Affinage

C1D

Nuclear nucleic acid-binding protein C1D · UniProt Q13901

Round 2 corrected
Length
141 aa
Mass
16.0 kDa
Annotated
2026-04-28
130 papers in source corpus 11 papers cited in narrative 11 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

C1D is a conserved nuclear nucleic acid-binding protein that operates at the intersection of DNA damage repair and RNA processing. It activates DNA-PK independently of DNA ends by directly binding DNA-PKcs, and its yeast orthologue is required for both non-homologous end joining and homologous recombination (PMID:9679063, PMID:12421302). C1D also functions as a transcriptional corepressor (SUN-CoR) that potentiates repression by thyroid hormone receptor and RevErb through interaction with N-CoR/SMRT (PMID:9405624). Through its conserved Sas10/C1D domain, C1D associates with the nuclear RNA exosome via PM/Scl-100, exhibits structured-RNA-binding activity, and is required for 3′-end processing of 5.8S rRNA precursors, while the orthologous yeast Rrp47 stabilizes the exoribonuclease Rrp6 and forms a composite surface that recruits the Mtr4 helicase (PMID:17412707, PMID:25319414).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1997 High

    Identification of C1D as a nuclear corepressor (SUN-CoR) established that this small nuclear protein amplifies transcriptional repression through nuclear hormone receptors and the N-CoR/SMRT corepressor complex.

    Evidence Cloning, in vivo reporter assays, in vitro binding, and co-immunoprecipitation with endogenous N-CoR

    PMID:9405624

    Open questions at the time
    • Endogenous genomic targets of SUN-CoR-mediated repression not identified
    • Whether DNA-repair and corepressor functions are mutually exclusive is unknown
  2. 1998 High

    Demonstration that C1D directly binds DNA-PKcs and activates DNA-PK without requiring DNA ends revealed an unusual mode of DNA-PK activation and positioned C1D as a DNA damage response factor.

    Evidence Yeast two-hybrid, co-immunoprecipitation, and in vitro kinase assay

    PMID:9679063

    Open questions at the time
    • Physiological conditions under which DNA-end-independent activation occurs in vivo are unclear
    • Downstream signaling targets of C1D-activated DNA-PK not defined
  3. 1999 Medium

    Overexpression studies showed C1D induces p53-dependent apoptosis with a bystander effect, linking its DNA damage signaling role to cell death outcomes.

    Evidence Transient transfection with C1D-EGFP, TUNEL assay, fluorescence microscopy, and co-culture experiments in tumor cell lines

    PMID:10362552

    Open questions at the time
    • Overexpression-only system; loss-of-function confirmation of apoptotic role absent
    • Mechanism of bystander effect uncharacterized
    • Relevance at endogenous expression levels not tested
  4. 2002 High

    Two studies collectively established C1D's role in double-strand break repair: the yeast orthologue is required for both NHEJ and homologous recombination, and C1D interacts with TRAX in a DNA-damage-dependent manner to modulate TRAX/Translin complex assembly.

    Evidence Yeast gene disruption with in vivo recombination assays; yeast two-hybrid and co-immunoprecipitation with gamma-irradiation in mammalian cells

    PMID:11801738 PMID:12421302

    Open questions at the time
    • Whether the C1D–TRAX interaction is conserved in human DSB repair in vivo is untested
    • Epistasis between C1D, DNA-PK, and TRAX pathways not resolved
  5. 2004 High

    Discovery that fission yeast C1D binds the condensin SMC hinge domain and suppresses condensin mutant phenotypes revealed a third route by which C1D promotes DNA repair—through the condensin complex.

    Evidence GST pull-down, co-immunoprecipitation, genetic dosage suppression, chromatin fractionation, and immunofluorescence in S. pombe

    PMID:15148393

    Open questions at the time
    • Whether human C1D–condensin interaction occurs is not established
    • Molecular mechanism by which C1D enhances condensin-mediated repair is unresolved
  6. 2007 High

    Identification of C1D as an RNA exosome cofactor that binds PM/Scl-100, localizes to nucleoli, binds structured RNAs, and is required for 5.8S rRNA 3′-end processing established a major non-repair function for C1D in ribosome biogenesis.

    Evidence Co-immunoprecipitation, immunofluorescence, in vitro trimeric complex reconstitution with MPP6 and PM/Scl-100, RNA-binding assay, and RNAi knockdown with Northern blot in human cells

    PMID:17412707

    Open questions at the time
    • Full spectrum of exosome RNA substrates requiring C1D is not mapped
    • How C1D partitions between DNA repair and RNA processing functions is unclear
  7. 2010 High

    Domain dissection of the yeast orthologue Rrp47 showed that the Sas10/C1D domain serves as a dual protein–nucleic acid docking module: its N-terminal portion binds Rrp6, while the C-terminal region binds RNA and snoRNP proteins Nop56/Nop58, and is specifically required for snoRNA 3′-end maturation.

    Evidence Deletion complementation in yeast, in vitro protein capture, filter binding RNA assays, synthetic lethality analysis

    PMID:20659009 PMID:21135092

    Open questions at the time
    • Whether human C1D retains the bipartite domain architecture with separable functions is untested
    • Structural basis for RNA substrate selectivity not determined at this point
  8. 2013 Medium

    Rrp47 was shown to stabilize Rrp6 protein and transcript levels in yeast, establishing a chaperone-like dependency between the Sas10/C1D-domain protein and its exonuclease partner.

    Evidence Western blot and Northern blot in rrp47Δ yeast, exogenous Rrp6 expression rescue

    PMID:24224060

    Open questions at the time
    • Whether human C1D similarly stabilizes EXOSC10/PM-Scl-100 is unknown
    • Mechanism of transcript-level regulation not dissected
  9. 2014 High

    Crystal structure of the Rrp6–Rrp47 N-terminal complex revealed a highly intertwined unit with a conserved groove that recruits the Mtr4 helicase to the exosome, providing the first atomic-resolution view of how the Sas10/C1D domain organizes exosome cofactor assembly.

    Evidence X-ray crystallography, structure-guided mutagenesis, in vitro binding, and yeast growth assays

    PMID:25319414

    Open questions at the time
    • No equivalent structural data for human C1D–EXOSC10 complex
    • How Mtr4 recruitment is coordinated with ongoing RNA processing is not resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How C1D partitions between its distinct functions in DNA repair (DNA-PK activation, NHEJ/HR, condensin interaction) and RNA processing (exosome cofactor, rRNA/snoRNA maturation), and whether these roles are regulated by post-translational modifications or damage signaling, remains an open question.
  • No systematic separation-of-function mutant analysis in mammalian cells
  • Post-translational regulation of C1D is uncharacterized
  • Structural basis of the human C1D–DNA-PKcs interaction is unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 3 GO:0003677 DNA binding 2 GO:0098772 molecular function regulator activity 2 GO:0140110 transcription regulator activity 1
Localization
GO:0005634 nucleus 2 GO:0005694 chromosome 1 GO:0005730 nucleolus 1
Pathway
R-HSA-8953854 Metabolism of RNA 5 R-HSA-73894 DNA Repair 4 R-HSA-5357801 Programmed Cell Death 1 R-HSA-74160 Gene expression (Transcription) 1
Partners
EXOSC10MPP6NCOR1NCOR2PRKDCSMC4TSNAX
Complex memberships
N-CoR/SMRT corepressor complexNuclear RNA exosome (via PM/Scl-100–MPP6 trimeric subcomplex)

Evidence

Reading pass · 11 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 C1D physically interacts with DNA-PKcs (via its putative leucine zipper region) and activates DNA-PK in a DNA end-independent manner. C1D was identified as a very effective DNA-PK substrate in vitro, and yeast two-hybrid and mammalian cell co-immunoprecipitation confirmed the interaction. Yeast two-hybrid screen, co-immunoprecipitation in mammalian cells, in vitro kinase assay Genes & development High 9679063
1999 Overexpression of C1D induces apoptosis in multiple tumor cell lines in a p53-dependent manner, with morphological hallmarks of apoptosis (membrane blebbing, nuclear disintegration, cytoplasmic vacuolation). C1D-induced apoptosis also produces a bystander effect on neighboring non-transfected cells, and cells with non-functional p53 are resistant. Transient transfection with C1D-EGFP fusion constructs, TUNEL assay, fluorescence microscopy, co-culture experiments Journal of cell science Medium 10362552
1997 C1D (identified as SUN-CoR, Small Unique Nuclear receptor CoRepressor) was cloned as a nuclear corepressor that potentiates transcriptional repression by thyroid hormone receptor and RevErb in vivo, represses transcription when fused to a heterologous DNA-binding domain, and interacts with RevErb, thyroid hormone receptor, N-CoR, and SMRT in vitro and with endogenous N-CoR in cells. Cloning, in vivo reporter assays, in vitro binding assays, co-immunoprecipitation Proceedings of the National Academy of Sciences of the United States of America High 9405624
2002 C1D interacts specifically with Translin-associated factor X (TRAX) in both yeast and mammalian cells, but this interaction in mammalian cells occurs only following gamma-irradiation, linking C1D and TRAX to DNA double-strand break repair signaling. C1D overexpression can prevent TRAX from associating with Translin. Yeast two-hybrid system, co-immunoprecipitation in mammalian cells, fluorescence microscopy with tagged proteins, gamma-irradiation treatment Journal of cell science Medium 11801738
2002 The Saccharomyces cerevisiae C1D homologue (YC1D) is required for both non-homologous DNA end joining (NHEJ) and homologous recombination. Disruption of YC1D causes temperature sensitivity and defects in accurate DNA repair, establishing a direct role for C1D in two major DSB repair pathways. Yeast gene disruption, plasmid-based in vivo recombination assay, DNA repair phenotype analysis, temperature sensitivity assay Molecular microbiology High 12421302
2004 Fission yeast C1D homologue Cti1 (SpC1D) physically interacts with the hinge domain of condensin subunit Cut3/SMC4, as confirmed by GST pull-down and co-immunoprecipitation. Elevated dosage of SpC1D suppresses temperature, UV, and hydroxyurea sensitivity of condensin non-SMC subunit (Cnd2) mutants, and SpC1D accumulates on nuclear chromatin upon hydroxyurea treatment, supporting a role in DNA repair through condensin. Yeast two-hybrid, GST pull-down, co-immunoprecipitation, genetic dosage suppression, chromatin fractionation, immunofluorescence Proceedings of the National Academy of Sciences of the United States of America High 15148393
2007 Human C1D associates with the exosome subunit PM/Scl-100 and co-localizes with it in the nucleoli of HEp-2 cells. C1D nucleolar accumulation is dependent on PM/Scl-100. C1D, MPP6, and PM/Scl-100 form a stable trimeric complex in vitro. C1D exhibits RNA-binding activity with preference for structured RNAs. RNAi knockdown of C1D causes accumulation of 3′-extended 5.8S rRNA precursors, demonstrating a role in pre-rRNA 3′-end processing. Co-immunoprecipitation, subcellular localization (immunofluorescence), in vitro trimeric complex reconstitution, RNA-binding assay, RNAi knockdown, Northern blot for rRNA processing intermediates Nucleic acids research High 17412707
2010 The Sas10/C1D domain of yeast Rrp47 (an exosome cofactor) forms a binding surface for specific protein-protein interactions and can simultaneously interact with RNA or DNA, suggesting this conserved domain functions as a docking module for nucleic acid substrates. The N-terminal Sas10/C1D domain of Rrp47 is sufficient for interaction with the PMC2NT domain of Rrp6 and for most RNA-processing functions in vivo. Deletion complementation analysis, in vitro protein interaction studies, filter binding RNA assays Biochemical Society transactions Medium 20659009
2010 In yeast, the C-terminal region of Rrp47 (which contains the Sas10/C1D domain in its N-terminal portion) mediates RNA binding and interaction with snoRNP proteins Nop56 and Nop58, and is specifically required for 3′-end maturation of box C/D snoRNAs. The N-terminal Sas10/C1D domain binds Rrp6, while the C-terminal lysine-rich region contributes to RNA binding. Deletion complementation in yeast, in vitro protein interaction (protein capture assay), filter binding RNA assays, synthetic lethality analysis The Journal of biological chemistry High 21135092
2013 In yeast, Rrp47 (which contains a Sas10/C1D domain) is critical for the stability and normal expression of its partner exoribonuclease Rrp6; loss of Rrp47 substantially reduces Rrp6 protein stability and transcript levels under minimal medium growth conditions. Exogenous Rrp6 expression suppresses most but not all RNA processing defects in rrp47Δ mutants. Yeast genetics, Western blot, Northern blot, synthetic lethality complementation, exogenous protein expression PloS one Medium 24224060
2014 In yeast, Rrp47 (Sas10/C1D domain protein) and Rrp6 together form a composite structural surface that recruits the Mtr4 helicase to the exosome. Crystallographic analysis reveals the N-terminal domains of Rrp6 and Rrp47 form a highly intertwined unit with a conserved groove that binds the N-terminus of Mtr4; mutations at this interface disrupt the interaction. In vitro binding assay, X-ray crystallography, structure-guided mutagenesis, yeast growth assays The EMBO journal High 25319414

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2018 High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Molecular cell 580 29395067
2010 An atlas of combinatorial transcriptional regulation in mouse and man. Cell 573 20211142
2020 LRP1 is a master regulator of tau uptake and spread. Nature 424 32296178
2005 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome research 409 16344560
2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Nature biotechnology 266 15146197
2017 Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies. Journal of lipid research 238 28381441
2017 Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition. The Journal of neuroscience : the official journal of the Society for Neuroscience 221 28275161
2024 Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation. Cell metabolism 174 38906140
2019 LRP1 activation attenuates white matter injury by modulating microglial polarization through Shc1/PI3K/Akt pathway after subarachnoid hemorrhage in rats. Redox biology 132 30703614
2011 Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. The Journal of biological chemistry 131 21832049
2019 APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1. The Journal of clinical investigation 129 30741718
2007 C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. Nucleic acids research 121 17412707
2015 Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain. The Journal of neuroscience : the official journal of the Society for Neuroscience 117 25855193
2007 Toward a confocal subcellular atlas of the human proteome. Molecular & cellular proteomics : MCP 114 18029348
2009 Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway. Science signaling 112 19401592
1997 Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex. Proceedings of the National Academy of Sciences of the United States of America 112 9405624
2016 LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways. Journal of neuroinflammation 108 27931217
1995 LRP1, a gene expressed in lateral and adventitious root primordia of arabidopsis. The Plant cell 104 7647564
2013 CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Molecular cell 102 23333304
2018 Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Molecular & cellular proteomics : MCP 101 30021884
2021 Lrp1 is a host entry factor for Rift Valley fever virus. Cell 99 34559985
2021 Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism. The Journal of biological chemistry 97 33930462
2010 Signaling through LRP1: Protection from atherosclerosis and beyond. Biochemical pharmacology 96 20920479
2014 The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase. The EMBO journal 94 25319414
2020 Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. Nature metabolism 92 32694731
2008 LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein. Journal of cell science 92 18285446
2022 LRP1 is a neuronal receptor for α-synuclein uptake and spread. Molecular neurodegeneration 88 36056345
2019 LRP1-upregulated nanoparticles for efficiently conquering the blood-brain barrier and targetedly suppressing multifocal and infiltrative brain metastases. Journal of controlled release : official journal of the Controlled Release Society 83 31026546
2014 Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation. Cell reports 80 24981860
2020 Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Cell reports 79 32814053
2017 LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis. eLife 76 29144234
2011 Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. PLoS biology 76 21264353
2016 Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections. American journal of human genetics 73 27569546
2018 TLR Crosstalk Activates LRP1 to Recruit Rab8a and PI3Kγ for Suppression of Inflammatory Responses. Cell reports 71 30208326
1998 DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D. Genes & development 71 9679063
2013 Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain. The Journal of neuroscience : the official journal of the Society for Neuroscience 66 23536074
2022 Exosomes from Adipose Stem Cells Promote Diabetic Wound Healing through the eHSP90/LRP1/AKT Axis. Cells 63 36291096
2019 Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1. Journal of cell science 63 31273033
2004 Expression of LRP1 by human osteoblasts: a mechanism for the delivery of lipoproteins and vitamin K1 to bone. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 63 15647823
2023 Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein-protein interactions in the human cell. Proceedings of the National Academy of Sciences of the United States of America 60 37071682
2017 Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin. Molecular neurobiology 58 29079999
2013 Low density receptor-related protein 1 (LRP1) promotes anti-inflammatory phenotype in murine macrophages. Cell and tissue research 58 23963646
2014 KIF13B enhances the endocytosis of LRP1 by recruiting LRP1 to caveolae. The Journal of cell biology 57 24469637
2019 Auxin signaling modulates LATERAL ROOT PRIMORDIUM1 (LRP1) expression during lateral root development in Arabidopsis. The Plant journal : for cell and molecular biology 55 31483536
2014 Lactoferrin stimulates osteoblast differentiation through PKA and p38 pathways independent of lactoferrin's receptor LRP1. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 53 24877241
2009 Common variation in genes related to innate immunity and risk of adult glioma. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 53 19423540
2015 Lrp1/LDL Receptor Play Critical Roles in Mannose 6-Phosphate-Independent Lysosomal Enzyme Targeting. Traffic (Copenhagen, Denmark) 52 25786328
2002 Phosphorylation of LRP1: regulation of transport and signal transduction. Trends in cardiovascular medicine 52 12069755
2007 Cell-surface transglutaminase undergoes internalization and lysosomal degradation: an essential role for LRP1. Journal of cell science 51 17711877
2022 Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1. Proceedings of the National Academy of Sciences of the United States of America 49 35939689
2002 DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX). Journal of cell science 49 11801738
2015 LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages. PloS one 48 26061292
2012 Role of LRP1 in transport of CCN2 protein in chondrocytes. Journal of cell science 48 22454511
2011 The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury. The Journal of neuroscience : the official journal of the Society for Neuroscience 48 21940431
2009 Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes. Blood 48 19605848
2018 Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions. Cell reports 47 29298432
2011 Rrp6, rrp47 and cofactors of the nuclear exosome. Advances in experimental medicine and biology 46 21713680
2015 The Matricellular Receptor LRP1 Forms an Interface for Signaling and Endocytosis in Modulation of the Extracellular Tumor Environment. Frontiers in pharmacology 45 26617523
2013 LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype. Molecular neurodegeneration 45 23866919
2014 LRP-1: functions, signaling and implications in kidney and other diseases. International journal of molecular sciences 44 25514242
2014 The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development. Development (Cambridge, England) 43 25377550
2013 Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease. Expert opinion on therapeutic targets 42 23573918
2010 Risk of meningioma and common variation in genes related to innate immunity. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 41 20406964
2018 The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. Cellular and molecular gastroenterology and hepatology 40 30480076
2017 LRP1: A chameleon receptor of lung inflammation and repair. Matrix biology : journal of the International Society for Matrix Biology 40 29262309
2015 LRP1 Regulates Retinal Angiogenesis by Inhibiting PARP-1 Activity and Endothelial Cell Proliferation. Arteriosclerosis, thrombosis, and vascular biology 40 26634655
2023 Targeted Lysosomal Degradation of Secreted and Cell Surface Proteins through the LRP-1 Pathway. Journal of the American Chemical Society 38 37590164
2018 p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. Cell reports 38 30089260
2015 Role of LRP1 and ERK and cAMP Signaling Pathways in Lactoferrin-Induced Lipolysis in Mature Rat Adipocytes. PloS one 38 26506094
2014 Regulation of LRP-1 expression: make the point. Pathologie-biologie 38 24661974
2012 A FAP46 mutant provides new insights into the function and assembly of the C1d complex of the ciliary central apparatus. Journal of cell science 38 22573824
2009 LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export. PloS one 37 19718435
2002 Saccharomyces cerevisiae C1D is implicated in both non-homologous DNA end joining and homologous recombination. Molecular microbiology 37 12421302
2023 FUT2 inhibits the EMT and metastasis of colorectal cancer by increasing LRP1 fucosylation. Cell communication and signaling : CCS 36 36973740
2021 The molecular mechanism of LRP1 in physiological vascular homeostasis and signal transduction pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 36 34243608
2020 Silencing of LRP1 Exacerbates Inflammatory Response Via TLR4/NF-κB/MAPKs Signaling Pathways in APP/PS1 Transgenic Mice. Molecular neurobiology 36 32572761
2010 The C-terminal region of the exosome-associated protein Rrp47 is specifically required for box C/D small nucleolar RNA 3'-maturation. The Journal of biological chemistry 36 21135092
2021 Brain endothelial LRP1 maintains blood-brain barrier integrity. Fluids and barriers of the CNS 35 34147102
2021 An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity. Cell chemical biology 35 34672954
2019 PRISMA: Protein Interaction Screen on Peptide Matrix Reveals Interaction Footprints and Modifications- Dependent Interactome of Intrinsically Disordered C/EBPβ. iScience 35 30884312
2010 Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling. The Journal of biological chemistry 34 20472562
2017 Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA. Cellular and molecular life sciences : CMLS 33 28799085
2004 Cti1/C1D interacts with condensin SMC hinge and supports the DNA repair function of condensin. Proceedings of the National Academy of Sciences of the United States of America 33 15148393
2014 Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma. Journal of hematology & oncology 29 25300797
2013 The exosome cofactor Rrp47 is critical for the stability and normal expression of its associated exoribonuclease Rrp6 in Saccharomyces cerevisiae. PloS one 29 24224060
2010 Polymorphisms in innate immunity genes and risk of childhood leukemia. Human immunology 29 20438785
2023 The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain. Nucleic acids research 28 36537216
2017 Deficiency of LRP1 in Mature Adipocytes Promotes Diet-Induced Inflammation and Atherosclerosis-Brief Report. Arteriosclerosis, thrombosis, and vascular biology 28 28473440
2014 Placental heme receptor LRP1 correlates with the heme exporter FLVCR1 and neonatal iron status. Reproduction (Cambridge, England) 28 24947444
2021 The disbalance of LRP1 and SIRPα by psychological stress dampens the clearance of tumor cells by macrophages. Acta pharmaceutica Sinica. B 27 35127380
2016 LRP1 Protein Deficiency Exacerbates Palmitate-induced Steatosis and Toxicity in Hepatocytes. The Journal of biological chemistry 27 27317662
2015 PAI-1 modulates cell migration in a LRP1-dependent manner via β-catenin and ERK1/2. Thrombosis and haemostasis 27 25694133
2023 Multi-faceted role of LRP1 in the immune system. Frontiers in immunology 26 37020553
2022 LDL receptor-related protein 1 (LRP1), a novel target for opening the blood-labyrinth barrier (BLB). Signal transduction and targeted therapy 26 35680846
2004 Expression of LRP1 in retinal pigment epithelial cells and its regulation by growth factors. Investigative ophthalmology & visual science 26 15161872
2024 A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor. Cell 25 39657676
2018 Macrophage LRP1 Promotes Diet-Induced Hepatic Inflammation and Metabolic Dysfunction by Modulating Wnt Signaling. Mediators of inflammation 25 30524198
2023 ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells. Nature communications 24 38123547
2022 Secreted HSP90α-LRP1 Signaling Promotes Tumor Metastasis and Chemoresistance in Pancreatic Cancer. International journal of molecular sciences 24 35628341
2022 Revealing Angiopep-2/LRP1 Molecular Interaction for Optimal Delivery to Glioblastoma (GBM). Molecules (Basel, Switzerland) 24 36235232
2014 LRP1-dependent pepsin clearance induced by 2'-hydroxycinnamaldehyde attenuates breast cancer cell invasion. The international journal of biochemistry & cell biology 24 24796846
2018 The fibrinolytic factor tPA drives LRP1-mediated melanoma growth and metastasis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23 30458112
2024 Novel insights into the multifaceted and tissue-specific roles of the endocytic receptor LRP1. The Journal of biological chemistry 22 38950861
2021 Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin. Nature communications 22 34489478
2023 LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4. JCI insight 21 37036005
2021 Ginsenoside compound K acts via LRP1 to alleviate Amyloid β42-induced neuroinflammation in microglia by suppressing NF-κB. Biochemical and biophysical research communications 21 34968779
2010 Rrp6, Rrp47 and cofactors of the nuclear exosome. Advances in experimental medicine and biology 21 21618877
2016 The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains. Molecular and cellular neurosciences 20 27565578
1999 Induction of apoptosis by overexpression of the DNA-binding and DNA-PK-activating protein C1D. Journal of cell science 20 10362552
2017 High Concentrations of Rosiglitazone Reduce mRNA and Protein Levels of LRP1 in HepG2 Cells. Frontiers in pharmacology 19 29201005
2024 YBX1 as a therapeutic target to suppress the LRP1-β-catenin-RRM1 axis and overcome gemcitabine resistance in pancreatic cancer. Cancer letters 18 39216548
2019 Midkine promotes articular chondrocyte proliferation through the MK-LRP1-nucleolin signaling pathway. Cellular signalling 18 31639491
2010 Rrp47 and the function of the Sas10/C1D domain. Biochemical Society transactions 18 20659009
2024 The aptamer BT200 blocks interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1. Blood 16 38996211
2022 Guiding Epilepsy Surgery with an LRP1-Targeted SPECT/SERRS Dual-Mode Imaging Probe. ACS applied materials & interfaces 16 35588160
2021 Apolipoprotein and LRP1-Based Peptides as New Therapeutic Tools in Atherosclerosis. Journal of clinical medicine 16 34441867
2019 Hemin induces autophagy in a leukemic erythroblast cell line through the LRP1 receptor. Bioscience reports 16 30523204
2025 Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression. Acta pharmaceutica Sinica. B 15 40177548
2024 Pathogenic variants in CFAP46, CFAP54, CFAP74 and CFAP221 cause primary ciliary dyskinesia with a defective C1d projection of the central apparatus. The European respiratory journal 15 39362668
2023 Andrographolide exerts a neuroprotective effect by regulating the LRP1-mediated PPARγ/NF-κB pathway. European journal of pharmacology 15 37179044
2023 Jun-APOE-LRP1 axis promotes tumor metastasis in colorectal cancer. Biomolecules & biomedicine 15 37310025
2016 Role of LRP-1 in cancer cell migration in 3-dimensional collagen matrix. Cell adhesion & migration 15 27463962