{"gene":"RSBN1L","run_date":"2026-06-10T07:46:28","timeline":{"discoveries":[],"current_model":"No mechanistic findings in the available literature."},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null},"prefetch_data":{"uniprot":{"accession":"Q6PCB5","full_name":"Lysine-specific demethylase RSBN1L","aliases":["Round spermatid basic protein 1-like protein"],"length_aa":846,"mass_kda":94.9,"function":"Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins","subcellular_location":"Nucleus","url":"https://www.uniprot.org/uniprotkb/Q6PCB5/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/RSBN1L","classification":"Not Classified","n_dependent_lines":4,"n_total_lines":1208,"dependency_fraction":0.0033112582781456954},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[{"gene":"DYNLL1","stoichiometry":0.2},{"gene":"DYNLL2","stoichiometry":0.2},{"gene":"HMGN5","stoichiometry":0.2},{"gene":"MAP4K4","stoichiometry":0.2},{"gene":"NPM1","stoichiometry":0.2},{"gene":"PPM1G","stoichiometry":0.2},{"gene":"PSPC1","stoichiometry":0.2},{"gene":"RACK1","stoichiometry":0.2},{"gene":"RPS16","stoichiometry":0.2},{"gene":"SRP9","stoichiometry":0.2}],"url":"https://opencell.sf.czbiohub.org/search/RSBN1L","total_profiled":1310},"omim":[{"mim_id":"616048","title":"ALU-MEDIATED CDKN1A/p21 TRANSCRIPTIONAL REGULATOR, NONCODING; APTR","url":"https://www.omim.org/entry/616048"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Supported","locations":[{"location":"Nuclear speckles","reliability":"Supported"},{"location":"Plasma membrane","reliability":"Additional"}],"tissue_specificity":"Low tissue specificity","tissue_distribution":"Detected in all","driving_tissues":[],"url":"https://www.proteinatlas.org/search/RSBN1L"},"hgnc":{"alias_symbol":["FLJ42526","FLJ45813","MGC71764"],"prev_symbol":[]},"alphafold":{"accession":"Q6PCB5","domains":[{"cath_id":"2.60.120.650","chopping":"400-532_561-694","consensus_level":"high","plddt":94.6146,"start":400,"end":694}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q6PCB5","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q6PCB5-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q6PCB5-F1-predicted_aligned_error_v6.png","plddt_mean":62.19},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=RSBN1L","jax_strain_url":"https://www.jax.org/strain/search?query=RSBN1L"},"sequence":{"accession":"Q6PCB5","fasta_url":"https://rest.uniprot.org/uniprotkb/Q6PCB5.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q6PCB5/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q6PCB5"}},"corpus_meta":[{"pmid":"36425075","id":"PMC_36425075","title":"Hsa_circ_0074158 regulates the endothelial barrier function in sepsis and its potential value as a biomarker.","date":"2022","source":"Frontiers in genetics","url":"https://pubmed.ncbi.nlm.nih.gov/36425075","citation_count":3,"is_preprint":false},{"pmid":"37657032","id":"PMC_37657032","title":"Analysis of genomic alterations in primary central nervous system lymphoma.","date":"2023","source":"Medicine","url":"https://pubmed.ncbi.nlm.nih.gov/37657032","citation_count":2,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":3531,"output_tokens":34,"usd":0.005552,"stage1_stop_reason":"end_turn"},"stage2":{"model":"","input_tokens":0,"output_tokens":0,"usd":0.0},"total_usd":0.005552,"stage1_batch_id":"msgbatch_013LWZZT6MWaqB9qyTSeQBmU","stage2_batch_id":"msgbatch_0194ZzQaTGNpruoNJBbEMbt3","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [],\n  \"current_model\": \"No mechanistic findings in the available literature.\"\n}\n```","stage2_raw":"","audit_flag":null,"evaluation":null}