{"gene":"TBC1D22A","run_date":"2026-04-28T21:42:58","timeline":{"discoveries":[{"year":2013,"finding":"TBC1D22A and TBC1D22B were identified as ACBD3 (GCP60)-interacting factors via affinity purification-mass spectrometry, functioning as putative Rab33 GTPase-activating proteins (RabGAPs). Fine-scale mapping revealed that TBC1D22A/B and PI4KB (phosphatidylinositol 4-kinase class III beta) compete for binding to the same region of ACBD3, making their interactions with ACBD3 mutually exclusive, suggesting a regulatory mechanism for PI4KB recruitment to the Golgi.","method":"Affinity purification-mass spectrometry, reciprocal co-immunoprecipitation, fine-scale domain mapping, mammalian two-hybrid assay","journal":"mBio","confidence":"High","confidence_rationale":"Tier 2 — reciprocal Co-IP and AP-MS with fine-scale domain mapping, multiple orthogonal methods in a single study","pmids":["23572552"],"is_preprint":false},{"year":2013,"finding":"Enteroviral and kobuviral 3A proteins differentially affect TBC1D22A/B interaction with ACBD3: kobuvirus (Aichi virus) 3A binds the GOLD domain of ACBD3 and disrupts TBC1D22A/B association, while enterovirus 3A modulates PI4KB recruitment via a distinct mechanism, demonstrating that viral replication proteins subvert the TBC1D22A–ACBD3–PI4KB regulatory axis.","method":"Mammalian two-hybrid assay, affinity purification, domain mapping","journal":"mBio","confidence":"Medium","confidence_rationale":"Tier 2 — multiple functional assays in one study but single lab","pmids":["23572552"],"is_preprint":false},{"year":2025,"finding":"TBC1D22B (the paralog of TBC1D22A) acts as a GAP for RAB1B to inhibit ER-to-Golgi trafficking; RAB1B silencing phenocopies TBC1D22B overexpression. TBC1D22A does not replicate this trafficking phenotype in 3D culture, indicating functional divergence between the two paralogs at the ER-to-Golgi trafficking step.","method":"RUSH system (Retention Using Selective Hooks) trafficking assay, co-immunoprecipitation proteomics, proximity labeling, RAB1B silencing, GAP-dead mutant overexpression, 3D spheroid culture","journal":"Advanced science","confidence":"Medium","confidence_rationale":"Tier 1-2 — functional trafficking assay with mechanistic mutagenesis for TBC1D22B; TBC1D22A distinction established by negative functional result in same system","pmids":["40878439"],"is_preprint":false},{"year":2013,"finding":"A locus on chromosome 22q13.31 containing TBC1D22A (which encodes a GTPase activator) was linked to autosomal recessive genetic epilepsy with febrile seizures plus (GEFS+) in a consanguineous Tunisian family by parametric linkage analysis and haplotype reconstruction; a microsatellite marker within an intronic region of TBC1D22A was homozygous in all affected individuals.","method":"Genome-wide SNP genotyping, parametric linkage analysis, haplotype reconstruction, microsatellite marker analysis, whole-exome sequencing","journal":"BMC genetics","confidence":"Low","confidence_rationale":"Tier 3 — genetic linkage only, no functional/molecular mechanism established for TBC1D22A protein itself","pmids":["24067191"],"is_preprint":false}],"current_model":"TBC1D22A is a putative Rab33 GTPase-activating protein (RabGAP) that interacts with the Golgi adaptor ACBD3 and competes with PI4KB for binding to the same ACBD3 domain, suggesting a role in regulating Golgi-associated PI4KB recruitment; it is functionally distinct from its close paralog TBC1D22B, which directly inactivates RAB1B to inhibit ER-to-Golgi trafficking, an activity TBC1D22A does not replicate."},"narrative":{"teleology":[{"year":2013,"claim":"Identification of TBC1D22A as an ACBD3-binding partner that competes with PI4KB for the same ACBD3 domain established a mutually exclusive regulatory mechanism governing PI4KB recruitment to the Golgi.","evidence":"Affinity purification-mass spectrometry, reciprocal co-immunoprecipitation, and mammalian two-hybrid domain mapping in mammalian cells","pmids":["23572552"],"confidence":"High","gaps":["Direct GAP activity of TBC1D22A toward Rab33 or any other Rab has not been reconstituted in vitro","Functional consequences of disrupting TBC1D22A–ACBD3 binding on Golgi PI4P levels have not been measured","Structural basis for the mutually exclusive ACBD3 binding by TBC1D22A versus PI4KB is unknown"]},{"year":2013,"claim":"Demonstrating that picornavirus 3A proteins differentially displace TBC1D22A from ACBD3 revealed that viruses exploit this regulatory axis to reorganize Golgi-associated lipid kinase signaling during replication.","evidence":"Mammalian two-hybrid and affinity purification with enteroviral and kobuviral 3A constructs, domain mapping of ACBD3 GOLD domain","pmids":["23572552"],"confidence":"Medium","gaps":["Effect of TBC1D22A displacement on viral replication efficiency has not been tested directly","Whether TBC1D22A displacement is sufficient to enhance PI4KB recruitment in the context of infection is unresolved"]},{"year":2013,"claim":"Genetic linkage of a chromosome 22q13.31 locus encompassing TBC1D22A to autosomal recessive GEFS+ in a consanguineous family raised the possibility of a neurological role, but no causative coding variant in TBC1D22A was identified.","evidence":"Genome-wide SNP genotyping, parametric linkage analysis, haplotype reconstruction, and whole-exome sequencing in a Tunisian family","pmids":["24067191"],"confidence":"Low","gaps":["No causative mutation in TBC1D22A has been identified; linkage interval contains other genes","No functional or expression data connect TBC1D22A to neuronal excitability or seizure phenotypes","Finding has not been replicated in independent cohorts"]},{"year":2025,"claim":"Functional comparison of TBC1D22A and TBC1D22B demonstrated that TBC1D22A lacks RAB1B GAP activity and does not inhibit ER-to-Golgi trafficking, establishing that the two paralogs have diverged in substrate specificity and cellular function.","evidence":"RUSH trafficking assay, co-immunoprecipitation proteomics, proximity labeling, RAB1B silencing, GAP-dead mutant analysis in 3D spheroid culture","pmids":["40878439"],"confidence":"Medium","gaps":["The bona fide Rab substrate of TBC1D22A GAP activity remains unidentified","Whether TBC1D22A regulates a trafficking step distinct from ER-to-Golgi transport is untested","Negative result based on a single culture system (3D spheroids); other cell types or conditions not explored"]},{"year":null,"claim":"The direct enzymatic GAP activity of TBC1D22A — its Rab substrate specificity and catalytic parameters — has never been reconstituted, leaving its core molecular function unresolved.","evidence":"","pmids":[],"confidence":"Low","gaps":["No in vitro GAP assay with purified TBC1D22A and candidate Rab GTPases has been reported","Loss-of-function phenotype in mammalian cells or animal models has not been characterized","Physiological context in which TBC1D22A–ACBD3 competition with PI4KB is rate-limiting is unknown"]}],"mechanism_profile":{"molecular_activity":[{"term_id":"GO:0003924","term_label":"GTPase activity","supporting_discovery_ids":[0,2]},{"term_id":"GO:0098772","term_label":"molecular function regulator activity","supporting_discovery_ids":[0,1]}],"localization":[{"term_id":"GO:0005794","term_label":"Golgi apparatus","supporting_discovery_ids":[0,1]}],"pathway":[{"term_id":"GO:0005794","term_label":"Golgi apparatus","supporting_discovery_ids":[0]}],"complexes":[],"partners":["ACBD3","PI4KB"],"other_free_text":[]},"mechanistic_narrative":"TBC1D22A is a TBC-domain-containing protein that binds the Golgi adaptor ACBD3 and competes with PI4KB for occupancy of the same ACBD3 region, thereby providing a mutually exclusive regulatory switch for PI4KB recruitment to the Golgi [PMID:23572552]. This ACBD3–TBC1D22A interaction is subverted by picornavirus 3A proteins, with kobuvirus 3A disrupting TBC1D22A binding via the ACBD3 GOLD domain [PMID:23572552]. Although annotated as a putative Rab33 GAP, TBC1D22A does not replicate the RAB1B-directed GAP activity or ER-to-Golgi trafficking inhibition exhibited by its paralog TBC1D22B, establishing functional divergence between the two paralogs [PMID:40878439]."},"prefetch_data":{"uniprot":{"accession":"Q8WUA7","full_name":"TBC1 domain family member 22A","aliases":[],"length_aa":517,"mass_kda":59.1,"function":"May act as a GTPase-activating protein for Rab family protein(s)","subcellular_location":"","url":"https://www.uniprot.org/uniprotkb/Q8WUA7/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/TBC1D22A","classification":"Not Classified","n_dependent_lines":0,"n_total_lines":1208,"dependency_fraction":0.0},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[],"url":"https://opencell.sf.czbiohub.org/search/TBC1D22A","total_profiled":1310},"omim":[{"mim_id":"616880","title":"TBC1 DOMAIN FAMILY, MEMBER 22B; TBC1D22B","url":"https://www.omim.org/entry/616880"},{"mim_id":"616879","title":"TBC1 DOMAIN FAMILY, MEMBER 22A; TBC1D22A","url":"https://www.omim.org/entry/616879"},{"mim_id":"606809","title":"ACYL-CoA-BINDING DOMAIN-CONTAINING PROTEIN 3; ACBD3","url":"https://www.omim.org/entry/606809"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Approved","locations":[{"location":"Golgi apparatus","reliability":"Approved"},{"location":"Nucleoplasm","reliability":"Additional"},{"location":"Vesicles","reliability":"Additional"}],"tissue_specificity":"Low tissue specificity","tissue_distribution":"Detected in all","driving_tissues":[],"url":"https://www.proteinatlas.org/search/TBC1D22A"},"hgnc":{"alias_symbol":[],"prev_symbol":["C22orf4"]},"alphafold":{"accession":"Q8WUA7","domains":[{"cath_id":"-","chopping":"208-374","consensus_level":"high","plddt":95.8136,"start":208,"end":374},{"cath_id":"1.10.472.80","chopping":"381-510","consensus_level":"high","plddt":96.9453,"start":381,"end":510}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q8WUA7","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q8WUA7-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q8WUA7-F1-predicted_aligned_error_v6.png","plddt_mean":76.12},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=TBC1D22A","jax_strain_url":"https://www.jax.org/strain/search?query=TBC1D22A"},"sequence":{"accession":"Q8WUA7","fasta_url":"https://rest.uniprot.org/uniprotkb/Q8WUA7.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q8WUA7/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q8WUA7"}},"corpus_meta":[{"pmid":"22326833","id":"PMC_22326833","title":"Gene deletions and amplifications in human hepatocellular carcinomas: correlation with hepatocyte growth regulation.","date":"2012","source":"The American journal of pathology","url":"https://pubmed.ncbi.nlm.nih.gov/22326833","citation_count":66,"is_preprint":false},{"pmid":"23572552","id":"PMC_23572552","title":"ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.","date":"2013","source":"mBio","url":"https://pubmed.ncbi.nlm.nih.gov/23572552","citation_count":56,"is_preprint":false},{"pmid":"29430824","id":"PMC_29430824","title":"DNA methylation analyses of the candidate genes identified by a methylome-wide association study revealed common epigenetic alterations in schizophrenia and bipolar disorder.","date":"2018","source":"Psychiatry and clinical neurosciences","url":"https://pubmed.ncbi.nlm.nih.gov/29430824","citation_count":26,"is_preprint":false},{"pmid":"34855995","id":"PMC_34855995","title":"New insights into genetics underlying of plumage color.","date":"2021","source":"Animal genetics","url":"https://pubmed.ncbi.nlm.nih.gov/34855995","citation_count":19,"is_preprint":false},{"pmid":"34664257","id":"PMC_34664257","title":"Genetic and metabolic profiling of individuals with Phelan-McDermid syndrome presenting with seizures.","date":"2021","source":"Clinical genetics","url":"https://pubmed.ncbi.nlm.nih.gov/34664257","citation_count":15,"is_preprint":false},{"pmid":"35167808","id":"PMC_35167808","title":"A functional genomics approach in Tanzanian population identifies distinct genetic regulators of cytokine production compared to European population.","date":"2022","source":"American journal of human genetics","url":"https://pubmed.ncbi.nlm.nih.gov/35167808","citation_count":13,"is_preprint":false},{"pmid":"30064533","id":"PMC_30064533","title":"Four-Generation Pedigree of Monozygotic Female Twins Reveals Genetic Factors in Twinning Process by Whole-Genome Sequencing.","date":"2018","source":"Twin research and human genetics : the official journal of the International Society for Twin Studies","url":"https://pubmed.ncbi.nlm.nih.gov/30064533","citation_count":12,"is_preprint":false},{"pmid":"24067191","id":"PMC_24067191","title":"A new locus on chromosome 22q13.31 linked to recessive genetic epilepsy with febrile seizures plus (GEFS+) in a Tunisian consanguineous family.","date":"2013","source":"BMC genetics","url":"https://pubmed.ncbi.nlm.nih.gov/24067191","citation_count":11,"is_preprint":false},{"pmid":"23526746","id":"PMC_23526746","title":"Genome-wide linkage and regional association study of obesity-related phenotypes: the GenSalt study.","date":"2013","source":"Obesity (Silver Spring, Md.)","url":"https://pubmed.ncbi.nlm.nih.gov/23526746","citation_count":10,"is_preprint":false},{"pmid":"40429797","id":"PMC_40429797","title":"Genotype-Phenotype Associations in Phelan-McDermid Syndrome: Insights into Novel Genes Beyond SHANK3.","date":"2025","source":"International journal of molecular sciences","url":"https://pubmed.ncbi.nlm.nih.gov/40429797","citation_count":4,"is_preprint":false},{"pmid":"40878439","id":"PMC_40878439","title":"TBC1D22B Regulates ER-to-Golgi Trafficking via RAB1B Inactivation and Promotes Oncogenic Programs in Breast Cancer.","date":"2025","source":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","url":"https://pubmed.ncbi.nlm.nih.gov/40878439","citation_count":2,"is_preprint":false},{"pmid":"21738310","id":"PMC_21738310","title":"HIV associated dementia and HIV encephalitis II: Genes on chromosome 22 expressed in individually microdissected Globus pallidus neurons (Preliminary analysis).","date":"2011","source":"Bioinformation","url":"https://pubmed.ncbi.nlm.nih.gov/21738310","citation_count":2,"is_preprint":false},{"pmid":"39449424","id":"PMC_39449424","title":"Network Pharmacology Approaches Used to Identify Therapeutic Molecules for Chronic Venous Disease Based on 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Fine-scale mapping revealed that TBC1D22A/B and PI4KB (phosphatidylinositol 4-kinase class III beta) compete for binding to the same region of ACBD3, making their interactions with ACBD3 mutually exclusive, suggesting a regulatory mechanism for PI4KB recruitment to the Golgi.\",\n      \"method\": \"Affinity purification-mass spectrometry, reciprocal co-immunoprecipitation, fine-scale domain mapping, mammalian two-hybrid assay\",\n      \"journal\": \"mBio\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 — reciprocal Co-IP and AP-MS with fine-scale domain mapping, multiple orthogonal methods in a single study\",\n      \"pmids\": [\"23572552\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2013,\n      \"finding\": \"Enteroviral and kobuviral 3A proteins differentially affect TBC1D22A/B interaction with ACBD3: kobuvirus (Aichi virus) 3A binds the GOLD domain of ACBD3 and disrupts TBC1D22A/B association, while enterovirus 3A modulates PI4KB recruitment via a distinct mechanism, demonstrating that viral replication proteins subvert the TBC1D22A–ACBD3–PI4KB regulatory axis.\",\n      \"method\": \"Mammalian two-hybrid assay, affinity purification, domain mapping\",\n      \"journal\": \"mBio\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 — multiple functional assays in one study but single lab\",\n      \"pmids\": [\"23572552\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2025,\n      \"finding\": \"TBC1D22B (the paralog of TBC1D22A) acts as a GAP for RAB1B to inhibit ER-to-Golgi trafficking; RAB1B silencing phenocopies TBC1D22B overexpression. TBC1D22A does not replicate this trafficking phenotype in 3D culture, indicating functional divergence between the two paralogs at the ER-to-Golgi trafficking step.\",\n      \"method\": \"RUSH system (Retention Using Selective Hooks) trafficking assay, co-immunoprecipitation proteomics, proximity labeling, RAB1B silencing, GAP-dead mutant overexpression, 3D spheroid culture\",\n      \"journal\": \"Advanced science\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 1-2 — functional trafficking assay with mechanistic mutagenesis for TBC1D22B; TBC1D22A distinction established by negative functional result in same system\",\n      \"pmids\": [\"40878439\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2013,\n      \"finding\": \"A locus on chromosome 22q13.31 containing TBC1D22A (which encodes a GTPase activator) was linked to autosomal recessive genetic epilepsy with febrile seizures plus (GEFS+) in a consanguineous Tunisian family by parametric linkage analysis and haplotype reconstruction; a microsatellite marker within an intronic region of TBC1D22A was homozygous in all affected individuals.\",\n      \"method\": \"Genome-wide SNP genotyping, parametric linkage analysis, haplotype reconstruction, microsatellite marker analysis, whole-exome sequencing\",\n      \"journal\": \"BMC genetics\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 3 — genetic linkage only, no functional/molecular mechanism established for TBC1D22A protein itself\",\n      \"pmids\": [\"24067191\"],\n      \"is_preprint\": false\n    }\n  ],\n  \"current_model\": \"TBC1D22A is a putative Rab33 GTPase-activating protein (RabGAP) that interacts with the Golgi adaptor ACBD3 and competes with PI4KB for binding to the same ACBD3 domain, suggesting a role in regulating Golgi-associated PI4KB recruitment; it is functionally distinct from its close paralog TBC1D22B, which directly inactivates RAB1B to inhibit ER-to-Golgi trafficking, an activity TBC1D22A does not replicate.\"\n}\n```","stage2_raw":"```json\n{\n  \"mechanistic_narrative\": \"TBC1D22A is a TBC-domain-containing protein that binds the Golgi adaptor ACBD3 and competes with PI4KB for occupancy of the same ACBD3 region, thereby providing a mutually exclusive regulatory switch for PI4KB recruitment to the Golgi [PMID:23572552]. This ACBD3–TBC1D22A interaction is subverted by picornavirus 3A proteins, with kobuvirus 3A disrupting TBC1D22A binding via the ACBD3 GOLD domain [PMID:23572552]. Although annotated as a putative Rab33 GAP, TBC1D22A does not replicate the RAB1B-directed GAP activity or ER-to-Golgi trafficking inhibition exhibited by its paralog TBC1D22B, establishing functional divergence between the two paralogs [PMID:40878439].\",\n  \"teleology\": [\n    {\n      \"year\": 2013,\n      \"claim\": \"Identification of TBC1D22A as an ACBD3-binding partner that competes with PI4KB for the same ACBD3 domain established a mutually exclusive regulatory mechanism governing PI4KB recruitment to the Golgi.\",\n      \"evidence\": \"Affinity purification-mass spectrometry, reciprocal co-immunoprecipitation, and mammalian two-hybrid domain mapping in mammalian cells\",\n      \"pmids\": [\"23572552\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\n        \"Direct GAP activity of TBC1D22A toward Rab33 or any other Rab has not been reconstituted in vitro\",\n        \"Functional consequences of disrupting TBC1D22A–ACBD3 binding on Golgi PI4P levels have not been measured\",\n        \"Structural basis for the mutually exclusive ACBD3 binding by TBC1D22A versus PI4KB is unknown\"\n      ]\n    },\n    {\n      \"year\": 2013,\n      \"claim\": \"Demonstrating that picornavirus 3A proteins differentially displace TBC1D22A from ACBD3 revealed that viruses exploit this regulatory axis to reorganize Golgi-associated lipid kinase signaling during replication.\",\n      \"evidence\": \"Mammalian two-hybrid and affinity purification with enteroviral and kobuviral 3A constructs, domain mapping of ACBD3 GOLD domain\",\n      \"pmids\": [\"23572552\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\n        \"Effect of TBC1D22A displacement on viral replication efficiency has not been tested directly\",\n        \"Whether TBC1D22A displacement is sufficient to enhance PI4KB recruitment in the context of infection is unresolved\"\n      ]\n    },\n    {\n      \"year\": 2013,\n      \"claim\": \"Genetic linkage of a chromosome 22q13.31 locus encompassing TBC1D22A to autosomal recessive GEFS+ in a consanguineous family raised the possibility of a neurological role, but no causative coding variant in TBC1D22A was identified.\",\n      \"evidence\": \"Genome-wide SNP genotyping, parametric linkage analysis, haplotype reconstruction, and whole-exome sequencing in a Tunisian family\",\n      \"pmids\": [\"24067191\"],\n      \"confidence\": \"Low\",\n      \"gaps\": [\n        \"No causative mutation in TBC1D22A has been identified; linkage interval contains other genes\",\n        \"No functional or expression data connect TBC1D22A to neuronal excitability or seizure phenotypes\",\n        \"Finding has not been replicated in independent cohorts\"\n      ]\n    },\n    {\n      \"year\": 2025,\n      \"claim\": \"Functional comparison of TBC1D22A and TBC1D22B demonstrated that TBC1D22A lacks RAB1B GAP activity and does not inhibit ER-to-Golgi trafficking, establishing that the two paralogs have diverged in substrate specificity and cellular function.\",\n      \"evidence\": \"RUSH trafficking assay, co-immunoprecipitation proteomics, proximity labeling, RAB1B silencing, GAP-dead mutant analysis in 3D spheroid culture\",\n      \"pmids\": [\"40878439\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\n        \"The bona fide Rab substrate of TBC1D22A GAP activity remains unidentified\",\n        \"Whether TBC1D22A regulates a trafficking step distinct from ER-to-Golgi transport is untested\",\n        \"Negative result based on a single culture system (3D spheroids); other cell types or conditions not explored\"\n      ]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"The direct enzymatic GAP activity of TBC1D22A — its Rab substrate specificity and catalytic parameters — has never been reconstituted, leaving its core molecular function unresolved.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Low\",\n      \"gaps\": [\n        \"No in vitro GAP assay with purified TBC1D22A and candidate Rab GTPases has been reported\",\n        \"Loss-of-function phenotype in mammalian cells or animal models has not been characterized\",\n        \"Physiological context in which TBC1D22A–ACBD3 competition with PI4KB is rate-limiting is unknown\"\n      ]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\n        \"term_id\": \"GO:0003924\",\n        \"supporting_discovery_ids\": [0, 2]\n      },\n      {\n        \"term_id\": \"GO:0098772\",\n        \"supporting_discovery_ids\": [0, 1]\n      }\n    ],\n    \"localization\": [\n      {\n        \"term_id\": \"GO:0005794\",\n        \"supporting_discovery_ids\": [0, 1]\n      }\n    ],\n    \"pathway\": [\n      {\n        \"term_id\": \"GO:0005794\",\n        \"supporting_discovery_ids\": [0]\n      }\n    ],\n    \"complexes\": [],\n    \"partners\": [\n      \"ACBD3\",\n      \"PI4KB\"\n    ],\n    \"other_free_text\": []\n  }\n}\n```"}