricular recombinant protein administration in mice with food intake/body weight readouts and reciprocal AgRP/Ctrp13 qPCR

    PMID:23638159

    Open questions at the time
    • Neurons mediating the anorexigenic effect not defined
    • Receptor in hypothalamus unknown
  3. 2016 High

    Defined C1QL3 as an activity-dependent synaptic organizer that binds the adhesion GPCR BAI3 and is required cell-autonomously to maintain specific excitatory circuits, identifying its receptor and a core CNS function.

    Evidence Conditional and constitutive knockout mice, circuit tracing, synapse density quantification, and fear-memory behavioral testing (Südhof group)

    PMID:27478018

    Open questions at the time
    • Signaling downstream of BAI3 engagement not resolved
    • Whether the same receptor mediates metabolic actions unknown
  4. 2017 Medium

    Generalized the synaptic role to circadian circuitry, showing C1QL3 maintains excitatory synapses in the SCN and is needed for normal circadian behavior.

    Evidence Constitutive Ctrp13 KO mice with SCN synapse density immunohistochemistry and circadian behavioral assays

    PMID:28553739

    Open questions at the time
    • Molecular link between synapse loss and circadian phenotype not established
    • Receptor partner in SCN not confirmed
  5. 2018 Medium

    Demonstrated a post-transcriptional anti-atherogenic mechanism whereby CTRP13 lowers CD36 via autophagy-lysosomal degradation, reducing foam-cell formation.

    Evidence Recombinant CTRP13 in primary macrophages with autophagy-lysosome pathway blockade and CD36 protein/mRNA and foam-cell assays; ApoE-/- mice

    PMID:30222079

    Open questions at the time
    • How CTRP13 triggers autophagic targeting of CD36 unknown
    • Receptor mediating macrophage response not identified
  6. 2019 Medium

    Defined two distinct vasoprotective signaling axes: PKA–PPARα–GCH1/BH4–eNOS coupling preserving endothelial function, and TTP-mediated Runx2 mRNA destabilization limiting vascular calcification.

    Evidence Ex vivo aortic relaxation and HUVEC assays with PKA activity and PPARα ChIP at GCH1 promoter; VSMC calcification assays with TTP binding and mRNA stability analysis in CRF rat model

    PMID:31145871 PMID:31676569

    Open questions at the time
    • Upstream receptor coupling to PKA not identified
    • How CTRP13 represses TTP phosphorylation unresolved
  7. 2020 Medium

    Extended vasoprotection to two additional mechanisms: CaMKKβ/AMPK protection of liver sinusoidal endothelium, and ubiquitin-proteasome stabilization of NAMPT1 mitigating aortic aneurysm.

    Evidence Lentiviral overexpression in rLSECs with CaMKKβ/AMPK inhibitor rescue; two murine AAA models with NAMPT1 knockdown epistasis and ubiquitination assays

    PMID:32554851 PMID:32966772

    Open questions at the time
    • How CTRP13 reduces NAMPT1 ubiquitination mechanistically unknown
    • Receptor upstream of CaMKKβ not defined
  8. 2021 Medium

    Identified C1QL3 as part of a tripartite trans-synaptic adhesion complex with BAI3 and neuronal pentraxins NPTX1/NPTXR, refining the molecular architecture of its synaptic action; in parallel showed cardioprotection through AMPK/Nrf2/ARE signaling.

    Evidence In vivo interactome pulldown with single-cell RNA-seq co-expression; H9c2 H/R model with AMPK inhibition and Nrf2 silencing epistasis and rat I/R validation

    PMID:33337553 PMID:34338573

    Open questions at the time
    • Stoichiometry and assembly order of the BAI3/NPTX1/NPTXR complex unknown
    • Whether the complex transduces signal bidirectionally not tested
  9. 2023 High

    Revealed a paradox by showing that constitutive loss of CTRP13 improves systemic metabolism, reframing the protein as a context-dependent negative metabolic regulator rather than a uniformly beneficial adipokine.

    Evidence Ctrp13 KO mice on chow and high-fat diets with comprehensive metabolic and transcriptomic phenotyping and human METSIM cohort mediation analyses

    PMID:37844630

    Open questions at the time
    • Reconciliation of loss-of-function benefit with gain-of-function recombinant effects unresolved
    • Tissue source driving the systemic phenotype not pinpointed
  10. 2024 Medium

    Linked C1QL3 to addiction-related memory and broader neuronal/glial integrity, and showed PFC-specific adult deletion is insufficient for cognitive-flexibility deficits, mapping circuit and developmental dependencies.

    Evidence Lentiviral C1QL3 knockdown in BLA with conditioned place aversion and PSD95 ubiquitination analysis; CRISPR KO rats with Golgi, microglia, and behavioral assays; conditional adult PFC deletion with attentional set-shifting

    PMID:38379452 PMID:38772224 PMID:40541605

    Open questions at the time
    • How C1QL3 controls PSD95 ubiquitination mechanistically unknown
    • Direct effect of C1QL3 on microglia versus secondary to synapse loss unresolved
  11. 2024 Medium

    Resolved additional vascular effector pathways: suppression of endothelial ferroptosis via GCH1/BH4 and AMPK/KLF4, and AMPK-alpha2-dependent restraint of endothelial proliferation through p53/p21/Rb.

    Evidence ox-LDL endothelial and ApoE-/- AAV models with GCH1/BH4 and Nrf2 epistasis; HUVEC cell-cycle analysis with isoform-specific dominant-negative/WT AMPK rescue

    PMID:38273650 PMID:39120321 PMID:39541845

    Open questions at the time
    • Receptor coupling CTRP13 to AMPK in endothelium not identified
    • AMPK/KLF4 ferroptosis link rests on correlative Western blot without inhibitor rescue
  12. 2025 Medium

    Provided the first endogenous mapping of C1QL3 protein, localizing it to specific synaptic clefts and defining its native oligomeric state with a knock-in reporter.

    Evidence C1ql3-2HA epitope-tagged knock-in mouse with native PAGE, brain-wide light-sheet microscopy, and super-resolution STED at mossy fiber synapses (preprint)

    PMID:41959109

    Open questions at the time
    • Preprint not yet peer-reviewed
    • Functional consequence of the mapped expanded expression sites not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • The central unresolved question is how one secreted gC1q protein reconciles its BAI3-mediated synaptic organizing role with diverse peripheral AMPK/PKA signaling, and why gain-of-function (recombinant) and loss-of-function (knockout) metabolic phenotypes diverge.
  • No identified receptor for peripheral metabolic/vascular actions
  • Mechanism unifying CNS and peripheral functions unknown
  • Source tissue of circulating CTRP13 driving systemic metabolism undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 2 GO:0060089 molecular transducer activity 2 GO:0098631 cell adhesion mediator activity 2
Localization
GO:0005576 extracellular region 3 GO:0005886 plasma membrane 2
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-112316 Neuronal System 3 R-HSA-1430728 Metabolism 3 R-HSA-1500931 Cell-Cell communication 2
Partners
ADGRB3C1QL2NPTX1NPTXR
Complex memberships
C1QL3–BAI3/ADGRB3–NPTX1–NPTXR trans-synaptic adhesion complex

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2011 CTRP13 is secreted as a disulfide-linked oligomeric protein, and when co-expressed with CTRP10 forms heteromeric complexes via a mechanism that does not involve conserved N-terminal Cys residues. Heterologous expression system, co-expression, biochemical characterization of secreted protein The Journal of biological chemistry Medium 21378161
2011 CTRP13 (CTRP13/C1QL3) promotes glucose uptake in adipocytes, myotubes, and hepatocytes via activation of the AMPK signaling pathway, as demonstrated using purified recombinant protein. In vitro glucose uptake assay with purified recombinant protein in primary adipocytes, myotubes, and hepatocytes; AMPK activation measured The Journal of biological chemistry High 21378161
2011 CTRP13 ameliorates lipid-induced insulin resistance in hepatocytes by suppressing SAPK/JNK stress signaling, and reduces hepatocyte glucose output by inhibiting mRNA expression of gluconeogenic enzymes glucose-6-phosphatase and cytosolic phosphoenolpyruvate carboxykinase. In vitro hepatocyte assay with purified recombinant CTRP13; mRNA expression analysis of gluconeogenic enzymes The Journal of biological chemistry High 21378161
2013 Central (intracerebroventricular) administration of recombinant CTRP13 suppressed food intake and reduced body weight in mice, establishing C1QL3 as an anorexigenic factor in the brain. Central administration of recombinant protein in mice; food intake and body weight measured PloS one Medium 23638159
2013 CTRP13 and the orexigenic neuropeptide AgRP reciprocally regulate each other's expression in the hypothalamus: central CTRP13 delivery suppressed Agrp expression, while AgRP delivery increased Ctrp13 expression, suggesting a hypothalamic feedback loop. Central delivery of recombinant proteins in mice; qPCR measurement of neuropeptide gene expression in hypothalamus PloS one Medium 23638159
2016 C1QL3 expression in neurons is activity-dependent and supports excitatory synapse density in cultured neurons; C1QL3-deficient mice have fewer excitatory synapses and exhibit impaired fear memories and other behavioral abnormalities. Conditional and constitutive C1ql3 knockout mice; synapse density quantification in cultured neurons and in vivo; behavioral testing including fear memory assays Neuron High 27478018
2016 C1QL3 is a secreted neuronal protein that binds to BAI3 (ADGRB3), an adhesion-class GPCR, and C1QL3 expression in basolateral amygdala neurons projecting to the medial prefrontal cortex is required for formation/maintenance of those efferent synapses. Circuit-tracing tools, conditional ablation targeted to specific brain regions, synapse density analysis Neuron High 27478018
2017 C1QL3 is robustly expressed in the suprachiasmatic nucleus (SCN); C1ql3 knockout mice have reduced density of excitatory synapses in the SCN and exhibit disrupted circadian behavior including less consolidated activity and period lengthening after a phase-delaying light pulse. C1ql3 knockout mice; immunohistochemistry for synapse density; circadian behavioral assays Journal of biological rhythms Medium 28553739
2018 CTRP13 reduces CD36 protein levels in macrophages through autophagy-lysosome-dependent degradation at the post-transcriptional level, thereby reducing oxidized LDL uptake and foam-cell formation. Primary peritoneal macrophages treated with recombinant CTRP13; autophagy-lysosome pathway blocking experiments; CD36 protein and mRNA analysis; foam cell formation assays FASEB journal Medium 30222079
2019 CTRP13 preserves endothelial function in diabetes by increasing GTP cyclohydrolase 1 (GCH1) expression and tetrahydrobiopterin (BH4) levels to ameliorate eNOS coupling; mechanistically, CTRP13 rescues high-glucose-induced inhibition of PKA activity, and increased PKA activity enhances phosphorylation of PPARα and its recruitment to the GCH1 promoter, activating GCH1 transcription. Ex vivo aortic relaxation assays in diabetic mice; in vitro HUVEC experiments; PKA activity assay; ChIP for PPARα at GCH1 promoter; recombinant CTRP13 treatment Diabetes Medium 31676569
2019 CTRP13 attenuates vascular calcification by repressing phosphorylation of tristetraprolin (TTP), thereby activating TTP, which binds the 3'UTR of Runx2 mRNA and accelerates Runx2 mRNA destabilization and degradation in vascular smooth muscle cells. In vitro VSMC calcification assay; Runx2 overexpression rescue; TTP binding assay; mRNA stability analysis; recombinant CTRP13 treatment in CRF rat model FASEB journal Medium 31145871
2020 CTRP13 protects rat liver sinusoidal endothelial cells from high-glucose-induced injury by activating the CaMKKβ/AMPK pathway, reducing laminin and caveolin-1 expression; inhibition of CaMKKβ or AMPK abolished the protective effects. Lentiviral CTRP13 overexpression in rLSECs; CaMKKβ/AMPK inhibitors (STO-609, Compound C); Western blot and qRT-PCR Aging Medium 32554851
2020 CTRP13 mitigates abdominal aortic aneurysm formation; mechanistically, CTRP13 stabilizes NAMPT1 protein by reducing its ubiquitination-proteasome-dependent degradation, and NAMPT1 knockdown blocks the beneficial effects of CTRP13 on vascular inflammation and smooth muscle cell apoptosis. Two murine AAA models (AngII in ApoE-/- and CaCl2 in C57BL/6J); recombinant CTRP13 infusion; NAMPT1 knockdown; ubiquitination assays Molecular therapy Medium 32966772
2021 C1QL3 mediates a novel cell-cell adhesion complex involving ADGRB3 (BAI3) and two neuronal pentraxins, NPTX1 and NPTXR, as identified by an in vivo interactome study; C1ql3, Nptx1, and Nptxr are highly co-expressed in the same excitatory neurons. In vivo interactome study (pulldown/co-IP); single-cell RNA-seq data analysis for co-expression FASEB journal Medium 33337553
2021 CTRP13 protects cardiomyocytes from hypoxia/reoxygenation injury via the AMPK/Nrf2/ARE signaling pathway; AMPK inhibition reversed CTRP13-mediated Nrf2/ARE activation, and Nrf2 silencing reversed CTRP13's protective effects against oxidative stress and apoptosis. H9c2 cell H/R model; CTRP13 overexpression and silencing; AMPK inhibitor (Compound C); Nrf2 siRNA; recombinant CTRP13 in rat I/R model Cell transplantation Medium 34338573
2023 Loss of CTRP13 in mice improves systemic metabolism (reduced body weight, improved glucose tolerance, insulin sensitivity, and triglyceride clearance), reduced hepatic glucose output, lower inflammatory profile in visceral fat and liver, and suppressed lipid synthesis with enhanced lipid catabolism gene expression, suggesting CTRP13 is a negative metabolic regulator. Ctrp13 knockout mice on chow and high-fat diet; comprehensive metabolic phenotyping; transcriptomic analyses of multiple tissues; mediation analyses with human METSIM cohort data Molecular metabolism High 37844630
2024 C1QL3 is required for formation of chronic morphine withdrawal memories in the basolateral amygdala (BLA); C1QL3 colocalizes with BAI3 in the BLA, and downregulation of C1QL3 in the BLA reduces conditioned place aversion scores; C1QL3 modulates ubiquitination-mediated degradation of PSD95, resulting in decreased PSD95 protein levels as a downstream effector. Immunofluorescence colocalization of C1QL3 and BAI3; lentiviral downregulation of C1QL3 in BLA; conditioned place aversion behavioral assay; chemogenetic BLA inhibition; ubiquitination/PSD95 protein analysis Biochemical and biophysical research communications Medium 38772224
2024 C1ql3 knockout in rats disrupts neuronal integrity (reduced dendritic arbors and spine density), alters microglial activation (increased ramified microglia, decreased hypertrophic microglia, increased amoeboid microglia and Arg-1 expression after LPS), and impairs short working memory with hyperactive behavior. CRISPR/Cas9 C1ql3 KO rats; Golgi staining for dendritic morphology; immunohistochemistry for microglia; MRI; behavioral tests (open field, Morris water maze, Y maze) Animal models and experimental medicine Medium 38379452
2024 CTRP13 inhibits ferroptosis of endothelial cells via the GCH1/BH4 signaling pathway, upregulating GPX4 and downregulating ACSL4; silencing GCH1 or inhibiting BH4 abolished the protective effects of CTRP13. ApoE-/- mice with C1ql3 overexpression AAV; ox-LDL-treated mouse aortic endothelial cells; GCH1 siRNA knockdown; BH4 inhibition; GPX4 and ACSL4 protein detection International immunopharmacology Medium 39541845
2024 CTRP13 prevents HUVEC ferroptosis induced by ox-LDL via the AMPK/KLF4 pathway, reducing ROS overproduction and mitochondrial dysfunction; CTRP13 increased p-AMPK/AMPK and decreased KLF4 expression. HUVEC ox-LDL model; CTRP13 recombinant protein treatment; Western blot for p-AMPK, KLF4, GPX4, ACSL4; mitochondrial function assays Medical science monitor Low 38273650
2024 CTRP13 reduces endothelial cell proliferation via AMPK (specifically alpha-2 AMPK), reduces cell cycle progression, increases p53 phosphorylation and p21 expression, and reduces Rb phosphorylation; these effects depended on alpha-2 AMPK as shown by adenoviral dominant-negative and wild-type AMPK overexpression. HUVEC culture; recombinant CTRP13 treatment; adenoviral DN/WT alpha-1/alpha-2 AMPK overexpression; cell cycle analysis; Western blot Cells Medium 39120321
2025 Brain-wide light-sheet microscopy using a novel C1ql3-2HA epitope-tagged knock-in mouse revealed an expanded neuroanatomical map of endogenous C1QL3 expression in cortical and subcortical regions and the retina; super-resolution STED microscopy localized C1QL3-2HA to hippocampal mossy fiber synapses positioned between pre- and post-synaptic markers; native PAGE determined the endogenous oligomeric state of C1QL3. Epitope-tagged knock-in mouse (C1ql3-2HA); native PAGE for oligomeric state; brain-wide light-sheet microscopy; dual immunohistochemistry; super-resolution STED microscopy bioRxivpreprint Medium 41959109
2025 Conditional deletion of C1ql3 from neurons specifically in the prefrontal cortex of adult mice was not sufficient to impair attentional set-shifting behavior, indicating C1ql3's role in cognitive flexibility requires expression in other brain circuits and/or neurodevelopmental processes. Conditional C1ql3 deletion in PFC neurons of adult mice; attentional set-shifting behavioral assay Neuroscience letters Medium 40541605

Source papers

Stage 0 corpus · 31 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling. The Journal of biological chemistry 120 21378161
2016 Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors. Neuron 91 27478018
1984 Lipopolysaccharide, capsule, and fimbriae as virulence factors among O1, O7, O16, O18, or O75 and K1, K5, or K100 Escherichia coli. Infection and immunity 88 6140224
1991 Virulence patterns and long-range genetic mapping of extraintestinal Escherichia coli K1, K5, and K100 isolates: use of pulsed-field gel electrophoresis. Infection and immunity 65 1677349
2017 Circulating C1q complement/TNF-related protein (CTRP) 1, CTRP9, CTRP12 and CTRP13 concentrations in Type 2 diabetes mellitus: In vivo regulation by glucose. PloS one 59 28207876
2016 Association of C1q/TNF-Related Protein-3 (CTRP3) and CTRP13 Serum Levels with Coronary Artery Disease in Subjects with and without Type 2 Diabetes Mellitus. PloS one 56 28033351
2013 A central role for C1q/TNF-related protein 13 (CTRP13) in modulating food intake and body weight. PloS one 50 23638159
2018 CTRP13 inhibits atherosclerosis via autophagy-lysosome-dependent degradation of CD36. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 41 30222079
2021 C1QL3 promotes cell-cell adhesion by mediating complex formation between ADGRB3/BAI3 and neuronal pentraxins. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 36 33337553
2019 CTRP13 Preserves Endothelial Function by Targeting GTP Cyclohydrolase 1 in Diabetes. Diabetes 24 31676569
2019 miR-124 regulates cerebromicrovascular function in APP/PS1 transgenic mice via C1ql3. Brain research bulletin 23 31499089
2017 Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus. Journal of biological rhythms 23 28553739
2020 CTRP13 Mitigates Abdominal Aortic Aneurysm Formation via NAMPT1. Molecular therapy : the journal of the American Society of Gene Therapy 22 32966772
2019 CTRP13 attenuates vascular calcification by regulating Runx2. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19 31145871
2017 The Circulating Levels of Complement-C1q/TNF-Related Protein 13 (CTRP13) in Patients with Type 2 Diabetes and its Association with Insulin Resistance. Clinical laboratory 16 28182339
2021 CTRP13 Protects H9c2 Cells Against Hypoxia/Reoxygenation (H/R)-Induced Injury Via Regulating the AMPK/Nrf2/ARE Signaling Pathway. Cell transplantation 15 34338573
2024 CTRP13 attenuates atherosclerosis by inhibiting endothelial cell ferroptosis via activating GCH1. International immunopharmacology 14 39541845
2023 Curcumin ameliorates traumatic brain injury via C1ql3-mediated microglia M2 polarization. Tissue & cell 13 37478644
2020 CTRP13 attenuates the expression of LN and CAV-1 Induced by high glucose via CaMKKβ/AMPK pathway in rLSECs. Aging 10 32554851
2019 Association of CTRP13 With Liver Enzymes and Cognitive Symptoms in Nonalcoholic Fatty Liver Disease. Nursing research 10 30247335
2023 CTRP13 ablation improves systemic glucose and lipid metabolism. Molecular metabolism 9 37844630
2023 Pleiotropy of C1QL proteins across physiological systems and their emerging role in synapse homeostasis. Biochemical Society transactions 6 37140354
2024 CTRP13 Mitigates Endothelial Cell Ferroptosis via the AMPK/KLF4 Pathway: Implications for Atherosclerosis Protection. Medical science monitor : international medical journal of experimental and clinical research 5 38273650
2024 C1ql3 knockout affects microglia activation, neuronal integrity, and spontaneous behavior in Wistar rats. Animal models and experimental medicine 5 38379452
2023 CTRP13 alleviates palmitic acid-induced inflammation, oxidative stress, apoptosis and endothelial cell dysfunction in HUVECs. Tissue & cell 5 37976900
2024 Formation of chronic morphine withdrawal memories requires C1QL3-mediated regulation of PSD95 in the mouse basolateral amygdala. Biochemical and biophysical research communications 3 38772224
2020 An ideal spacing is required for the control of Class II CRP-dependent promoters by the status of CRP K100. FEMS microbiology letters 3 33095239
2025 C1ql3 promotes cognitive flexibility behavior in mice. Neuroscience letters 2 40541605
2026 Brain-wide mapping and synaptic localization of C1QL3 using a novel epitope-tagged knock-in mouse. bioRxiv : the preprint server for biology 0 41959109
2024 CTRP13-Mediated Effects on Endothelial Cell Function and Their Potential Role in Obesity. Cells 0 39120321
2023 Adiponectin C1q/Tumor Necrosis Factor-Related Protein 13 (CTRP13) Protects against Renal Inflammation and Fibrosis in Obstructive Nephropathy. Biomedicines 0 38255158

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