{"gene":"WDR90","run_date":"2026-06-11T09:02:06","timeline":{"discoveries":[{"year":2017,"finding":"WDR90 (human homolog of Chlamydomonas POC16) localizes to a region of human centrioles analogous to the central core region of Chlamydomonas centrioles, and is required for ciliogenesis in human cells. POC16 in Chlamydomonas was identified as a central core region protein whose distribution correlates with tubulin glutamylation, and poc16 mutants exhibit flagellar defects.","method":"Quantitative mass spectrometry on purified Chlamydomonas centrioles, super-resolution microscopy, RNAi/knockdown with ciliogenesis readout in human cells","journal":"Current biology : CB","confidence":"High","confidence_rationale":"Tier 2 / Strong — multiple orthogonal methods (MS, super-resolution microscopy, functional knockdown) across two organisms, replicated in subsequent studies","pmids":["28781053"],"is_preprint":false},{"year":2020,"finding":"WDR90 is a component of the microtubule wall along the central core region of the centriole, functions as an evolutionarily conserved microtubule-associated protein, and its depletion impairs the localization of inner scaffold components leading to centriole structural abnormalities in human cells.","method":"Ultrastructure expansion microscopy (U-ExM) for nanoscale protein mapping, WDR90 depletion (knockdown) with structural phenotype readout in human cells","journal":"eLife","confidence":"High","confidence_rationale":"Tier 2 / Strong — nanoscale localization via U-ExM combined with functional depletion and structural phenotype, replicated across studies","pmids":["32946374"],"is_preprint":false},{"year":2017,"finding":"WDR90 was predicted and experimentally validated as a cilia basal body/centriolar satellite protein in a model vertebrate, consistent with a role in ciliopathy pathways.","method":"Computational prediction from hu.MAP protein complex map followed by in vivo validation in a model vertebrate (zebrafish)","journal":"Molecular systems biology","confidence":"Medium","confidence_rationale":"Tier 3 / Moderate — in vivo validation in vertebrate model, but derived from large-scale interactome map with limited mechanistic detail specific to WDR90","pmids":["28596423"],"is_preprint":false},{"year":2022,"finding":"CEP350 controls centriolar localization of WDR90, and the CEP350-FOP-WDR90 axis secures centriole integrity. Loss of CEP350 disrupts WDR90 localization at centrioles.","method":"Genetic knockout (CEP350-/-) with immunofluorescence readout of WDR90 localization; epistasis analysis of CEP350-FOP-WDR90 pathway","journal":"The Journal of cell biology","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — clean KO with defined localization phenotype and pathway placement, single lab","pmids":["36315013"],"is_preprint":false},{"year":2019,"finding":"WDR90 is a component of the NLRC4 inflammasome; it physically interacts with NLRC4 (but not NLRP3 or AIM2), alters the cellular distribution of NLRC4, acts upstream of Caspa/caspase-1 and ASC, and its forced expression increases caspase-1 activity and resistance to Salmonella Typhimurium infection in zebrafish.","method":"Co-immunoprecipitation in HEK293 reconstitution experiments, overexpression in zebrafish larvae with caspase-1 activity assay and infection survival readout, epistasis (wdr90 acts upstream of Caspa and Asc)","journal":"Developmental and comparative immunology","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — Co-IP plus functional in vivo epistasis in zebrafish and reconstitution in human HEK293 cells, single lab, two orthogonal approaches","pmids":["31276698"],"is_preprint":false}],"current_model":"WDR90 is an evolutionarily conserved microtubule-associated protein that localizes to the central core region of centrioles, where it maintains centriole structural integrity by supporting inner scaffold component localization (downstream of CEP350-FOP axis); it is required for ciliogenesis, and has also been identified as a physical interactor of NLRC4 that acts upstream of caspase-1 in inflammasome signaling."},"narrative":{"mechanistic_narrative":"WDR90 is an evolutionarily conserved microtubule-associated protein that localizes to the central core region of centrioles and is required for ciliogenesis [PMID:28781053]. It is integrated into the microtubule wall along the centriole central core, where its depletion impairs the recruitment of inner scaffold components and produces centriole structural abnormalities, establishing WDR90 as a determinant of centriole integrity [PMID:32946374]. Its centriolar recruitment is governed by CEP350 as part of a CEP350–FOP–WDR90 axis that secures centriole architecture [PMID:36315013]. Independent of this centriolar role, WDR90 physically associates with NLRC4 (but not NLRP3 or AIM2), alters NLRC4 distribution, and acts upstream of caspase-1 and ASC to potentiate inflammasome activity and antibacterial defense [PMID:31276698].","teleology":[{"year":2017,"claim":"Established WDR90 as the human homolog of a centriolar central core protein and tied it to ciliogenesis, defining its core cellular compartment and function.","evidence":"Quantitative mass spectrometry on purified Chlamydomonas centrioles, super-resolution microscopy, and RNAi knockdown with ciliogenesis readout in human cells","pmids":["28781053"],"confidence":"High","gaps":["Molecular mechanism by which WDR90 supports ciliogenesis not resolved","Direct microtubule-binding biochemistry not established at this stage"]},{"year":2017,"claim":"Independent interactome-based prediction and vertebrate validation reinforced WDR90 as a basal body/centriolar satellite protein within ciliopathy pathways.","evidence":"Computational prediction from hu.MAP protein complex map with in vivo zebrafish validation","pmids":["28596423"],"confidence":"Medium","gaps":["Derived from large-scale interactome with limited WDR90-specific mechanism","Specific complex partners not defined"]},{"year":2019,"claim":"Identified a non-centriolar role: WDR90 as a selective NLRC4 inflammasome component acting upstream of caspase-1, expanding its functional scope into innate immunity.","evidence":"Co-IP in HEK293 reconstitution, zebrafish overexpression with caspase-1 activity and Salmonella infection survival assays, and epistasis placing wdr90 upstream of Caspa and Asc","pmids":["31276698"],"confidence":"Medium","gaps":["Single lab; reciprocal validation of the NLRC4 interaction in human cells limited","Relationship between centriolar and inflammasome functions unknown","Direct binding interface with NLRC4 not mapped"]},{"year":2020,"claim":"Resolved where WDR90 sits at nanoscale and what it does there—mapping it to the centriole microtubule wall and showing it is required for inner scaffold component localization and structural integrity.","evidence":"Ultrastructure expansion microscopy (U-ExM) with WDR90 depletion and structural phenotype readout in human cells","pmids":["32946374"],"confidence":"High","gaps":["Direct biochemical interactions with inner scaffold proteins not defined","Whether WDR90 binds microtubules directly versus via partners not resolved"]},{"year":2022,"claim":"Placed WDR90 in an ordered recruitment pathway, showing CEP350 controls its centriolar localization via a CEP350-FOP-WDR90 axis.","evidence":"CEP350 knockout with immunofluorescence readout of WDR90 localization and epistasis analysis","pmids":["36315013"],"confidence":"Medium","gaps":["Single lab","Direct versus indirect dependency on FOP not biochemically dissected","Molecular nature of the CEP350-WDR90 connection unknown"]},{"year":null,"claim":"How WDR90's centriolar scaffold function relates to its NLRC4 inflammasome role, and whether these reflect distinct pools or a shared mechanism, remains unresolved.","evidence":"","pmids":[],"confidence":"Medium","gaps":["No mechanistic link between centriole and inflammasome functions","No structural model of WDR90 in either context","Direct microtubule- and partner-binding biochemistry not established"]}],"mechanism_profile":{"molecular_activity":[{"term_id":"GO:0008092","term_label":"cytoskeletal protein binding","supporting_discovery_ids":[0,1]}],"localization":[{"term_id":"GO:0005929","term_label":"cilium","supporting_discovery_ids":[0]},{"term_id":"GO:0005815","term_label":"microtubule organizing center","supporting_discovery_ids":[2]}],"pathway":[{"term_id":"R-HSA-1852241","term_label":"Organelle biogenesis and maintenance","supporting_discovery_ids":[0,1]},{"term_id":"R-HSA-168256","term_label":"Immune System","supporting_discovery_ids":[4]}],"complexes":["NLRC4 inflammasome"],"partners":["NLRC4","CEP350"],"other_free_text":[]}},"prefetch_data":{"uniprot":{"accession":"Q96KV7","full_name":"WD repeat-containing protein 90","aliases":[],"length_aa":1748,"mass_kda":187.4,"function":"Microtubule-binding protein that plays a crucial role in ensuring inner core protein localization within the centriole core, as well as in maintaining the microtubule wall integrity and the overall centriole roundness and stability (PubMed:32946374). Required for efficient primary cilium formation (PubMed:28781053)","subcellular_location":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite","url":"https://www.uniprot.org/uniprotkb/Q96KV7/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/WDR90","classification":"Not Classified","n_dependent_lines":0,"n_total_lines":1208,"dependency_fraction":0.0},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[],"url":"https://opencell.sf.czbiohub.org/search/WDR90","total_profiled":1310},"omim":[{"mim_id":"618290","title":"WD REPEAT-CONTAINING PROTEIN 90; WDR90","url":"https://www.omim.org/entry/618290"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Supported","locations":[{"location":"Centrosome","reliability":"Supported"},{"location":"Basal body","reliability":"Supported"},{"location":"Plasma membrane","reliability":"Additional"}],"tissue_specificity":"Tissue enhanced","tissue_distribution":"Detected in all","driving_tissues":[{"tissue":"testis","ntpm":59.4}],"url":"https://www.proteinatlas.org/search/WDR90"},"hgnc":{"alias_symbol":["FLJ36483","KIAA1924","POC16"],"prev_symbol":["C16orf17","C16orf15","C16orf16","C16orf19","C16orf18"]},"alphafold":{"accession":"Q96KV7","domains":[{"cath_id":"2.60.120","chopping":"10-225","consensus_level":"high","plddt":79.8279,"start":10,"end":225},{"cath_id":"2.130.10.10","chopping":"709-829","consensus_level":"medium","plddt":89.3939,"start":709,"end":829},{"cath_id":"2.130.10.10","chopping":"1125-1248","consensus_level":"medium","plddt":86.074,"start":1125,"end":1248},{"cath_id":"2.130.10.10","chopping":"1262-1433","consensus_level":"medium","plddt":84.6644,"start":1262,"end":1433},{"cath_id":"2.130.10.10","chopping":"1438-1559","consensus_level":"medium","plddt":88.6823,"start":1438,"end":1559}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q96KV7","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q96KV7-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q96KV7-F1-predicted_aligned_error_v6.png","plddt_mean":77.0},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=WDR90","jax_strain_url":"https://www.jax.org/strain/search?query=WDR90"},"sequence":{"accession":"Q96KV7","fasta_url":"https://rest.uniprot.org/uniprotkb/Q96KV7.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q96KV7/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q96KV7"}},"corpus_meta":[{"pmid":"28596423","id":"PMC_28596423","title":"Integration of over 9,000 mass spectrometry experiments builds a global map of human protein complexes.","date":"2017","source":"Molecular systems biology","url":"https://pubmed.ncbi.nlm.nih.gov/28596423","citation_count":144,"is_preprint":false},{"pmid":"32946374","id":"PMC_32946374","title":"WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity.","date":"2020","source":"eLife","url":"https://pubmed.ncbi.nlm.nih.gov/32946374","citation_count":50,"is_preprint":false},{"pmid":"28781053","id":"PMC_28781053","title":"Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis.","date":"2017","source":"Current biology : CB","url":"https://pubmed.ncbi.nlm.nih.gov/28781053","citation_count":47,"is_preprint":false},{"pmid":"36315013","id":"PMC_36315013","title":"The central scaffold protein CEP350 coordinates centriole length, stability, and maturation.","date":"2022","source":"The Journal of cell biology","url":"https://pubmed.ncbi.nlm.nih.gov/36315013","citation_count":17,"is_preprint":false},{"pmid":"35564499","id":"PMC_35564499","title":"Global DNA Methylation Profiles in Peripheral Blood of WTC-Exposed Community Members with Breast Cancer.","date":"2022","source":"International journal of environmental research and public health","url":"https://pubmed.ncbi.nlm.nih.gov/35564499","citation_count":8,"is_preprint":false},{"pmid":"31276698","id":"PMC_31276698","title":"WDR90 is a new component of the NLRC4 inflammasome involved in Salmonella Typhimurium resistance.","date":"2019","source":"Developmental and comparative immunology","url":"https://pubmed.ncbi.nlm.nih.gov/31276698","citation_count":7,"is_preprint":false},{"pmid":"38571402","id":"PMC_38571402","title":"Perturbation of the insomnia WDR90 genome-wide association studies locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q.","date":"2024","source":"Sleep","url":"https://pubmed.ncbi.nlm.nih.gov/38571402","citation_count":3,"is_preprint":false},{"pmid":"37645863","id":"PMC_37645863","title":"Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q.","date":"2023","source":"bioRxiv : the preprint server for biology","url":"https://pubmed.ncbi.nlm.nih.gov/37645863","citation_count":1,"is_preprint":false},{"pmid":"41026804","id":"PMC_41026804","title":"Meta-evolutionary exome analysis identifies novel type 2 diabetes mellitus genes in the UK Biobank and all of us.","date":"2025","source":"PLoS genetics","url":"https://pubmed.ncbi.nlm.nih.gov/41026804","citation_count":0,"is_preprint":false},{"pmid":"41387293","id":"PMC_41387293","title":"Primary Cutaneous CD30-Positive Lymphoproliferative Disorder With Gamma-Delta T-Cells: A Molecular-Annotated Case With a Classic Clinical Appearance and Behavior.","date":"2025","source":"Journal of cutaneous pathology","url":"https://pubmed.ncbi.nlm.nih.gov/41387293","citation_count":0,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":7453,"output_tokens":1279,"usd":0.020772,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":7861,"output_tokens":1935,"usd":0.04384,"stage2_stop_reason":"end_turn"},"total_usd":0.064612,"stage1_batch_id":"msgbatch_01UT1AahFPCAyn2uVweS7A9z","stage2_batch_id":"msgbatch_01HuKWtKNT4Pqj1bc8eEP5RV","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2017,\n      \"finding\": \"WDR90 (human homolog of Chlamydomonas POC16) localizes to a region of human centrioles analogous to the central core region of Chlamydomonas centrioles, and is required for ciliogenesis in human cells. POC16 in Chlamydomonas was identified as a central core region protein whose distribution correlates with tubulin glutamylation, and poc16 mutants exhibit flagellar defects.\",\n      \"method\": \"Quantitative mass spectrometry on purified Chlamydomonas centrioles, super-resolution microscopy, RNAi/knockdown with ciliogenesis readout in human cells\",\n      \"journal\": \"Current biology : CB\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Strong — multiple orthogonal methods (MS, super-resolution microscopy, functional knockdown) across two organisms, replicated in subsequent studies\",\n      \"pmids\": [\"28781053\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2020,\n      \"finding\": \"WDR90 is a component of the microtubule wall along the central core region of the centriole, functions as an evolutionarily conserved microtubule-associated protein, and its depletion impairs the localization of inner scaffold components leading to centriole structural abnormalities in human cells.\",\n      \"method\": \"Ultrastructure expansion microscopy (U-ExM) for nanoscale protein mapping, WDR90 depletion (knockdown) with structural phenotype readout in human cells\",\n      \"journal\": \"eLife\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Strong — nanoscale localization via U-ExM combined with functional depletion and structural phenotype, replicated across studies\",\n      \"pmids\": [\"32946374\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2017,\n      \"finding\": \"WDR90 was predicted and experimentally validated as a cilia basal body/centriolar satellite protein in a model vertebrate, consistent with a role in ciliopathy pathways.\",\n      \"method\": \"Computational prediction from hu.MAP protein complex map followed by in vivo validation in a model vertebrate (zebrafish)\",\n      \"journal\": \"Molecular systems biology\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 3 / Moderate — in vivo validation in vertebrate model, but derived from large-scale interactome map with limited mechanistic detail specific to WDR90\",\n      \"pmids\": [\"28596423\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2022,\n      \"finding\": \"CEP350 controls centriolar localization of WDR90, and the CEP350-FOP-WDR90 axis secures centriole integrity. Loss of CEP350 disrupts WDR90 localization at centrioles.\",\n      \"method\": \"Genetic knockout (CEP350-/-) with immunofluorescence readout of WDR90 localization; epistasis analysis of CEP350-FOP-WDR90 pathway\",\n      \"journal\": \"The Journal of cell biology\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — clean KO with defined localization phenotype and pathway placement, single lab\",\n      \"pmids\": [\"36315013\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2019,\n      \"finding\": \"WDR90 is a component of the NLRC4 inflammasome; it physically interacts with NLRC4 (but not NLRP3 or AIM2), alters the cellular distribution of NLRC4, acts upstream of Caspa/caspase-1 and ASC, and its forced expression increases caspase-1 activity and resistance to Salmonella Typhimurium infection in zebrafish.\",\n      \"method\": \"Co-immunoprecipitation in HEK293 reconstitution experiments, overexpression in zebrafish larvae with caspase-1 activity assay and infection survival readout, epistasis (wdr90 acts upstream of Caspa and Asc)\",\n      \"journal\": \"Developmental and comparative immunology\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — Co-IP plus functional in vivo epistasis in zebrafish and reconstitution in human HEK293 cells, single lab, two orthogonal approaches\",\n      \"pmids\": [\"31276698\"],\n      \"is_preprint\": false\n    }\n  ],\n  \"current_model\": \"WDR90 is an evolutionarily conserved microtubule-associated protein that localizes to the central core region of centrioles, where it maintains centriole structural integrity by supporting inner scaffold component localization (downstream of CEP350-FOP axis); it is required for ciliogenesis, and has also been identified as a physical interactor of NLRC4 that acts upstream of caspase-1 in inflammasome signaling.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"WDR90 is an evolutionarily conserved microtubule-associated protein that localizes to the central core region of centrioles and is required for ciliogenesis [#0]. It is integrated into the microtubule wall along the centriole central core, where its depletion impairs the recruitment of inner scaffold components and produces centriole structural abnormalities, establishing WDR90 as a determinant of centriole integrity [#1]. Its centriolar recruitment is governed by CEP350 as part of a CEP350–FOP–WDR90 axis that secures centriole architecture [#3]. Independent of this centriolar role, WDR90 physically associates with NLRC4 (but not NLRP3 or AIM2), alters NLRC4 distribution, and acts upstream of caspase-1 and ASC to potentiate inflammasome activity and antibacterial defense [#4].\",\n  \"teleology\": [\n    {\n      \"year\": 2017,\n      \"claim\": \"Established WDR90 as the human homolog of a centriolar central core protein and tied it to ciliogenesis, defining its core cellular compartment and function.\",\n      \"evidence\": \"Quantitative mass spectrometry on purified Chlamydomonas centrioles, super-resolution microscopy, and RNAi knockdown with ciliogenesis readout in human cells\",\n      \"pmids\": [\"28781053\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"Molecular mechanism by which WDR90 supports ciliogenesis not resolved\", \"Direct microtubule-binding biochemistry not established at this stage\"]\n    },\n    {\n      \"year\": 2017,\n      \"claim\": \"Independent interactome-based prediction and vertebrate validation reinforced WDR90 as a basal body/centriolar satellite protein within ciliopathy pathways.\",\n      \"evidence\": \"Computational prediction from hu.MAP protein complex map with in vivo zebrafish validation\",\n      \"pmids\": [\"28596423\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Derived from large-scale interactome with limited WDR90-specific mechanism\", \"Specific complex partners not defined\"]\n    },\n    {\n      \"year\": 2019,\n      \"claim\": \"Identified a non-centriolar role: WDR90 as a selective NLRC4 inflammasome component acting upstream of caspase-1, expanding its functional scope into innate immunity.\",\n      \"evidence\": \"Co-IP in HEK293 reconstitution, zebrafish overexpression with caspase-1 activity and Salmonella infection survival assays, and epistasis placing wdr90 upstream of Caspa and Asc\",\n      \"pmids\": [\"31276698\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Single lab; reciprocal validation of the NLRC4 interaction in human cells limited\", \"Relationship between centriolar and inflammasome functions unknown\", \"Direct binding interface with NLRC4 not mapped\"]\n    },\n    {\n      \"year\": 2020,\n      \"claim\": \"Resolved where WDR90 sits at nanoscale and what it does there—mapping it to the centriole microtubule wall and showing it is required for inner scaffold component localization and structural integrity.\",\n      \"evidence\": \"Ultrastructure expansion microscopy (U-ExM) with WDR90 depletion and structural phenotype readout in human cells\",\n      \"pmids\": [\"32946374\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"Direct biochemical interactions with inner scaffold proteins not defined\", \"Whether WDR90 binds microtubules directly versus via partners not resolved\"]\n    },\n    {\n      \"year\": 2022,\n      \"claim\": \"Placed WDR90 in an ordered recruitment pathway, showing CEP350 controls its centriolar localization via a CEP350-FOP-WDR90 axis.\",\n      \"evidence\": \"CEP350 knockout with immunofluorescence readout of WDR90 localization and epistasis analysis\",\n      \"pmids\": [\"36315013\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Single lab\", \"Direct versus indirect dependency on FOP not biochemically dissected\", \"Molecular nature of the CEP350-WDR90 connection unknown\"]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"How WDR90's centriolar scaffold function relates to its NLRC4 inflammasome role, and whether these reflect distinct pools or a shared mechanism, remains unresolved.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"No mechanistic link between centriole and inflammasome functions\", \"No structural model of WDR90 in either context\", \"Direct microtubule- and partner-binding biochemistry not established\"]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\"term_id\": \"GO:0008092\", \"supporting_discovery_ids\": [0, 1]}\n    ],\n    \"localization\": [\n      {\"term_id\": \"GO:0005814\", \"supporting_discovery_ids\": [0, 1, 3]},\n      {\"term_id\": \"GO:0005929\", \"supporting_discovery_ids\": [0]},\n      {\"term_id\": \"GO:0005815\", \"supporting_discovery_ids\": [2]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"R-HSA-1852241\", \"supporting_discovery_ids\": [0, 1]},\n      {\"term_id\": \"R-HSA-168256\", \"supporting_discovery_ids\": [4]}\n    ],\n    \"complexes\": [\"NLRC4 inflammasome\"],\n    \"partners\": [\"NLRC4\", \"CEP350\"],\n    \"other_free_text\": []\n  }\n}","audit_flag":null,"evaluation":{"pairwise":"win","faith_supported":4,"faith_total":4,"faith_pct":100.0}}