{"gene":"ZNF629","run_date":"2026-04-28T23:00:24","timeline":{"discoveries":[],"current_model":"No mechanistic findings about ZNF629 in the available literature (corpus appears contaminated with off-target papers)."},"narrative":{"teleology":[],"mechanism_profile":null,"mechanistic_narrative":"No mechanistic findings about ZNF629 in the available literature (corpus appears contaminated with off-target papers)."},"prefetch_data":{"uniprot":{"accession":"Q9UEG4","full_name":"Zinc finger protein 629","aliases":["Zinc finger protein 65"],"length_aa":869,"mass_kda":96.6,"function":"May be involved in transcriptional regulation","subcellular_location":"Nucleus","url":"https://www.uniprot.org/uniprotkb/Q9UEG4/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/ZNF629","classification":"Not 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spontaneous abortion. No mechanistic findings about ZNF629 protein function. → EXCLUDE (expression/genomic association, no mechanism)\n- Papers [2], [3], [7] (BioPlex series): Large-scale interactome maps that may include ZNF629 as a data point, but no specific mechanistic findings about ZNF629. → EXCLUDE (no specific ZNF629 mechanism)\n- Papers [4], [5], [9], [10], [11], [12]: Large-scale proteomics/interactome studies. No specific mechanistic findings about ZNF629. → EXCLUDE\n- Papers [6], [14], [15], [19], [20], [22], [23], [24], [25], [27], [29], [30]: About other proteins (VIRMA/m6A, p53/UFMylation, BRCA1-BARD1, bromodomain, EZH2, RNF4, U1-70K, Cbl-b, CIC, 14-3-3, GLDC, SLX4). → EXCLUDE (alias collision or unrelated)\n- Papers [1] (PMID:12477932): MGC cDNA sequencing — no specific ZNF629 mechanism. → EXCLUDE\n- Papers [13], [26], [28]: General zinc finger gene characterization papers. Not specific to ZNF629 mechanistic findings. → EXCLUDE\n- Papers [16], [17], [18], [21]: GWAS, transcription factor networks, proteome atlas, genetic interactions. No specific ZNF629 mechanism. → EXCLUDE\n- Paper [8]: GO phylogenetic annotation — no specific ZNF629 mechanism. → EXCLUDE\n\nAfter applying the ROUND-2 GUARD, **zero papers** contain mechanistic findings about ZNF629 specifically.\n\n```json\n{\n  \"discoveries\": [],\n  \"current_model\": \"No mechanistic findings about ZNF629 in the available literature (corpus appears contaminated with off-target papers).\"\n}\n```","stage2_raw":"\n\n--- ROUND 2 (refusal — no on-target evidence) ---\n"}