Affinage

ABCC1

Multidrug resistance-associated protein 1 · UniProt P33527

Length
1531 aa
Mass
171.6 kDa
Annotated
2026-06-09
100 papers in source corpus 30 papers cited in narrative 31 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/7 claims corpus-supported (86%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ABCC1/MRP1 is an ATP-dependent plasma membrane efflux pump with broad substrate specificity that links cellular export of glutathione (GSH) conjugates and signaling lipids to innate immunity, redox homeostasis, hormone availability, and multidrug resistance (PMID:8663001, PMID:36070769). Its prototypical substrate is the GSH conjugate leukotriene C4, and competitive-inhibition kinetics show that diverse compounds — glutathione-platinum complexes, anthracycline-GSH conjugates, and stable copper(II)-GSH thiosemicarbazone adducts — gain recognition at a shared substrate-binding site once conjugated to GSH (PMID:8663001, PMID:9647783, PMID:33190481). The transporter also exports the STING agonist cGAMP, thereby limiting cell-intrinsic STING signaling and restraining cGAS-dependent autoimmunity (PMID:36070769), and exports sphingosine-1-phosphate to drive ERK signaling and a SphK1 feed-forward loop promoting breast tumor growth and metastasis (PMID:20110355, PMID:29523764). Substrate handling is governed by specific transmembrane helices (TM6, 8, 10, 11, 14) and cytoplasmic-loop architecture: TM8/TM9 and Tyr440 are required for GSH-conjugate binding, cytoplasmic loop 5 and its interface with NBD2 (residues including Glu521/Glu535) are essential for interdomain folding, plasma-membrane expression, and catalysis, and N-glycosylation at Asn19/Asn23 together with phosphorylation at Tyr920/Ser921 reciprocally tune substrate affinity and transport capacity (PMID:14722114, PMID:18775981, PMID:21177244, PMID:22232552, PMID:27297967). Physiologically, ABCC1 selectively exports corticosterone but not cortisol to control tissue glucocorticoid availability in adipose (PMID:27535620), detoxifies heavy metals including methylmercury and arsenic-GSH while protecting against oxidative stress (PMID:20842442, PMID:32915249), and is required for dendritic cell differentiation (PMID:16621983). Transcriptionally it is activated by Notch1/CBF1, ATF4 downstream of TGF-β/SMAD2/3, SOX2, and NRF2/oxidative-stress signaling, and repressed by KDM5c-mediated H3K4me3 demethylation, coupling its expression to chemoresistance and ferroptosis sensitivity in multiple cancers (PMID:22143792, PMID:33782384, PMID:31883360, PMID:35803910, PMID:30257334). A heterozygous p.Asn590Ser variant that mislocalizes the protein and reduces efflux causes nonsyndromic hearing loss (PMID:31273342).

Mechanistic history

Synthesis pass · year-by-year structured walk · 23 steps
  1. 1996 High

    Established that MRP1 is an ATP-dependent GS-X pump exporting both a physiological GSH conjugate (LTC4) and a glutathione-drug complex through a shared binding site, defining its core transport mechanism and substrate logic.

    Evidence ATP-dependent transport and competitive inhibition kinetics in membrane vesicles from MRP1-overexpressing cells

    PMID:8663001

    Open questions at the time
    • Did not resolve the structural identity of the shared binding site
    • Did not address GSH cotransport requirements for non-conjugated drugs
  2. 1998 High

    Extended the shared-binding-site model by showing anthracyclines become ABCC1 substrates only after glutathionation, explaining how broad chemoresistance arises from GSH conjugation.

    Evidence In vitro LTC4 transport competitive inhibition with chemically synthesized GS-anthracycline conjugates

    PMID:9647783

    Open questions at the time
    • Whether conjugates are transported intact versus co-transported with GSH not directly shown
  3. 1998 Medium

    Showed ABCC1 expression is governed by intracellular redox state, linking the transporter to oxidative-stress adaptation rather than constitutive housekeeping.

    Evidence Pro-oxidant treatment and γ-GCSh overexpression with ROI and Northern-blot readouts

    PMID:9813007

    Open questions at the time
    • Did not identify the transcription factors mediating ROI-driven induction
    • Single lab
  4. 2004 High

    Mapped specific transmembrane proline residues (TM6, 8, 10, 11, 14) and a cytoplasmic-loop proline as critical determinants of organic-anion transport and ATP dependence, beginning the structure-function dissection of substrate handling.

    Evidence Alanine-scanning mutagenesis with vesicular transport assays across multiple substrates

    PMID:14722114

    Open questions at the time
    • No structural model of how these helices form the translocation pathway
  5. 2005 Medium

    Demonstrated that a natural coding SNP (Ala989Thr) lowers substrate affinity, providing pharmacogenetic evidence that ABCC1 sequence variation alters transport.

    Evidence Site-directed mutagenesis of 10 SNPs with vesicular transport assays in HEK cells

    PMID:16041243

    Open questions at the time
    • Clinical consequence of the variant not established
    • Single lab
  6. 2006 Medium

    Revealed a developmental role beyond drug efflux: ABCC1 transport activity is required for dendritic cell differentiation, with endogenous CD1 ligands as candidate substrates.

    Evidence MRP1-specific pharmacological inhibition during in vitro DC differentiation with surface-marker and MLR readouts

    PMID:16621983

    Open questions at the time
    • Exogenous substrate addition did not rescue differentiation, leaving the relevant transported molecule unconfirmed
    • Pharmacological rather than genetic loss-of-function
  7. 2008 High

    Localized GSH-conjugate binding to TM8/TM9 and cytoplasmic loops, identifying Tyr440 as a key residue whose mutation reduces LTC4 affinity and photolabeling.

    Evidence MRP1/MRP3 chimeras, point mutagenesis, and photoaffinity labeling with [3H]LTC4 and azido-GSH

    PMID:18775981

    Open questions at the time
    • Did not resolve whether Tyr440 contacts GSH or the conjugated moiety
  8. 2010 Medium

    Identified S1P as an ABCC1 export substrate coupling the transporter to ERK signaling, expanding its role into lipid-mediated signal transduction.

    Evidence siRNA knockdown and inhibitor studies with S1P export and ERK phosphorylation in MCF-7 cells

    PMID:20110355

    Open questions at the time
    • Direct ATP-dependent S1P transport not reconstituted
    • Single lab
  9. 2010 High

    Established cytoplasmic loop 5 and its NBD2 interface as essential for membrane expression and catalysis, distinguishing folding/trafficking determinants from the catalytic cycle.

    Evidence Site-directed mutagenesis with expression, azido-ATP trapping, and vesicular transport assays

    PMID:21177244

    Open questions at the time
    • Structural basis of the CL5-NBD2 interface not defined
  10. 2010 Medium

    Demonstrated an in vivo metal-detoxification role using a transport-dead mutant, separating transport activity from mere expression.

    Evidence abcc1 and transport-dead G1420D overexpression in zebrafish embryos with heavy-metal survival assays

    PMID:20842442

    Open questions at the time
    • Mammalian relevance not established in this study
    • Specific metal-GSH species transported not identified
  11. 2011 High

    Defined Notch1/CBF1 as a direct transcriptional activator of ABCC1, providing a signaling-to-expression axis underlying drug resistance.

    Evidence γ-secretase inhibition, shRNA, promoter-reporter, ChIP, EMSA, and CBF1-site mutagenesis

    PMID:22143792

    Open questions at the time
    • Tissue contexts where Notch dominates ABCC1 regulation not delineated
  12. 2012 High

    Resolved differential folding requirements of CL5 glutamates, showing distinct conformational defects rescuable by chemical chaperone, refining the interdomain assembly model.

    Evidence Mutagenesis with proteasome/4-PBA rescue, conformational antibodies, and transport assays

    PMID:22232552

    Open questions at the time
    • Atomic-level conformational changes inferred indirectly via antibody reactivity
  13. 2012 Medium

    Connected extracellular matrix signaling to ABCC1, showing collagen/β1-integrin-ERK signaling upregulates the transporter to confer doxorubicin resistance.

    Evidence Integrin/ERK inhibition and ABCC1 knockdown with intracellular drug and apoptosis readouts in leukemic T-cells

    PMID:22787275

    Open questions at the time
    • Transcriptional effectors downstream of ERK not identified
    • Single lab
  14. 2016 High

    Established ABCC1 as a selective glucocorticoid exporter (corticosterone not cortisol), giving it a tissue-specific endocrine function in adipose.

    Evidence Probenecid inhibition and Abcc1 knockout mice with mass-spec steroid measurement and glucocorticoid-responsive gene expression

    PMID:27535620

    Open questions at the time
    • Structural basis of corticosterone/cortisol discrimination not determined
  15. 2016 High

    Showed post-translational modifications (glycosylation at Asn19/23, phosphorylation at Tyr920/Ser921) reciprocally and epistatically tune substrate affinity and capacity, adding a regulatory layer to transport.

    Evidence Systematic PTM-site mutagenesis with As(GS)3 vesicular transport kinetics and phosphatase-inhibitor controls

    PMID:27297967

    Open questions at the time
    • Kinases/phosphatases acting on Tyr920/Ser921 not identified
    • Generality across other substrates not tested
  16. 2020 Medium

    Identified ABCC1 as the effector of a EFHD2-NOX4-ROS axis controlling its membrane localization and cisplatin resistance, integrating redox signaling with transporter trafficking.

    Evidence EFHD2/ABCC1 overexpression and knockdown, NOX4 inhibition, ROS measurement, and xenografts

    PMID:32446175

    Open questions at the time
    • Mechanism of ROS-driven membrane insertion not defined
    • Single lab
  17. 2020 Medium

    Showed ABCC1 mediates polarized placental mercury export and protects against methylmercury oxidative cytotoxicity, defining a barrier-detoxification role.

    Evidence Transwell transport in MDCKII cells, siRNA knockdown in placental cells, mercury/GSH/apoptosis readouts

    PMID:32915249

    Open questions at the time
    • In vivo placental contribution not directly tested
    • Single lab
  18. 2020 Medium

    Clarified substrate-recognition chemistry by showing ABCC1 transports thiosemicarbazones only when they form stable non-reducible copper(II)-GSH adducts, refining the GSH-conjugate recognition rule.

    Evidence COTI-2-resistant ABCC1-overexpressing line, inhibitor reversal, and copper-GSH complex characterization

    PMID:33190481

    Open questions at the time
    • Binding-site interactions with the copper adduct not mapped
    • Single lab
  19. 2021 Medium

    Added ATF4 (downstream of CAF-derived TGF-β1/SMAD2/3) as a direct transcriptional activator of ABCC1, linking the tumor microenvironment to gemcitabine resistance.

    Evidence ATF4 ChIP at ABCC1 promoter, ATF4 silencing, and TGF-β1/SMAD pathway analysis

    PMID:33782384

    Open questions at the time
    • Relative contribution versus other activators not assessed
    • Single lab
  20. 2022 High

    Defined ABCC1 as the exporter limiting cell-intrinsic STING activation through cGAMP efflux, placing it as a regulator of innate immunity and autoimmunity.

    Evidence Reciprocal gain/loss-of-function cGAMP export assays and Trex1-/- mouse epistasis

    PMID:36070769

    Open questions at the time
    • Whether cGAMP shares the GSH-conjugate binding site not addressed
    • Intercellular cGAMP transfer consequences not fully mapped
  21. 2022 Medium

    Showed NRF2-driven ABCC1 exports GSH to create collateral ferroptosis sensitivity in glioblastoma when system xc- is blocked, revealing a redox-balance role that can be therapeutically exploited.

    Evidence NRF2/ABCC1 silencing with Erastin/RSL3 ferroptosis induction, GSH measurement, and TMZ sensitivity in glioblastoma cells

    PMID:35803910

    Open questions at the time
    • In vivo ferroptosis relevance not tested
    • Single lab
  22. 2018 Medium

    Identified KDM5c-mediated H3K4me3 demethylation at the ABCC1 TSS as an epigenetic repressor, complementing the transcription-factor regulation and linking chromatin state to chemoresistance.

    Evidence KDM5c overexpression/knockdown with ChIP-qPCR of H3K4me3 and KDM5c at the ABCC1 TSS and drug-resistance assays

    PMID:30257334

    Open questions at the time
    • Upstream regulators of KDM5c recruitment unknown
    • Single lab
  23. 2019 Medium

    Provided direct disease evidence: a heterozygous p.Asn590Ser ABCC1 variant causing mislocalization and reduced efflux underlies nonsyndromic hearing loss, establishing cochlear ABCC1 function in hearing.

    Evidence Linkage/exome sequencing with co-segregation, localization, mRNA-stability, efflux assays, and cochlear expression mapping

    PMID:31273342

    Open questions at the time
    • Mechanism by which efflux loss damages cochlea not defined
    • Single family/lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the single broad substrate-binding pocket simultaneously accommodates GSH conjugates, cGAMP, S1P, and steroids, and how PTMs and trafficking signals are coordinated in vivo to dictate tissue-specific substrate preference, remains unresolved.
  • No atomic-resolution structure of ABCC1 with diverse substrates in the corpus
  • Physiological hierarchy among competing substrates not established
  • Coupling between redox-driven trafficking and transcriptional/epigenetic regulation unmapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 5 GO:0140657 ATP-dependent activity 3
Localization
GO:0005886 plasma membrane 4
Pathway
R-HSA-382551 Transport of small molecules 4 R-HSA-1643685 Disease 3 R-HSA-168256 Immune System 2 R-HSA-8953897 Cellular responses to stimuli 2

Evidence

Reading pass · 31 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2022 ABCC1 directly exports cyclic GMP-AMP (cGAMP) in an ATP-dependent manner. ABCC1 overexpression enhanced cGAMP export and limited STING signaling, while ABCC1 loss reduced cGAMP export and potentiated STING signaling. ABCC1 deficiency exacerbated cGAS-dependent autoimmunity in Trex1-/- mice, establishing ABCC1-mediated cGAMP export as a key regulatory mechanism limiting cell-intrinsic STING activation. Overexpression and loss-of-function studies in mouse and human cells, cGAMP export assays, Trex1-/- mouse model epistasis Immunity High 36070769
1996 MRP1/ABCC1 (GS-X pump) transports both leukotriene C4 (LTC4) and the glutathione-platinum complex (GS-Pt) in an ATP-dependent manner. Glutathione-platinum complex, but not cisplatin itself, competitively inhibited ATP-dependent LTC4 transport in membrane vesicles from MRP1-overexpressing cells, indicating a shared binding site. ATP-dependent transport assays in plasma membrane vesicles from MRP1-overexpressing cells; competitive inhibition kinetics The Journal of biological chemistry High 8663001
2010 ABCC1 exports sphingosine 1-phosphate (S1P) and dihydro-S1P from breast cancer cells. Estradiol-induced S1P export required estrogen receptor-alpha and was suppressed by pharmacological inhibitors or siRNA knockdown of ABCC1. This ABCC1-mediated S1P export activated ERK1/2 signaling downstream. Pharmacological inhibition and siRNA knockdown of ABCC1, S1P export measurement, ERK1/2 phosphorylation assays in MCF-7 cells The Journal of biological chemistry Medium 20110355
2018 ABCC1-exported S1P (produced by SphK1) promotes breast cancer tumor growth, angiogenesis, lymphangiogenesis, metastasis, and upregulates SphK1 transcription in a feed-forward manner. Overexpression of ABCC1 (but not ABCB1) in breast cancer cells enhanced S1P secretion, proliferation, migration, and tumor growth in mouse mammary fat pad implantation models. ABCC1 overexpression in MCF-7 and 4T1 cells, in vivo mammary fat pad tumor implantation, S1P secretion measurement Molecular cancer research : MCR Medium 29523764
1998 Doxorubicin- and daunorubicin-glutathione conjugates (but not unconjugated drugs) competitively inhibit LTC4 transport by MRP1/GS-X pump, with Ki values of 60–200 nM, indicating that glutathionation enables anthracycline recognition at the shared substrate-binding site of ABCC1. In vitro LTC4 transport assay using MRP1-overexpressing membrane vesicles; competitive inhibition kinetics with synthesized GS-conjugates Biochemical and biophysical research communications High 9647783
2011 Notch1 intracellular domain (N1IC) transcriptionally upregulates ABCC1/MRP1 expression via the transcription factor CBF1 binding to specific sites in the ABCC1 promoter. Reducing N1IC (by γ-secretase inhibitor or shRNA) decreased ABCC1 expression; ectopic N1IC increased ABCC1 and drug resistance. ChIP and gel-shift assays confirmed N1IC-activated CBF1 interaction with the ABCC1 promoter; mutation of CBF1 binding sites attenuated promoter activity. γ-secretase inhibitor and shRNA knockdown, ectopic overexpression, ABCC1 promoter-reporter assay, ChIP, gel-shift (EMSA), site-directed mutagenesis of CBF1 binding sites Proceedings of the National Academy of Sciences of the United States of America High 22143792
2014 NOTCH1 intracellular domain (ICN1) directly binds to the promoter region of ABCC1 to transactivate its expression in prostate cancer stem cells, resulting in enhanced chemoresistance. ChIP-PCR confirmed ICN1 occupancy at the ABCC1 promoter; shRNA knockdown of NOTCH1 decreased ABCC1 expression and improved chemosensitivity. ChIP-PCR, shRNA knockdown, quantitative RT-PCR, Western blot, MTT chemosensitivity assay Molecular and cellular biochemistry Medium 24782036
2004 Proline residues in transmembrane helices 6, 8, 10, 11 (MSD2) and 14 (MSD3) of MRP1/ABCC1 are critical for organic anion transport function. Ala substitution of TM6-Pro343, TM8-Pro448, TM10-Pro557, TM11-Pro595, and TM14-Pro1088 significantly reduced transport of five organic anion substrates. Pro1150 in cytoplasmic loop 7 (CL7) differentially modulates substrate-specific transport and ATP dependence. Alanine-scanning mutagenesis of 18 Pro residues; vesicular transport assays for multiple organic anion substrates; ATP binding studies in HEK cells The Journal of biological chemistry High 14722114
2010 Cytoplasmic loop 5 (CL5) of MRP1/ABCC1 is critical for plasma membrane expression and transport function. Ala substitution of conserved charged residues Lys513, Lys516, Glu521, and Glu535 markedly reduced MRP1 protein levels; NBD2 residues His1364 and Arg1367 at the CL5 interface also reduced MRP1 levels, indicating a critical role for the CL5-NBD2 interface in membrane expression. Gly511 mutation reduced vanadate-induced ADP trapping, indicating altered catalytic activity without affecting ATP binding. Site-directed mutagenesis, immunoblotting, plasma membrane expression assays, 32P-azido-ATP binding and vanadate-induced trapping assays, vesicular transport assays in HEK cells The Journal of biological chemistry High 21177244
2012 Glu521 and Glu535 in CL5 of MRP1/ABCC1 are differentially required for proper interdomain folding and transport function. E521A and E535A mutants misfold and are degraded by the proteasome; chemical chaperone 4-PBA rescues plasma membrane expression of both but reveals distinct conformational defects: E535A shows reduced substrate affinity affecting both halves of the transporter, while E521A shows altered ATP interactions and a distinct conformational change in the COOH-proximal half. Site-directed mutagenesis, proteasome inhibitor and chemical chaperone rescue (4-PBA), immunoblotting, confocal microscopy, vesicular transport assays, conformational antibody studies in HEK cells The Journal of biological chemistry High 22232552
2008 Transmembrane helices 8 and 9 and portions of cytoplasmic loops 4 and 5 of MRP1/ABCC1 (particularly Tyr440) are critical for binding and transport of glutathione conjugates including LTC4. Substitution of Tyr440 with Phe (as in MRP3) reduced LTC4 and GSH-stimulated estrone-3-sulfate transport by increasing Km for LTC4 5-fold and substantially reducing photolabeling by [3H]LTC4 and azidophenacyl-[35S]GSH. MRP1/MRP3 chimeric protein construction, site-directed mutagenesis, vesicular transport assays, photoaffinity labeling with [3H]LTC4 and azidophenacyl-[35S]GSH Drug metabolism and disposition: the biological fate of chemicals High 18775981
2016 ABCC1 exports corticosterone but not cortisol, whereas ABCB1 exports cortisol but not corticosterone. ABCC1 (but not ABCB1) is expressed in human adipose tissue; ABCC1 inhibition with probenecid or Abcc1 knockout in mice increased intracellular corticosterone but not cortisol in adipose, sufficient to induce glucocorticoid-responsive gene transcription. ABCC1 pharmacological inhibition (probenecid), Abcc1 knockout mice, corticosteroid infusion in adrenalectomized animals, mass spectrometry measurement of steroid concentrations, glucocorticoid-responsive gene expression in adipose Science translational medicine High 27535620
2016 Phosphorylation of Tyr920/Ser921 and N-linked glycosylation at Asn19/Asn23 of MRP1/ABCC1 selectively modify As(GS)3 transport kinetics. Phosphorylation-mimicking double mutation Tyr920/Ser921 switches MRP1 to a lower-affinity, higher-capacity As(GS)3 transporter; glycosylation at Asn19/Asn23 increases substrate affinity. Cross-talk between these two modifications was demonstrated: phosphorylation-mimicking substitutions abrogated the effect of Asn19/23Gln glycosylation on As(GS)3 kinetics. Site-directed mutagenesis of glycosylation (N19Q, N23Q, N1006Q) and phosphorylation (Y920F, S921A, and combinations) sites; membrane vesicle transport assays with As(GS)3; prepared with/without phosphatase inhibitors in HEK293 and HeLa cells Molecular pharmacology High 27297967
2005 MRP1/ABCC1 Ala989Thr (SNP) causes a significant decrease in estradiol 17β-glucuronide transport due to decreased apparent affinity (increased Km), as determined by vesicular transport assays in HEK cells transfected with site-directed mutants. Nine other naturally occurring missense variants did not substantially alter transport function. Site-directed mutagenesis recreating 10 SNPs, transient transfection in HEK cells, vesicular transport assays, immunoblotting Pharmacogenetics and genomics Medium 16041243
2012 Collagen/β1 integrin signaling upregulates ABCC1 expression and function via the ERK/MAPK pathway and requires actin polymerization. Inhibition or knockdown of ABCC1 prevented collagen-mediated reduction of intracellular doxorubicin and collagen-mediated protection from doxorubicin-induced apoptosis in leukemic T-cells. β1 integrin signaling with collagen/fibronectin, ERK inhibitor and siRNA knockdown, ABCC1 knockdown, intracellular doxorubicin measurement, apoptosis assays in Jurkat and HSB2 cells Molecular biology of the cell Medium 22787275
1998 MRP1/ABCC1 gene expression is induced by pro-oxidants (tert-butylhydroquinone, DMNO, menadione) that increase intracellular reactive oxygen intermediates (ROI). Elevated intracellular GSH (via γ-GCSh overexpression) suppresses endogenous MRP1 and γ-GCSh expression by reducing ROI levels, indicating that intracellular ROI levels regulate MRP1 expression. Pro-oxidant treatment, flow cytometry (ROI measurement with dihydrorhodamine 123), stable γ-GCSh-transfected cell lines, Northern blot, GSH depletion experiments The Journal of biological chemistry Medium 9813007
2007 Induction of ABCC1 by oxidative stress (tBHQ) is Nrf2-independent but Keap1-dependent: siRNA-mediated Nrf2 knockdown did not suppress tBHQ-induced ABCC1 mRNA elevation, whereas Keap1-specific siRNA knockdown increased ABCC1 mRNA. By contrast, ABCC2 and ABCG2 induction by tBHQ is Nrf2/Keap1-dependent. siRNA knockdown of Nrf2 and Keap1, real-time PCR for ABC transporter mRNA, tBHQ treatment in HepG2 cells, Nrf2 nuclear translocation assay Journal of experimental therapeutics & oncology Medium 18038766
2006 MRP1/ABCC1 transporter activity is required for dendritic cell (DC) differentiation. Inhibition of MRP1 (but not P-glycoprotein) during in vitro DC differentiation impaired early DC development, resulting in morphological and phenotypic changes including maintained CD14 expression and decreased CD1a, CD1c, Langerin, CD40, CD86, and HLA-DR expression, and reduced ability to stimulate allogeneic T cells. Endogenous CD1 ligands sulfatide and GM1 were identified as MRP1 substrates, though exogenous addition did not restore DC differentiation. Specific MRP1 inhibitors during in vitro DC differentiation from monocytes, flow cytometry for surface markers, mixed lymphocyte reaction, substrate identification assay Journal of immunology Medium 16621983
2020 EFHD2 promotes cisplatin resistance in NSCLC via the NOX4-ROS-ABCC1 axis: EFHD2 overexpression induces NOX4-mediated ROS production, which activates membrane expression of ABCC1 for drug efflux. EFHD2 knockdown reduced ABCC1 membrane expression and improved cisplatin sensitivity; ABCC1 knockdown phenocopied EFHD2 loss. EFHD2 overexpression and knockdown, NOX4 inhibition, ROS measurement, ABCC1 membrane expression by Western blot/flow cytometry, cisplatin resistance assays, murine xenograft model Redox biology Medium 32446175
2021 ATF4 directly binds to the ABCC1 promoter region to activate its transcription in pancreatic cancer cells. TGF-β1 secreted by cancer-associated fibroblasts upregulates ATF4 via the SMAD2/3 pathway, which in turn transactivates ABCC1 to drive gemcitabine resistance. Chromatin immunoprecipitation (ChIP) of ATF4 at ABCC1 promoter, ATF4 silencing, TGF-β1 treatment, SMAD2/3 pathway analysis, gemcitabine resistance assays Cell death & disease Medium 33782384
2022 NRF2-dependent ABCC1 upregulation in glioblastoma promotes GSH depletion when system xc- is blocked (by Erastin), sensitizing cells to ferroptosis. ABCC1 silencing in T98G-shNRF2 cells reversed GSH depletion and conferred ferroptosis resistance while increasing TMZ sensitivity, establishing ABCC1 as a pro-ferroptotic NRF2 target responsible for collateral sensitivity. NRF2 and ABCC1 siRNA/shRNA silencing, ferroptosis inducers (Erastin, RSL3), Ferrostatin-1 rescue, GSH measurement, cell viability assays in U251MG and T98G glioblastoma cells Cell death & disease Medium 35803910
2019 A heterozygous missense variant in ABCC1 (p.Asn590Ser) causes nonsyndromic hearing loss. The variant results in altered subcellular distribution (cytomembrane and cytoplasm vs. cytomembrane only for wild-type), unstable mRNA, and decreased efflux capacity, establishing ABCC1 function in cochlea (stria vascularis and auditory nerve) as important for hearing. Genetic linkage analysis, exome sequencing, co-segregation analysis, immunofluorescence localization, real-time qPCR for mRNA stability, flow cytometry efflux assay, cochlear expression by in situ hybridization/immunostaining in mouse Genetics in medicine Medium 31273342
2010 MRP1/ABCC1 plays a role in heavy metal detoxification in zebrafish. Overexpression of abcc1 improved survival of embryos exposed to Cd, Hg, and As, while overexpression of a transport-dead mutant (ABCC1-G1420D) sensitized embryos to toxic metals. abcc1 mRNA was induced by CdCl2, HgCl2, Pb(NO3)2, and arsenate in ZF4 cells and embryos. abcc1 overexpression and G1420D mutant expression in zebrafish embryos, heavy metal exposure survival assays, whole-mount in situ hybridization, real-time PCR Molecular biology reports Medium 20842442
2020 MRP1/ABCC1 mediates polarized apical-to-basolateral mercury export in placental epithelial cells, regulates intracellular GSH status, and protects placental cells from methyl mercury-induced oxidative stress, cytotoxicity, and apoptosis. siRNA-mediated MRP1 knockdown in HTR-8/SVneo cells caused mercury accumulation, reduced cell viability, increased apoptosis and oxidative stress. Transwell transport assays in MRP1-overexpressing MDCKII cells, siRNA knockdown in HTR-8/SVneo placental cells, mercury accumulation measurement, GSH status, cell viability, apoptosis and ROS assays, immunofluorescence localization in placental tissue Archives of toxicology Medium 32915249
2018 KDM5c (a histone demethylase) downregulates ABCC1 expression by demethylating H3K4me3 at the ABCC1 transcription start site (TSS). ChIP-qPCR confirmed that both H3K4me3 and KDM5c act on the same TSS region of the ABCC1 gene; KDM5c overexpression decreased ABCC1 mRNA/protein and reduced drug resistance, while KDM5c knockdown increased ABCC1 and drug resistance. KDM5c overexpression and siRNA knockdown, ChIP-qPCR for H3K4me3 and KDM5c at ABCC1 TSS, qPCR and Western blot for ABCC1, MTT drug resistance assay in HCT-8 and RKO colon cancer cells Biomedicine & pharmacotherapy Medium 30257334
2009 Chinese ABCC1 SNP Arg723Gln significantly reduces MRP1-mediated resistance to daunorubicin, doxorubicin, etoposide, vinblastine, and vincristine in HEK293 and CHO-K1 cells. Thr73Ile reduced resistance to methotrexate and etoposide; Arg1058Gln increased resistance to anthracyclines and etoposide. None of the variants affected MRP1 expression or trafficking. Site-directed mutagenesis recreating 4 SNPs, stable transfection in HEK293 and CHO-K1, immunoblotting, confocal microscopy, MTT drug resistance assay Pharmacogenetics and genomics Medium 19214144
2004 Cellular folate status influences the transport activity of MRP1/ABCC1: folate-free conditions decreased MRP1-mediated daunorubicin efflux to 43% of normal, which was restored by leucovorin or folic acid repletion. This occurred without changes in MRP1 protein expression or cellular ATP/ADP pools, suggesting folate acts as a cofactor or allosteric modulator of MRP1 transport activity. MRP1-transfected ovarian carcinoma cells (2008/MRP1), folate deprivation/repletion, benzbromarone (MRP1-specific inhibitor) blockade, daunorubicin efflux assays Biochemical pharmacology Medium 15041471
2016 As(GS)3 transport by MRP1/ABCC1 is modulated by N-linked glycosylation at Asn19/Asn23: glycosylation-deficient mutants display low Km (high affinity) similar to dephosphorylated wild-type, indicating that the default glycosylated form has lower affinity for As(GS)3. Cross-talk with phosphorylation at Tyr920/Ser921 controls transport kinetics. N-glycosylation site mutagenesis (N19Q/N23Q/N1006Q), membrane vesicle transport assays prepared with or without phosphatase inhibitors, in HEK293 and HeLa cells Molecular pharmacology High 27297967
2019 SOX2 transcriptionally upregulates ABCC1 to promote side population (SP) cell chemoresistance to paclitaxel in melanoma. SOX2 knockout depleted SP cells and reduced ABCC1 expression; SOX2 induction upregulated SP cells and ABCC1; ABCC1 knockout increased paclitaxel sensitivity. SOX2 was identified as a transcriptional activator of ABCC1. SOX2 knockout and inducible overexpression, ABCC1 knockout, side population assay (Hoechst 33342 exclusion), paclitaxel cytotoxicity assay, reporter assay for SOX2-ABCC1 transcription in melanoma cell lines Molecular carcinogenesis Medium 31883360
2012 ApoE/ApoE receptor-2/c-Jun N-terminal kinase (JNK) pathway regulates ABCC1 expression on cerebral microvessels. Methamphetamine reduced abluminal ABCC1 expression on cerebral microvessels; this was prevented by ApoE receptor-2 inhibition (receptor-associated protein) and inducible nitric oxide synthase inhibition (1400W), indicating ApoE signaling through ApoER2 deactivates JNK1/2 to regulate ABCC1. Methamphetamine treatment in C57BL/6J mice, ApoE receptor-2 inhibitor (RAP), iNOS inhibitor (1400W), Western blots of cerebral microvessel extracts, immunoprecipitation, immunohistochemistry Stroke Medium 22426312
2020 ABCC1 is a substrate transporter for COTI-2, a thiosemicarbazone anticancer compound, and confers resistance via efflux. ABCC1 recognition of COTI-2 requires formation of stable, non-reducible copper(II)-glutathione adducts; thiosemicarbazones forming reducible copper complexes with GSH are not ABCC1 substrates. Established COTI-2-resistant cell line (SW480/Coti) with confirmed ABCC1 overexpression, ABCC1 inhibitor reversal, copper complex synthesis and characterization, reduction kinetics with GSH, drug resistance assays Journal of medicinal chemistry Medium 33190481

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain. Neuroscience 284 15501592
2001 Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters. Toxicology 284 11557126
2014 Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter. The Journal of biological chemistry 279 25281745
2013 Targeting multidrug resistance protein 1 (MRP1, ABCC1): past, present, and future. Annual review of pharmacology and toxicology 267 24050699
1996 Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells. The Journal of biological chemistry 241 8663001
2013 ABCC1, an ATP binding cassette protein from grape berry, transports anthocyanidin 3-O-Glucosides. The Plant cell 222 23723325
2010 Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. The Journal of biological chemistry 217 20110355
2005 Substrate recognition and transport by multidrug resistance protein 1 (ABCC1). FEBS letters 217 16387301
1998 FROM VACUOLAR GS-X PUMPS TO MULTISPECIFIC ABC TRANSPORTERS. Annual review of plant physiology and plant molecular biology 181 15012252
2007 Role of the MRP1/ABCC1 multidrug transporter protein in cancer. IUBMB life 173 18085475
2006 Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin. Molecular and cellular biochemistry 170 16960658
2009 ABC transporter (P-gp/ABCB1, MRP1/ABCC1, BCRP/ABCG2) expression in the developing human CNS. Neuropediatrics 146 19165709
1998 Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress. The Journal of biological chemistry 143 9813007
2018 LncRNA NR2F1-AS1 regulates hepatocellular carcinoma oxaliplatin resistance by targeting ABCC1 via miR-363. Journal of cellular and molecular medicine 138 29602203
2006 Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1). Pflugers Archiv : European journal of physiology 134 17187268
2008 Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces. The Journal of comparative neurology 119 18680196
2022 ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP. Immunity 115 36070769
2011 Structural and functional properties of human multidrug resistance protein 1 (MRP1/ABCC1). Current medicinal chemistry 109 21143116
2006 Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by nucleoside, nucleotide, and non-nucleoside reverse transcriptase inhibitors. Drug metabolism and disposition: the biological fate of chemicals 109 17172311
2011 Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells. Proceedings of the National Academy of Sciences of the United States of America 92 22143792
2020 Exosomes from CD133+ cells carrying circ-ABCC1 mediate cell stemness and metastasis in colorectal cancer. Journal of cellular biochemistry 86 31960989
2020 CircPVT1 contributes to chemotherapy resistance of lung adenocarcinoma through miR-145-5p/ABCC1 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 86 31986409
2017 LncRNA FENDRR sensitizes doxorubicin-resistance of osteosarcoma cells through down-regulating ABCB1 and ABCC1. Oncotarget 84 29069754
2022 High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation. Cell death & disease 81 35803910
2007 Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress. Journal of experimental therapeutics & oncology 80 18038766
2009 Vandetanib (Zactima, ZD6474) antagonizes ABCC1- and ABCG2-mediated multidrug resistance by inhibition of their transport function. PloS one 78 19390592
2005 Polymorphisms of MRP1 (ABCC1) and related ATP-dependent drug transporters. Pharmacogenetics and genomics 73 16006996
2021 Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation. Cell death & disease 72 33782384
2018 Long non-coding RNA KCNQ1OT1 modulates oxaliplatin resistance in hepatocellular carcinoma through miR-7-5p/ ABCC1 axis. Biochemical and biophysical research communications 70 29966655
2004 Expression of P-glycoprotein (ABCB1) and Mrp1 (ABCC1) in adult rat brain: focus on astrocytes. Brain research 70 15328029
2015 miR-7 modulates chemoresistance of small cell lung cancer by repressing MRP1/ABCC1. International journal of experimental pathology 69 26108539
2009 Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma. BMC urology 69 19552816
2008 Pharmacogenomics of MRP transporters (ABCC1-5) and BCRP (ABCG2). Drug metabolism reviews 68 18464048
2005 Functional characterization of non-synonymous single nucleotide polymorphisms in the gene encoding human multidrug resistance protein 1 (MRP1/ABCC1). Pharmacogenetics and genomics 68 16041243
2009 Combined pharmacophore modeling, docking, and 3D QSAR studies of ABCB1 and ABCC1 transporter inhibitors. ChemMedChem 67 19768722
1998 Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump. Biochemical and biophysical research communications 65 9647783
2018 ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer. Molecular cancer research : MCR 62 29523764
2021 ABCB1, ABCG2, ABCC1, ABCC2, and ABCC3 drug transporter polymorphisms and their impact on drug bioavailability: what is our current understanding? Expert opinion on drug metabolism & toxicology 59 33459081
2010 Molecular analysis and heavy metal detoxification of ABCC1/MRP1 in zebrafish. Molecular biology reports 58 20842442
2009 Characterization and analyses of multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms in Chinese population. Pharmacogenetics and genomics 58 19214144
2007 MRP1/GS-X pump ATPase expression: is this the explanation for the cytoprotection of the heart against oxidative stress-induced redox imbalance in comparison to skeletal muscle cells? Cell biochemistry and function 57 16868918
2004 Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions. The Journal of biological chemistry 56 14722114
2018 miR-1268a regulates ABCC1 expression to mediate temozolomide resistance in glioblastoma. Journal of neuro-oncology 55 29876787
2013 Genetic variability in the multidrug resistance associated protein-1 (ABCC1/MRP1) predicts hematological toxicity in breast cancer patients receiving (neo-)adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC). Annals of oncology : official journal of the European Society for Medical Oncology 55 23396606
2013 Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters. Analytical biochemistry 54 23470221
2006 Dendritic cells require multidrug resistance protein 1 (ABCC1) transporter activity for differentiation. Journal of immunology (Baltimore, Md. : 1950) 53 16621983
2012 Collagen/β1 integrin signaling up-regulates the ABCC1/MRP-1 transporter in an ERK/MAPK-dependent manner. Molecular biology of the cell 52 22787275
2020 Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux. Journal of medicinal chemistry 50 33190481
2015 Involvement of miR-133a and miR-326 in ADM resistance of HepG2 through modulating expression of ABCC1. Journal of drug targeting 50 25714665
2016 Targeting ABCB1 and ABCC1 with their Specific Inhibitor CBT-1® can Overcome Drug Resistance in Osteosarcoma. Current cancer drug targets 49 26548759
2014 NOTCH1 signaling promotes chemoresistance via regulating ABCC1 expression in prostate cancer stem cells. Molecular and cellular biochemistry 49 24782036
2021 Friend or foe: ABCG2, ABCC1 and ABCB1 expression in triple-negative breast cancer. Breast cancer (Tokyo, Japan) 48 33420675
2020 EFHD2 contributes to non-small cell lung cancer cisplatin resistance by the activation of NOX4-ROS-ABCC1 axis. Redox biology 48 32446175
2016 ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone: A rationale for safer glucocorticoid replacement therapy. Science translational medicine 48 27535620
2011 Modulation of Mrp1 (ABCc1) and Pgp (ABCb1) by bilirubin at the blood-CSF and blood-brain barriers in the Gunn rat. PloS one 48 21297965
2021 Exosomal circ_PIP5K1A regulates the progression of non-small cell lung cancer and cisplatin sensitivity by miR-101/ABCC1 axis. Molecular and cellular biochemistry 47 33570734
2011 Multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphism: from discovery to clinical application. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 46 22086004
2014 Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary. Mechanisms of ageing and development 45 25218792
2013 Clinicopathological impact of ABCC1/MRP1 and ABCC4/MRP4 in epithelial ovarian carcinoma. BioMed research international 45 24024181
2016 Pyrrolopyrimidine Derivatives as Novel Inhibitors of Multidrug Resistance-Associated Protein 1 (MRP1, ABCC1). Journal of medicinal chemistry 41 26943020
2008 Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3). Drug metabolism and disposition: the biological fate of chemicals 40 18775981
2018 ANRIL promotes chemoresistance via disturbing expression of ABCC1 by regulating the expression of Let-7a in colorectal cancer. Bioscience reports 37 30279206
2008 A novel arsenical has antitumor activity toward As2O3-resistant and MRP1/ABCC1-overexpressing cell lines. Leukemia 36 18633430
2016 Promoter methylation patterns of ABCB1, ABCC1 and ABCG2 in human cancer cell lines, multidrug-resistant cell models and tumor, tumor-adjacent and tumor-distant tissues from breast cancer patients. Oncotarget 35 27689338
2021 Circular RNAcirc_0076305 Promotes Cisplatin (DDP) Resistance of Non-Small Cell Lung Cancer Cells by Regulating ABCC1 Through miR-186-5p. Cancer biotherapy & radiopharmaceuticals 34 34339285
2004 Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1). Biochemical pharmacology 34 15041471
2018 KDM5c inhibits multidrug resistance of colon cancer cell line by down-regulating ABCC1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 33 30257334
2021 Sphingosine 1-phosphate (S1P) produced by sphingosine kinase 1 (SphK1) and exported via ABCC1 is related to hepatocellular carcinoma (HCC) progression. American journal of cancer research 32 34659894
2020 LINC00470 promotes tumour proliferation and invasion, and attenuates chemosensitivity through the LINC00470/miR-134/Myc/ABCC1 axis in glioma. Journal of cellular and molecular medicine 32 32916774
2019 The A-B-C of small-molecule ABC transport protein modulators: From inhibition to activation-a case study of multidrug resistance-associated protein 1 (ABCC1). Medicinal research reviews 32 30941807
2018 Down-regulation of miR-210-3p encourages chemotherapy resistance of renal cell carcinoma via modulating ABCC1. Cell & bioscience 32 29445446
2011 Variation and evolution of the ABC transporter genes ABCB1, ABCC1, ABCG2, ABCG5 and ABCG8: implication for pharmacogenetics and disease. Drug metabolism and drug interactions 32 22098604
2008 ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment. Biochemical pharmacology 32 18851956
2022 Upregulation of USP22 and ABCC1 during Sorafenib Treatment of Hepatocellular Carcinoma Contribute to Development of Resistance. Cells 30 35203285
2015 Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization. European journal of medicinal chemistry 30 26774038
2010 Expression and function of human MRP1 (ABCC1) is dependent on amino acids in cytoplasmic loop 5 and its interface with nucleotide binding domain 2. The Journal of biological chemistry 30 21177244
2012 Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1). The Journal of biological chemistry 28 22232552
2021 Ursolic Acid Enhances Cytotoxicity of Doxorubicin-Resistant Triple-Negative Breast Cancer Cells via ZEB1-AS1/miR-186-5p/ABCC1 Axis. Cancer biotherapy & radiopharmaceuticals 27 33493421
2020 Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines. International journal of molecular sciences 27 33081264
2016 MOLECULAR CLONING, EXPRESSION PATTERN OF MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1 (MRP1, ABCC1) GENE, AND THE SYNERGISTIC EFFECTS OF VERAPAMIL ON TOXICITY OF TWO INSECTICIDES IN THE BIRD CHERRY-OAT APHID. Archives of insect biochemistry and physiology 27 27110952
2015 Dinaciclib, a cyclin-dependent kinase inhibitor, is a substrate of human ABCB1 and ABCG2 and an inhibitor of human ABCC1 in vitro. Biochemical pharmacology 27 26300056
2012 Detection of ABCC1 expression in classical Hodgkin lymphoma is associated with increased risk of treatment failure using standard chemotherapy protocols. Journal of hematology & oncology 27 22871336
2022 LncRNA SNHG11 enhances bevacizumab resistance in colorectal cancer by mediating miR-1207-5p/ABCC1 axis. Anti-cancer drugs 26 35324517
2021 Overexpression of ABCC1 Confers Drug Resistance to Betulin. Frontiers in oncology 26 33718236
2014 Jadomycins are cytotoxic to ABCB1-, ABCC1-, and ABCG2-overexpressing MCF7 breast cancer cells. Anti-cancer drugs 26 24231527
2023 Overexpression of ABCC1 and ABCG2 confers resistance to talazoparib, a poly (ADP-Ribose) polymerase inhibitor. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 25 38340425
2015 Interactions of cyclin-dependent kinase inhibitors AT-7519, flavopiridol and SNS-032 with ABCB1, ABCG2 and ABCC1 transporters and their potential to overcome multidrug resistance in vitro. Cancer chemotherapy and pharmacology 25 25986678
2017 miR-133b down-regulates ABCC1 and enhances the sensitivity of CRC to anti-tumor drugs. Oncotarget 24 28881788
2001 Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum. Human mutation 24 11139250
2001 Antiproliferative prostaglandins and the MRP/GS-X pump role in cancer immunosuppression and insight into new strategies in cancer gene therapy. Biochemical pharmacology 24 11543717
2022 Sec24C mediates a Golgi-independent trafficking pathway that is required for tonoplast localisation of ABCC1 and ABCC2. The New phytologist 23 35510797
2020 Superior Pyrimidine Derivatives as Selective ABCG2 Inhibitors and Broad-Spectrum ABCB1, ABCC1, and ABCG2 Antagonists. Journal of medicinal chemistry 23 32787102
2020 In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta. Archives of toxicology 23 32915249
2019 Extrusion pump ABCC1 was first linked with nonsyndromic hearing loss in humans by stepwise genetic analysis. Genetics in medicine : official journal of the American College of Medical Genetics 22 31273342
2018 Specific Binding Protein ABCC1 Is Associated With Cry2Ab Toxicity in Helicoverpa armigera. Frontiers in physiology 22 29971014
2016 Pyrrolopyrimidine derivatives and purine analogs as novel activators of Multidrug Resistance-associated Protein 1 (MRP1, ABCC1). Biochimica et biophysica acta. Biomembranes 22 27810353
2013 Two polymorphic variants of ABCC1 selectively alter drug resistance and inhibitor sensitivity of the multidrug and organic anion transporter multidrug resistance protein 1. Drug metabolism and disposition: the biological fate of chemicals 22 24080162
2012 Apolipoprotein-E controls adenosine triphosphate-binding cassette transporters ABCB1 and ABCC1 on cerebral microvessels after methamphetamine intoxication. Stroke 22 22426312
2019 SOX2 upregulates side population cells and enhances their chemoresistant ability by transactivating ABCC1 expression contributing to intrinsic resistance to paclitaxel in melanoma. Molecular carcinogenesis 21 31883360
2016 Arsenic Triglutathione [As(GS)3] Transport by Multidrug Resistance Protein 1 (MRP1/ABCC1) Is Selectively Modified by Phosphorylation of Tyr920/Ser921 and Glycosylation of Asn19/Asn23. Molecular pharmacology 21 27297967

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