Affinage

ALOX5AP

Arachidonate 5-lipoxygenase-activating protein · UniProt P20292

Length
161 aa
Mass
18.2 kDa
Annotated
2026-06-09
100 papers in source corpus 9 papers cited in narrative 9 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ALOX5AP (FLAP) is a membrane-anchored scaffolding protein at the nuclear envelope of leukocytes that is essential for cellular leukotriene biosynthesis (PMID:12895592, PMID:25034252, PMID:19876784). It enables efficient transfer of endogenous arachidonic acid to 5-lipoxygenase: FLAP is dispensable when exogenous arachidonic acid is supplied but required for processing of endogenous substrate, so its loss sharply reduces 5-LO product formation (PMID:12895592, PMID:25034252). FLAP organizes assembly of the leukotriene synthetic machinery at the nuclear envelope, supporting the perinuclear redistribution of 5-LO upon stimulation and stabilizing downstream conversion of LTA4 to LTC4, thereby enabling both LTB4 and cysteinyl leukotriene production (PMID:25034252, PMID:19876784). Its catalytic output is not fixed: adipose overexpression in mice shifts the lipid mediator profile toward lipoxin A4 rather than LTB4, conferring protection against diet-induced obesity and browning of white adipose tissue (PMID:27207555). FLAP expression is transcriptionally controlled — its promoter carries a glucocorticoid receptor element and is upregulated by dexamethasone in monocytic cells (PMID:1673682, PMID:9375956) — and post-transcriptionally repressed by miR-146a binding to its 3'-UTR, a circuit operative in lung and hepatocellular carcinoma cells (PMID:29928483, PMID:35410355).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 1991 Medium

    Establishing the genomic and transcriptional architecture of FLAP defined how its expression is controlled and revealed its tissue-restricted, macrophage-biased expression.

    Evidence Gene cloning, Southern blot, and transient CAT reporter promoter analysis in macrophage versus hepatoma lines

    PMID:1673682

    Open questions at the time
    • Transcription factors driving macrophage-specific enhancer activity not identified
    • Glucocorticoid response element identified by sequence but not functionally validated in this study
  2. 1997 Medium

    Showing glucocorticoids upregulate FLAP while downregulating COX-2 answered how leukotriene biosynthesis is maintained under glucocorticoid suppression of other eicosanoid enzymes.

    Evidence Northern/Western blot and leukotriene release ELISA in dexamethasone-treated THP-1 monocytic cells

    PMID:9375956

    Open questions at the time
    • Direct GR occupancy at the FLAP promoter not demonstrated
    • Single cell line
  3. 1999 Medium

    Determining whether the FLAP inhibitor MK886 acts through FLAP clarified that its apoptotic effect is FLAP-independent, separating pharmacological off-target activity from FLAP's true function.

    Evidence Apoptosis and viability assays in a FLAP-null cell line plus antisense knockdown

    PMID:10333477

    Open questions at the time
    • Does not define the actual target mediating MK886-induced apoptosis
    • Negative result limited to the cell lines tested
  4. 2003 High

    Synthesis of knockdown and reconstitution data established FLAP as a helper protein required specifically for utilization of endogenous arachidonic acid by 5-LO.

    Evidence Review integrating knockdown and inhibitor studies with biochemical readouts

    PMID:12895592

    Open questions at the time
    • Structural basis of arachidonic acid transfer not resolved
    • Stoichiometry of FLAP-5-LO interaction not defined
  5. 2009 Medium

    Framing FLAP as a nuclear-envelope scaffold for the leukotriene pathway connected its substrate-transfer role to assembly of the full biosynthetic machinery producing both LTB4 and cysteinyl leukotrienes.

    Evidence Pharmacological inhibition studies and review of pathway reconstitution

    PMID:19876784

    Open questions at the time
    • Review-level synthesis; no new primary assembly data
    • Direct binding partners within the assembled complex not mapped
  6. 2014 High

    Direct knockdown experiments resolved which steps of leukotriene synthesis depend on FLAP, showing it controls perinuclear 5-LO redistribution and stabilizes LTC4 synthase activity without altering 5LO-CLP complex formation.

    Evidence siRNA knockdown in Mono Mac 6 cells and primary macrophages with co-IP, immunofluorescence, and product assays

    PMID:25034252

    Open questions at the time
    • Molecular mechanism by which FLAP stabilizes LTC4 synthase not defined
    • Direct physical contact between FLAP and LTC4 synthase not shown
  7. 2016 Medium

    Adipose-specific overexpression revealed that FLAP can redirect output toward lipoxin A4 rather than LTB4, linking it to metabolic regulation and adipose browning.

    Evidence Transgenic mouse overexpression with lipid mediator quantification and LXA4 rescue

    PMID:27207555

    Open questions at the time
    • Mechanism dictating LXA4 versus LTB4 output in adipose tissue unexplained
    • Single lab; relevance to endogenous FLAP levels unclear
  8. 2022 Medium

    Identifying miR-146a as a direct repressor of FLAP defined a post-transcriptional control circuit and linked FLAP levels to tumor cell behavior in lung and hepatocellular carcinoma.

    Evidence Dual luciferase 3'-UTR reporter assays plus miR-146a gain/loss and proliferation/migration/invasion assays in HepG2 and lung cancer cells

    PMID:29928483 PMID:35410355

    Open questions at the time
    • Whether FLAP's pro-tumor effects depend on leukotriene output not established
    • Single-lab functional assays per cancer type

Open questions

Synthesis pass · forward-looking unresolved questions
  • How FLAP physically presents arachidonic acid to 5-LO and what determines whether the pathway yields pro-inflammatory leukotrienes versus pro-resolving lipoxins remains unresolved.
  • No structural model of the FLAP-5-LO substrate-transfer interface in the corpus
  • Switch governing LTB4 vs LXA4 output uncharacterized at the molecular level

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3 GO:0008289 lipid binding 2
Localization
GO:0005635 nuclear envelope 2
Pathway
R-HSA-1430728 Metabolism 3 R-HSA-168256 Immune System 2
Partners
ALOX5

Evidence

Reading pass · 9 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 FLAP (5-lipoxygenase-activating protein) acts as a helper/scaffolding protein required for efficient utilization of endogenous arachidonic acid substrate by 5-lipoxygenase (5-LO) in intact cells, enabling leukotriene biosynthesis. Without FLAP, 5-LO can still process exogenous arachidonic acid but not endogenous substrate. Review synthesizing knockdown/inhibitor studies and biochemical reconstitution; knockdown experiments showing FLAP is dispensable with exogenous AA but required for endogenous substrate Prostaglandins, leukotrienes, and essential fatty acids High 12895592
2014 FLAP acts as a scaffolding protein at the nuclear envelope for assembly of enzymes in the leukotriene synthetic pathway. FLAP knockdown in human monocytic MM6 cells led to prominent reductions in 5-LO product formation from endogenous substrate but only minor effects with exogenous arachidonic acid; FLAP knockdown also reduced conversion of LTA4 to LTC4, suggesting a role in stabilizing LTC4 synthase activity. FLAP-deficient cells showed compromised perinuclear redistribution of 5-LO upon stimulation. Co-immunoprecipitation confirmed that 5LO-CLP complex formation was unaffected by FLAP knockdown. siRNA knockdown in Mono Mac 6 cells and primary macrophages; co-immunoprecipitation; immunofluorescence for subcellular localization; product formation assays Proceedings of the National Academy of Sciences of the United States of America High 25034252
2009 FLAP acts as a scaffolding protein for the assembly of other enzymes involved in the leukotriene synthetic pathway occurring at the nuclear envelope of leukocytes, enabling both LTB4 and cysteinyl leukotriene production. FLAP inhibitors (MK-886, MK-0591, BAY-X-1005) block this assembly and prevent leukotriene synthesis. Pharmacological inhibition studies and review of biochemical pathway reconstitution Current opinion in investigational drugs (London, England : 2000) Medium 19876784
1991 The human FLAP gene spans >31 kilobases, consists of five exons and four introns, is present as a single copy per haploid genome, and its promoter contains a TATA box, AP-2 and glucocorticoid receptor binding sites. Functional promoter analysis by transient transfection showed tissue-specific expression (active in macrophage P388D1 cells, minimal in hepatoma HepG2 cells) and enhancer-like activities in the macrophage cell line. Gene cloning, Southern blot, transient transfection with CAT reporter gene, transcription initiation site mapping The Journal of biological chemistry Medium 1673682
1999 MK886 (a FLAP inhibitor) induces apoptosis independently of FLAP. WSU cells lacking FLAP protein and mRNA still undergo apoptosis upon MK886 treatment; antisense-mediated reduction of FLAP expression by >50% in FL5.12 cells does not increase apoptosis and does not alter MK886-induced apoptosis, demonstrating that MK886's apoptotic effect is FLAP-independent. Apoptosis assays in FLAP-null cell line; antisense oligonucleotide knockdown of FLAP; cell viability assays; oxidative stress measurement by carboxydichlorofluorescein fluorescence The Biochemical journal Medium 10333477
1997 Dexamethasone differentially regulates FLAP and COX-2 in monocytic THP-1 cells: while glucocorticoid treatment downregulates COX-2 mRNA and protein, it upregulates FLAP mRNA and protein (>2-fold after 24h) in differentiated monocyte-like cells. This provides a mechanism to maintain leukotriene biosynthesis through more efficient arachidonic acid transfer to 5-LO, despite glucocorticoid-mediated inhibition of other biosynthetic pathway enzymes. Northern blot and Western blot analyses of mRNA and protein levels in THP-1 cells; ELISA for prostaglandin E2 and peptidoleukotriene release British journal of pharmacology Medium 9375956
2016 Transgenic overexpression of ALOX5AP in adipose tissue leads to elevated LXA4 (lipoxin A4) rather than elevated LTB4 production, resulting in protection against diet-induced obesity, increased energy expenditure, browning of white adipose tissue, and upregulation of hepatic LXR/Cyp7a1 pathway. Treatment of wild-type mice with LXA4 recapitulated the browning phenotype, identifying LXA4 as the responsible mediator. Transgenic mouse overexpression of ALOX5AP in adipose tissue; lipid mediator quantification; LXA4 administration in wild-type mice; metabolic phenotyping Diabetes Medium 27207555
2018 miR-146a directly targets the FLAP 3'-UTR to repress FLAP expression post-transcriptionally in lung cancer cells, reducing LTB4 production. Reporter assays confirmed direct interaction between miR-146a and the FLAP 3'-UTR. miR-146a promoter is hypermethylated in lung cancer cell lines. Transient and stable transfections of miR-146a; 3'-UTR luciferase reporter assays; LTB4 ELISA; methylation analysis Oncotarget Medium 29928483
2022 miR-146a-5p directly targets FLAP mRNA (confirmed by dual luciferase reporter assay), suppressing FLAP protein expression in HepG2 hepatocellular carcinoma cells; knockdown of miR-146a increases FLAP expression. Restoration of FLAP by miR-146a silencing led to reduced HepG2 cell proliferation, cell cycle progression, migration, and invasion. Dual luciferase reporter assay; miR-146a knockdown/overexpression in HepG2 cells; cell proliferation, migration, and invasion assays Cancer cell international Medium 35410355

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Flap endonuclease 1: a central component of DNA metabolism. Annual review of biochemistry 325 15189154
2013 Flap endonuclease 1. Annual review of biochemistry 234 23451868
2002 Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression. Proceedings of the National Academy of Sciences of the United States of America 207 12119409
1998 Involvement of flap endonuclease 1 in base excision DNA repair. The Journal of biological chemistry 184 9535864
2014 Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction. Nature chemical biology 173 24390428
2003 5-lipoxygenase and FLAP. Prostaglandins, leukotrienes, and essential fatty acids 166 12895592
2005 ALOX5AP gene and the PDE4D gene in a central European population of stroke patients. Stroke 164 15731479
2008 Flap endonuclease 1 contributes to telomere stability. Current biology : CB 116 18394896
1998 5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension. American journal of respiratory and critical care medicine 107 9445303
2016 Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression. EBioMedicine 106 27852524
2017 Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability. Nature communications 97 28653660
2003 Stimulation of flap endonuclease-1 by the Bloom's syndrome protein. The Journal of biological chemistry 86 14688284
1991 Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP). The Journal of biological chemistry 81 1673682
1999 The 5-lipoxygenase-activating protein (FLAP) inhibitor, MK886, induces apoptosis independently of FLAP. The Biochemical journal 72 10333477
2004 Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability. Molecular and cellular biology 65 15082797
2009 Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of stroke: a HuGE gene-disease association review and meta-analysis. American journal of epidemiology 62 19126581
2009 Mitochondrial DNA replication and repair: all a flap. Trends in biochemical sciences 60 19559620
2006 ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance. International journal of obesity (2005) 59 16261187
2022 Highly multiplex PCR assays by coupling the 5'-flap endonuclease activity of Taq DNA polymerase and molecular beacon reporters. Proceedings of the National Academy of Sciences of the United States of America 55 35197282
2010 Association of a genetic variant in the ALOX5AP with higher risk of ischemic stroke: a case-control, meta-analysis and functional study. Cerebrovascular diseases (Basel, Switzerland) 51 20357438
2017 Drug discovery approaches targeting 5-lipoxygenase-activating protein (FLAP) for inhibition of cellular leukotriene biosynthesis. European journal of medicinal chemistry 50 28784429
2009 The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis. The Journal of biological chemistry 49 19525235
2008 Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease. Human genetics 48 18369664
2012 The wonders of flap endonucleases: structure, function, mechanism and regulation. Sub-cellular biochemistry 47 22918592
2016 ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance. Diabetes 46 27207555
2003 Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 46 12911785
2008 The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility. Allergy 41 18547289
2007 Infrahyoid fascio-myocutaneous flap as an alternative to free radial forearm flap in head and neck reconstruction. Head & neck 41 17230563
2010 Substrate recognition and catalysis by flap endonucleases and related enzymes. Biochemical Society transactions 40 20298197
2004 Growth factors and flap survival. Microsurgery 40 15160372
2021 Flap Endonuclease 1-Assisted DNA Walkers for Sensitively and Specifically Sensing ctDNAs. Analytical chemistry 39 34191475
2009 FLAP inhibitors for the treatment of inflammatory diseases. Current opinion in investigational drugs (London, England : 2000) 39 19876784
2007 PDE4D and ALOX5AP genetic variants and risk for Ischemic Cerebrovascular Disease in Sweden. Journal of the neurological sciences 39 17655870
2009 Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates. Nucleic acids research 37 19934252
2007 ALOX5AP gene variants and risk of coronary artery disease: an angiography-based study. European journal of human genetics : EJHG 37 17505527
2012 Why haematomas cause flap failure: an evidence-based paradigm. Journal of plastic, reconstructive & aesthetic surgery : JPRAS 36 22226889
2005 5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease. Medical hypotheses 36 16278051
2021 MIF is a 3' flap nuclease that facilitates DNA replication and promotes tumor growth. Nature communications 35 34012010
2014 Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis. Proceedings of the National Academy of Sciences of the United States of America 35 25034252
2016 Direct observation of DNA threading in flap endonuclease complexes. Nature structural & molecular biology 34 27273516
2007 Karapandzic flap for reconstruction of lip defects. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 33 18022478
2018 Missed cleavage opportunities by FEN1 lead to Okazaki fragment maturation via the long-flap pathway. Nucleic acids research 32 29420814
2009 Association of three-gene interaction among MTHFR, ALOX5AP and NOTCH3 with thrombotic stroke: a multicenter case-control study. Human genetics 32 19373490
2015 Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand. The Journal of biological chemistry 31 25922071
2018 miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells. Oncotarget 30 29928483
2010 The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 30 20067482
2016 Submental flap as an alternative to microsurgical flap in intraoral post-oncological reconstruction in the elderly. International journal of surgery (London, England) 29 27255573
2014 Flap prefabrication and stem cell-assisted tissue expansion: how we acquire a monoblock flap for full face resurfacing. The Journal of craniofacial surgery 29 24406553
2003 Modeling of flap endonuclease interactions with DNA substrate. Journal of molecular biology 29 12706715
1997 Differential regulation of cyclo-oxygenase-2 and 5-lipoxygenase-activating protein (FLAP) expression by glucocorticoids in monocytic cells. British journal of pharmacology 27 9375956
2015 Genome-wide search followed by replication reveals genetic interaction of CD80 and ALOX5AP associated with systemic lupus erythematosus in Asian populations. Annals of the rheumatic diseases 26 25862617
2006 Polymorphism of SG13S114T/A in the ALOX5AP gene and the risk for stroke in a large Chinese cohort. Yi chuan xue bao = Acta genetica Sinica 25 16939001
2006 Retrotransposon suicide: formation of Ty1 circles and autointegration via a central DNA flap. Journal of virology 25 17005648
2006 Flap endonuclease disengages Dna2 helicase/nuclease from Okazaki fragment flaps. The Journal of biological chemistry 25 17038322
2008 Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia. Atherosclerosis 24 18775537
2018 Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1. Nucleic acids research 23 30295841
2008 ALOX5AP variants are associated with in-stent restenosis after percutaneous coronary intervention. Atherosclerosis 23 18374923
2020 Ureteral Reimplantation, Psoas Hitch, and Boari Flap. Journal of endourology 21 32459151
2015 Decellularization of a Fasciocutaneous Flap for Use as a Perfusable Scaffold. Annals of plastic surgery 21 24667881
2005 Experimental cooling-induced preconditioning attenuates skin flap failure. The British journal of surgery 21 16184623
2017 Genetic Variations of Oxidative Stress Related Genes ALOX5, ALOX5AP and MPO Modulate Ischemic Stroke Susceptibility Through Main Effects and Epistatic Interactions in a Chinese Population. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20 29041000
2015 Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study. Atherosclerosis 20 25721704
2010 Human RECQL5beta stimulates flap endonuclease 1. Nucleic acids research 20 20081208
2004 Flap prefabrication and prelamination with tissue-engineered cartilage. Journal of reconstructive microsurgery 20 15534783
2011 Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of ischemic stroke in Han Chinese of eastern China. Journal of biomedical research 19 23554707
2015 Oropharyngeal reconstruction with a pedicled submandibular gland flap. The British journal of oral & maxillofacial surgery 18 26388070
2013 Oral reconstruction with submental flap. Annals of maxillofacial surgery 18 24205473
2011 Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2. The Journal of biological chemistry 18 21572043
2011 Genetic variants in the promoter region of the ALOX5AP gene and susceptibility of ischemic stroke. Cerebrovascular diseases (Basel, Switzerland) 17 21893978
2015 Systemic and flap inflammatory response associates with thrombosis in flap venous crisis. Inflammation 16 25448261
2015 A method for constructing vascularized muscle flap. Methods (San Diego, Calif.) 16 25843607
2013 Interaction between ALOX5AP-SG13S114A/T and COX-2-765G/C increases susceptibility to cerebral infarction in a Chinese population. Genetics and molecular research : GMR 16 23765972
2022 Ferroptosis-Related APOE, BCL3 and ALOX5AP Gene Polymorphisms are Associated with the Risk of Thyroid Cancer. Pharmacogenomics and personalized medicine 15 35241926
2021 The 3'-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching. Cell reports 15 34592150
2014 Flap endonuclease activity of gene 6 exonuclease of bacteriophage T7. The Journal of biological chemistry 15 24394415
2012 Association of ALOX5AP gene single nucleotide polymorphisms and cerebral infarction in the Han population of northern China. BMC medical genetics 15 22849376
2011 The musculocutaneous infrahyoid flap: surgical key points. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 15 21845436
2010 ALOX5AP and LTA4H polymorphisms modify augmentation of bronchodilator responsiveness by leukotriene modifiers in Latinos. The Journal of allergy and clinical immunology 15 20810156
2010 Variants of arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of coronary heart disease: A meta-analysis. Archives of medical research 15 21199733
2017 DNA flap creation by the RarA/MgsA protein of Escherichia coli. Nucleic acids research 14 28053120
2009 5-Lipoxygenase activating protein (ALOX5AP) gene variants associate with the presence of xanthomas in familial hypercholesterolemia. Atherosclerosis 14 19361804
1998 Methanococcus jannaschii flap endonuclease: expression, purification, and substrate requirements. Journal of bacteriology 14 9765572
2023 Saxagliptin promotes random skin flap survival. International immunopharmacology 13 37224651
2021 Extended, Double-Pedicled Facial Artery Musculomucosal (dpFAMM) Flap in Tongue Reconstruction in Edentulous Patients: Preliminary Report and Flap Design. Medicina (Kaunas, Lithuania) 13 34440964
2019 Inhibition of AKT Sensitizes Cancer Cells to Antineoplastic Drugs by Downregulating Flap Endonuclease 1. Molecular cancer therapeutics 13 31467180
2004 Gene therapy in flap survival. Microsurgery 13 15160373
2022 MicroRNA-146a promotes proliferation, migration, and invasion of HepG2 via regulating FLAP. Cancer cell international 12 35410355
2017 Naringin improves random skin flap survival in rats. Oncotarget 12 29212216
2016 Genetic polymorphisms of T-1131C APOA5 and ALOX5AP SG13S114 with the susceptibility of ischaemic stroke in Morocco. Journal of genetics 12 27350673
2014 Interaction between ALOX5AP and CYP3A5 gene variants significantly increases the risk for cerebral infarctions in Chinese. Neuroreport 12 24368493
2013 The arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene SG13S114 polymorphism and ischemic stroke in Chinese population: a meta-analysis. Gene 12 24148560
2011 The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers. BMC medical genetics 12 22206291
2017 The SG13S114 polymorphism of the ALOX5AP gene is associated with ischemic stroke in Europeans: a meta-analysis of 8062 subjects. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 11 28101761
2015 Inhibition of the Notch Pathway Promotes Flap Survival by Inducing Functional Neoangiogenesis. Annals of plastic surgery 11 25180956
2023 Bacillus subtilis encodes a discrete flap endonuclease that cleaves RNA-DNA hybrids. PLoS genetics 10 37146086
2020 Combination of Mustardè cheek advancement flap and paramedian forehead flap as a reconstructive option in orbital exenteration. European journal of ophthalmology 10 33238764
2018 Positioning the 5'-flap junction in the active site controls the rate of flap endonuclease-1-catalyzed DNA cleavage. The Journal of biological chemistry 10 29462789
2018 Inhibition of autophagy after perforator flap surgery increases flap survival and angiogenesis. The Journal of surgical research 10 30278973
2015 Variants in the Atherogenic ALOX5AP, THBD, and KNG1 Genes Potentiate the Risk of Ischemic Stroke via a Genetic Main Effect and Epistatic Interactions in a Chinese Population. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 10 26159646
2012 Association of ALOX5AP with ischemic stroke in eastern Chinese. World journal of emergency medicine 10 25215047

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