Affinage

ARSA

ATPase GET3 · UniProt O43681

Length
348 aa
Mass
38.8 kDa
Annotated
2026-06-09
100 papers in source corpus 11 papers cited in narrative 11 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ARSA encodes lysosomal arylsulfatase A, a sulfatase whose loss causes the demyelinating disorder metachromatic leukodystrophy (MLD), with disease severity tracking residual enzyme activity (PMID:1684088, PMID:36240581). Pathogenic missense alleles abolish or sharply reduce catalytic activity, and reduced activity frequently reflects protein misfolding and instability rather than direct active-site disruption: the Gly309Ser enzyme is correctly trafficked to lysosomes yet unstable, and the F219V substitution produces a misfolded, unstable polypeptide with under 1% specific activity (PMID:8101038, PMID:15710861). Quantitatively, the genotype-activity-phenotype relationship is graded, with residual activity below 1% predicting early-onset, rapidly progressive disease and partial-activity alleles associated with late-infantile or adult-onset forms (PMID:1684088, PMID:8101038, PMID:15710861, PMID:36240581). Beyond the CNS, lysosomal ARSA is required in Sertoli cells for degradation of the sulfatide seminolipid (SGG); its loss in mice causes lysosomal SGG accumulation, elevated ROS, increased apoptosis, and male subfertility (PMID:34199863). ARSA deficiency is correctable: secreted enzyme is taken up by deficient patient fibroblasts to restore near-normal activity (cross-correction), and AAV-delivered ARSA reconstitutes enzyme activity in primate brain (PMID:19837699, PMID:18797988).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1991 High

    Established that distinct ARSA mutation classes produce graded enzymatic deficits that map onto MLD onset, distinguishing residual-activity alleles from null alleles.

    Evidence Site-directed mutagenesis and transient expression of patient mutations in BHK cells with enzyme activity assay

    PMID:1684088

    Open questions at the time
    • Did not resolve the structural basis of the residual-activity deficit
    • Limited to two alleles in one patient
  2. 1993 High

    Showed that residual-activity MLD can arise from a correctly trafficked but unstable enzyme, identifying protein instability rather than mislocalization as a disease mechanism.

    Evidence Transient expression of Gly309Ser ARSA with activity assay and lysosomal targeting by subcellular fractionation

    PMID:8101038

    Open questions at the time
    • Mechanism of instability (degradation pathway, half-life) not defined
    • Did not test all clinical subtypes
  3. 1993 Medium

    Implicated a strictly conserved residue (T274M) as catalytically critical by cross-species conservation, linking it to late-infantile MLD.

    Evidence SSCP/direct sequencing of ARSA exons and conservation analysis across 10 sulfatases in a 29-patient cohort

    PMID:8104633

    Open questions at the time
    • No in vitro enzyme assay of the mutant in this study
    • Causal contribution to catalysis inferred from conservation, not measured
  4. 2005 High

    Demonstrated directly that an adult-onset MLD allele (F219V) produces a misfolded, unstable enzyme with <1% activity, consolidating misfolding as a core loss-of-function route.

    Evidence Transient transfection with metabolic labeling and immunoprecipitation of mutant ARSA polypeptides plus activity assay

    PMID:15710861

    Open questions at the time
    • Did not identify the chaperone/degradation machinery handling the misfolded protein
    • Single allele
  5. 2010 Medium

    Resolved earlier chromosomal localization questions, placing ARSA at 22q13.31→qter and establishing conserved synteny with mouse chromosome 15.

    Evidence Somatic cell hybrid analysis with X;22, 1;22 and t(15;22) translocations and enzyme activity segregation

    PMID:6118238 PMID:7192199

    Open questions at the time
    • Gene-level structure and regulatory elements not addressed
    • Mapping is biochemical, not sequence-resolved
  6. 2008 Medium

    Established that ARSA deficiency is correctable in trans, showing secreted enzyme is taken up by deficient fibroblasts to restore near-normal activity (cross-correction).

    Evidence Microencapsulated recombinant BHK cells co-cultured with MLD patient fibroblasts; activity assay over 4 weeks

    PMID:18797988

    Open questions at the time
    • Uptake receptor/mechanism not dissected here
    • In vitro fibroblast model, not CNS
  7. 2010 High

    Provided in vivo proof that vector-delivered ARSA produces active enzyme distributed across brain tissue, supporting gene-delivery restoration of activity.

    Evidence Intracerebral AAV5-ARSA injection in non-human primates with brain enzyme activity assay and vector genome detection

    PMID:19837699

    Open questions at the time
    • Did not assess sulfatide clearance or demyelination reversal
    • Distribution limited to fraction of injected hemisphere
  8. 2021 High

    Defined a distinct physiological role for ARSA in male reproduction, showing it degrades seminolipid in Sertoli cell lysosomes and that its loss drives ROS-mediated subfertility.

    Evidence Arsa-null mouse with lipid mass spectrometry for SGG, ROS quantification, apoptosis and spermatogenesis analysis

    PMID:34199863

    Open questions at the time
    • Mechanistic link between SGG accumulation and ROS generation not fully defined
    • Relevance to human male fertility not established
  9. 2022 Medium

    Quantified the genotype-activity-phenotype relationship, establishing that residual activity below 1% predicts early-onset, rapidly progressive MLD.

    Evidence Refined leukocyte ARSA activity assay (69 patients), sequencing (84 patients), and clinical correlation across a 96-patient cohort

    PMID:36240581

    Open questions at the time
    • Single-center cohort
    • Does not explain modifiers of onset within similar activity ranges

Open questions

Synthesis pass · forward-looking unresolved questions
  • Whether ARSA has a non-catalytic chaperone role (e.g. preventing α-synuclein aggregation) distinct from its lysosomal sulfatase activity remains unresolved.
  • Interaction not validated by primary biochemical evidence in this corpus
  • Physiological relevance to Parkinsonian phenotype unestablished

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016787 hydrolase activity 4 GO:0140096 catalytic activity, acting on a protein 1
Localization
GO:0005764 lysosome 2
Pathway
R-HSA-1643685 Disease 2 R-HSA-1430728 Metabolism 1

Evidence

Reading pass · 11 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1991 Two pathogenic ARSA mutations were identified in a juvenile MLD patient: a missense mutation in exon 3 (isoleucine to serine substitution) that reduced ARSA activity to ~5% of control on transient expression in BHK cells, and a splice-site mutation after exon 7 that abolished ARSA activity and immunoreactive protein entirely. The residual-activity missense allele was associated with late-onset MLD. PCR amplification of ARSA gene, site-directed mutagenesis, transient expression in BHK cells with enzyme activity assay American journal of human genetics High 1684088
1993 A Gly309→Ser substitution (exon 5) in ARSA results in only 13% of normal enzyme activity on transient expression; the mutant ARSA protein is correctly targeted to lysosomes but is unstable. This mutation was associated with late-infantile MLD despite ~10% residual ARSA activity in fibroblasts, showing that late-infantile MLD is not always associated with complete absence of ARSA activity. Transient expression of mutant ARSA in cell lines, enzyme activity assay, lysosomal targeting assessed by subcellular fractionation/immunology American journal of human genetics High 8101038
1993 The missense mutation T274M (C→T transition in exon IV) in the ARSA gene causes late-infantile MLD; the substituted threonine residue is strictly conserved among 10 sulfatases from E. coli to humans, indicating this residue is critical for ARSA catalytic function. PCR amplification and SSCP/direct sequencing of ARSA exons; patient genotyping across 29 MLD patients Human mutation Medium 8104633
2005 The novel F219V substitution in exon 3 of ARSA causes a misfolded, unstable enzyme with specific activity less than 1% of normal, as shown by metabolic labeling and immunoprecipitation; this mutation was associated with adult-onset MLD without peripheral nervous system involvement. DNA sequence analysis, transient transfection, metabolic labeling, immunoprecipitation of mutant ARSA polypeptides Archives of neurology High 15710861
1980 ARSA was regionally localized to chromosome 22q13→22qter by somatic cell hybrid analysis using translocations, placing it in the distal sub-band of 22q13. Somatic cell hybrid clones with X;22 and 1;22 translocations; enzyme activity segregation analysis Cytogenetics and cell genetics Medium 6118238 7192199
1981 ARSA was assigned to mouse chromosome 15 by somatic cell hybrid analysis, establishing a conserved syntenic relationship with human chromosome 22; human ARSA and DIA1 were mapped to region 22q13.31→qter, separated from ACO2 by the translocation breakpoint. Chinese hamster × mouse somatic cell hybrids; enzyme activity segregation; t(15;22) translocation mapping Cytogenetics and cell genetics Medium 6118238
2010 Intracerebral injection of AAV5 vector encoding human ARSA into non-human primates resulted in ARSA enzyme expression and activity over a brain volume of 12–15 cm³ (37–46% of injected hemisphere), with a 12–38% increase in ARSA activity across 50–65% of the injected hemisphere, demonstrating functional in vivo ARSA protein delivery and activity restoration. Intracerebral AAV5 injection in non-human primates; ARSA enzyme activity assay in brain tissue; vector genome detection Human molecular genetics High 19837699
2008 Encapsulated BHK cells overexpressing ARSA secreted functional enzyme that was taken up by MLD patient fibroblasts, restoring ARSA activity to near-normal levels (23.42 nmol/h/mg vs. 23.9 nmol/h/mg normal; untreated MLD: 2.22 nmol/h/mg), demonstrating cross-correction of ARSA deficiency via extracellular enzyme uptake. Microencapsulated recombinant BHK cells co-cultured with MLD patient fibroblasts; ARSA enzyme activity assay over 4 weeks Metabolic brain disease Medium 18797988
2021 In aging Arsa-null male mice, accumulation of seminolipid (SGG) in Sertoli cell lysosomes was associated with elevated superoxide and H2O2 in Sertoli cells and increased ROS in testicular germ cells, elevated apoptosis, decreased spermatogenesis, and increased abnormal sperm, establishing that lysosomal ARSA is required for SGG degradation in Sertoli cells and that its absence causes ROS-mediated male subfertility. Arsa knockout mouse model; ROS quantification (superoxide, H2O2 assays); apoptosis assay; spermatogenesis analysis; lipid mass spectrometry for SGG Antioxidants (Basel, Switzerland) High 34199863
2020 ASA (arylsulfatase A) may function as a molecular chaperone that interacts with α-synuclein (SNCA) in the cytoplasm, preventing its aggregation, secretion, and cell-to-cell propagation, based on in vitro and in vivo studies reviewed; reduced ARSA enzymatic activity was associated with an atypical Parkinson's disease phenotype including early cognitive impairment. Review summarizing in vitro interaction studies and in vivo models; specific methods not detailed in abstract Brain sciences Low 33036336
2022 Residual ARSA enzyme activity below 1% of controls (measured with a refined leukocyte assay) predicted early-onset MLD and rapid disease progression; bi-allelic protein-truncating ARSA variants resulted in minimal residual activity and early motor decline, establishing a genotype-activity-phenotype correlation for ARSA. Refined ARSA enzyme activity assay in leukocytes (69 patients); Sanger and NGS sequencing (84 patients); clinical outcome correlation in 96-patient cohort Molecular genetics and metabolism Medium 36240581

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2000 Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pump. The EMBO journal 138 10970874
2007 Rationale, design and baseline data of a randomized, double-blind, controlled trial comparing two antithrombotic regimens (a fixed-dose combination of extended-release dipyridamole plus ASA with clopidogrel) and telmisartan versus placebo in patients with strokes: the Prevention Regimen for Effectively Avoiding Second Strokes Trial (PRoFESS). Cerebrovascular diseases (Basel, Switzerland) 131 17337887
2023 Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease. Nature medicine 121 36823301
1988 Molecular characterization of an anion pump. The arsA gene product is an arsenite(antimonate)-stimulated ATPase. The Journal of biological chemistry 114 2449436
2004 Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase. Human genetics 111 14749922
2019 A WRKY transcription factor PbrWRKY53 from Pyrus betulaefolia is involved in drought tolerance and AsA accumulation. Plant biotechnology journal 107 30801865
2017 Exogenous Silicon Attenuates Cadmium-Induced Oxidative Stress in Brassica napus L. by Modulating AsA-GSH Pathway and Glyoxalase System. Frontiers in plant science 107 28674552
1990 Molecular characterization of an anion pump. The ArsB protein is the membrane anchor for the ArsA protein. The Journal of biological chemistry 107 1688427
2000 Thermodynamic analysis of interactions between denaturants and protein surface exposed on unfolding: interpretation of urea and guanidinium chloride m-values and their correlation with changes in accessible surface area (ASA) using preferential interaction coefficients and the local-bulk domain model. Proteins 98 11013402
2017 The C2H2 zinc-finger protein SlZF3 regulates AsA synthesis and salt tolerance by interacting with CSN5B. Plant biotechnology journal 96 29193661
2015 Mutation Update of ARSA and PSAP Genes Causing Metachromatic Leukodystrophy. Human mutation 93 26462614
2020 The endophytic bacterium Sphingomonas SaMR12 alleviates Cd stress in oilseed rape through regulation of the GSH-AsA cycle and antioxidative enzymes. BMC plant biology 64 32028891
2017 ASA Classification as a Risk Stratification Tool in Adult Spinal Deformity Surgery: A Study of 5805 Patients. Global spine journal 64 29238634
2004 5-ASA and lycopene decrease the oxidative stress and inflammation induced by iron in rats with colitis. Journal of gastroenterology 64 15235867
2006 5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint. Gastroenterology 63 17241873
2010 Efficient intracerebral delivery of AAV5 vector encoding human ARSA in non-human primate. Human molecular genetics 62 19837699
1997 Tryptophan fluorescence reports nucleotide-induced conformational changes in a domain of the ArsA ATPase. The Journal of biological chemistry 62 9242630
1991 Two new arylsulfatase A (ARSA) mutations in a juvenile metachromatic leukodystrophy (MLD) patient. American journal of human genetics 55 1684088
1995 Role of cysteinyl residues in metalloactivation of the oxyanion-translocating ArsA ATPase. The Journal of biological chemistry 53 7744758
2002 Aspirin (ASA) regulates 5-lipoxygenase activity and peroxisome proliferator-activated receptor alpha-mediated CINC-1 release in rat liver cells: novel actions of lipoxin A4 (LXA4) and ASA-triggered 15-epi-LXA4. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 52 12368230
1980 Regional localization of the genes coding for human ACO2, ARSA, and NAGA on chromosome 22. Cytogenetics and cell genetics 45 7192199
1999 Mechanism of the ArsA ATPase. Biochimica et biophysica acta 40 10581357
1996 Intranasal challenge with aspirin induces cell influx and activation of eosinophils and mast cells in nasal secretions of ASA-sensitive patients. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 38 8842555
2000 [Azathioprine and 5-ASA in the prevention of postoperative recurrence of Crohn's disease]. Gastroenterologia y hepatologia 37 11227650
2020 Maize bHLH55 functions positively in salt tolerance through modulation of AsA biosynthesis by directly regulating GDP-mannose pathway genes. Plant science : an international journal of experimental plant biology 36 33288001
2023 Regulation of proline metabolism, AsA-GSH cycle, cadmium uptake and subcellular distribution in Brassica napus L. under the effect of nano-silicon. Environmental pollution (Barking, Essex : 1987) 34 37544403
2006 Dextran and 5-aminosalicylic acid (5-ASA) conjugates: synthesis, characterisation and enzymic hydrolysis. Carbohydrate research 34 16973138
1993 High residual arylsulfatase A (ARSA) activity in a patient with late-infantile metachromatic leukodystrophy. American journal of human genetics 34 8101038
2018 AsA-GSH Cycle and Antioxidant Enzymes Play Important Roles in Cd Tolerance of Wheat. Bulletin of environmental contamination and toxicology 31 30353306
2017 Genomic characterization of tobacco/nut chewing HPV-negative early stage tongue tumors identify MMP10 asa candidate to predict metastases. Oral oncology 31 28939077
1993 An arylsulfatase A (ARSA) missense mutation (T274M) causing late-infantile metachromatic leukodystrophy. Human mutation 31 8104633
2021 Three metabolic pathways are responsible for the accumulation and maintenance of high AsA content in kiwifruit (Actinidia eriantha). BMC genomics 30 33407094
2017 5-ASA-loaded SiO2 nanoparticles-a novel drug delivery system targeting therapy on ulcerative colitis in mice. Molecular medicine reports 30 28138699
2016 Hypobaric Treatment Effects on Chilling Injury, Mitochondrial Dysfunction, and the Ascorbate-Glutathione (AsA-GSH) Cycle in Postharvest Peach Fruit. Journal of agricultural and food chemistry 30 27195461
2010 The effects of the histone deacetylase inhibitor romidepsin (FK228) are enhanced by aspirin (ASA) in COX-1 positive ovarian cancer cells through augmentation of p21. Cancer biology & therapy 30 20404564
2005 Mutations c.459+1G>A and p.P426L in the ARSA gene: prevalence in metachromatic leukodystrophy patients from European countries. Molecular genetics and metabolism 29 16140556
1996 Isolation of the ATP-binding human homolog of the arsA component of the bacterial arsenite transporter. Genomics 29 8884272
2022 Predicting clinical phenotypes of metachromatic leukodystrophy based on the arylsulfatase A activity and the ARSA genotype? - Chances and challenges. Molecular genetics and metabolism 28 36240581
2011 Fetal aberrant right subclavian artery (ARSA) - a potential new soft marker in the genetic scan? Ultraschall in der Medizin (Stuttgart, Germany : 1980) 28 21614745
2022 Modelling the benefits of an optimised treatment strategy for 5-ASA in mild-to-moderate ulcerative colitis. BMJ open gastroenterology 27 35165124
2006 Antioxidative enzyme and glutathione S-transferase activities in diabetic rats exposed to long-term ASA treatment. Life sciences 26 16815474
1981 Conserved autosomal syntenic group on mouse (MMU) chromosome 15 and human (HSA) chromosome 22: assignment of a gene for arylsulfatase A to MMU 15 and regional mapping of DIA1, ARSA, and ACO2 on HSA 22. Cytogenetics and cell genetics 26 6118238
2018 Clinical significance of serum DRAM1 mRNA, ARSA mRNA, hsa-miR-2053 and lncRNA-RP1-86D1.3 axis expression in malignant pleural mesothelioma. Journal of cellular biochemistry 25 30362153
2007 Caenorhabditis elegans expresses a functional ArsA. The FEBS journal 25 17419726
2006 Cys-113 and Cys-422 form a high affinity metalloid binding site in the ArsA ATPase. The Journal of biological chemistry 25 16467301
2013 Reducing AsA leads to leaf lesion and defence response in knock-down of the AsA biosynthetic enzyme GDP-D-mannose pyrophosphorylase gene in tomato plant. PloS one 23 23626761
2010 5-aminosalicylic acid (5-ASA) can reduce levels of oxidative DNA damage in cells of colonic mucosa with and without fecal stream. Digestive diseases and sciences 23 21042854
2006 Randomized comparison of the effects of ASA plus clopidogrel versus ASA alone on early platelet activation in acute coronary syndromes with elevated high-sensitivity C-reactive protein and soluble CD40 ligand levels. Clinical therapeutics 22 16860169
2000 The linker peptide of the ArsA ATPase. Molecular microbiology 22 10652096
1995 Interaction of substrate and effector binding sites in the ArsA ATPase. Biochemistry 22 7577951
1999 Asp45 is a Mg2+ ligand in the ArsA ATPase. The Journal of biological chemistry 21 10318792
1999 The ATPase mechanism of ArsA, the catalytic subunit of the arsenite pump. The Journal of biological chemistry 21 10347168
2005 Adult onset metachromatic leukodystrophy without electroclinical peripheral nervous system involvement: a new mutation in the ARSA gene. Archives of neurology 20 15710861
2003 Identification of nine novel arylsulfatase a (ARSA) gene mutations in patients with metachromatic leukodystrophy (MLD). Human mutation 20 14517960
2002 Effects of paracetamol and propacetamol on gastric mucosal damage and gastric lipid peroxidation caused by acetylsalicylic acid (ASA) in rats. Pharmacological research 20 12220953
1991 Trinitrophenyl-ATP binding to the ArsA protein: the catalytic subunit of an anion pump. Archives of biochemistry and biophysics 20 1832838
2018 KLF4 Mediates the Effect of 5-ASA on the β-Catenin Pathway in Colon Cancer Cells. Cancer prevention research (Philadelphia, Pa.) 19 29794245
2020 Transcriptomic analysis reveals the changes of energy production and AsA-GSH cycle in oat embryos during seed ageing. Plant physiology and biochemistry : PPB 18 32474385
2020 Metachromatic leukodystrophy genotypes in The Netherlands reveal novel pathogenic ARSA variants in non-Caucasian patients. Neurogenetics 18 32632536
2005 Polymorphisms of high-affinity IgE receptor and histamine-related genes in patients with ASA-induced urticaria/angioedema. Journal of Korean medical science 18 15953854
1999 Can NSAID/ASA-induced erosions of the gastric mucosa be identified at histology? Pathology, research and practice 18 10220792
2021 Accumulation of Seminolipid in Sertoli Cells Is Associated with Increased Levels of Reactive Oxygen Species and Male Subfertility: Studies in Aging Arsa Null Male Mice. Antioxidants (Basel, Switzerland) 17 34199863
2019 Spectrum of ARSA variations in Asian Indian patients with Arylsulfatase A deficient metachromatic leukodystrophy. Journal of human genetics 17 30674982
2018 The novel EHEC gene asa overlaps the TEGT transporter gene in antisense and is regulated by NaCl and growth phase. Scientific reports 17 30552341
2013 Effect of ASA dose doubling versus switching to clopidogrel on plasma inflammatory markers concentration in patients with type 2 diabetes and high platelet reactivity: the AVOCADO study. Cardiology journal 17 24469880
2010 Propensity vectors of low-ASA residue pairs in the distinction of protein interactions. Proteins 17 19768686
2010 Development and characterization of colon specific drug delivery system bearing 5-ASA and Camylofine dihydrochloride for the treatment of ulcerative colitis. Journal of drug targeting 17 20088681
2006 Changes in urinary LTE4 and nasal functions following nasal provocation test with ASA in ASA-tolerant and -intolerant asthmatics. Respiratory medicine 17 16678396
1997 Antitumor and cytogenetic effects of esteric (ASE) and amidic (ASA) steroidal derivative of p-bis (2-chloroethyl) amino phenylacetic acid (CAPA). A comparative study. Anticancer research 17 9494562
2022 Acetylsalicylic-acid (ASA) regulation of osteo/odontogenic differentiation and proliferation of human dental pulp stem cells (DPSCs) in vitro. Archives of oral biology 16 36215814
2020 Nitrate reductase is required for salicylic acid-induced water stress tolerance of pepper by upraising the AsA-GSH pathway and glyoxalase system. Physiologia plantarum 16 32542778
2005 The relation between health-related quality of life, past medical history, and American Society of Anesthesiologists' ASA grade in patients having primary operations for oral and oropharyngeal cancer. The British journal of oral & maxillofacial surgery 16 15749214
2011 Population carrier rates of pathogenic ARSA gene mutations: is metachromatic leukodystrophy underdiagnosed? PloS one 15 21695197
1998 Nucleotide binding to the C-terminal nucleotide binding domain of ArsA. Studies with an ATP analogue, 5'-p-fluorosulfonylbenzoyladenosine. The Journal of biological chemistry 15 9535916
2021 Genome-Wide Analysis of MDHAR Gene Family in Four Cotton Species Provides Insights into Fiber Development via Regulating AsA Redox Homeostasis. Plants (Basel, Switzerland) 14 33503886
2021 Management of chronic rhinosinusitis with nasal polyps in Samter triad by low-dose ASA desensitization or dupilumab. Medicine 14 34622875
2019 Prevention of haemoglobin glycation by acetylsalicylic acid (ASA): A new view on old mechanism. PloS one 14 30986221
2019 Effects of 5-FU and anti-EGFR antibody in combination with ASA on the spherical culture system of HCT116 and HT29 colorectal cancer cell lines. International journal of oncology 14 31180528
2017 Combination of measures of handgrip strength and red cell distribution width can predict in-hospital complications better than the ASA grade after hip fracture surgery in the elderly. BMC musculoskeletal disorders 14 28854917
2013 A homozygote for the c.459+1G>A mutation in the ARSA gene presents with cerebellar ataxia as the only first clinical sign of metachromatic leukodystrophy. Journal of the neurological sciences 14 24411407
1999 The anion-stimulated ATPase ArsA shows unisite and multisite catalytic activity. The Journal of biological chemistry 14 10464326
2020 Arylsulfatase A (ASA) in Parkinson's Disease: From Pathogenesis to Biomarker Potential. Brain sciences 13 33036336
2008 In vitro correction of ARSA deficiency in human skin fibroblasts from metachromatic leukodystrophy patients after treatment with microencapsulated recombinant cells. Metabolic brain disease 13 18797988
2024 Silicon nanoparticles (SiNPs) mediate GABA, SOD and ASA-GSH cycle to improve cd stress tolerance in Solanum lycopersicum. Scientific reports 12 39304700
2022 Antofine Triggers the Resistance Against Penicillium italicum in Ponkan Fruit by Driving AsA-GSH Cycle and ROS-Scavenging System. Frontiers in microbiology 12 35495682
2022 Double-stranded RNA induction asa potential dynamic biomarkerfor DNA-demethylating agents. Molecular therapy. Nucleic acids 12 36035755
2018 Identification of Novel ARSA Mutations in Chinese Patients with Metachromatic Leukodystrophy. International journal of genomics 12 30057904
2007 Human sperm protein encyclopedia and alloantigen index: mining novel allo-antigens using sera from ASA-positive infertile patients and vasectomized men. Journal of reproductive immunology 12 17548113
2001 Glucocorticoids and IL-10, but not 6-MP, 5-ASA or sulfasalazine block endothelial expression of MAdCAM-1: implications for inflammatory bowel disease therapy. Alimentary pharmacology & therapeutics 12 11472325
1991 Substrate-induced dimerization of the ArsA protein, the catalytic component of an anion-translocating ATPase. The Journal of biological chemistry 12 1824941
2025 PbNAC3 coordinates AsA generation and ABA biosynthesis to improve salt tolerance in pear. The Plant journal : for cell and molecular biology 11 40265652
2023 Safety and Efficacy of Intravenous and Intrathecal Delivery of AAV9-Mediated ARSA in Minipigs. International journal of molecular sciences 11 37298156
2022 Dysregulation of the miRNome unveils a crosstalk between obesity and prostate cancer: miR-107 asa personalized diagnostic and therapeutic tool. Molecular therapy. Nucleic acids 11 35282415
2021 APICAL SPIKELET ABORTION (ASA) Controls Apical Panicle Development in Rice by Regulating Salicylic Acid Biosynthesis. Frontiers in plant science 11 33719311
2020 Effect of LTRA in L-ASA Challenge for Aspirin-Exacerbated Respiratory Disease Diagnosis. The journal of allergy and clinical immunology. In practice 11 33160093
2007 ARSA gene mutations in five Chinese metachromatic leukodystrophy patients. Pediatric neurology 11 17560502
1992 Construction of a chimeric ArsA-ArsB protein for overexpression of the oxyanion-translocating ATPase. The Journal of biological chemistry 11 1281474
2017 Four novel ARSA gene mutations with pathogenic impacts on metachromatic leukodystrophy: a bioinformatics approach to predict pathogenic mutations. Therapeutics and clinical risk management 10 28670130
2017 Metachromatic Leukodystrophy (MLD): a Pakistani Family with Novel ARSA Gene Mutation. Journal of molecular neuroscience : MN 10 28799099
1991 Ligand interactions in the ArsA protein, the catalytic component of an anion-translocating adenosinetriphosphatase. Biochemistry 10 1825784

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