{"gene":"SNRNP40","run_date":"2026-06-10T07:46:37","timeline":{"discoveries":[{"year":2019,"finding":"SNRNP40 encodes a subunit of the U5 small nuclear ribonucleoprotein (snRNP) complex of the spliceosome; loss-of-function (hypomorphic mutation) in mice causes increased splicing errors, predominantly intron retention, in several hundred mRNAs in hematopoietic stem cells and T cells, leading to altered expression of proteins associated with immune cell function and a syndromic immune disorder with lymphoid developmental defects and hypersusceptibility to viral infection.","method":"Hypomorphic mouse genetic model, RNA splicing analysis in primary hematopoietic stem cells and T cells (intron retention quantification), cell-intrinsic rescue experiments with mutant hematopoietic stem cells","journal":"Nature immunology","confidence":"High","confidence_rationale":"Tier 2 / Strong — clean loss-of-function genetic model with defined cellular phenotype, splicing analysis across hundreds of mRNAs, cell-intrinsic confirmation, published in high-tier journal","pmids":["31427773"],"is_preprint":false},{"year":2021,"finding":"SNRNP40 is a component of the U5 snRNP, a subunit of the spliceosome; recurrent somatic mutations and altered expression levels of SNRNP40 have been associated with human cancers, placing it functionally within the U5 snRNP alongside PRPF6, PRPF8, EFTUD2, and DDX23.","method":"Literature review and synthesis of genetic variant/expression data across U5 snRNP components in human disease cohorts","journal":"Frontiers in genetics","confidence":"Medium","confidence_rationale":"Tier 3 / Moderate — review synthesizing multiple studies, no new direct experiment, but consistent with primary mechanistic data from PMID:31427773","pmids":["33584830"],"is_preprint":false},{"year":2016,"finding":"Engineered variable (low) expression of the spliceosomal gene SNRNP40 in breast cancer cells promotes metastatic colonization; cells with low SNRNP40 expression are the primary driver of enhanced metastatic fitness within variable subpopulations.","method":"Engineered expression manipulation (variable/low expression) in breast cancer cell lines with in vivo metastasis assays","journal":"Nature communications","confidence":"Medium","confidence_rationale":"Tier 2 / Weak — single lab, defined cellular phenotype (metastasis) with engineered expression perturbation, but no molecular mechanism beyond spliceosomal context established","pmids":["27138336"],"is_preprint":false},{"year":2018,"finding":"SNRNP40 was identified as a potential nuclear binding partner of the transcription factor KLF5 in bladder cancer cells by co-immunoprecipitation followed by LC-MS/MS proteomics, though the functional significance of this interaction was not further characterized in the study.","method":"Co-immunoprecipitation of KLF5 from nuclear extracts followed by LC-MS/MS mass spectrometry in TSU-Pr1 bladder cancer cells","journal":"International journal of cancer","confidence":"Low","confidence_rationale":"Tier 3 / Weak — single Co-IP/MS experiment, SNRNP40 was one of 122 candidate interactors and was not functionally followed up","pmids":["30289973"],"is_preprint":false}],"current_model":"SNRNP40 is an essential subunit of the U5 snRNP complex of the spliceosome; its deficiency causes widespread pre-mRNA splicing errors (predominantly intron retention) across hundreds of transcripts in lymphoid and hematopoietic cells, leading to reduced expression of critical immune proteins and a syndromic immunodeficiency, while variable/low expression in cancer cells promotes metastatic fitness."},"narrative":{"mechanistic_narrative":"SNRNP40 is a subunit of the U5 small nuclear ribonucleoprotein (snRNP) complex of the spliceosome, where it acts alongside core U5 components including PRPF6, PRPF8, EFTUD2, and DDX23 to support accurate pre-mRNA splicing [PMID:31427773, PMID:33584830]. Hypomorphic loss of function in mice produces widespread splicing errors, predominantly intron retention, across several hundred mRNAs in hematopoietic stem cells and T cells, altering expression of immune-associated proteins and causing a syndromic immune disorder with lymphoid developmental defects and viral hypersusceptibility [PMID:31427773]. Engineered low expression of SNRNP40 in breast cancer cells enhances metastatic colonization, identifying it as a driver of metastatic fitness within variable subpopulations [PMID:27138336]. Beyond its placement in the U5 snRNP and these phenotypic links to immune development and metastasis, the precise molecular contribution of SNRNP40 to spliceosome assembly or catalysis has not been characterized in the available corpus.","teleology":[{"year":2016,"claim":"Established that expression level of SNRNP40 functionally modulates cancer cell behavior, showing a spliceosomal gene can act as a determinant of metastatic colonization.","evidence":"Engineered variable/low expression in breast cancer cell lines with in vivo metastasis assays","pmids":["27138336"],"confidence":"Medium","gaps":["No molecular mechanism linking SNRNP40 level to metastasis was established beyond its spliceosomal context","Specific splicing targets driving the phenotype not identified","Single-lab finding without orthogonal mechanistic follow-up"]},{"year":2018,"claim":"Tested whether SNRNP40 physically associates with transcriptional machinery, recovering it as a candidate nuclear interactor of KLF5.","evidence":"Co-immunoprecipitation of KLF5 followed by LC-MS/MS in TSU-Pr1 bladder cancer cells","pmids":["30289973"],"confidence":"Low","gaps":["Single Co-IP/MS without reciprocal validation; SNRNP40 was one of 122 candidates","Functional significance of the interaction not characterized","Cannot distinguish direct binding from co-complex or contaminant"]},{"year":2019,"claim":"Defined the in vivo physiological consequence of SNRNP40 deficiency, demonstrating that the U5 snRNP subunit is required for splicing fidelity in hematopoietic and lymphoid cells and that its loss causes a syndromic immunodeficiency.","evidence":"Hypomorphic mouse genetic model with intron-retention quantification in primary HSCs and T cells plus cell-intrinsic rescue","pmids":["31427773"],"confidence":"High","gaps":["Molecular role of SNRNP40 within U5 snRNP assembly or catalysis not resolved","Why intron retention predominates over other splicing error classes unexplained","Mechanism linking specific mis-spliced transcripts to immune phenotype not dissected"]},{"year":2021,"claim":"Consolidated SNRNP40 within the U5 snRNP module and linked recurrent somatic mutations and altered expression to human cancers.","evidence":"Literature review synthesizing genetic variant and expression data across U5 snRNP components in disease cohorts","pmids":["33584830"],"confidence":"Medium","gaps":["No new direct experiment; relies on synthesis of prior studies","Causal contribution of SNRNP40 mutations to cancer not experimentally tested","Functional distinction from other U5 components not addressed"]},{"year":null,"claim":"How SNRNP40 contributes mechanistically to U5 snRNP function and how its dosage produces opposite-direction phenotypes in immune cells versus metastatic cancer cells remains unresolved.","evidence":"","pmids":[],"confidence":"Medium","gaps":["No structural or biochemical definition of SNRNP40's role in spliceosome assembly","Direct substrate/transcript determinants of phenotypes not mapped","Reconciliation of immune-loss and cancer-fitness roles not established"]}],"mechanism_profile":{"molecular_activity":[{"term_id":"GO:0140098","term_label":"catalytic activity, acting on RNA","supporting_discovery_ids":[0,1]}],"localization":[{"term_id":"GO:0005634","term_label":"nucleus","supporting_discovery_ids":[0,3]}],"pathway":[{"term_id":"R-HSA-8953854","term_label":"Metabolism of RNA","supporting_discovery_ids":[0,1]}],"complexes":["U5 snRNP","spliceosome"],"partners":["PRPF6","PRPF8","EFTUD2","DDX23"],"other_free_text":[]}},"prefetch_data":{"uniprot":{"accession":"Q96DI7","full_name":"U5 small nuclear ribonucleoprotein 40 kDa protein","aliases":["38 kDa-splicing factor","Prp8-binding protein","hPRP8BP","U5 snRNP-specific 40 kDa protein","WD repeat-containing protein 57"],"length_aa":357,"mass_kda":39.3,"function":"Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:30315277, PubMed:30705154). Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome (PubMed:16723661, PubMed:26912367, PubMed:9774689). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)","subcellular_location":"Nucleus","url":"https://www.uniprot.org/uniprotkb/Q96DI7/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":true,"resolved_as":"","url":"https://depmap.org/portal/gene/SNRNP40","classification":"Common Essential","n_dependent_lines":1095,"n_total_lines":1208,"dependency_fraction":0.9064569536423841},"opencell":{"profiled":true,"resolved_as":"","ensg_id":"ENSG00000060688","cell_line_id":"CID001463","localizations":[{"compartment":"chromatin","grade":3}],"interactors":[{"gene":"PRPF8","stoichiometry":10.0},{"gene":"SNRNP200","stoichiometry":10.0},{"gene":"EFTUD2","stoichiometry":10.0},{"gene":"SNRPD2","stoichiometry":10.0},{"gene":"SF3A2","stoichiometry":4.0},{"gene":"PRPF6","stoichiometry":4.0},{"gene":"SART1","stoichiometry":4.0},{"gene":"PRPF4","stoichiometry":4.0},{"gene":"USP39","stoichiometry":4.0},{"gene":"DDX23","stoichiometry":4.0}],"url":"https://opencell.sf.czbiohub.org/target/CID001463","total_profiled":1310},"omim":[{"mim_id":"617470","title":"UBIQUITIN-SPECIFIC PEPTIDASE-LIKE 1; USPL1","url":"https://www.omim.org/entry/617470"},{"mim_id":"613979","title":"PRE-mRNA-PROCESSING FACTOR 6; PRPF6","url":"https://www.omim.org/entry/613979"},{"mim_id":"607797","title":"SMALL NUCLEAR RIBONUCLEOPROTEIN, 40-KD; SNRNP40","url":"https://www.omim.org/entry/607797"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Supported","locations":[{"location":"Nuclear speckles","reliability":"Supported"}],"tissue_specificity":"Low tissue specificity","tissue_distribution":"Detected in all","driving_tissues":[],"url":"https://www.proteinatlas.org/search/SNRNP40"},"hgnc":{"alias_symbol":["PRP8BP","SPF38","PRPF8BP","HPRP8BP"],"prev_symbol":["WDR57"]},"alphafold":{"accession":"Q96DI7","domains":[{"cath_id":"2.130.10.10","chopping":"58-354","consensus_level":"medium","plddt":93.3829,"start":58,"end":354}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q96DI7","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q96DI7-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q96DI7-F1-predicted_aligned_error_v6.png","plddt_mean":85.25},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=SNRNP40","jax_strain_url":"https://www.jax.org/strain/search?query=SNRNP40"},"sequence":{"accession":"Q96DI7","fasta_url":"https://rest.uniprot.org/uniprotkb/Q96DI7.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q96DI7/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q96DI7"}},"corpus_meta":[{"pmid":"27138336","id":"PMC_27138336","title":"Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness.","date":"2016","source":"Nature communications","url":"https://pubmed.ncbi.nlm.nih.gov/27138336","citation_count":111,"is_preprint":false},{"pmid":"33584830","id":"PMC_33584830","title":"The Role of the U5 snRNP in Genetic Disorders and Cancer.","date":"2021","source":"Frontiers in genetics","url":"https://pubmed.ncbi.nlm.nih.gov/33584830","citation_count":43,"is_preprint":false},{"pmid":"32114312","id":"PMC_32114312","title":"Analysis of testis metabolome and transcriptome from the oriental river prawn (Macrobrachium nipponense) in response to different temperatures and illumination times.","date":"2020","source":"Comparative biochemistry and physiology. Part D, Genomics & proteomics","url":"https://pubmed.ncbi.nlm.nih.gov/32114312","citation_count":35,"is_preprint":false},{"pmid":"34411647","id":"PMC_34411647","title":"Identification of biomarkers for acute leukemia via machine learning-based stemness index.","date":"2021","source":"Gene","url":"https://pubmed.ncbi.nlm.nih.gov/34411647","citation_count":24,"is_preprint":false},{"pmid":"30289973","id":"PMC_30289973","title":"CINP is a novel cofactor of KLF5 required for its role in the promotion of cell proliferation, survival and tumor growth.","date":"2018","source":"International journal of cancer","url":"https://pubmed.ncbi.nlm.nih.gov/30289973","citation_count":15,"is_preprint":false},{"pmid":"34504491","id":"PMC_34504491","title":"The Role of Hemoglobin Subunit Delta in the Immunopathy of Multiple Sclerosis: Mitochondria Matters.","date":"2021","source":"Frontiers in immunology","url":"https://pubmed.ncbi.nlm.nih.gov/34504491","citation_count":14,"is_preprint":false},{"pmid":"31427773","id":"PMC_31427773","title":"Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40.","date":"2019","source":"Nature immunology","url":"https://pubmed.ncbi.nlm.nih.gov/31427773","citation_count":13,"is_preprint":false},{"pmid":"35941161","id":"PMC_35941161","title":"Analysis of genomic alterations in cancer associated human pancreatic stellate cells.","date":"2022","source":"Scientific reports","url":"https://pubmed.ncbi.nlm.nih.gov/35941161","citation_count":4,"is_preprint":false},{"pmid":"36101459","id":"PMC_36101459","title":"Tandem Mass Tag-Based Quantitative Proteomics Analysis of Gonads Reveals New Insight into Sexual Reversal Mechanism in Chinese Soft-Shelled Turtles.","date":"2022","source":"Biology","url":"https://pubmed.ncbi.nlm.nih.gov/36101459","citation_count":4,"is_preprint":false},{"pmid":"37054626","id":"PMC_37054626","title":"Novel genetic variants linked to prelabor rupture of membranes among Chinese pregnant women.","date":"2023","source":"Placenta","url":"https://pubmed.ncbi.nlm.nih.gov/37054626","citation_count":1,"is_preprint":false},{"pmid":"41587934","id":"PMC_41587934","title":"Proteomic Profiling of Non-Muscle Invasive Bladder Cancer Reveals Potential Biomarkers for Recurrence and Progression Risk.","date":"2026","source":"Journal of proteome research","url":"https://pubmed.ncbi.nlm.nih.gov/41587934","citation_count":0,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":8100,"output_tokens":1060,"usd":0.0201,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":7621,"output_tokens":1925,"usd":0.043115,"stage2_stop_reason":"end_turn"},"total_usd":0.063215,"stage1_batch_id":"msgbatch_013LWZZT6MWaqB9qyTSeQBmU","stage2_batch_id":"msgbatch_0194ZzQaTGNpruoNJBbEMbt3","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2019,\n      \"finding\": \"SNRNP40 encodes a subunit of the U5 small nuclear ribonucleoprotein (snRNP) complex of the spliceosome; loss-of-function (hypomorphic mutation) in mice causes increased splicing errors, predominantly intron retention, in several hundred mRNAs in hematopoietic stem cells and T cells, leading to altered expression of proteins associated with immune cell function and a syndromic immune disorder with lymphoid developmental defects and hypersusceptibility to viral infection.\",\n      \"method\": \"Hypomorphic mouse genetic model, RNA splicing analysis in primary hematopoietic stem cells and T cells (intron retention quantification), cell-intrinsic rescue experiments with mutant hematopoietic stem cells\",\n      \"journal\": \"Nature immunology\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Strong — clean loss-of-function genetic model with defined cellular phenotype, splicing analysis across hundreds of mRNAs, cell-intrinsic confirmation, published in high-tier journal\",\n      \"pmids\": [\"31427773\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2021,\n      \"finding\": \"SNRNP40 is a component of the U5 snRNP, a subunit of the spliceosome; recurrent somatic mutations and altered expression levels of SNRNP40 have been associated with human cancers, placing it functionally within the U5 snRNP alongside PRPF6, PRPF8, EFTUD2, and DDX23.\",\n      \"method\": \"Literature review and synthesis of genetic variant/expression data across U5 snRNP components in human disease cohorts\",\n      \"journal\": \"Frontiers in genetics\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 3 / Moderate — review synthesizing multiple studies, no new direct experiment, but consistent with primary mechanistic data from PMID:31427773\",\n      \"pmids\": [\"33584830\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2016,\n      \"finding\": \"Engineered variable (low) expression of the spliceosomal gene SNRNP40 in breast cancer cells promotes metastatic colonization; cells with low SNRNP40 expression are the primary driver of enhanced metastatic fitness within variable subpopulations.\",\n      \"method\": \"Engineered expression manipulation (variable/low expression) in breast cancer cell lines with in vivo metastasis assays\",\n      \"journal\": \"Nature communications\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Weak — single lab, defined cellular phenotype (metastasis) with engineered expression perturbation, but no molecular mechanism beyond spliceosomal context established\",\n      \"pmids\": [\"27138336\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2018,\n      \"finding\": \"SNRNP40 was identified as a potential nuclear binding partner of the transcription factor KLF5 in bladder cancer cells by co-immunoprecipitation followed by LC-MS/MS proteomics, though the functional significance of this interaction was not further characterized in the study.\",\n      \"method\": \"Co-immunoprecipitation of KLF5 from nuclear extracts followed by LC-MS/MS mass spectrometry in TSU-Pr1 bladder cancer cells\",\n      \"journal\": \"International journal of cancer\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 3 / Weak — single Co-IP/MS experiment, SNRNP40 was one of 122 candidate interactors and was not functionally followed up\",\n      \"pmids\": [\"30289973\"],\n      \"is_preprint\": false\n    }\n  ],\n  \"current_model\": \"SNRNP40 is an essential subunit of the U5 snRNP complex of the spliceosome; its deficiency causes widespread pre-mRNA splicing errors (predominantly intron retention) across hundreds of transcripts in lymphoid and hematopoietic cells, leading to reduced expression of critical immune proteins and a syndromic immunodeficiency, while variable/low expression in cancer cells promotes metastatic fitness.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"SNRNP40 is a subunit of the U5 small nuclear ribonucleoprotein (snRNP) complex of the spliceosome, where it acts alongside core U5 components including PRPF6, PRPF8, EFTUD2, and DDX23 to support accurate pre-mRNA splicing [#0, #1]. Hypomorphic loss of function in mice produces widespread splicing errors, predominantly intron retention, across several hundred mRNAs in hematopoietic stem cells and T cells, altering expression of immune-associated proteins and causing a syndromic immune disorder with lymphoid developmental defects and viral hypersusceptibility [#0]. Engineered low expression of SNRNP40 in breast cancer cells enhances metastatic colonization, identifying it as a driver of metastatic fitness within variable subpopulations [#2]. Beyond its placement in the U5 snRNP and these phenotypic links to immune development and metastasis, the precise molecular contribution of SNRNP40 to spliceosome assembly or catalysis has not been characterized in the available corpus.\",\n  \"teleology\": [\n    {\n      \"year\": 2016,\n      \"claim\": \"Established that expression level of SNRNP40 functionally modulates cancer cell behavior, showing a spliceosomal gene can act as a determinant of metastatic colonization.\",\n      \"evidence\": \"Engineered variable/low expression in breast cancer cell lines with in vivo metastasis assays\",\n      \"pmids\": [\"27138336\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\n        \"No molecular mechanism linking SNRNP40 level to metastasis was established beyond its spliceosomal context\",\n        \"Specific splicing targets driving the phenotype not identified\",\n        \"Single-lab finding without orthogonal mechanistic follow-up\"\n      ]\n    },\n    {\n      \"year\": 2018,\n      \"claim\": \"Tested whether SNRNP40 physically associates with transcriptional machinery, recovering it as a candidate nuclear interactor of KLF5.\",\n      \"evidence\": \"Co-immunoprecipitation of KLF5 followed by LC-MS/MS in TSU-Pr1 bladder cancer cells\",\n      \"pmids\": [\"30289973\"],\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\n        \"Single Co-IP/MS without reciprocal validation; SNRNP40 was one of 122 candidates\",\n        \"Functional significance of the interaction not characterized\",\n        \"Cannot distinguish direct binding from co-complex or contaminant\"\n      ]\n    },\n    {\n      \"year\": 2019,\n      \"claim\": \"Defined the in vivo physiological consequence of SNRNP40 deficiency, demonstrating that the U5 snRNP subunit is required for splicing fidelity in hematopoietic and lymphoid cells and that its loss causes a syndromic immunodeficiency.\",\n      \"evidence\": \"Hypomorphic mouse genetic model with intron-retention quantification in primary HSCs and T cells plus cell-intrinsic rescue\",\n      \"pmids\": [\"31427773\"],\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\n        \"Molecular role of SNRNP40 within U5 snRNP assembly or catalysis not resolved\",\n        \"Why intron retention predominates over other splicing error classes unexplained\",\n        \"Mechanism linking specific mis-spliced transcripts to immune phenotype not dissected\"\n      ]\n    },\n    {\n      \"year\": 2021,\n      \"claim\": \"Consolidated SNRNP40 within the U5 snRNP module and linked recurrent somatic mutations and altered expression to human cancers.\",\n      \"evidence\": \"Literature review synthesizing genetic variant and expression data across U5 snRNP components in disease cohorts\",\n      \"pmids\": [\"33584830\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\n        \"No new direct experiment; relies on synthesis of prior studies\",\n        \"Causal contribution of SNRNP40 mutations to cancer not experimentally tested\",\n        \"Functional distinction from other U5 components not addressed\"\n      ]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"How SNRNP40 contributes mechanistically to U5 snRNP function and how its dosage produces opposite-direction phenotypes in immune cells versus metastatic cancer cells remains unresolved.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\n        \"No structural or biochemical definition of SNRNP40's role in spliceosome assembly\",\n        \"Direct substrate/transcript determinants of phenotypes not mapped\",\n        \"Reconciliation of immune-loss and cancer-fitness roles not established\"\n      ]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\"term_id\": \"GO:0140098\", \"supporting_discovery_ids\": [0, 1]}\n    ],\n    \"localization\": [\n      {\"term_id\": \"GO:0005634\", \"supporting_discovery_ids\": [0, 3]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"R-HSA-8953854\", \"supporting_discovery_ids\": [0, 1]}\n    ],\n    \"complexes\": [\"U5 snRNP\", \"spliceosome\"],\n    \"partners\": [\"PRPF6\", \"PRPF8\", \"EFTUD2\", \"DDX23\"],\n    \"other_free_text\": []\n  }\n}","audit_flag":null,"evaluation":{"pairwise":"win","faith_supported":3,"faith_total":3,"faith_pct":100.0}}