{"gene":"TENM1","run_date":"2026-06-10T10:51:54","timeline":{"discoveries":[{"year":2016,"finding":"ODZ1/TENM1, a type II transmembrane protein, undergoes proteolytic cleavage by signal peptide peptidase-like 2a (SPPL2a) upon differentiation of glioblastoma stem-like cells, releasing an intracellular fragment that translocates to the nucleus and promotes cytoskeletal remodelling and invasion of GBM cells both in vitro and in vivo.","method":"Proteolytic cleavage assay, nuclear fractionation, in vitro invasion assay, xenograft mouse model, siRNA knockdown, gene deletion","journal":"Oncogene","confidence":"High","confidence_rationale":"Tier 2 / Strong — multiple orthogonal methods (knockdown, gene deletion, in vivo xenograft, cleavage assay, nuclear fractionation) in a single rigorous study with both gain- and loss-of-function approaches","pmids":["27641332"],"is_preprint":false},{"year":2016,"finding":"The nuclear intracellular fragment of ODZ1/TENM1 activates a transcriptional pathway via the E-box binding Myc protein, upregulating RhoA expression and activity, which subsequently activates ROCK to drive GBM cell invasion.","method":"siRNA knockdown, overexpression, transcriptional reporter assay, Western blotting, invasion assay","journal":"Oncogene","confidence":"High","confidence_rationale":"Tier 2 / Strong — pathway placement by epistasis (Myc→RhoA→ROCK) confirmed with knockdown and overexpression using multiple orthogonal methods in a single rigorous study","pmids":["27641332"],"is_preprint":false},{"year":2016,"finding":"TENM1 plays a role in olfaction: Tenm1 knockout mice (Tenm1−/−) and point-mutated Tenm1(A/A) mice showed an altered ability to locate a buried food pellet, and Tenm1(A/A) mice displayed an altered ability to sense aversive odors, consistent with a function in olfactory synaptic partner-matching.","method":"CRISPR-Cas9 knockout mouse generation, buried food pellet assay, aversive odor behavioral assay","journal":"Clinical genetics","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — clean KO and point-mutation knock-in with defined behavioral phenotype, single lab, two behavioral assays","pmids":["27040985"],"is_preprint":false},{"year":2016,"finding":"TENM1 expression in the mid-secretory endometrium is directly regulated downstream of the EMX2 transcription factor; in infertile women with Müllerian duct anomaly (partially septate uterus), EMX2 and TENM1 mRNA and protein levels were both significantly elevated compared to controls, placing TENM1 as a downstream target of the HOXA10–EMX2 axis in the endometrium.","method":"qRT-PCR, Western blotting of endometrial tissue samples from patients vs. controls","journal":"Reproductive biomedicine online","confidence":"Low","confidence_rationale":"Tier 3 / Weak — single lab, correlative expression measurements without direct manipulation of TENM1; pathway placement inferred from prior literature rather than direct experiment in this study","pmids":["26896429"],"is_preprint":false},{"year":2022,"finding":"HIF2α transcriptionally upregulates ODZ1/TENM1 in glioblastoma stem cells under hypoxia: HIF2α knockdown by siRNA downregulated ODZ1 expression, and a HIF consensus binding site (GCGTG) 1358 bp from the TENM1 transcription start site and a HIF-like site (CCGTG) 826 bp from the TSS were identified; luciferase reporter assays confirmed that HIF stabilization increased ODZ1 promoter activity.","method":"siRNA knockdown of HIF2α, HIF stabilizer (DMOG) treatment, luciferase reporter assay with cloned ODZ1 promoter, qRT-PCR and Western blotting","journal":"International journal of molecular sciences","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — reciprocal knockdown plus luciferase reporter assay with defined binding sites; single lab, two orthogonal methods","pmids":["35054927"],"is_preprint":false},{"year":2019,"finding":"TENM1 is a direct functional target of miR-486 in papillary thyroid carcinoma cells: miR-486 restoration suppressed TENM1 expression and inhibited cell proliferation, invasion, and migration via modulation of ERK and Akt signaling pathways and epithelial-mesenchymal transition; dual-luciferase reporter assay confirmed direct binding of miR-486 to TENM1 3′UTR.","method":"Dual-luciferase reporter assay, qRT-PCR, Western blot, MTT proliferation assay, Transwell invasion/migration assay, xenograft mouse model","journal":"European review for medical and pharmacological sciences","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — direct 3′UTR binding confirmed by luciferase reporter plus multiple functional readouts; single lab","pmids":["31646573"],"is_preprint":false}],"current_model":"TENM1/ODZ1 is a type II transmembrane protein that, upon proteolytic cleavage by SPPL2a, releases a nuclear intracellular fragment that drives glioblastoma invasion by activating a Myc-dependent transcriptional program upregulating RhoA and ROCK; it is transcriptionally induced by HIF2α under hypoxia and is targeted (repressed) by miR-486, and in vivo mouse models implicate it in olfactory synaptic connectivity and odor sensing."},"narrative":{"mechanistic_narrative":"TENM1 (ODZ1) is a type II transmembrane protein that functions both as a regulator of tumor cell invasion and in olfactory neural connectivity [PMID:27641332, PMID:27040985]. In glioblastoma stem-like cells, TENM1 is cleaved by signal peptide peptidase-like 2a (SPPL2a) upon differentiation, releasing an intracellular fragment that translocates to the nucleus and drives cytoskeletal remodelling and invasion in vitro and in vivo [PMID:27641332]. The nuclear fragment activates a Myc-dependent E-box transcriptional program that upregulates RhoA expression and activity, which in turn activates ROCK to promote invasion [PMID:27641332]. TENM1 transcription is induced by HIF2α under hypoxia through defined HIF consensus sites in its promoter [PMID:35054927], and it is directly repressed by miR-486 binding to its 3′UTR, with miR-486 restoration suppressing proliferation, invasion, and migration via ERK/Akt signaling and EMT in papillary thyroid carcinoma [PMID:31646573]. In vivo, Tenm1 knockout and point-mutant mice display altered odor localization and aversive odor sensing, consistent with a role in olfactory synaptic partner-matching [PMID:27040985].","teleology":[{"year":2016,"claim":"Established that TENM1 is not merely a transmembrane protein but a regulated proteolytic substrate whose cleaved intracellular fragment acts in the nucleus to drive glioblastoma invasion.","evidence":"Cleavage assay, nuclear fractionation, invasion assay, xenograft, with siRNA knockdown and gene deletion in GBM stem-like cells","pmids":["27641332"],"confidence":"High","gaps":["Precise cleavage site and topology of the released fragment not mapped","Whether SPPL2a cleavage operates outside GBM is unknown"]},{"year":2016,"claim":"Placed the TENM1 nuclear fragment within a defined transcriptional cascade, explaining how it mechanistically converts to a pro-invasive signal.","evidence":"Epistasis by knockdown/overexpression, transcriptional reporter, Western blot, invasion assay (Myc→RhoA→ROCK)","pmids":["27641332"],"confidence":"High","gaps":["Direct DNA binding of the fragment vs. cofactor role with Myc not resolved","Whether the fragment directly contacts the RhoA promoter is unknown"]},{"year":2016,"claim":"Demonstrated a physiological neural function for TENM1 in olfaction distinct from its tumor role, linking it to synaptic partner-matching.","evidence":"CRISPR-Cas9 knockout and point-mutant mice, buried food pellet and aversive odor behavioral assays","pmids":["27040985"],"confidence":"Medium","gaps":["Molecular mechanism of synaptic partner-matching not defined","Trans-synaptic binding partners not identified","Cellular site of action in the olfactory circuit not mapped"]},{"year":2019,"claim":"Identified an upstream post-transcriptional repressor of TENM1, showing its expression is constrained by miR-486 in a second cancer context.","evidence":"Dual-luciferase 3′UTR reporter, qRT-PCR, Western, proliferation/invasion/migration assays, xenograft in papillary thyroid carcinoma","pmids":["31646573"],"confidence":"Medium","gaps":["Whether TENM1 cleavage/nuclear signaling operates in thyroid carcinoma not tested","Direct contribution of TENM1 vs. other miR-486 targets to phenotype not isolated"]},{"year":2022,"claim":"Connected the hypoxic tumor microenvironment to TENM1 by showing HIF2α directly drives its transcription, providing an inducing signal upstream of the invasion cascade.","evidence":"HIF2α siRNA knockdown, DMOG stabilization, luciferase reporter with cloned promoter and defined HIF binding sites, qRT-PCR/Western in GBM stem cells","pmids":["35054927"],"confidence":"Medium","gaps":["Direct HIF2α occupancy at the identified sites (e.g. ChIP) not shown","Coupling between hypoxic induction and SPPL2a cleavage not established"]},{"year":null,"claim":"How the membrane-anchored, neural partner-matching function of TENM1 mechanistically relates to its proteolytically released nuclear pro-invasive function remains unresolved.","evidence":"","pmids":[],"confidence":"Low","gaps":["No structural model of the protein or its cleaved fragment","Trans-cellular binding partners not identified in the corpus","Whether the nuclear fragment binds DNA directly is unknown"]}],"mechanism_profile":{"molecular_activity":[{"term_id":"GO:0140110","term_label":"transcription regulator activity","supporting_discovery_ids":[0,1]}],"localization":[{"term_id":"GO:0005886","term_label":"plasma membrane","supporting_discovery_ids":[0]},{"term_id":"GO:0005634","term_label":"nucleus","supporting_discovery_ids":[0,1]}],"pathway":[{"term_id":"R-HSA-1643685","term_label":"Disease","supporting_discovery_ids":[0,1]},{"term_id":"R-HSA-162582","term_label":"Signal Transduction","supporting_discovery_ids":[1,4]}],"complexes":[],"partners":[],"other_free_text":[]}},"prefetch_data":{"uniprot":{"accession":"Q9UKZ4","full_name":"Teneurin-1","aliases":["Protein Odd Oz/ten-m homolog 1","Tenascin-M1","Ten-m1","Teneurin transmembrane protein 1"],"length_aa":2725,"mass_kda":305.0,"function":"Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity) Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Also acts as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity) Induces gene transcription activation","subcellular_location":"Nucleus; Cytoplasm; Cell membrane","url":"https://www.uniprot.org/uniprotkb/Q9UKZ4/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/TENM1","classification":"Not Classified","n_dependent_lines":0,"n_total_lines":1208,"dependency_fraction":0.0},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[],"url":"https://opencell.sf.czbiohub.org/search/TENM1","total_profiled":1310},"omim":[{"mim_id":"616417","title":"ADHESION G PROTEIN-COUPLED RECEPTOR L3; ADGRL3","url":"https://www.omim.org/entry/616417"},{"mim_id":"616416","title":"ADHESION G PROTEIN-COUPLED RECEPTOR L1; ADGRL1","url":"https://www.omim.org/entry/616416"},{"mim_id":"607018","title":"ADHESION G PROTEIN-COUPLED RECEPTOR L2; ADGRL2","url":"https://www.omim.org/entry/607018"},{"mim_id":"301700","title":"ANOSMIA, ISOLATED CONGENITAL, X-LINKED","url":"https://www.omim.org/entry/301700"},{"mim_id":"300588","title":"TENEURIN TRANSMEMBRANE PROTEIN 1; TENM1","url":"https://www.omim.org/entry/300588"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Approved","locations":[{"location":"Nucleoplasm","reliability":"Approved"},{"location":"Plasma membrane","reliability":"Approved"}],"tissue_specificity":"Tissue enhanced","tissue_distribution":"Detected in many","driving_tissues":[{"tissue":"brain","ntpm":18.1}],"url":"https://www.proteinatlas.org/search/TENM1"},"hgnc":{"alias_symbol":["TEN-M1","TEN1"],"prev_symbol":["ODZ3","TNM","ODZ1"]},"alphafold":{"accession":"Q9UKZ4","domains":[],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q9UKZ4","model_url":"","pae_url":"","plddt_mean":null},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=TENM1","jax_strain_url":"https://www.jax.org/strain/search?query=TENM1"},"sequence":{"accession":"Q9UKZ4","fasta_url":"https://rest.uniprot.org/uniprotkb/Q9UKZ4.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q9UKZ4/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q9UKZ4"}},"corpus_meta":[{"pmid":"28555375","id":"PMC_28555375","title":"Overview of the 8th Edition TNM Classification for Head and Neck Cancer.","date":"2017","source":"Current treatment options in 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    \"finding\": \"ODZ1/TENM1, a type II transmembrane protein, undergoes proteolytic cleavage by signal peptide peptidase-like 2a (SPPL2a) upon differentiation of glioblastoma stem-like cells, releasing an intracellular fragment that translocates to the nucleus and promotes cytoskeletal remodelling and invasion of GBM cells both in vitro and in vivo.\",\n      \"method\": \"Proteolytic cleavage assay, nuclear fractionation, in vitro invasion assay, xenograft mouse model, siRNA knockdown, gene deletion\",\n      \"journal\": \"Oncogene\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Strong — multiple orthogonal methods (knockdown, gene deletion, in vivo xenograft, cleavage assay, nuclear fractionation) in a single rigorous study with both gain- and loss-of-function approaches\",\n      \"pmids\": [\"27641332\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2016,\n      \"finding\": \"The nuclear intracellular fragment of ODZ1/TENM1 activates a transcriptional pathway via the E-box binding Myc protein, upregulating RhoA expression and activity, which subsequently activates ROCK to drive GBM cell invasion.\",\n      \"method\": \"siRNA knockdown, overexpression, transcriptional reporter assay, Western blotting, invasion assay\",\n      \"journal\": \"Oncogene\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Strong — pathway placement by epistasis (Myc→RhoA→ROCK) confirmed with knockdown and overexpression using multiple orthogonal methods in a single rigorous study\",\n      \"pmids\": [\"27641332\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2016,\n      \"finding\": \"TENM1 plays a role in olfaction: Tenm1 knockout mice (Tenm1−/−) and point-mutated Tenm1(A/A) mice showed an altered ability to locate a buried food pellet, and Tenm1(A/A) mice displayed an altered ability to sense aversive odors, consistent with a function in olfactory synaptic partner-matching.\",\n      \"method\": \"CRISPR-Cas9 knockout mouse generation, buried food pellet assay, aversive odor behavioral assay\",\n      \"journal\": \"Clinical genetics\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — clean KO and point-mutation knock-in with defined behavioral phenotype, single lab, two behavioral assays\",\n      \"pmids\": [\"27040985\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2016,\n      \"finding\": \"TENM1 expression in the mid-secretory endometrium is directly regulated downstream of the EMX2 transcription factor; in infertile women with Müllerian duct anomaly (partially septate uterus), EMX2 and TENM1 mRNA and protein levels were both significantly elevated compared to controls, placing TENM1 as a downstream target of the HOXA10–EMX2 axis in the endometrium.\",\n      \"method\": \"qRT-PCR, Western blotting of endometrial tissue samples from patients vs. controls\",\n      \"journal\": \"Reproductive biomedicine online\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 3 / Weak — single lab, correlative expression measurements without direct manipulation of TENM1; pathway placement inferred from prior literature rather than direct experiment in this study\",\n      \"pmids\": [\"26896429\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2022,\n      \"finding\": \"HIF2α transcriptionally upregulates ODZ1/TENM1 in glioblastoma stem cells under hypoxia: HIF2α knockdown by siRNA downregulated ODZ1 expression, and a HIF consensus binding site (GCGTG) 1358 bp from the TENM1 transcription start site and a HIF-like site (CCGTG) 826 bp from the TSS were identified; luciferase reporter assays confirmed that HIF stabilization increased ODZ1 promoter activity.\",\n      \"method\": \"siRNA knockdown of HIF2α, HIF stabilizer (DMOG) treatment, luciferase reporter assay with cloned ODZ1 promoter, qRT-PCR and Western blotting\",\n      \"journal\": \"International journal of molecular sciences\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — reciprocal knockdown plus luciferase reporter assay with defined binding sites; single lab, two orthogonal methods\",\n      \"pmids\": [\"35054927\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2019,\n      \"finding\": \"TENM1 is a direct functional target of miR-486 in papillary thyroid carcinoma cells: miR-486 restoration suppressed TENM1 expression and inhibited cell proliferation, invasion, and migration via modulation of ERK and Akt signaling pathways and epithelial-mesenchymal transition; dual-luciferase reporter assay confirmed direct binding of miR-486 to TENM1 3′UTR.\",\n      \"method\": \"Dual-luciferase reporter assay, qRT-PCR, Western blot, MTT proliferation assay, Transwell invasion/migration assay, xenograft mouse model\",\n      \"journal\": \"European review for medical and pharmacological sciences\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — direct 3′UTR binding confirmed by luciferase reporter plus multiple functional readouts; single lab\",\n      \"pmids\": [\"31646573\"],\n      \"is_preprint\": false\n    }\n  ],\n  \"current_model\": \"TENM1/ODZ1 is a type II transmembrane protein that, upon proteolytic cleavage by SPPL2a, releases a nuclear intracellular fragment that drives glioblastoma invasion by activating a Myc-dependent transcriptional program upregulating RhoA and ROCK; it is transcriptionally induced by HIF2α under hypoxia and is targeted (repressed) by miR-486, and in vivo mouse models implicate it in olfactory synaptic connectivity and odor sensing.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"TENM1 (ODZ1) is a type II transmembrane protein that functions both as a regulator of tumor cell invasion and in olfactory neural connectivity [#0, #2]. In glioblastoma stem-like cells, TENM1 is cleaved by signal peptide peptidase-like 2a (SPPL2a) upon differentiation, releasing an intracellular fragment that translocates to the nucleus and drives cytoskeletal remodelling and invasion in vitro and in vivo [#0]. The nuclear fragment activates a Myc-dependent E-box transcriptional program that upregulates RhoA expression and activity, which in turn activates ROCK to promote invasion [#1]. TENM1 transcription is induced by HIF2\\u03b1 under hypoxia through defined HIF consensus sites in its promoter [#4], and it is directly repressed by miR-486 binding to its 3\\u2032UTR, with miR-486 restoration suppressing proliferation, invasion, and migration via ERK/Akt signaling and EMT in papillary thyroid carcinoma [#5]. In vivo, Tenm1 knockout and point-mutant mice display altered odor localization and aversive odor sensing, consistent with a role in olfactory synaptic partner-matching [#2].\",\n  \"teleology\": [\n    {\n      \"year\": 2016,\n      \"claim\": \"Established that TENM1 is not merely a transmembrane protein but a regulated proteolytic substrate whose cleaved intracellular fragment acts in the nucleus to drive glioblastoma invasion.\",\n      \"evidence\": \"Cleavage assay, nuclear fractionation, invasion assay, xenograft, with siRNA knockdown and gene deletion in GBM stem-like cells\",\n      \"pmids\": [\"27641332\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"Precise cleavage site and topology of the released fragment not mapped\", \"Whether SPPL2a cleavage operates outside GBM is unknown\"]\n    },\n    {\n      \"year\": 2016,\n      \"claim\": \"Placed the TENM1 nuclear fragment within a defined transcriptional cascade, explaining how it mechanistically converts to a pro-invasive signal.\",\n      \"evidence\": \"Epistasis by knockdown/overexpression, transcriptional reporter, Western blot, invasion assay (Myc\\u2192RhoA\\u2192ROCK)\",\n      \"pmids\": [\"27641332\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"Direct DNA binding of the fragment vs. cofactor role with Myc not resolved\", \"Whether the fragment directly contacts the RhoA promoter is unknown\"]\n    },\n    {\n      \"year\": 2016,\n      \"claim\": \"Demonstrated a physiological neural function for TENM1 in olfaction distinct from its tumor role, linking it to synaptic partner-matching.\",\n      \"evidence\": \"CRISPR-Cas9 knockout and point-mutant mice, buried food pellet and aversive odor behavioral assays\",\n      \"pmids\": [\"27040985\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Molecular mechanism of synaptic partner-matching not defined\", \"Trans-synaptic binding partners not identified\", \"Cellular site of action in the olfactory circuit not mapped\"]\n    },\n    {\n      \"year\": 2019,\n      \"claim\": \"Identified an upstream post-transcriptional repressor of TENM1, showing its expression is constrained by miR-486 in a second cancer context.\",\n      \"evidence\": \"Dual-luciferase 3\\u2032UTR reporter, qRT-PCR, Western, proliferation/invasion/migration assays, xenograft in papillary thyroid carcinoma\",\n      \"pmids\": [\"31646573\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Whether TENM1 cleavage/nuclear signaling operates in thyroid carcinoma not tested\", \"Direct contribution of TENM1 vs. other miR-486 targets to phenotype not isolated\"]\n    },\n    {\n      \"year\": 2022,\n      \"claim\": \"Connected the hypoxic tumor microenvironment to TENM1 by showing HIF2\\u03b1 directly drives its transcription, providing an inducing signal upstream of the invasion cascade.\",\n      \"evidence\": \"HIF2\\u03b1 siRNA knockdown, DMOG stabilization, luciferase reporter with cloned promoter and defined HIF binding sites, qRT-PCR/Western in GBM stem cells\",\n      \"pmids\": [\"35054927\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Direct HIF2\\u03b1 occupancy at the identified sites (e.g. ChIP) not shown\", \"Coupling between hypoxic induction and SPPL2a cleavage not established\"]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"How the membrane-anchored, neural partner-matching function of TENM1 mechanistically relates to its proteolytically released nuclear pro-invasive function remains unresolved.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Low\",\n      \"gaps\": [\"No structural model of the protein or its cleaved fragment\", \"Trans-cellular binding partners not identified in the corpus\", \"Whether the nuclear fragment binds DNA directly is unknown\"]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\"term_id\": \"GO:0140110\", \"supporting_discovery_ids\": [0, 1]}\n    ],\n    \"localization\": [\n      {\"term_id\": \"GO:0005886\", \"supporting_discovery_ids\": [0]},\n      {\"term_id\": \"GO:0005634\", \"supporting_discovery_ids\": [0, 1]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"R-HSA-1643685\", \"supporting_discovery_ids\": [0, 1]},\n      {\"term_id\": \"R-HSA-162582\", \"supporting_discovery_ids\": [1, 4]}\n    ],\n    \"complexes\": [],\n    \"partners\": [],\n    \"other_free_text\": []\n  }\n}","audit_flag":null,"evaluation":{"pairwise":"win","faith_supported":5,"faith_total":5,"faith_pct":100.0}}