Affinage

AIDA

Axin interactor, dorsalization-associated protein · UniProt Q96BJ3

Length
306 aa
Mass
35.0 kDa
Annotated
2026-04-28
100 papers in source corpus 17 papers cited in narrative 17 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

AIDA functions as a multifunctional scaffold protein that couples signal-dependent phosphorylation to organelle-specific protein trafficking and ubiquitin-dependent quality control across diverse cell types. In brown adipocytes, PKA phosphorylates AIDA at S161, triggering its translocation to the mitochondrial intermembrane space where it directly activates UCP1-mediated thermogenesis by promoting UCP1 cysteine oxidation (PMID:33664495); in intestinal epithelium and vascular smooth muscle cells, AIDA serves as an essential cofactor for the HRD1 E3 ubiquitin ligase, targeting acyltransferases (GPAT3, MOGAT2, DGAT2) for ERAD-dependent degradation to limit fat absorption (PMID:29617643) and scaffolding K63-ubiquitination of VAMP3 to drive CD36 membrane translocation and foam cell formation (PMID:42013606). In neurons, the AIDA-1 isoform (encoded by ANKS1B) organizes postsynaptic signaling by binding PSD-95 PDZ domains, facilitating GluN2B-containing NMDAR transport from the ER to synapses, and undergoing CaMKII-dependent dispersal from the PSD core upon excitatory activity; NMDAR activation additionally triggers its nuclear translocation—governed by regulated unmasking of an NLS within its tandem SAM domains—where it promotes Cajal body–nucleolar association and global protein synthesis (PMID:17334360, PMID:26085624, PMID:19666031, PMID:27477489). During embryogenesis, AIDA blocks Axin-mediated JNK activation by disrupting Axin homodimerization through its C2 domain, which binds phosphoinositides in a Ca²⁺-independent manner (PMID:17681137, PMID:25117763).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2004 Medium

    Before any signaling role was established, AIDA-1 was shown to physically interact with APP, suggesting it participates in APP-associated protein complexes and raising the question of its broader interacting network.

    Evidence Co-immunoprecipitation in vitro and in living cells, with subcellular redistribution upon APP overexpression

    PMID:15004329

    Open questions at the time
    • No downstream signaling consequence of the AIDA-1–APP interaction was defined
    • Single-lab observation without independent replication
    • Functional relevance to APP processing or Alzheimer's pathology not tested
  2. 2005 Medium

    AIDA-1 was linked to nuclear body organization through its interaction with the Cajal body marker coilin, establishing a nuclear role for this predominantly synaptic protein.

    Evidence Co-immunoprecipitation, competition binding with SmB', siRNA knockdown altering Cajal body morphology

    PMID:15862129

    Open questions at the time
    • Mechanism by which AIDA-1 regulates Cajal body integrity not defined
    • Single-lab finding
    • Relationship to synaptic AIDA-1 function unclear
  3. 2007 High

    Two independent studies simultaneously established AIDA's dual identity: as a PSD-95-binding postsynaptic scaffold (AIDA-1d/ANKS1B) that undergoes NMDAR-triggered nuclear translocation to regulate Cajal body–nucleolar association and protein synthesis, and as a distinct protein (Aida) that inhibits Axin-mediated JNK signaling by disrupting Axin homodimerization during vertebrate dorsalization.

    Evidence Biochemical binding assays, live-cell imaging, and protein synthesis measurement for AIDA-1d; co-IP, zebrafish morpholino knockdown with JNK/MKK4 epistasis for Aida

    PMID:17334360 PMID:17681137

    Open questions at the time
    • Signal that triggers SAM domain opening for nuclear import was unknown
    • Whether Aida's anti-JNK role operates in mammalian tissues was untested
    • Connection between the two gene products (ANKS1B vs. AIDA/C15orf29) was ambiguous
  4. 2009 High

    The NMR structure of the AIDA-1 tandem SAM domains revealed that the nuclear localization signal is buried at the SAM–SAM interface, providing a structural mechanism for how nuclear translocation is gated by conformational change.

    Evidence NMR structure determination of SAM domain tandem with thermal stability assays

    PMID:19666031

    Open questions at the time
    • The upstream signal or post-translational modification that triggers SAM domain decoupling was not identified
    • No in vivo validation that SAM opening is required for nuclear import
  5. 2014 High

    Crystallography of Aida's C-terminal C2 domain showed it binds phosphoinositides Ca²⁺-independently via a basic loop, and mutagenesis demonstrated this membrane-binding surface is required for the Aida–Axin interaction and JNK inhibition, linking lipid binding to signaling scaffold function.

    Evidence X-ray crystallography, phosphoinositide-binding assay, site-directed mutagenesis, JNK activity assay

    PMID:25117763

    Open questions at the time
    • Whether membrane recruitment is the proximate trigger for Axin interaction was not resolved
    • In vivo relevance of C2 domain lipid binding untested in mammalian systems
  6. 2015 High

    Two studies established that AIDA-1 undergoes activity-dependent redistribution within the PSD and is required for proper GluN2B-containing NMDAR trafficking from the ER to synapses, defining its core synaptic function as a subunit-selective NMDAR transport facilitator.

    Evidence Forebrain-specific conditional KO mice with biochemical fractionation and electrophysiology; immuno-gold EM of cultured hippocampal neurons under excitatory conditions

    PMID:26085624 PMID:26356309

    Open questions at the time
    • Direct cargo-binding interface between AIDA-1 and GluN2B not structurally defined
    • Whether AIDA-1 acts as an adaptor on KIF17 vesicles or as a quality-control factor in the ER was unclear
  7. 2016 Medium

    CaMKII was identified as the kinase responsible for AIDA-1 phosphorylation and displacement from the PSD core, resolving the enzymatic basis of activity-dependent AIDA-1 redistribution.

    Evidence PSD fractionation with phosphorylation assay and immuno-EM with pharmacological CaMKII inhibition (tatCN21) in hippocampal neurons

    PMID:27477489

    Open questions at the time
    • Specific phosphorylation site(s) on AIDA-1 targeted by CaMKII not identified
    • Functional consequence of CaMKII-dependent dispersal for synaptic plasticity not directly tested
  8. 2018 High

    AIDA was established as an essential HRD1 E3-ligase cofactor in intestinal epithelium, controlling dietary fat absorption by targeting acyltransferases (GPAT3, MOGAT2, DGAT2) for ERAD-dependent degradation — its first defined role outside the nervous system and in ubiquitin-dependent protein quality control.

    Evidence Whole-body and intestine-specific knockout mice with metabolic phenotyping and protein abundance measurements

    PMID:29617643

    Open questions at the time
    • Structural basis for AIDA–HRD1 interaction not defined
    • Whether AIDA functions as a substrate adaptor or an allosteric activator of HRD1 was not distinguished
  9. 2019 Medium

    ANKS1B haploinsufficiency was shown to reduce AIDA-1 levels and produce neurodevelopmental phenotypes (social deficits, hyperactivity, sensorimotor dysfunction) in mice, with interactome proteomics delineating its synaptic protein network.

    Evidence Haploinsufficiency mouse model, quantitative interactome proteomics, behavioral phenotyping, iPSC-derived neurons

    PMID:31287004 PMID:31388001

    Open questions at the time
    • Specific interactors driving behavioral phenotypes not isolated
    • Human genetic validation of ANKS1B haploinsufficiency as a neurodevelopmental syndrome was limited
  10. 2021 High

    PKA-dependent phosphorylation of AIDA at S161 was shown to drive its translocation to the mitochondrial intermembrane space where it directly activates UCP1 thermogenesis by promoting UCP1 cysteine oxidation, establishing AIDA as a signal-transducing activator of non-shivering thermogenesis.

    Evidence Adipocyte-specific KO mice, S161A phospho-dead mutagenesis, in vitro PKA assay, co-IP, UCP1 uncoupling activity assay, sympathetic denervation

    PMID:33664495

    Open questions at the time
    • Identity of the cysteine residue(s) on UCP1 oxidized by AIDA not determined
    • How AIDA crosses the outer mitochondrial membrane upon phosphorylation was not resolved
  11. 2023 High

    Cell-type-specific loss of Anks1b in oligodendrocyte lineage cells revealed a non-neuronal role for AIDA-1 in oligodendrocyte maturation and myelination through Rac1, expanding its function beyond neurons and demonstrating that social and sensory deficits can arise from glial AIDA-1 loss.

    Evidence Oligodendrocyte-specific conditional KO mice, Rac1 activity assay, myelination analysis, behavioral rescue with clemastine

    PMID:38129387

    Open questions at the time
    • Mechanism by which AIDA-1 regulates Rac1 activity in oligodendrocytes not defined
    • Whether neuronal and glial AIDA-1 functions are additive in behavioral phenotypes untested
  12. 2024 High

    The crystal structure of the AIDA-1 PTB domain bound to SynGAP's NPxF motif defined a high-affinity postsynaptic interaction, expanding the repertoire of AIDA-1's PSD binding partners beyond PSD-95.

    Evidence X-ray crystallography of PTB–SynGAP complex, affinity purification, biochemical binding assays

    PMID:38759928

    Open questions at the time
    • Functional consequence of AIDA-1–SynGAP interaction for Ras-GAP signaling at synapses not tested
    • Whether this interaction competes with or complements PSD-95 binding unclear
  13. 2026 High

    In vascular smooth muscle cells, AIDA was shown to scaffold HRD1-mediated K63-ubiquitination of VAMP3, driving CD36 membrane translocation and foam cell formation, demonstrating that its HRD1 cofactor function extends to non-canonical (K63) ubiquitin linkages and atherosclerosis.

    Evidence VSMC-specific KO in ApoE⁻/⁻ mice, co-IP, ubiquitination profiling, cholesterol flux assays

    PMID:42013606

    Open questions at the time
    • Whether AIDA determines HRD1 linkage-type specificity (K48 vs K63) or substrate specificity is unknown
    • Relevance to human atherosclerosis not validated

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: how AIDA selects between ERAD degradation (K48) and non-degradative (K63) ubiquitin signaling in different tissues; the structural basis of the AIDA–HRD1 interface; the identity of UCP1 cysteine residues oxidized through AIDA; and whether the neuronal (ANKS1B/AIDA-1) and non-neuronal (AIDA/C15orf29) gene products share any mechanistic logic beyond scaffolding.
  • No structural model of AIDA–HRD1 complex
  • Ubiquitin linkage selectivity mechanism unknown
  • Relationship between the two distinct genes encoding 'AIDA' proteins mechanistically unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 5 GO:0098772 molecular function regulator activity 2 GO:0008289 lipid binding 1
Localization
GO:0005634 nucleus 3 GO:0005829 cytosol 2 GO:0005739 mitochondrion 1 GO:0005783 endoplasmic reticulum 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-112316 Neuronal System 4 R-HSA-1430728 Metabolism 2 R-HSA-162582 Signal Transduction 2 R-HSA-392499 Metabolism of proteins 2 R-HSA-1643685 Disease 1
Partners
AXIN1CAMK2AGLUN2BHRD1PSD95SYNGAP1UCP1VAMP3
Complex memberships
HRD1/ERAD complex

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 AIDA-1d (encoded by ANKS1B) binds to the first two PDZ domains of the scaffolding protein PSD-95 via its C-terminal three amino acids. NMDA receptor stimulation causes Ca2+-independent translocation of AIDA-1d to the nucleus, where it couples to Cajal bodies and induces Cajal body-nucleolar association, resulting in increased nucleolar numbers and global protein synthesis. Biochemical binding assays, live-cell imaging, NMDA receptor stimulation with functional readout (nucleolar number and protein synthesis measurement) Nature neuroscience High 17334360
2007 Aida (axin interactor, dorsalization-associated) blocks Axin-mediated JNK activation by disrupting Axin homodimerization, thereby antagonizing a beta-catenin-independent dorsalization pathway during vertebrate embryogenesis. Morpholino knockdown of Aida in zebrafish leads to dorsalized embryos; this effect is rescued by JNK-MO or MKK4-MO injection, placing Aida upstream of JNK/MKK4 in the Axin signaling axis. Co-immunoprecipitation, zebrafish morpholino knockdown/overexpression with epistasis analysis, JNK activity assays Developmental cell High 17681137
2015 AIDA-1 (ANKS1B) regulates synaptic NMDAR subunit composition by facilitating transport of GluN2B-containing NMDARs from the ER to synapses. Forebrain-specific AIDA-1 conditional knockout mice show reduced GluN2B and increased GluN2A at synaptic junctions; GluN2B accumulates in ER-enriched fractions. AIDA-1 preferentially associates with GluN2B and with the adaptor proteins CaMKII and KIF17, which regulate GluN2B transport. Conditional knockout mice, biochemical fractionation, co-immunoprecipitation, electrophysiology, immunocytochemistry, lentiviral shRNA knockdown The Journal of neuroscience High 26085624
2018 AIDA acts as an essential cofactor for the E3 ubiquitin ligase HRD1 of the ERAD pathway to downregulate rate-limiting acyltransferases GPAT3, MOGAT2, and DGAT2, thereby controlling intestinal triacylglycerol synthesis and fat absorption. Aida-/- mice and intestine-specific Aida knockout mice display increased intestinal fatty acid re-esterification, elevated circulating and tissue triacylglycerol, and increased adiposity. Whole-body and intestine-specific knockout mice, protein abundance assays, fat absorption measurements, in vivo metabolic phenotyping Cell metabolism High 29617643
2021 AIDA is phosphorylated at S161 by catecholamine-activated PKA on the outer mitochondrial membrane. Phosphorylated AIDA translocates to the intermembrane space, where it binds UCP1 and activates its uncoupling activity by promoting cysteine oxidation of UCP1. Adipocyte-specific AIDA depletion abrogates UCP1-dependent thermogenesis. Re-expression of S161A-AIDA (phospho-dead mutant) fails to restore the acute cold response. Adipocyte-specific knockout mice, phospho-site mutagenesis (S161A), in vitro PKA phosphorylation assay, co-immunoprecipitation, UCP1 uncoupling activity assay, sympathetic denervation experiment Nature cell biology High 33664495
2009 The nuclear localization signal (NLS) of AIDA-1 is buried at the interface between its two tandemly arranged SAM domains. The NMR structure reveals the two SAM domains are fused head-to-tail; the NLS becomes accessible only when the second SAM domain decouples from the first, suggesting a mechanism for regulated nuclear import of AIDA-1. NMR structure determination of SAM domain tandem, thermal stability assays Journal of molecular biology High 19666031
2014 The C-terminal C2 domain of Aida adopts a conventional C2 domain topology and binds phosphoinositides in a Ca2+-independent manner via a positively charged basic loop, enabling membrane association. Mutation of the basic loop disrupts membrane association and the Aida-Axin interaction, resulting in impaired JNK inhibition. X-ray crystallography, phosphoinositide-binding assay, site-directed mutagenesis, co-immunoprecipitation, JNK activity assay The FEBS journal High 25117763
2004 AIDA-1 proteins (AIDA-1a, AIDA-1b, AIDA-1bΔAnk) interact with APP (AbetaPP) in vitro, in transfected living cells, and endogenously in leukemia cell lines. The intracellular distribution of AIDA-1a is altered by overexpression of AbetaPP, indicating AbetaPP regulates AIDA-1 localization. Co-immunoprecipitation in vitro and in vivo, overexpression with subcellular localization readout Journal of Alzheimer's disease Medium 15004329
2005 A novel isoform AIDA-1c interacts with the Cajal body marker protein coilin in vivo, competing with SmB' for coilin binding sites. Knockdown of EB-1/AIDA-1 isoforms by siRNA alters Cajal body organization and reduces cell viability. Co-immunoprecipitation, competition binding assay, siRNA knockdown with Cajal body morphology readout BMC cell biology Medium 15862129
2016 CaMKII activation mediates phosphorylation of AIDA-1 and causes its displacement from the postsynaptic density (PSD) core. Treatment of hippocampal neurons with NMDA causes an ~30 nm shift in AIDA-1 median distance from the postsynaptic membrane, an effect blocked by the CaMKII inhibitor tatCN21. PSD fractionation with phosphorylation assay, immuno-electron microscopy of hippocampal neurons with pharmacological CaMKII inhibition FEBS letters Medium 27477489
2015 Under excitatory conditions (high K+ or NMDA application), AIDA-1 moves out of the PSD core, with label density at the core reduced to 40% of controls and median distance from postsynaptic membrane increasing from ~30 nm to ~55 nm; this redistribution is reversible within 30 minutes. Immunogold electron microscopy of cultured rat hippocampal neurons under basal and excitatory conditions PloS one Medium 26356309
2019 Loss-of-function experiments using CRISPR/Cas9 deletion of a TNFα-sensitive regulatory element in endothelial cells reduce AIDA expression, implicating AIDA as regulated by a CAD-associated genetic locus in the vascular endothelium. CRISPR/Cas9 deletion of regulatory element with gene expression measurement Genome biology Low 31287004
2023 Selective loss of Anks1b (encoding AIDA-1) from the oligodendrocyte lineage (but not neuronal populations) leads to deficits in oligodendrocyte maturation, myelination, and Rac1 function, causing social preference and sensory reactivity deficits. Treatment with clemastine rescues social preference deficits in Anks1b-deficient mice. Cell-type-specific conditional knockout mice, myelination assays, Rac1 activity assay, behavioral phenotyping, pharmacological rescue Nature communications High 38129387
2024 The PTB domain of AIDA-1d binds with high affinity to an extended NPx[F/Y]-motif of SynGAP family Ras-GTPase activating proteins. The crystal structure of AIDA-1 PTB domain in complex with the SynGAP NPxF-motif revealed the molecular basis for this specific interaction. Affinity purification, biochemical binding assays, X-ray crystallography of PTB–SynGAP complex Journal of molecular biology High 38759928
2026 AIDA scaffolds HRD1-mediated K63-linked ubiquitination of VAMP3, facilitating VAMP3-CD36 interaction and CD36 membrane translocation in VSMCs. VSMC-specific AIDA knockout attenuates atherosclerotic plaque burden and suppresses oxLDL uptake and foam cell formation by impairing CD36 membrane trafficking without affecting cholesterol efflux. VSMC-specific knockout in ApoE-/- mice, co-immunoprecipitation, cholesterol flux assays, ubiquitination profiling, adenoviral shRNA silencing Atherosclerosis High 42013606
2019 Haploinsufficiency of ANKS1B causes loss of the synaptic protein AIDA-1. Quantitative proteomics of the AIDA-1 interactome in haploinsufficient mice revealed protein networks involved in synaptic function. Anks1b haploinsufficient mice recapitulate social deficits, hyperactivity, and sensorimotor dysfunction. Transgenic haploinsufficiency mouse model, quantitative proteomics (interactome), behavioral phenotyping, iPSC-derived neurons Nature communications Medium 31388001
2012 Chronic ethanol exposure increases synaptic clustering of AIDA-1 in hippocampal neurons, an effect prevented by concurrent NMDA receptor stimulation. AIDA-1 localization to the PSD does not require its association with PSD-95 (palmitoylation inhibition declusters PSD-95 but not AIDA-1). AIDA-1 knockdown does not affect GluN1 or GluN2B protein levels. Lentiviral shRNA knockdown, chronic ethanol treatment, immunofluorescence colocalization, palmitoylation inhibition Alcohol Medium 22703994

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1997 Molecular remission in PML/RAR alpha-positive acute promyelocytic leukemia by combined all-trans retinoic acid and idarubicin (AIDA) therapy. Gruppo Italiano-Malattie Ematologiche Maligne dell'Adulto and Associazione Italiana di Ematologia ed Oncologia Pediatrica Cooperative Groups. Blood 427 9242531
1998 Early detection of relapse by prospective reverse transcriptase-polymerase chain reaction analysis of the PML/RARalpha fusion gene in patients with acute promyelocytic leukemia enrolled in the GIMEMA-AIEOP multicenter "AIDA" trial. GIMEMA-AIEOP Multicenter "AIDA" Trial. Blood 231 9680345
1996 AIDA (all-trans retinoic acid + idarubicin) in newly diagnosed acute promyelocytic leukemia: a Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) pilot study. Blood 206 8695858
1989 Cloning and expression of an adhesin (AIDA-I) involved in diffuse adherence of enteropathogenic Escherichia coli. Infection and immunity 189 2565291
2011 AIDA 0493 protocol for newly diagnosed acute promyelocytic leukemia: very long-term results and role of maintenance. Blood 161 21385856
2002 Alterations of the FLT3 gene in acute promyelocytic leukemia: association with diagnostic characteristics and analysis of clinical outcome in patients treated with the Italian AIDA protocol. Leukemia 153 12399960
1992 AIDA-I, the adhesin involved in diffuse adherence of the diarrhoeagenic Escherichia coli strain 2787 (O126:H27), is synthesized via a precursor molecule. Molecular microbiology 150 1625582
2001 Glycosylation with heptose residues mediated by the aah gene product is essential for adherence of the AIDA-I adhesin. Molecular microbiology 142 11442838
2004 Novel roles for the AIDA adhesin from diarrheagenic Escherichia coli: cell aggregation and biofilm formation. Journal of bacteriology 140 15547278
1999 Characterization of the essential transport function of the AIDA-I autotransporter and evidence supporting structural predictions. Journal of bacteriology 99 10559167
2003 Isolation and association of Escherichia coli AIDA-I/STb, rather than EAST1 pathotype, with diarrhea in piglets and antibiotic sensitivity of isolates. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 98 12735346
2007 Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons. Nature neuroscience 96 17334360
1992 Isolation and serologic characterization of AIDA-I, the adhesin mediating the diffuse adherence phenotype of the diarrhea-associated Escherichia coli strain 2787 (O126:H27). Infection and immunity 95 1729177
2000 Autodisplay: functional display of active beta-lactamase on the surface of Escherichia coli by the AIDA-I autotransporter. Journal of bacteriology 86 10850987
2001 The AIDA autotransporter system is associated with F18 and stx2e in Escherichia coli isolates from pigs diagnosed with edema disease and postweaning diarrhea. Clinical and diagnostic laboratory immunology 77 11139209
1999 Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid). European journal of pharmacology 69 10096765
1996 Processing of the AIDA-I precursor: removal of AIDAc and evidence for the outer membrane anchoring as a beta-barrel structure. Molecular microbiology 67 8899706
2017 Quorum sensing network in clinical strains of A. baumannii: AidA is a new quorum quenching enzyme. PloS one 53 28328989
2018 AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity. Cell metabolism 51 29617643
2000 Cell surface presentation of recombinant (poly-) peptides including functional T-cell epitopes by the AIDA autotransporter system. FEMS immunology and medical microbiology 50 10727888
2007 A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Developmental cell 49 17681137
2002 Functional substitution of the TibC protein of enterotoxigenic Escherichia coli strains for the autotransporter adhesin heptosyltransferase of the AIDA system. Infection and immunity 49 11953358
2015 AIDA: ab initio domain assembly for automated multi-domain protein structure prediction and domain-domain interaction prediction. Bioinformatics (Oxford, England) 47 25701568
2000 AIDA reduces glutamate release and attenuates mechanical allodynia after spinal cord injury. Neuroreport 43 11043525
2001 Modular organization of the AIDA autotransporter translocator: the N-terminal beta1-domain is surface-exposed and stabilizes the transmembrane beta2-domain. Antonie van Leeuwenhoek 41 11761364
2002 Invasion activity of a Mycobacterium tuberculosis peptide presented by the Escherichia coli AIDA autotransporter. Infection and immunity 39 12438361
2004 The anxiolytic-like activity of AIDA (1-aminoindan-1,5-dicarboxylic acid), an mGLu 1 receptor antagonist. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 37 15082872
2003 The Escherichia coli AIDA autotransporter adhesin recognizes an integral membrane glycoprotein as receptor. Microbiology (Reading, England) 37 12855738
2002 DNA sequences coding for the F18 fimbriae and AIDA adhesin are localised on the same plasmid in Escherichia coli isolates from piglets. Veterinary microbiology 37 11955780
2021 AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1. Nature cell biology 35 33664495
2017 Combining DNA Vaccine and AIDA-1 in Attenuated Salmonella Activates Tumor-Specific CD4+ and CD8+ T-cell Responses. Cancer immunology research 35 28468915
2014 AIDA: ab initio domain assembly server. Nucleic acids research 35 24831546
2006 Proteolytic processing is not essential for multiple functions of the Escherichia coli autotransporter adhesin involved in diffuse adherence (AIDA-I). Journal of bacteriology 35 17041044
2015 ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization. The Journal of neuroscience : the official journal of the Society for Neuroscience 34 26085624
2019 Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene. Genome biology 33 31287004
2009 A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear import. Journal of molecular biology 32 19666031
2004 The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing. Journal of Alzheimer's disease : JAD 31 15004329
2009 Autoprocessing of the Escherichia coli AIDA-I autotransporter: a new mechanism involving acidic residues in the junction region. The Journal of biological chemistry 30 19398552
2004 Clinico-biological features and outcome of acute promyelocytic leukemia patients with persistent polymerase chain reaction-detectable disease after the AIDA front-line induction and consolidation therapy. Haematologica 30 14754603
2001 Group I mGluR antagonist AIDA protects nigral DA cells from MPTP-induced injury. Neuroreport 30 11522935
2019 Haploinsufficiency in the ANKS1B gene encoding AIDA-1 leads to a neurodevelopmental syndrome. Nature communications 28 31388001
2006 Contribution of AIDA-I to the pathogenicity of a porcine diarrheagenic Escherichia coli and to intestinal colonization through biofilm formation in pigs. Veterinary microbiology 27 17140750
2020 Clinical Features at Onset and Genetic Characterization of Pediatric and Adult Patients with TNF-α Receptor-Associated Periodic Syndrome (TRAPS): A Series of 80 Cases from the AIDA Network. Mediators of inflammation 25 32831641
2011 Optimisation of surface expression using the AIDA autotransporter. Microbial cell factories 25 21917130
2008 Presentation of functional organophosphorus hydrolase fusions on the surface of Escherichia coli by the AIDA-I autotransporter pathway. Biotechnology and bioengineering 25 17615561
2008 The Escherichia coli AIDA-I autotransporter undergoes cytoplasmic glycosylation independently of export. Research in microbiology 25 18657609
2022 Development and Implementation of the AIDA International Registry for Patients With VEXAS Syndrome. Frontiers in medicine 24 35899212
1999 The class I metabotropic glutamate receptor antagonist, AIDA, improves short-term and impairs long-term memory in a spatial task for rats. Neuropharmacology 23 10465685
2002 AIDA, a class I metabotropic glutamate-receptor antagonist limits kainate-induced hippocampal dysfunction. Epilepsia 22 12423379
2009 Surface display of the receptor-binding domain of the F17a-G fimbrial adhesin through the autotransporter AIDA-I leads to permeability of bacterial cells. Microbiology (Reading, England) 19 19202095
1992 Protein design on computers. Five new proteins: Shpilka, Grendel, Fingerclasp, Leather, and Aida. Proteins 19 1603799
2024 Efficacy and safety of Janus kinase inhibitors in non-infectious inflammatory ocular diseases: a prospective cohort study from the international AIDA network registries. Frontiers in medicine 18 39247640
2009 Identification of novel putative virulence factors, adhesin AIDA and type VI secretion system, in atypical strains of fish pathogenic Edwardsiella tarda by genomic subtractive hybridization. Microbiology and immunology 18 19302523
2005 A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin. BMC cell biology 17 15862129
2023 Derivation and validation of four patient clusters in Still's disease, results from GIRRCS AOSD-study group and AIDA Network Still Disease Registry. RMD open 16 37989322
2022 Canakinumab as first-line biological therapy in Still's disease and differences between the systemic and the chronic-articular courses: Real-life experience from the international AIDA registry. Frontiers in medicine 16 36619631
2008 Analysis of the AIDA-I gene sequence and prevalence in Escherichia coli isolates from pigs with post-weaning diarrhoea and oedema disease. Veterinary journal (London, England : 1997) 15 18077196
2023 ANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function. Nature communications 12 38129387
2003 Intraocular microablation of choroidal tissue by a 308 nm AIDA excimer laser for RPE-transplantation in patients with age-related macular degeneration. Biomedizinische Technik. Biomedical engineering 12 12749285
1993 Diffuse adherence of enteropathogenic Escherichia coli strains--processing of AIDA-I. Zentralblatt fur Bakteriologie : international journal of medical microbiology 12 8347926
2021 Drug survival of anakinra and canakinumab in monogenic autoinflammatory diseases: observational study from the International AIDA Registry. Rheumatology (Oxford, England) 10 33961014
2016 CaMKII-mediated displacement of AIDA-1 out of the postsynaptic density core. FEBS letters 10 27477489
2025 Efficacy and safety profile of biotechnological agents and Janus kinase inhibitors in VEXAS syndrome: data from the international AIDA Network VEXAS registry. Frontiers in pharmacology 9 40046741
2024 Investigation of an AIDA-I based expression system for display of various affinity proteins on Escherichia coli. Biochemical and biophysical research communications 9 38241810
2007 Mutations affecting the biogenesis of the AIDA-I autotransporter. Research in microbiology 9 17446047
2022 MiR-32-5p/AIDA Mediates OxLDL-Induced Endothelial Injury and Inflammation. International heart journal 8 36184552
2010 Modulation of transcription and characterization of the promoter organization of the autotransporter adhesin heptosyltransferase and the autotransporter adhesin AIDA-I. Microbiology (Reading, England) 8 20056708
2004 Metabotropic glutamate receptor antagonist AIDA blocks induction of mossy fiber-CA3 LTP in vivo. Journal of neurophysiology 8 15548625
2000 Effects of intra-vestibular nucleus injection of the group I metabotropic glutamate receptor antagonist AIDA on vestibular compensation in guinea pigs. Experimental brain research 8 11026728
2021 Biotechnological Agents for Patients With Tumor Necrosis Factor Receptor Associated Periodic Syndrome-Therapeutic Outcome and Predictors of Response: Real-Life Data From the AIDA Network. Frontiers in medicine 7 34307404
2010 Growth-phase-dependent expression of the operon coding for the glycosylated autotransporter adhesin AIDA-I of pathogenic Escherichia coli. FEMS microbiology letters 7 20831592
2005 Characterization and immuno-detection of AIDA-I adhesin isolated from porcine Escherichia coli. Veterinary microbiology 7 15950405
2001 AIDA influences behavior in rats pretreated with baclofen. Polish journal of pharmacology 7 11785925
2020 Role of Colchicine Treatment in Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS): Real-Life Data from the AIDA Network. Mediators of inflammation 6 32565720
2015 A statistical approach to virtual cellular experiments: improved causal discovery using accumulation IDA (aIDA). Bioinformatics (Oxford, England) 6 26249813
2015 AIDA-1 Moves out of the Postsynaptic Density Core under Excitatory Conditions. PloS one 6 26356309
2024 Influence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registry. Joint bone spine 5 39549971
2014 Structure and mechanism of the unique C2 domain of Aida. The FEBS journal 5 25117763
2012 Chronic ethanol up-regulates the synaptic expression of the nuclear translational regulatory protein AIDA-1 in primary hippocampal neurons. Alcohol (Fayetteville, N.Y.) 5 22703994
2025 Efficacy and safety of conventional disease-modifying antirheumatic drugs in VEXAS syndrome: real-world data from the international AIDA network. Frontiers in pharmacology 4 40124776
2025 Predictors of proteinuria, amyloidosis and kidney failure in familial Mediterranean fever: data from the International AIDA Network Registry. Rheumatology (Oxford, England) 4 40175882
2014 Proteomics profiling of keratocystic odontogenic tumours reveals AIDA as novel biomarker candidate. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 4 25040847
2012 Identification and mechanism of evolution of new alleles coding for the AIDA-I autotransporter of porcine pathogenic Escherichia coli. Applied and environmental microbiology 4 22522689
2024 Corrigendum: Efficacy and safety of Janus kinase inhibitors in non-infectious inflammatory ocular diseases: a prospective cohort study from the international AIDA network registries. Frontiers in medicine 3 39346944
2013 Purification, crystallization and preliminary X-ray crystallographic analysis of the transport unit of the monomeric autotransporter AIDA-I from Escherichia coli. Acta crystallographica. Section F, Structural biology and crystallization communications 3 24100572
2007 Isolation and identification of AIDA-I receptors in porcine intestinal mucus. Veterinary microbiology 3 17764859
2024 AIDA-1/ANKS1B Binds to the SynGAP Family RasGAPs with High Affinity and Specificity. Journal of molecular biology 2 38759928
2022 Acute promyelocytic leukemia in childhood and adolescence: treatment results of a modified AIDA protocol at a Brazilian center. Hematology, transfusion and cell therapy 2 36804019
2021 Anakinra and canakinumab for patients with R92Q-associated autoinflammatory syndrome: a multicenter observational study from the AIDA Network. Therapeutic advances in musculoskeletal disease 2 34527082
2009 Effect of the class I metabotropic glutamate receptor antagonist AIDA on certain behaviours in rats with experimental chronic hyperammonemia. Advances in medical sciences 1 19875354
2004 Automated in vitro dermal absorption (AIDA): development of a cost-effective diffusion cell. Toxicology mechanisms and methods 1 20021103
2026 Clinical and laboratory markers to distinguish VEXAS from Schnitzler's syndrome: data from the AIDA network registries. Frontiers in medicine 0 41601749
2026 VEXAS syndrome and cancer: Insights about a possible "Tip of the Iceberg". Ambidirectional data from the international AIDA network registries. Seminars in arthritis and rheumatism 0 41619570
2026 Recurrent fever and association with severe organ involvement, mortality and treatment outcomes in VEXAS syndrome: data from the AIDA Network. Frontiers in immunology 0 41909650
2026 Proteomic and experimental analyses reveal molecular signatures of flexural atopic dermatitis in antecubital and popliteal fossae and the therapeutic effect of Aida lotion. Frontiers in immunology 0 41988190
2026 Inhibiting AIDA suppresses VSMC-derived foam cell formation and atherosclerosis by hindering CD36 membrane translocation. Atherosclerosis 0 42013606
2025 Development and implementation of the International AIDA Network Castleman's disease registry. Frontiers in medicine 0 40969814
2025 IL-1 targeting agents in Schnitzler syndrome: a multicentre, real-world study from the international AIDA Network Schnitzler Registry. Clinical and experimental rheumatology 0 41133355
2024 Insertional mutagenesis of AIDA or CYP720B1 in the green alga Chlamydomonas reinhardtii confers copper(II) tolerance and increased biomass. Journal of hazardous materials 0 39740551
2023 Knowledge and Current Practices in Monogenic Uveitis: An International Survey by IUSG and AIDA Network. Ophthalmology and therapy 0 37924480