{"gene":"ZBTB26","run_date":"2026-06-11T09:02:06","timeline":{"discoveries":[{"year":2024,"finding":"BTB domains of certain ZBTB family members (including ZBTB8A and ZBTB18, with ZBTB26 predicted among up to 21 family members) form concentration-dependent higher-order filamentous assemblies; crystal structures of BTB-domain filaments were solved, and filamentation supports clustering of full-length proteins into dynamic nuclear foci and contributes to transcriptional repression.","method":"Crystal structure determination, solution-phase oligomerization assays, live-cell imaging of nuclear foci, reporter gene repression assay","journal":"Molecular cell","confidence":"Medium","confidence_rationale":"Tier 1 / Weak — crystal structures and in vitro assays are Tier 1 methods, but ZBTB26 itself is only predicted (not directly demonstrated) to share this filamentation behavior; direct experimental evidence is for ZBTB8A and ZBTB18","pmids":["38996459"],"is_preprint":false},{"year":2021,"finding":"Morpholino knockdown of zbtb26 in Xenopus laevis results in significantly smaller thyroid anlagen and reduced expression of PAX8 (a transcription factor required for thyroid development); this phenotype is rescued by adding back zbtb26, placing ZBTB26 upstream of PAX8 in thyroid development.","method":"Morpholino knockdown in Xenopus laevis, marker gene expression analysis, rescue experiment","journal":"Genes","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — clean loss-of-function with defined cellular phenotype and rescue experiment in a vertebrate model, single lab","pmids":["34946811"],"is_preprint":false},{"year":2026,"finding":"ZBTB26 physically interacts with the Integrator auxiliary module via INTS10 and INTS13, directly binds a specific DNA motif, co-occupies select promoters and enhancers with Integrator and active histone markers genome-wide, and is required for Integrator recruitment to target loci; the ZBTB26-Integrator axis sustains active chromatin states and drives transcriptional programs involved in stimulus response, development, and differentiation.","method":"Co-immunoprecipitation/interaction assays (ZBTB26–INTS10/INTS13), DNA-binding assay, ChIP-seq, loss-of-function (ZBTB26 depletion) with transcriptomic readout","journal":"FASEB journal","confidence":"High","confidence_rationale":"Tier 2 / Moderate — reciprocal protein interaction, direct DNA-binding, genome-wide occupancy by ChIP-seq, and functional loss-of-function all in one study; multiple orthogonal methods","pmids":["42219880"],"is_preprint":false},{"year":2024,"finding":"ACE transcription is regulated by ZBTB26, as demonstrated by chromatin immunoprecipitation and luciferase reporter assays in ccRCC cells.","method":"Chromatin immunoprecipitation (ChIP), luciferase reporter assay","journal":"Biologics : targets & therapy","confidence":"Medium","confidence_rationale":"Tier 2 / Weak — ChIP and reporter assay provide direct evidence of ZBTB26 binding and transcriptional regulation of ACE, but single lab and limited follow-up on ZBTB26 mechanism specifically","pmids":["39717370"],"is_preprint":false},{"year":2025,"finding":"The T allele of rs4573350 combined with cigarette smoke extract promotes ZBTB26 expression by modulating binding of transcription factor FOXA1 to the ZBTB26 locus; ZBTB26 in turn regulates tumorigenesis of lung squamous cell carcinoma in vitro and in vivo by affecting expression of PCNA, which promotes cell cycle progression.","method":"Allele-specific transcription factor binding assay (FOXA1), cell-based and xenograft (in vivo) functional experiments, PCNA expression measurement","journal":"Carcinogenesis","confidence":"Medium","confidence_rationale":"Tier 2 / Weak — direct binding assay for FOXA1 at ZBTB26 locus, in vitro and in vivo loss/gain-of-function with PCNA readout, but single lab and limited mechanistic depth on ZBTB26 itself","pmids":["40168134"],"is_preprint":false}],"current_model":"ZBTB26 is a BTB-zinc finger transcription factor that directly binds specific DNA motifs and recruits the Integrator auxiliary module (via INTS10/INTS13) to target promoters and enhancers to sustain active transcriptional programs; it functions upstream of PAX8 in thyroid development (established in Xenopus), transcriptionally activates ACE in renal cells, and regulates PCNA-dependent cell cycle progression in lung squamous cell carcinoma, while its BTB domain is predicted to support higher-order filamentous assemblies analogous to other ZBTB family members."},"narrative":{"mechanistic_narrative":"ZBTB26 is a BTB-zinc finger transcription factor that binds specific DNA motifs and shapes active transcriptional programs governing stimulus response, development, and differentiation [PMID:42219880]. It executes this role in part by physically recruiting the Integrator auxiliary module through interactions with INTS10 and INTS13, co-occupying promoters and enhancers marked by active histone modifications, where its depletion abolishes Integrator recruitment and disrupts the associated active chromatin states [PMID:42219880]. In developmental and disease contexts, ZBTB26 acts upstream of PAX8 to support thyroid anlagen formation in Xenopus [PMID:34946811], transcriptionally regulates ACE in renal carcinoma cells [PMID:39717370], and drives lung squamous cell carcinoma progression by modulating PCNA expression and cell cycle advance [PMID:40168134]. Its BTB domain is predicted, by analogy to related ZBTB members whose BTB domains form filamentous assemblies underlying nuclear foci and repression, to support higher-order assembly, though this behavior has been directly demonstrated only for other family members and not ZBTB26 itself [PMID:38996459].","teleology":[{"year":2021,"claim":"Established the first in vivo developmental role for ZBTB26, placing it genetically upstream of the master thyroid factor PAX8.","evidence":"Morpholino knockdown with rescue in Xenopus laevis and marker gene analysis","pmids":["34946811"],"confidence":"Medium","gaps":["Does not define the direct DNA targets or whether PAX8 regulation is direct","Single model organism, single lab","Molecular mechanism of transcriptional control not addressed"]},{"year":2024,"claim":"Demonstrated ZBTB26 acts as a direct transcriptional regulator of a defined target gene, ACE, in renal cancer cells.","evidence":"ChIP and luciferase reporter assays in ccRCC cells","pmids":["39717370"],"confidence":"Medium","gaps":["Cofactors and chromatin context of ACE regulation unknown","Whether activation or repression mechanism is used not resolved","Single cell-type context"]},{"year":2024,"claim":"Provided structural context for the BTB family, raising the possibility that ZBTB26 forms filamentous higher-order assemblies, but only by prediction.","evidence":"Crystal structures, oligomerization assays, and live-cell foci imaging of related ZBTB members (ZBTB8A, ZBTB18)","pmids":["38996459"],"confidence":"Medium","gaps":["ZBTB26 filamentation is predicted, not experimentally demonstrated","No structure of the ZBTB26 BTB domain","Functional consequence of any ZBTB26 assembly untested"]},{"year":2025,"claim":"Connected a smoking-associated regulatory variant to ZBTB26 expression and a downstream cell-cycle effector, defining an oncogenic axis in lung squamous cell carcinoma.","evidence":"Allele-specific FOXA1 binding assay at rs4573350 plus in vitro and xenograft functional assays with PCNA readout","pmids":["40168134"],"confidence":"Medium","gaps":["Whether ZBTB26 binds and regulates PCNA directly is not established","Single lab","Generalizability beyond lung SCC unknown"]},{"year":2026,"claim":"Defined the molecular mechanism of ZBTB26 action: direct DNA binding coupled to recruitment of the Integrator auxiliary module to sustain active chromatin and transcription genome-wide.","evidence":"Reciprocal Co-IP with INTS10/INTS13, DNA-binding assay, ChIP-seq co-occupancy, and depletion with transcriptomic readout","pmids":["42219880"],"confidence":"High","gaps":["Structural basis of the ZBTB26-INTS10/INTS13 interaction not resolved","Consensus DNA motif sequence and selectivity not fully characterized","Whether developmental and oncogenic roles operate through the Integrator axis untested"]},{"year":null,"claim":"Whether ZBTB26 itself forms BTB-domain filaments and whether its diverse phenotypic roles (thyroid development, ACE regulation, lung tumorigenesis) all funnel through the Integrator-recruitment mechanism remains unresolved.","evidence":"","pmids":[],"confidence":"Medium","gaps":["No direct demonstration of ZBTB26 self-assembly","No unifying mechanism linking the context-specific target genes","Activator vs repressor logic not consolidated across systems"]}],"mechanism_profile":{"molecular_activity":[{"term_id":"GO:0140110","term_label":"transcription regulator activity","supporting_discovery_ids":[1,2,3,4]},{"term_id":"GO:0003677","term_label":"DNA binding","supporting_discovery_ids":[2,3]},{"term_id":"GO:0060090","term_label":"molecular adaptor activity","supporting_discovery_ids":[2]}],"localization":[{"term_id":"GO:0005634","term_label":"nucleus","supporting_discovery_ids":[2]}],"pathway":[{"term_id":"R-HSA-74160","term_label":"Gene expression (Transcription)","supporting_discovery_ids":[2,3]},{"term_id":"R-HSA-1266738","term_label":"Developmental Biology","supporting_discovery_ids":[1,2]},{"term_id":"R-HSA-4839726","term_label":"Chromatin organization","supporting_discovery_ids":[2]}],"complexes":[],"partners":["INTS10","INTS13"],"other_free_text":[]}},"prefetch_data":{"uniprot":{"accession":"Q9HCK0","full_name":"Zinc finger and BTB domain-containing protein 26","aliases":["Zinc finger protein 481","Zinc finger protein Bioref"],"length_aa":441,"mass_kda":50.0,"function":"May be involved in transcriptional regulation","subcellular_location":"Nucleus","url":"https://www.uniprot.org/uniprotkb/Q9HCK0/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/ZBTB26","classification":"Not Classified","n_dependent_lines":0,"n_total_lines":1208,"dependency_fraction":0.0},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[],"url":"https://opencell.sf.czbiohub.org/search/ZBTB26","total_profiled":1310},"omim":[{"mim_id":"620164","title":"ZINC FINGER- AND BTB DOMAIN-CONTAINING PROTEIN 26; ZBTB26","url":"https://www.omim.org/entry/620164"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"","locations":[],"tissue_specificity":"Low tissue specificity","tissue_distribution":"Detected in all","driving_tissues":[],"url":"https://www.proteinatlas.org/search/ZBTB26"},"hgnc":{"alias_symbol":[],"prev_symbol":["ZNF481"]},"alphafold":{"accession":"Q9HCK0","domains":[{"cath_id":"3.30.710","chopping":"16-94","consensus_level":"high","plddt":45.5971,"start":16,"end":94},{"cath_id":"3.30.160.60","chopping":"298-351","consensus_level":"medium","plddt":78.5065,"start":298,"end":351},{"cath_id":"3.30.160","chopping":"355-382","consensus_level":"medium","plddt":76.8993,"start":355,"end":382}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q9HCK0","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q9HCK0-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q9HCK0-F1-predicted_aligned_error_v6.png","plddt_mean":53.53},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=ZBTB26","jax_strain_url":"https://www.jax.org/strain/search?query=ZBTB26"},"sequence":{"accession":"Q9HCK0","fasta_url":"https://rest.uniprot.org/uniprotkb/Q9HCK0.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q9HCK0/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q9HCK0"}},"corpus_meta":[{"pmid":"38996459","id":"PMC_38996459","title":"Dynamic BTB-domain filaments promote clustering of ZBTB proteins.","date":"2024","source":"Molecular cell","url":"https://pubmed.ncbi.nlm.nih.gov/38996459","citation_count":15,"is_preprint":false},{"pmid":"39717370","id":"PMC_39717370","title":"ACE Loss Drives Renal Cell Carcinoma Growth and Invasion by Modulating AKT-FOXO1.","date":"2024","source":"Biologics : targets & therapy","url":"https://pubmed.ncbi.nlm.nih.gov/39717370","citation_count":4,"is_preprint":false},{"pmid":"34946811","id":"PMC_34946811","title":"Identification of ZBTB26 as a Novel Risk Factor for Congenital Hypothyroidism.","date":"2021","source":"Genes","url":"https://pubmed.ncbi.nlm.nih.gov/34946811","citation_count":3,"is_preprint":false},{"pmid":"42219880","id":"PMC_42219880","title":"A ZBTB26-Integrator Axis Mediates Targeted Transcriptional Activation.","date":"2026","source":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","url":"https://pubmed.ncbi.nlm.nih.gov/42219880","citation_count":0,"is_preprint":false},{"pmid":"40168134","id":"PMC_40168134","title":"Genetic susceptibility to lung squamous cell carcinoma: new insights on 9q33.2 variants and tobacco smoking.","date":"2025","source":"Carcinogenesis","url":"https://pubmed.ncbi.nlm.nih.gov/40168134","citation_count":0,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":4708,"output_tokens":1395,"usd":0.017524,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":8080,"output_tokens":2167,"usd":0.047288,"stage2_stop_reason":"end_turn"},"total_usd":0.064812,"stage1_batch_id":"msgbatch_01UT1AahFPCAyn2uVweS7A9z","stage2_batch_id":"msgbatch_01HuKWtKNT4Pqj1bc8eEP5RV","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2024,\n      \"finding\": \"BTB domains of certain ZBTB family members (including ZBTB8A and ZBTB18, with ZBTB26 predicted among up to 21 family members) form concentration-dependent higher-order filamentous assemblies; crystal structures of BTB-domain filaments were solved, and filamentation supports clustering of full-length proteins into dynamic nuclear foci and contributes to transcriptional repression.\",\n      \"method\": \"Crystal structure determination, solution-phase oligomerization assays, live-cell imaging of nuclear foci, reporter gene repression assay\",\n      \"journal\": \"Molecular cell\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 1 / Weak — crystal structures and in vitro assays are Tier 1 methods, but ZBTB26 itself is only predicted (not directly demonstrated) to share this filamentation behavior; direct experimental evidence is for ZBTB8A and ZBTB18\",\n      \"pmids\": [\"38996459\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2021,\n      \"finding\": \"Morpholino knockdown of zbtb26 in Xenopus laevis results in significantly smaller thyroid anlagen and reduced expression of PAX8 (a transcription factor required for thyroid development); this phenotype is rescued by adding back zbtb26, placing ZBTB26 upstream of PAX8 in thyroid development.\",\n      \"method\": \"Morpholino knockdown in Xenopus laevis, marker gene expression analysis, rescue experiment\",\n      \"journal\": \"Genes\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — clean loss-of-function with defined cellular phenotype and rescue experiment in a vertebrate model, single lab\",\n      \"pmids\": [\"34946811\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2026,\n      \"finding\": \"ZBTB26 physically interacts with the Integrator auxiliary module via INTS10 and INTS13, directly binds a specific DNA motif, co-occupies select promoters and enhancers with Integrator and active histone markers genome-wide, and is required for Integrator recruitment to target loci; the ZBTB26-Integrator axis sustains active chromatin states and drives transcriptional programs involved in stimulus response, development, and differentiation.\",\n      \"method\": \"Co-immunoprecipitation/interaction assays (ZBTB26–INTS10/INTS13), DNA-binding assay, ChIP-seq, loss-of-function (ZBTB26 depletion) with transcriptomic readout\",\n      \"journal\": \"FASEB journal\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — reciprocal protein interaction, direct DNA-binding, genome-wide occupancy by ChIP-seq, and functional loss-of-function all in one study; multiple orthogonal methods\",\n      \"pmids\": [\"42219880\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2024,\n      \"finding\": \"ACE transcription is regulated by ZBTB26, as demonstrated by chromatin immunoprecipitation and luciferase reporter assays in ccRCC cells.\",\n      \"method\": \"Chromatin immunoprecipitation (ChIP), luciferase reporter assay\",\n      \"journal\": \"Biologics : targets & therapy\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Weak — ChIP and reporter assay provide direct evidence of ZBTB26 binding and transcriptional regulation of ACE, but single lab and limited follow-up on ZBTB26 mechanism specifically\",\n      \"pmids\": [\"39717370\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2025,\n      \"finding\": \"The T allele of rs4573350 combined with cigarette smoke extract promotes ZBTB26 expression by modulating binding of transcription factor FOXA1 to the ZBTB26 locus; ZBTB26 in turn regulates tumorigenesis of lung squamous cell carcinoma in vitro and in vivo by affecting expression of PCNA, which promotes cell cycle progression.\",\n      \"method\": \"Allele-specific transcription factor binding assay (FOXA1), cell-based and xenograft (in vivo) functional experiments, PCNA expression measurement\",\n      \"journal\": \"Carcinogenesis\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Weak — direct binding assay for FOXA1 at ZBTB26 locus, in vitro and in vivo loss/gain-of-function with PCNA readout, but single lab and limited mechanistic depth on ZBTB26 itself\",\n      \"pmids\": [\"40168134\"],\n      \"is_preprint\": false\n    }\n  ],\n  \"current_model\": \"ZBTB26 is a BTB-zinc finger transcription factor that directly binds specific DNA motifs and recruits the Integrator auxiliary module (via INTS10/INTS13) to target promoters and enhancers to sustain active transcriptional programs; it functions upstream of PAX8 in thyroid development (established in Xenopus), transcriptionally activates ACE in renal cells, and regulates PCNA-dependent cell cycle progression in lung squamous cell carcinoma, while its BTB domain is predicted to support higher-order filamentous assemblies analogous to other ZBTB family members.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"ZBTB26 is a BTB-zinc finger transcription factor that binds specific DNA motifs and shapes active transcriptional programs governing stimulus response, development, and differentiation [#2]. It executes this role in part by physically recruiting the Integrator auxiliary module through interactions with INTS10 and INTS13, co-occupying promoters and enhancers marked by active histone modifications, where its depletion abolishes Integrator recruitment and disrupts the associated active chromatin states [#2]. In developmental and disease contexts, ZBTB26 acts upstream of PAX8 to support thyroid anlagen formation in Xenopus [#1], transcriptionally regulates ACE in renal carcinoma cells [#3], and drives lung squamous cell carcinoma progression by modulating PCNA expression and cell cycle advance [#4]. Its BTB domain is predicted, by analogy to related ZBTB members whose BTB domains form filamentous assemblies underlying nuclear foci and repression, to support higher-order assembly, though this behavior has been directly demonstrated only for other family members and not ZBTB26 itself [#0].\",\n  \"teleology\": [\n    {\n      \"year\": 2021,\n      \"claim\": \"Established the first in vivo developmental role for ZBTB26, placing it genetically upstream of the master thyroid factor PAX8.\",\n      \"evidence\": \"Morpholino knockdown with rescue in Xenopus laevis and marker gene analysis\",\n      \"pmids\": [\"34946811\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\"Does not define the direct DNA targets or whether PAX8 regulation is direct\", \"Single model organism, single lab\", \"Molecular mechanism of transcriptional control not addressed\"]\n    },\n    {\n      \"year\": 2024,\n      \"claim\": \"Demonstrated ZBTB26 acts as a direct transcriptional regulator of a defined target gene, ACE, in renal cancer cells.\",\n      \"evidence\": \"ChIP and luciferase reporter assays in ccRCC cells\",\n      \"pmids\": [\"39717370\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\"Cofactors and chromatin context of ACE regulation unknown\", \"Whether activation or repression mechanism is used not resolved\", \"Single cell-type context\"]\n    },\n    {\n      \"year\": 2024,\n      \"claim\": \"Provided structural context for the BTB family, raising the possibility that ZBTB26 forms filamentous higher-order assemblies, but only by prediction.\",\n      \"evidence\": \"Crystal structures, oligomerization assays, and live-cell foci imaging of related ZBTB members (ZBTB8A, ZBTB18)\",\n      \"pmids\": [\"38996459\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\"ZBTB26 filamentation is predicted, not experimentally demonstrated\", \"No structure of the ZBTB26 BTB domain\", \"Functional consequence of any ZBTB26 assembly untested\"]\n    },\n    {\n      \"year\": 2025,\n      \"claim\": \"Connected a smoking-associated regulatory variant to ZBTB26 expression and a downstream cell-cycle effector, defining an oncogenic axis in lung squamous cell carcinoma.\",\n      \"evidence\": \"Allele-specific FOXA1 binding assay at rs4573350 plus in vitro and xenograft functional assays with PCNA readout\",\n      \"pmids\": [\"40168134\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\"Whether ZBTB26 binds and regulates PCNA directly is not established\", \"Single lab\", \"Generalizability beyond lung SCC unknown\"]\n    },\n    {\n      \"year\": 2026,\n      \"claim\": \"Defined the molecular mechanism of ZBTB26 action: direct DNA binding coupled to recruitment of the Integrator auxiliary module to sustain active chromatin and transcription genome-wide.\",\n      \"evidence\": \"Reciprocal Co-IP with INTS10/INTS13, DNA-binding assay, ChIP-seq co-occupancy, and depletion with transcriptomic readout\",\n      \"pmids\": [\"42219880\"],\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\"Structural basis of the ZBTB26-INTS10/INTS13 interaction not resolved\", \"Consensus DNA motif sequence and selectivity not fully characterized\", \"Whether developmental and oncogenic roles operate through the Integrator axis untested\"]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"Whether ZBTB26 itself forms BTB-domain filaments and whether its diverse phenotypic roles (thyroid development, ACE regulation, lung tumorigenesis) all funnel through the Integrator-recruitment mechanism remains unresolved.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\"No direct demonstration of ZBTB26 self-assembly\", \"No unifying mechanism linking the context-specific target genes\", \"Activator vs repressor logic not consolidated across systems\"]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\"term_id\": \"GO:0140110\", \"supporting_discovery_ids\": [1, 2, 3, 4]},\n      {\"term_id\": \"GO:0003677\", \"supporting_discovery_ids\": [2, 3]},\n      {\"term_id\": \"GO:0060090\", \"supporting_discovery_ids\": [2]}\n    ],\n    \"localization\": [\n      {\"term_id\": \"GO:0005634\", \"supporting_discovery_ids\": [2]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"R-HSA-74160\", \"supporting_discovery_ids\": [2, 3]},\n      {\"term_id\": \"R-HSA-1266738\", \"supporting_discovery_ids\": [1, 2]},\n      {\"term_id\": \"R-HSA-4839726\", \"supporting_discovery_ids\": [2]}\n    ],\n    \"complexes\": [],\n    \"partners\": [\"INTS10\", \"INTS13\"],\n    \"other_free_text\": []\n  }\n}","audit_flag":null,"evaluation":{"faith_supported":4,"faith_total":4,"faith_pct":100.0}}