{"gene":"TEX15","run_date":"2026-06-10T10:51:54","timeline":{"discoveries":[{"year":2008,"finding":"TEX15 is required for loading of DNA repair proteins RAD51 and DMC1 onto sites of meiotic DNA double-strand breaks (DSBs) in spermatocytes. Loss of TEX15 in male mice causes failure of chromosomal synapsis and meiotic arrest; DSBs form normally but RAD51/DMC1 localization to meiotic chromosomes is severely impaired.","method":"Knockout mouse model with immunofluorescence localization of RAD51 and DMC1 on meiotic chromosomes; cytological analysis of chromosomal synapsis","journal":"The Journal of cell biology","confidence":"High","confidence_rationale":"Tier 2 / Strong — clean KO mouse with defined cellular phenotype and direct localization experiments showing specific failure of RAD51/DMC1 loading, replicated across multiple analyses in one rigorous study","pmids":["18283110"],"is_preprint":false},{"year":2020,"finding":"TEX15 associates with the PIWI protein MIWI2 in fetal gonocytes and is required for piRNA-directed de novo DNA methylation of transposable elements (TEs), but is not required for piRNA biogenesis itself. TEX15 is predominantly a nuclear protein in this context.","method":"Co-immunoprecipitation (MIWI2–TEX15 association), knockout mouse model with bisulfite sequencing for TE methylation, small RNA sequencing for piRNA levels, subcellular fractionation/immunofluorescence for localization","journal":"Nature communications","confidence":"High","confidence_rationale":"Tier 2 / Moderate — reciprocal Co-IP plus KO with orthogonal methylation sequencing and piRNA profiling in a single rigorous study establishing nuclear localization and downstream function","pmids":["32719317"],"is_preprint":false},{"year":2020,"finding":"TEX15 associates with the PIWI protein MILI in testis and is required for TE silencing by DNA methylation. Loss of TEX15 causes DNA hypomethylation at TEs at a level similar to Mili and Dnmt3c mutants but not Miwi2 mutants, suggesting TEX15 functions as a nuclear effector of MILI-directed TE silencing. piRNA production remains intact in Tex15 mutants.","method":"Co-immunoprecipitation (TEX15–MILI), knockout mouse model with whole-genome bisulfite sequencing, RNA-seq for TE expression, small RNA sequencing for piRNAs","journal":"Genes & development","confidence":"High","confidence_rationale":"Tier 2 / Moderate — Co-IP plus KO with orthogonal bisulfite sequencing, RNA-seq, and small RNA profiling, with genetic epistasis via comparison to Mili/Miwi2/Dnmt3c mutants placing TEX15 in the MILI branch","pmids":["32381626"],"is_preprint":false},{"year":2025,"finding":"Tex15 is transiently expressed in vomeronasal sensory neuron (VSN) precursors and is required for diverse vomeronasal receptor (VR) choice. Loss of Tex15 results in a dysregulated and less diverse repertoire of V1R- and V2R-expressing cells, reduced activation of the Accessory Olfactory Bulb after male odorant exposure, and loss of stereotyped intermale aggression.","method":"Knockout mouse model, immunofluorescence/in situ hybridization for VR expression, AOB activation assays, behavioral aggression assays","journal":"bioRxiv","confidence":"Medium","confidence_rationale":"Tier 2 / Weak — clean KO with defined cellular and behavioral phenotype, single lab preprint, no independent replication","pmids":["41415471"],"is_preprint":true}],"current_model":"TEX15 is a testis-enriched nuclear protein that acts downstream of the PIWI pathway to silence transposable elements via DNA methylation (associating with both MIWI2 and MILI to direct de novo methylation without affecting piRNA biogenesis), and independently regulates the loading of meiotic DNA repair proteins RAD51 and DMC1 onto double-strand break sites to enable chromosomal synapsis; additionally, transient expression of TEX15 in vomeronasal sensory neuron precursors is required for diverse olfactory receptor gene choice."},"narrative":{"mechanistic_narrative":"TEX15 is a testis-enriched nuclear protein with dual roles in meiotic genome maintenance and piRNA-directed transposon silencing [PMID:18283110, PMID:32381626]. During male meiosis it is required for loading of the recombinases RAD51 and DMC1 onto sites of programmed DNA double-strand breaks; in its absence DSBs form normally but recombinase recruitment fails, blocking chromosomal synapsis and arresting meiosis [PMID:18283110]. In fetal and postnatal germ cells TEX15 functions as a nuclear effector of the PIWI pathway: it physically associates with the PIWI proteins MIWI2 and MILI and is required for de novo DNA methylation that silences transposable elements, while piRNA biogenesis remains intact [PMID:32719317, PMID:32381626]. Genetic epistasis places TEX15 in the MILI branch of this pathway, with TE hypomethylation in Tex15 mutants paralleling that of Mili and Dnmt3c mutants [PMID:32381626]. Beyond germ cells, transient TEX15 expression in vomeronasal sensory neuron precursors is required for diverse vomeronasal receptor gene choice and stereotyped intermale aggression [PMID:41415471].","teleology":[{"year":2008,"claim":"Established the first mechanistic role for TEX15 by showing it is required for recombinase loading at meiotic DSBs, separating break formation from repair-protein recruitment.","evidence":"Knockout mouse with immunofluorescence localization of RAD51/DMC1 on meiotic chromosomes and cytological synapsis analysis","pmids":["18283110"],"confidence":"High","gaps":["Does not define how TEX15 promotes RAD51/DMC1 loading at the molecular level","No direct biochemical interaction with the recombinases shown","Relationship to its later-described piRNA role unaddressed"]},{"year":2020,"claim":"Placed TEX15 downstream of the PIWI pathway as a nuclear effector of piRNA-directed de novo TE methylation, distinguishing its role from piRNA production.","evidence":"Reciprocal Co-IP (MIWI2–TEX15 and TEX15–MILI), knockout mice with bisulfite/whole-genome bisulfite sequencing, RNA-seq, and small RNA sequencing; epistasis against Mili/Miwi2/Dnmt3c mutants","pmids":["32719317","32381626"],"confidence":"High","gaps":["Mechanism by which TEX15 directs DNMT machinery to TE loci not resolved","How nuclear TEX15 links cytoplasmic piRNA signals to methylation unclear","Relationship between the MIWI2 and MILI associations not reconciled"]},{"year":2025,"claim":"Extended TEX15 function beyond germ cells, implicating transient expression in vomeronasal neuron precursors in receptor gene choice and innate behavior.","evidence":"Knockout mouse, immunofluorescence/in situ for VR expression, AOB activation assays, behavioral aggression assays (preprint)","pmids":["41415471"],"confidence":"Medium","gaps":["Single-lab preprint without independent replication","Molecular mechanism linking TEX15 to receptor gene choice unknown","Whether the methylation/chromatin functions seen in germ cells operate in neurons untested"]},{"year":null,"claim":"How a single nuclear protein mechanistically bridges recombinase loading, piRNA-directed methylation, and neuronal receptor choice remains unresolved.","evidence":"","pmids":[],"confidence":"Low","gaps":["No structural or biochemical model of TEX15 domains and partners","No identified direct enzymatic activity","Unclear whether the three roles share a common molecular mechanism"]}],"mechanism_profile":{"molecular_activity":[],"localization":[{"term_id":"GO:0005634","term_label":"nucleus","supporting_discovery_ids":[1,2]}],"pathway":[{"term_id":"R-HSA-73894","term_label":"DNA Repair","supporting_discovery_ids":[0]},{"term_id":"R-HSA-4839726","term_label":"Chromatin organization","supporting_discovery_ids":[1,2]},{"term_id":"R-HSA-1474165","term_label":"Reproduction","supporting_discovery_ids":[0]}],"complexes":[],"partners":["MIWI2","MILI"],"other_free_text":[]}},"prefetch_data":{"uniprot":{"accession":"Q9BXT5","full_name":"Testis-expressed protein 15","aliases":["Cancer/testis antigen 42","CT42"],"length_aa":2789,"mass_kda":315.3,"function":"Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair (By similarity). Essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (By similarity). PIWIL4-piRNA binds to nascent transposon transcripts and interacts with TEX15, which may in turn recruit the epigenetic silencing machinery to the transposon loci (By similarity). Not required for piRNA biosynthesis (By similarity)","subcellular_location":"Cytoplasm; Nucleus","url":"https://www.uniprot.org/uniprotkb/Q9BXT5/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/TEX15","classification":"Not Classified","n_dependent_lines":0,"n_total_lines":1208,"dependency_fraction":0.0},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[],"url":"https://opencell.sf.czbiohub.org/search/TEX15","total_profiled":1310},"omim":[{"mim_id":"617960","title":"SPERMATOGENIC FAILURE 25; SPGF25","url":"https://www.omim.org/entry/617960"},{"mim_id":"616729","title":"OLFACTORY RECEPTOR, FAMILY 2, SUBFAMILY W, MEMBER 3; OR2W3","url":"https://www.omim.org/entry/616729"},{"mim_id":"611127","title":"UBIQUITIN-LIKE 4B; UBL4B","url":"https://www.omim.org/entry/611127"},{"mim_id":"605795","title":"TESTIS-EXPRESSED GENE 15; TEX15","url":"https://www.omim.org/entry/605795"},{"mim_id":"258150","title":"SPERMATOGENIC FAILURE 1; SPGF1","url":"https://www.omim.org/entry/258150"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Approved","locations":[{"location":"Nucleoplasm","reliability":"Approved"},{"location":"Cytosol","reliability":"Approved"}],"tissue_specificity":"Group enriched","tissue_distribution":"Detected in some","driving_tissues":[{"tissue":"endometrium 1","ntpm":6.3},{"tissue":"smooth muscle","ntpm":4.9},{"tissue":"testis","ntpm":11.3}],"url":"https://www.proteinatlas.org/search/TEX15"},"hgnc":{"alias_symbol":["CT42"],"prev_symbol":[]},"alphafold":{"accession":"Q9BXT5","domains":[],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q9BXT5","model_url":"","pae_url":"","plddt_mean":null},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=TEX15","jax_strain_url":"https://www.jax.org/strain/search?query=TEX15"},"sequence":{"accession":"Q9BXT5","fasta_url":"https://rest.uniprot.org/uniprotkb/Q9BXT5.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q9BXT5/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q9BXT5"}},"corpus_meta":[{"pmid":"18283110","id":"PMC_18283110","title":"Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis.","date":"2008","source":"The Journal of cell biology","url":"https://pubmed.ncbi.nlm.nih.gov/18283110","citation_count":117,"is_preprint":false},{"pmid":"26199321","id":"PMC_26199321","title":"Exome sequencing reveals a nonsense mutation in TEX15 causing spermatogenic failure in a Turkish family.","date":"2015","source":"Human molecular genetics","url":"https://pubmed.ncbi.nlm.nih.gov/26199321","citation_count":95,"is_preprint":false},{"pmid":"32719317","id":"PMC_32719317","title":"TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.","date":"2020","source":"Nature communications","url":"https://pubmed.ncbi.nlm.nih.gov/32719317","citation_count":55,"is_preprint":false},{"pmid":"32381626","id":"PMC_32381626","title":"TEX15 associates with MILI and silences transposable elements in male germ cells.","date":"2020","source":"Genes & development","url":"https://pubmed.ncbi.nlm.nih.gov/32381626","citation_count":44,"is_preprint":false},{"pmid":"28355598","id":"PMC_28355598","title":"Two Novel TEX15 Mutations in a Family with Nonobstructive Azoospermia.","date":"2017","source":"Gynecologic and obstetric investigation","url":"https://pubmed.ncbi.nlm.nih.gov/28355598","citation_count":41,"is_preprint":false},{"pmid":"22016351","id":"PMC_22016351","title":"Association study of single-nucleotide polymorphisms in FASLG, JMJDIA, LOC203413, TEX15, BRDT, OR2W3, INSR, and TAS2R38 genes with male infertility.","date":"2011","source":"Journal of andrology","url":"https://pubmed.ncbi.nlm.nih.gov/22016351","citation_count":37,"is_preprint":false},{"pmid":"29932616","id":"PMC_29932616","title":"Expression analysis of genes encoding TEX11, TEX12, TEX14 and TEX15 in testis tissues of men with non-obstructive azoospermia.","date":"2018","source":"JBRA assisted reproduction","url":"https://pubmed.ncbi.nlm.nih.gov/29932616","citation_count":27,"is_preprint":false},{"pmid":"22581801","id":"PMC_22581801","title":"Genetic variants in TEX15 gene conferred susceptibility to spermatogenic failure in the Chinese Han population.","date":"2012","source":"Reproductive sciences (Thousand Oaks, Calif.)","url":"https://pubmed.ncbi.nlm.nih.gov/22581801","citation_count":25,"is_preprint":false},{"pmid":"28386063","id":"PMC_28386063","title":"Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility.","date":"2017","source":"Scientific reports","url":"https://pubmed.ncbi.nlm.nih.gov/28386063","citation_count":19,"is_preprint":false},{"pmid":"28730685","id":"PMC_28730685","title":"TEX15: A DNA repair gene associated with prostate cancer risk in Han Chinese.","date":"2017","source":"The Prostate","url":"https://pubmed.ncbi.nlm.nih.gov/28730685","citation_count":10,"is_preprint":false},{"pmid":"37234866","id":"PMC_37234866","title":"Genomic study of TEX15 variants: prevalence and allelic heterogeneity in men with spermatogenic failure.","date":"2023","source":"Frontiers in genetics","url":"https://pubmed.ncbi.nlm.nih.gov/37234866","citation_count":7,"is_preprint":false},{"pmid":"35103426","id":"PMC_35103426","title":"Correlation of Novel Single Nucleotide Polymorphisms ofUSP26, TEX15, and TNP2 Genes with Male Infertility in North West of Iran.","date":"2022","source":"International journal of fertility & sterility","url":"https://pubmed.ncbi.nlm.nih.gov/35103426","citation_count":4,"is_preprint":false},{"pmid":"40438407","id":"PMC_40438407","title":"Genome editing in mouse spermatogonial stem cell lines targeting the Tex15 gene using CRISPR/Cas9.","date":"2025","source":"Frontiers in veterinary science","url":"https://pubmed.ncbi.nlm.nih.gov/40438407","citation_count":0,"is_preprint":false},{"pmid":"41415471","id":"PMC_41415471","title":"Tex15 is required for vomeronasal sensory neuron diversity and male pheromone detection.","date":"2025","source":"bioRxiv : the preprint server for biology","url":"https://pubmed.ncbi.nlm.nih.gov/41415471","citation_count":0,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":8972,"output_tokens":1214,"usd":0.022563,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":7820,"output_tokens":1634,"usd":0.039975,"stage2_stop_reason":"end_turn"},"total_usd":0.062538,"stage1_batch_id":"msgbatch_017qqVz33Ga63SCDwzb35XPb","stage2_batch_id":"msgbatch_01Scr2Ei9x4HJMiRGxwrmvLK","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2008,\n      \"finding\": \"TEX15 is required for loading of DNA repair proteins RAD51 and DMC1 onto sites of meiotic DNA double-strand breaks (DSBs) in spermatocytes. Loss of TEX15 in male mice causes failure of chromosomal synapsis and meiotic arrest; DSBs form normally but RAD51/DMC1 localization to meiotic chromosomes is severely impaired.\",\n      \"method\": \"Knockout mouse model with immunofluorescence localization of RAD51 and DMC1 on meiotic chromosomes; cytological analysis of chromosomal synapsis\",\n      \"journal\": \"The Journal of cell biology\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Strong — clean KO mouse with defined cellular phenotype and direct localization experiments showing specific failure of RAD51/DMC1 loading, replicated across multiple analyses in one rigorous study\",\n      \"pmids\": [\"18283110\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2020,\n      \"finding\": \"TEX15 associates with the PIWI protein MIWI2 in fetal gonocytes and is required for piRNA-directed de novo DNA methylation of transposable elements (TEs), but is not required for piRNA biogenesis itself. TEX15 is predominantly a nuclear protein in this context.\",\n      \"method\": \"Co-immunoprecipitation (MIWI2–TEX15 association), knockout mouse model with bisulfite sequencing for TE methylation, small RNA sequencing for piRNA levels, subcellular fractionation/immunofluorescence for localization\",\n      \"journal\": \"Nature communications\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — reciprocal Co-IP plus KO with orthogonal methylation sequencing and piRNA profiling in a single rigorous study establishing nuclear localization and downstream function\",\n      \"pmids\": [\"32719317\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2020,\n      \"finding\": \"TEX15 associates with the PIWI protein MILI in testis and is required for TE silencing by DNA methylation. Loss of TEX15 causes DNA hypomethylation at TEs at a level similar to Mili and Dnmt3c mutants but not Miwi2 mutants, suggesting TEX15 functions as a nuclear effector of MILI-directed TE silencing. piRNA production remains intact in Tex15 mutants.\",\n      \"method\": \"Co-immunoprecipitation (TEX15–MILI), knockout mouse model with whole-genome bisulfite sequencing, RNA-seq for TE expression, small RNA sequencing for piRNAs\",\n      \"journal\": \"Genes & development\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — Co-IP plus KO with orthogonal bisulfite sequencing, RNA-seq, and small RNA profiling, with genetic epistasis via comparison to Mili/Miwi2/Dnmt3c mutants placing TEX15 in the MILI branch\",\n      \"pmids\": [\"32381626\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2025,\n      \"finding\": \"Tex15 is transiently expressed in vomeronasal sensory neuron (VSN) precursors and is required for diverse vomeronasal receptor (VR) choice. Loss of Tex15 results in a dysregulated and less diverse repertoire of V1R- and V2R-expressing cells, reduced activation of the Accessory Olfactory Bulb after male odorant exposure, and loss of stereotyped intermale aggression.\",\n      \"method\": \"Knockout mouse model, immunofluorescence/in situ hybridization for VR expression, AOB activation assays, behavioral aggression assays\",\n      \"journal\": \"bioRxiv\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Weak — clean KO with defined cellular and behavioral phenotype, single lab preprint, no independent replication\",\n      \"pmids\": [\"41415471\"],\n      \"is_preprint\": true\n    }\n  ],\n  \"current_model\": \"TEX15 is a testis-enriched nuclear protein that acts downstream of the PIWI pathway to silence transposable elements via DNA methylation (associating with both MIWI2 and MILI to direct de novo methylation without affecting piRNA biogenesis), and independently regulates the loading of meiotic DNA repair proteins RAD51 and DMC1 onto double-strand break sites to enable chromosomal synapsis; additionally, transient expression of TEX15 in vomeronasal sensory neuron precursors is required for diverse olfactory receptor gene choice.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"TEX15 is a testis-enriched nuclear protein with dual roles in meiotic genome maintenance and piRNA-directed transposon silencing [#0, #2]. During male meiosis it is required for loading of the recombinases RAD51 and DMC1 onto sites of programmed DNA double-strand breaks; in its absence DSBs form normally but recombinase recruitment fails, blocking chromosomal synapsis and arresting meiosis [#0]. In fetal and postnatal germ cells TEX15 functions as a nuclear effector of the PIWI pathway: it physically associates with the PIWI proteins MIWI2 and MILI and is required for de novo DNA methylation that silences transposable elements, while piRNA biogenesis remains intact [#1, #2]. Genetic epistasis places TEX15 in the MILI branch of this pathway, with TE hypomethylation in Tex15 mutants paralleling that of Mili and Dnmt3c mutants [#2]. Beyond germ cells, transient TEX15 expression in vomeronasal sensory neuron precursors is required for diverse vomeronasal receptor gene choice and stereotyped intermale aggression [#3].\",\n  \"teleology\": [\n    {\n      \"year\": 2008,\n      \"claim\": \"Established the first mechanistic role for TEX15 by showing it is required for recombinase loading at meiotic DSBs, separating break formation from repair-protein recruitment.\",\n      \"evidence\": \"Knockout mouse with immunofluorescence localization of RAD51/DMC1 on meiotic chromosomes and cytological synapsis analysis\",\n      \"pmids\": [\"18283110\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"Does not define how TEX15 promotes RAD51/DMC1 loading at the molecular level\", \"No direct biochemical interaction with the recombinases shown\", \"Relationship to its later-described piRNA role unaddressed\"]\n    },\n    {\n      \"year\": 2020,\n      \"claim\": \"Placed TEX15 downstream of the PIWI pathway as a nuclear effector of piRNA-directed de novo TE methylation, distinguishing its role from piRNA production.\",\n      \"evidence\": \"Reciprocal Co-IP (MIWI2–TEX15 and TEX15–MILI), knockout mice with bisulfite/whole-genome bisulfite sequencing, RNA-seq, and small RNA sequencing; epistasis against Mili/Miwi2/Dnmt3c mutants\",\n      \"pmids\": [\"32719317\", \"32381626\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"Mechanism by which TEX15 directs DNMT machinery to TE loci not resolved\", \"How nuclear TEX15 links cytoplasmic piRNA signals to methylation unclear\", \"Relationship between the MIWI2 and MILI associations not reconciled\"]\n    },\n    {\n      \"year\": 2025,\n      \"claim\": \"Extended TEX15 function beyond germ cells, implicating transient expression in vomeronasal neuron precursors in receptor gene choice and innate behavior.\",\n      \"evidence\": \"Knockout mouse, immunofluorescence/in situ for VR expression, AOB activation assays, behavioral aggression assays (preprint)\",\n      \"pmids\": [\"41415471\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Single-lab preprint without independent replication\", \"Molecular mechanism linking TEX15 to receptor gene choice unknown\", \"Whether the methylation/chromatin functions seen in germ cells operate in neurons untested\"]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"How a single nuclear protein mechanistically bridges recombinase loading, piRNA-directed methylation, and neuronal receptor choice remains unresolved.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Low\",\n      \"gaps\": [\"No structural or biochemical model of TEX15 domains and partners\", \"No identified direct enzymatic activity\", \"Unclear whether the three roles share a common molecular mechanism\"]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [],\n    \"localization\": [\n      {\"term_id\": \"GO:0005634\", \"supporting_discovery_ids\": [1, 2]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"R-HSA-73894\", \"supporting_discovery_ids\": [0]},\n      {\"term_id\": \"R-HSA-4839726\", \"supporting_discovery_ids\": [1, 2]},\n      {\"term_id\": \"R-HSA-1474165\", \"supporting_discovery_ids\": [0]}\n    ],\n    \"complexes\": [],\n    \"partners\": [\"MIWI2\", \"MILI\"],\n    \"other_free_text\": []\n  }\n}","audit_flag":null,"evaluation":{"pairwise":"win","faith_supported":5,"faith_total":5,"faith_pct":100.0}}