- Length
- 2303 aa
- Mass
- 243.9 kDa
- Annotated
- 2026-04-28
83 papers in source corpus
32 papers cited in narrative
32 extracted findings
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
Insufficient on-target evidence to synthesize a narrative — discovery timeline does not match the canonical APC2 protein.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Evidence
Reading pass · 32 per-paper findings extracted from the source corpus
| Year | Finding | Method | Journal | Conf | PMIDs |
|---|---|---|---|---|---|
| 1999 | APC2 (APCL) was identified as a mammalian homologue of APC containing two SAMP domains both required for binding to conductin/axin, and shown to regulate beta-catenin–TCF transcriptional complexes in APC-/- colon carcinoma cells, indicating a conserved role in Wnt signaling. | Transient transcriptional activation assays, domain mapping, binding assays in APC-/- cells | Current biology : CB | High | 10021369 |
| 1998 | APCL (APC2) was identified as a brain-specific APC homologue whose 20-amino-acid repeat domain binds beta-catenin and depletes the intracellular beta-catenin pool, and can regulate beta-catenin–TCF interactions in reporter assays. | Yeast two-hybrid, reporter gene assay, transfection | Cancer research | Medium | 9823329 |
| 1999 | Drosophila APC2 (dAPC2) binds Armadillo (beta-catenin homologue), colocalizes with actin in multiple cellular contexts, shows asymmetric distribution in neuroblasts, and acts as a negative regulator of Wingless signaling in the embryonic epidermis genetically upstream of arm and dTCF but surprisingly also upstream of dishevelled. | Genetic mutant analysis, epistasis, immunolocalization, co-immunoprecipitation | The Journal of cell biology | High | 10491393 |
| 2001 | The heterodimeric complex of APC/C subunit APC2 (cullin) and APC11 (RING) reconstituted in vitro is the minimal ubiquitin ligase module of the anaphase-promoting complex, sufficient to catalyze ubiquitination of securin and cyclin B1 with Ubc4 or UbcH10; both APC11 and UbcH10 bind the C-terminal cullin homology domain of APC2, while Ubc4 binds APC11 directly. | Baculoviral reconstitution, in vitro ubiquitination assay, mutagenesis, zinc-binding experiments | Molecular biology of the cell | High | 11739784 |
| 2001 | Drosophila APC2 and Armadillo (beta-catenin) colocalize at sites of cortical spindle attachment in early Drosophila embryos, and APC2-Armadillo complexes often colocalize with interphase microtubules; loss of APC2 disrupts spindle anchoring during syncytial mitoses, and Zeste-white 3 kinase regulates the localization of APC2-Armadillo complexes and is crucial for spindle positioning. | Live imaging, immunolocalization, genetic analysis, epistasis with zw3 kinase | Nature cell biology | High | 11584277 |
| 2001 | Human APC2 overexpressed in SKOV3 ovarian cancer cells localizes to the Golgi apparatus, actin-containing structures, and occasionally microtubules; endogenous APC2 colocalizes with both the Golgi apparatus and actin filaments and remains associated with actin filaments after cytochalasin D treatment. | Immunofluorescence, subcellular fractionation, cytochalasin D treatment | Cancer research | Medium | 11691822 |
| 2000 | APCL (APC2) binds p53-binding protein 2 (53BP2) through the Src-homology-3 and ankyrin-repeat domains of 53BP2 interacting with the unique C-terminus of APCL, and this interaction regulates the cytoplasmic perinuclear localization of 53BP2 in normal mammalian cells. | Yeast two-hybrid, in vitro binding assay, confocal microscopy | Cancer research | Medium | 10646860 |
| 2002 | Simultaneous reduction of both Drosophila APC proteins (Apc1 and Apc2) causes global nuclear accumulation of Armadillo/beta-catenin and constitutive activation of Wingless transduction throughout development, demonstrating that Apc1 and Apc2 are functionally redundant regulators of beta-catenin in all cells. | Genetic double mutant analysis, immunostaining for nuclear Armadillo, epistasis | Development (Cambridge, England) | High | 11923210 |
| 2002 | APC1 and APC2 play overlapping roles in regulating Wingless signaling in the embryonic epidermis and imaginal discs; their overlapping function exists despite striking differences in intracellular localization, and APC1 function in embryos occurs at nearly undetectable expression levels. | Genetic double mutant analysis, RNA in situ hybridization, immunostaining | Developmental biology | High | 12297098 |
| 2002 | In the larval brain, APC2 localizes to the cell cortex while APC1 localizes to centrosomes and microtubules; despite distinct localizations, they play redundant roles as double mutants show severely reduced neuroblast numbers through a mechanism that does not involve Wg signaling misregulation, suggesting a cytoskeletal or adhesive function. | Genetic double mutant analysis, immunostaining, neuroblast counting | Developmental biology | High | 12297097 |
| 2002 | Inversin interacts with the APC/C subunit Apc2 through D-box motifs; site-directed mutagenesis of the conserved D-box residues abrogates the inversin–Apc2 interaction, suggesting inversin is a substrate/binding partner of the APC/C. | Co-immunoprecipitation, site-directed mutagenesis of D-box | Human molecular genetics | Medium | 12471060 |
| 2005 | Cryo-EM localization of the APC/C coactivator Cdh1 and the cullin subunit Apc2 reveals they reside on the same side of the asymmetric APC/C particle, identifying the face where substrates are ubiquitinated; Cdh1 binding induces a conformational change in a large flexible APC/C domain, suggesting Cdh1 activates APC/C both by recruiting substrates and inducing conformational changes. | Cryo-EM angular reconstitution, random conical tilt analysis, STEM mass measurement | Molecular cell | High | 16364912 |
| 2009 | APC2 is distributed along microtubules in growth cones and axon shafts of retinal axons; overexpression of APC2 stabilizes microtubules in cultured cells, while APC2 knockdown reduces microtubule stability in retinal axons, impairs response to ephrin-A2, and causes drastic alterations in retinotectal projections in vivo. | shRNA knockdown, immunohistochemistry, microtubule stability assays, in vitro axon guidance assay, in vivo retinotectal projection analysis | The Journal of neuroscience | High | 19759310 |
| 2011 | In Drosophila S2 cells and embryos, both the Armadillo repeats and a novel C-terminal domain of APC2 are necessary but neither alone sufficient for cortical localization; cortical localization is required for APC2 function in actin organization but is dispensable for its role in Wnt signaling. | Domain deletion analysis, rescue experiments in APC mutant embryos, immunostaining | Journal of cell science | High | 21486956 |
| 2013 | APC2 loss in Drosophila embryos leads to increased chromosome segregation errors through a cascade beginning with incomplete centrosome separation, leading to ectopic cleavage furrow formation, mitotic defects, and DNA damage; APC2 functions at the embryonic cortex together with Axin to promote mitotic fidelity through cytoskeletal regulation. | Live imaging, genetic analysis, epistasis with Axin, cytoskeletal analysis in fly embryos | Development (Cambridge, England) | High | 24026117 |
| 2014 | The spliceosome subunit SNW1 is required for proper splicing of APC2 pre-mRNA; SNW1 depletion reduces APC2 protein levels, decreases APC/C activity, and indirectly causes sister chromatid cohesion defects by delaying mitosis and inducing cohesion fatigue; simultaneous re-expression of sororin and APC2 from intron-less cDNAs rescues cohesion in SNW1-depleted cells. | siRNA depletion, transcriptome-wide splicing analysis, rescue with intron-less cDNAs, cohesion assays | The EMBO journal | High | 25257309 |
| 2015 | A homozygous frameshift mutation in APC2 causes Sotos syndrome features; Apc2-/- mice show impaired learning/memory and abnormal head shape; endogenous Apc2 expression is downregulated by Nsd1 knockdown, indicating APC2 is a downstream effector of NSD1; Apc2 loss impairs cortical neuron migration and laminar positioning, which is rescued by forced Apc2 expression. | Whole-exome sequencing, Apc2 knockout mice, Nsd1 knockdown, cortical neuron migration assay, rescue by forced expression | Cell reports | High | 25753423 |
| 2016 | Tankyrase (TNKS) binds a C-terminal RPQPSG motif in Drosophila APC2 (conserved in human APC2 but not APC1), recruits TNKS into the beta-catenin destruction complex, and directly PARylates both Axin and APC2; unlike Axin, APC2 PARylation does not globally regulate APC2 protein levels, indicating TNKS regulates destruction complex activity at the level of both Axin and APC2. | Yeast two-hybrid screen, Co-IP, in vitro PARylation assay, motif mutagenesis, colon cancer cell Wnt reporter assays | The Journal of biological chemistry | High | 27068743 |
| 2016 | Concomitant loss of Apc and Apc2 in mouse mammary epithelium disrupts beta-catenin homeostasis, epithelial integrity, cohesion and polarity, increases cell division, and drives development of Wnt-activated mammary carcinomas with squamous differentiation; loss of either protein alone has no effect, demonstrating functional redundancy. | Conditional mouse transgenics (mammary-specific deletion), histology, beta-catenin immunostaining, tumor analysis | Oncogene | High | 27694902 |
| 2018 | APC2 localizes as distinct clusters along microtubule bundles in dendrites through LC8-binding and two separate microtubule-interacting domains; APC2 depletion reduces plus-end dynamics of minus-end-out oriented microtubules, increases microtubule sliding, and causes defects in dendritic morphology, indicating APC2 promotes dynamics of minus-end-out microtubules to maintain mixed polarity. | siRNA knockdown, live imaging, TIRF microscopy, domain analysis, microtubule dynamics measurements | Nature communications | High | 30018294 |
| 2018 | Drosophila APC2 regulates cortical actin dynamics in follicular epithelium and nurse cells of the Drosophila ovary; cortical localization of APC2 is governed by self-association through the N-terminal APC Self-Association Domain (ASAD) and a highly conserved coiled-coil within the C-terminal 30 amino acids (C30 domain). | Domain deletion analysis in S2 cells, actin dynamics assays in ovarian tissue, immunostaining | Cytoskeleton (Hoboken, N.J.) | Medium | 30019417 |
| 2018 | Brain Tumor (Brat) regulates the expression and localization of Apc2 at microtubule plus ends in commissural axons through its B-Box domains; Brat and Apc2 promote axon growth across the midline independently of Wnt/beta-catenin transcriptional regulation, suggesting a non-canonical role for Apc2 in microtubule-based axon guidance. | Genetic analysis in Drosophila, epistasis, immunostaining, cell-autonomous rescue | PLoS genetics | Medium | 29617376 |
| 2018 | Positioning of Apc2 at dendrite branch points in Drosophila neurons requires four modules: mitochondrial energy production (spastin → mitochondria), Nrg/Ank2, branched actin generated by Arp2/3 (via Rac1), and Fz/G-proteins/Axin signaling; Axin co-localizes with Apc2 at branch points and Frizzled/G-protein signaling controls their joint localization. | RNAi screen, candidate secondary screens, live imaging of Apc2-GFP, localization assays | G3 (Bethesda, Md.) | Medium | 29602811 |
| 2019 | APC2 deficiency in mice results in activation of ovarian Wnt signaling, subfertility driven by perturbed follicular growth, reduced ovulation and corpora lutea formation unrescuable by gonadotrophins, and defects in steroidogenesis and follicular vascularity; aged APC2-deficient mice carrying a hypomorphic Apc allele develop granulosa cell tumors with acute Wnt-signaling activation. | APC2 knockout mice, ovarian histology, qRT-PCR, gonadotrophin rescue experiments, tumor analysis | BMC cancer | Medium | 31291912 |
| 2019 | Bi-allelic loss-of-function mutations in APC2 in humans cause a unique lissencephaly with posterior predominance and subcortical heterotopia, linking APC2's established role in integrating actin and microtubule cytoskeletons to neuronal migration disorders alongside other lissencephaly proteins CTNNA2 and PAFAH1B1/LIS1. | Whole-exome sequencing in 12 individuals from 8 families, brain MRI characterization | American journal of human genetics | Medium | 31585108 |
| 2020 | APC/C subunit APC2 (APC2^CDH1) is enriched at the post-synapse of neuromuscular junctions in postmitotic myotubes and, in response to agrin stimulation, promotes ubiquitination of DOK7 at lysine 243 for proteolytic degradation, requiring MuSK kinase activity and phosphorylation of tyrosine 106 in DOK7, thereby negatively regulating acetylcholine receptor clustering. | Co-immunoprecipitation, ubiquitination assay, site-directed mutagenesis, immunostaining at NMJs, AChR clustering assay | FASEB journal | High | 32687671 |
| 2021 | FOXO4 binds the promoter region of APC2 to upregulate its expression as a transcription factor (demonstrated by ChIP), increasing phosphorylated degradation of beta-catenin and suppressing stemness genes; APC2 knockdown reverses FOXO4-mediated inhibition of EMT and metastasis in colorectal cancer cells. | Chromatin immunoprecipitation, gene knockdown, migration/invasion assays, xenograft model | Frontiers in cell and developmental biology | Medium | 34631691 |
| 2012 | In Drosophila, Apc11 (LmgA) interacts directly with Morula/Apc2 and together they form a binding site for Vihar (the E2-C ubiquitin conjugating enzyme), forming a ternary complex that constitutes the catalytic core of the Drosophila APC/C. | Co-immunoprecipitation, complementation of yeast apc11 mutant, genetic analysis | Cell division | Medium | 22417125 |
| 1998 | Budding yeast RSI1/APC2 is an essential APC/C subunit required for anaphase initiation; temperature-sensitive rsi1/apc2 mutants arrest in metaphase and fail to degrade Clb2p; the arrest is overcome by deletion of PDS1 (securin); and Rsi1p/Apc2p co-immunoprecipitates with the APC/C subunit Cdc23p. | Genetic screen, temperature-sensitive mutant analysis, co-immunoprecipitation, epistasis with pds1Δ | The EMBO journal | High | 9430641 |
| 1999 | APC11 specifically interacts with APC2, a cullin-related APC/C subunit, while the ROC1/ROC2 RING finger proteins interact with all cullins; APC11 immunocomplexes catalyze polyubiquitin chain formation in an E1- and E2-dependent manner. | Co-immunoprecipitation, in vitro ubiquitination assay, mutagenesis | Molecular cell | High | 10230407 |
| 2024 | Cryo-EM structures of S. cerevisiae APC/C reveal that, unlike human APC/C where coactivator CDH1 induces a conformational change of the catalytic module APC2:APC11 to allow E2 binding, in yeast apo-APC/C the catalytic module is already positioned to bind E2, demonstrating a mechanistic difference in coactivator-mediated E2 stimulation between species. | Cryo-EM structure determination of multiple yeast APC/C complexes (apo, CDH1-substrate ternary, phosphorylated) | bioRxivpreprint | Medium | bio_10.1101_2024.06.19.599685 |
| 2025 | The BubR1 TPR domain interacts with Apc2 (as well as Mad2 and Cdc20-APC/C), guided by the cryo-EM structure of the MCC-APC/C complex; an intramolecular 'lasso' structure involving the TPR domain enhances Cdc20-APC/C engagement to promote MCC assembly and MCC-APC/C binding for spindle assembly checkpoint activation. | Cryo-EM-guided mutagenesis, biochemical interaction assays, functional SAC assays | bioRxivpreprint | Medium | bio_10.1101_2025.10.13.682252 |
Source papers
Stage 0 corpus · 83 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Proceedings of the National Academy of Sciences of the United States of America | 1479 | 12477932 |
| 2006 | A probability-based approach for high-throughput protein phosphorylation analysis and site localization. | Nature biotechnology | 1336 | 16964243 |
| 2015 | The BioPlex Network: A Systematic Exploration of the Human Interactome. | Cell | 1118 | 26186194 |
| 2017 | Architecture of the human interactome defines protein communities and disease networks. | Nature | 1085 | 28514442 |
| 2015 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. | Cell | 1015 | 26496610 |
| 2020 | A reference map of the human binary protein interactome. | Nature | 849 | 32296183 |
| 2008 | Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. | Cell | 787 | 18854154 |
| 2001 | Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. | The Journal of cell biology | 726 | 11535616 |
| 2012 | Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. | Cell | 708 | 22939624 |
| 2021 | Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. | Cell | 705 | 33961781 |
| 2012 | A census of human soluble protein complexes. | Cell | 689 | 22939629 |
| 2011 | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Briefings in bioinformatics | 656 | 21873635 |
| 2008 | Genome-scale RNAi screen for host factors required for HIV replication. | Cell host & microbe | 627 | 18976975 |
| 2011 | Global landscape of HIV-human protein complexes. | Nature | 593 | 22190034 |
| 1998 | The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. | Genes & development | 507 | 9637688 |
| 2008 | Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. | Cell | 442 | 18485873 |
| 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Genome research | 438 | 15489334 |
| 2022 | OpenCell: Endogenous tagging for the cartography of human cellular organization. | Science (New York, N.Y.) | 432 | 35271311 |
| 2010 | Systematic analysis of human protein complexes identifies chromosome segregation proteins. | Science (New York, N.Y.) | 421 | 20360068 |
| 1999 | ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. | Molecular cell | 410 | 10230407 |
| 2015 | Panorama of ancient metazoan macromolecular complexes. | Nature | 407 | 26344197 |
| 2001 | Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. | The Journal of cell biology | 372 | 11285280 |
| 2000 | Mitotic regulation of the APC activator proteins CDC20 and CDH1. | Molecular biology of the cell | 363 | 10793135 |
| 2000 | Characterization of vertebrate cohesin complexes and their regulation in prophase. | The Journal of cell biology | 358 | 11076961 |
| 2003 | Mitotic regulation of the human anaphase-promoting complex by phosphorylation. | The EMBO journal | 341 | 14657031 |
| 2021 | A proximity-dependent biotinylation map of a human cell. | Nature | 339 | 34079125 |
| 2010 | Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. | Cell | 318 | 21145461 |
| 2007 | Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. | Nature | 301 | 17443186 |
| 2002 | Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. | The Journal of cell biology | 274 | 12070128 |
| 2011 | A directed protein interaction network for investigating intracellular signal transduction. | Science signaling | 258 | 21900206 |
| 1999 | Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. | The Journal of cell biology | 162 | 10491393 |
| 2001 | APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. | Molecular biology of the cell | 156 | 11739784 |
| 2001 | Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin. | Nature cell biology | 141 | 11584277 |
| 2002 | Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle. | Human molecular genetics | 123 | 12471060 |
| 1999 | Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. | Current biology : CB | 106 | 10021369 |
| 2003 | The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit. | The Plant cell | 99 | 14508008 |
| 2019 | Hsa_circ_0009361 acts as the sponge of miR-582 to suppress colorectal cancer progression by regulating APC2 expression. | Clinical science (London, England : 1979) | 97 | 31109967 |
| 1998 | Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin. | Cancer research | 89 | 9823329 |
| 2018 | Overexpressing circular RNA hsa_circ_0002052 impairs osteosarcoma progression via inhibiting Wnt/β-catenin pathway by regulating miR-1205/APC2 axis. | Biochemical and biophysical research communications | 84 | 29852168 |
| 2002 | Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development. | Development (Cambridge, England) | 84 | 11923210 |
| 2005 | Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. | Molecular cell | 81 | 16364912 |
| 2002 | Drosophila APC2 and APC1 have overlapping roles in the larval brain despite their distinct intracellular localizations. | Developmental biology | 57 | 12297097 |
| 2002 | Drosophila APC2 and APC1 play overlapping roles in wingless signaling in the embryo and imaginal discs. | Developmental biology | 57 | 12297098 |
| 2015 | MiR-939 promotes the proliferation of human ovarian cancer cells by repressing APC2 expression. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | 55 | 25960217 |
| 1998 | Budding yeast RSI1/APC2, a novel gene necessary for initiation of anaphase, encodes an APC subunit. | The EMBO journal | 51 | 9430641 |
| 2019 | circ-PKD2 inhibits carcinogenesis via the miR-204-3p/APC2 axis in oral squamous cell carcinoma. | Molecular carcinogenesis | 49 | 31206208 |
| 2014 | SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs. | The EMBO journal | 49 | 25257309 |
| 2015 | Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features. | Cell reports | 37 | 25753423 |
| 2009 | APC2 plays an essential role in axonal projections through the regulation of microtubule stability. | The Journal of neuroscience : the official journal of the Society for Neuroscience | 36 | 19759310 |
| 2000 | APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus. | Cancer research | 35 | 10646860 |
| 2016 | The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2. | The Journal of biological chemistry | 34 | 27068743 |
| 2020 | SMYD2 suppresses APC2 expression to activate the Wnt/β-catenin pathway and promotes epithelial-mesenchymal transition in colorectal cancer. | American journal of cancer research | 30 | 32266106 |
| 2019 | Panobinostat (LBH589) inhibits Wnt/β-catenin signaling pathway via upregulating APCL expression in breast cancer. | Cellular signalling | 30 | 30880222 |
| 2001 | Human APC2 localization and allelic imbalance. | Cancer research | 30 | 11691822 |
| 2018 | APC2 controls dendrite development by promoting microtubule dynamics. | Nature communications | 25 | 30018294 |
| 2016 | Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium. | Oncogene | 25 | 27694902 |
| 2011 | Cortical localization of APC2 plays a role in actin organization but not in Wnt signaling in Drosophila. | Journal of cell science | 24 | 21486956 |
| 2017 | miR-4326 promotes lung cancer cell proliferation through targeting tumor suppressor APC2. | Molecular and cellular biochemistry | 23 | 29101731 |
| 2019 | APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression. | BMC cancer | 22 | 31291912 |
| 2019 | microRNA-1205 promotes cell growth by targeting APC2 in lung adenocarcinoma. | European review for medical and pharmacological sciences | 20 | 30779081 |
| 2019 | Bi-allelic Loss of Human APC2, Encoding Adenomatous Polyposis Coli Protein 2, Leads to Lissencephaly, Subcortical Heterotopia, and Global Developmental Delay. | American journal of human genetics | 20 | 31585108 |
| 2021 | FOXO4 Inhibits the Migration and Metastasis of Colorectal Cancer by Regulating the APC2/β-Catenin Axis. | Frontiers in cell and developmental biology | 18 | 34631691 |
| 2013 | APC2 and Axin promote mitotic fidelity by facilitating centrosome separation and cytoskeletal regulation. | Development (Cambridge, England) | 16 | 24026117 |
| 2015 | Overexpression of lipocalins and pro-inflammatory chemokines and altered methylation of PTGS2 and APC2 in oral squamous cell carcinomas induced in rats by 4-nitroquinoline-1-oxide. | PloS one | 15 | 25635769 |
| 2015 | The expression pattern of APC2 and APC7 in various cancer cell lines and AML patients. | Advances in medical sciences | 15 | 26046517 |
| 2017 | Subtle Deregulation of the Wnt-Signaling Pathway Through Loss of Apc2 Reduces the Fitness of Intestinal Stem Cells. | Stem cells (Dayton, Ohio) | 14 | 29027285 |
| 2023 | Recessive APC2 missense variants associated with epilepsies without neurodevelopmental disorders. | Seizure | 10 | 37657306 |
| 2018 | Identification of Proteins Required for Precise Positioning of Apc2 in Dendrites. | G3 (Bethesda, Md.) | 10 | 29602811 |
| 2017 | Hsa-miR-11181 regulates Wnt signaling pathway through targeting of APC2 transcripts in SW480 cell line. | Gene | 10 | 29111205 |
| 2002 | Expression of Apc2 during mouse development. | Brain research. Gene expression patterns | 10 | 15018807 |
| 2020 | APC2CDH1 negatively regulates agrin signaling by promoting the ubiquitination and proteolytic degradation of DOK7. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 9 | 32687671 |
| 2018 | Brain Tumor promotes axon growth across the midline through interactions with the microtubule stabilizing protein Apc2. | PLoS genetics | 9 | 29617376 |
| 2020 | An LCI-like protein APC2 protects ginseng root from Fusarium solani infection. | Journal of applied microbiology | 8 | 32639629 |
| 2018 | Hypermethylation of APC2 Is a Predictive Epigenetic Biomarker for Chinese Colorectal Cancer. | Disease markers | 8 | 30510602 |
| 2012 | lemmingA encodes the Apc11 subunit of the APC/C in Drosophila melanogaster that forms a ternary complex with the E2-C type ubiquitin conjugating enzyme, Vihar and Morula/Apc2. | Cell division | 8 | 22417125 |
| 2016 | APC2 and CYP1B1 methylation changes in the bone marrow of acute myeloid leukemia patients during chemotherapy. | Experimental and therapeutic medicine | 7 | 27882114 |
| 2010 | FBG1 is a promiscuous ubiquitin ligase that sequesters APC2 and causes S-phase arrest. | Cell cycle (Georgetown, Tex.) | 7 | 21135578 |
| 1999 | Analysis of APCL, a brain-specific adenomatous polyposis coli homologue, for mutations and expression in brain tumors. | Japanese journal of cancer research : Gann | 7 | 10551328 |
| 2018 | APC2 associates with the actin cortex through a multipart mechanism to regulate cortical actin organization and dynamics in the Drosophila ovary. | Cytoskeleton (Hoboken, N.J.) | 5 | 30019417 |
| 2024 | Reprint of: Recessive APC2 missense variants associated with epilepsies without neurodevelopmental disorders. | Seizure | 4 | 38523034 |
| 2022 | Methylation of APC2, NR3C1, and DRD2 gene promoters in turkish patients with tobacco use disorder. | Nigerian journal of clinical practice | 2 | 35170441 |
| 2021 | High miR-3648 expression and low APC2 expression are associated with shorter survival and tumor progression in NSCLC. | Histology and histopathology | 1 | 34927228 |
| 2026 | Human papillomavirus16 E7 enhances cell stemness by regulating the APC2/SPIN4/β-catenin axis in cervical cancer. | Oncogenesis | 0 | 41730837 |