{"gene":"RBM33","run_date":"2026-06-10T06:43:36","timeline":{"discoveries":[{"year":2023,"finding":"RBM33 is an m6A RNA-binding protein that forms a complex with the m6A demethylase ALKBH5, recruits ALKBH5 to m6A-marked substrate mRNAs, and activates ALKBH5 demethylase activity through removal of ALKBH5 SUMOylation, thereby directing selective demethylation of a subset of mRNA transcripts.","method":"Co-immunoprecipitation, m6A sequencing, identification of SUMOylation removal, mechanistic epistasis in HNSCC cells","journal":"Molecular cell","confidence":"High","confidence_rationale":"Tier 2 / Moderate — reciprocal complex formation, multiple orthogonal methods (Co-IP, m6A-seq, SUMOylation assay, functional rescue), single lab but comprehensive mechanistic dissection","pmids":["37257451"],"is_preprint":false},{"year":2023,"finding":"RBM33 promotes autophagy in head-neck squamous cell carcinoma (HNSCC) cells by recruiting ALKBH5 to demethylate and stabilize DDIT4 mRNA, identifying a specific substrate-pathway axis downstream of RBM33–ALKBH5 complex activity.","method":"m6A-seq, mRNA stability assay, RBM33 knockdown/overexpression with autophagy readouts in HNSCC cells","journal":"Molecular cell","confidence":"Medium","confidence_rationale":"Tier 2 / Weak — clean KD/OE with defined cellular phenotype (autophagy, DDIT4 stabilization), single lab, single study","pmids":["37257451"],"is_preprint":false},{"year":2022,"finding":"RBM33 directly binds GC-rich elements in target transcripts and recruits components of the TREX-NXF1/NXT1 RNA export pathway to direct nuclear export of transcripts with high GC content, including the intronless lncRNA NORAD.","method":"Genome-wide CRISPR screen, RNA binding assays, nuclear export assays, identification of TREX-NXF1/NXT1 as recruited effectors","journal":"Genes & development","confidence":"High","confidence_rationale":"Tier 2 / Moderate — genome-wide genetic screen plus direct RNA binding and pathway placement via TREX-NXF1/NXT1 recruitment, multiple orthogonal methods in a single rigorous study","pmids":["35589130"],"is_preprint":false},{"year":2024,"finding":"RBM33 binds RNA at specific nucleotide-level sites in HEK293T cells, as demonstrated by PAR-CLIP-seq using a FLAG-RBM33 stable cell line.","method":"PAR-CLIP-seq (photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation followed by next-generation sequencing)","journal":"STAR protocols","confidence":"Medium","confidence_rationale":"Tier 2 / Weak — single lab, transcriptome-scale direct RNA binding mapping, protocol paper with limited functional follow-up reported in abstract","pmids":["38300798"],"is_preprint":false}],"current_model":"RBM33 is an m6A RNA-binding protein that (1) directly binds GC-rich RNA elements and recruits the TREX-NXF1/NXT1 export machinery to drive nuclear export of GC-rich transcripts, and (2) forms a complex with the m6A demethylase ALKBH5, recruits it to specific m6A-marked mRNA substrates, and activates its demethylase activity by removing its SUMOylation, thereby enabling selective m6A demethylation and downstream regulation of processes such as autophagy via DDIT4 mRNA stabilization."},"narrative":{"mechanistic_narrative":"RBM33 is an m6A-binding protein that couples direct RNA recognition to two distinct post-transcriptional control mechanisms: selective m6A demethylation and nuclear RNA export [PMID:37257451, PMID:35589130]. In one axis, RBM33 forms a complex with the m6A demethylase ALKBH5, recruits it to specific m6A-marked mRNA substrates, and activates its catalytic activity by removing ALKBH5 SUMOylation, thereby directing demethylation of a defined subset of transcripts [PMID:37257451]; through this route it stabilizes DDIT4 mRNA to promote autophagy in head-neck squamous cell carcinoma cells [PMID:37257451]. In a parallel axis, RBM33 binds GC-rich elements in target transcripts and recruits the TREX-NXF1/NXT1 export machinery to drive nuclear export of high-GC-content RNAs, including the intronless lncRNA NORAD [PMID:35589130]. Nucleotide-resolution mapping of RBM33 RNA-binding sites confirms direct, site-specific RNA engagement [PMID:38300798].","teleology":[{"year":2022,"claim":"Establishing how RBM33 acts on RNA, a genome-wide screen placed it as a direct GC-rich RNA binder that channels high-GC transcripts into the nuclear export pathway.","evidence":"Genome-wide CRISPR screen with RNA binding and nuclear export assays identifying TREX-NXF1/NXT1 recruitment","pmids":["35589130"],"confidence":"High","gaps":["Sequence/structural basis of GC-rich element recognition not defined","Breadth of the export-dependent transcriptome beyond NORAD not delineated","Relationship between the export function and m6A binding not resolved"]},{"year":2023,"claim":"To explain selective m6A demethylation, RBM33 was shown to act as a substrate-selecting cofactor for ALKBH5, recruiting and activating the demethylase by removing its SUMOylation.","evidence":"Co-IP, m6A-seq, SUMOylation assay, and functional rescue in HNSCC cells","pmids":["37257451"],"confidence":"High","gaps":["Enzyme/mechanism stripping ALKBH5 SUMO not identified","Rules governing which m6A substrates are selected unclear","Whether RBM33 m6A binding and demethylation are coupled to its export role unknown"]},{"year":2023,"claim":"A concrete substrate-pathway axis was defined: RBM33-directed ALKBH5 demethylation stabilizes DDIT4 mRNA to promote autophagy in HNSCC.","evidence":"m6A-seq, mRNA stability assay, and knockdown/overexpression with autophagy readouts in HNSCC cells","pmids":["37257451"],"confidence":"Medium","gaps":["Single cell-context study; generality across tissues untested","Other physiological substrates of the axis not catalogued","Quantitative contribution of DDIT4 stabilization to autophagy phenotype not isolated"]},{"year":2024,"claim":"Nucleotide-resolution binding maps confirmed direct, site-specific RNA engagement by RBM33 transcriptome-wide.","evidence":"PAR-CLIP-seq using a FLAG-RBM33 stable cell line in HEK293T","pmids":["38300798"],"confidence":"Medium","gaps":["Protocol-focused report with limited functional interpretation","Binding-site motifs not linked to specific downstream outcomes here","Overlap between mapped sites and m6A/GC-rich functional targets not analyzed"]},{"year":null,"claim":"How RBM33's two activities — GC-rich export and ALKBH5-dependent demethylation — are mechanistically integrated, and whether they operate on shared transcripts, remains unresolved.","evidence":"","pmids":[],"confidence":"Medium","gaps":["No structural model of RBM33 RNA recognition","Coordination between export and demethylation functions undefined","Physiological scope beyond HNSCC and cultured cells unknown"]}],"mechanism_profile":{"molecular_activity":[{"term_id":"GO:0003723","term_label":"RNA binding","supporting_discovery_ids":[0,2,3]},{"term_id":"GO:0098772","term_label":"molecular function regulator activity","supporting_discovery_ids":[0]},{"term_id":"GO:0060090","term_label":"molecular adaptor activity","supporting_discovery_ids":[0,2]}],"localization":[{"term_id":"GO:0005634","term_label":"nucleus","supporting_discovery_ids":[2]}],"pathway":[{"term_id":"R-HSA-8953854","term_label":"Metabolism of RNA","supporting_discovery_ids":[0,2]},{"term_id":"R-HSA-9612973","term_label":"Autophagy","supporting_discovery_ids":[1]}],"complexes":["RBM33-ALKBH5 complex"],"partners":["ALKBH5","NXF1","NXT1"],"other_free_text":[]}},"prefetch_data":{"uniprot":{"accession":"Q96EV2","full_name":"RNA-binding protein 33","aliases":["Proline-rich protein 8","RNA-binding motif protein 33"],"length_aa":1170,"mass_kda":130.0,"function":"RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as mRNA export, mRNA stability and/or translation (PubMed:35589130, PubMed:37257451). Binds a subset of intronless RNAs containing GC-rich elements, such as NORAD, and promotes their nuclear export by recruiting target RNAs to components of the NXF1-NXT1 RNA export machinery (PubMed:35589130). Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, promoting their demethylation by ALKBH5 (PubMed:37257451). Acts as an molecular adapter, which (1) promotes ALKBH5 recruitment to m6A-containing transcripts and (2) activates ALKBH5 demethylase activity by recruiting SENP1, leading to ALKBH5 deSUMOylation and subsequent activation (PubMed:37257451)","subcellular_location":"Nucleus; Cytoplasm","url":"https://www.uniprot.org/uniprotkb/Q96EV2/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/RBM33","classification":"Not Classified","n_dependent_lines":347,"n_total_lines":1208,"dependency_fraction":0.28725165562913907},"opencell":{"profiled":true,"resolved_as":"","ensg_id":"ENSG00000184863","cell_line_id":"CID001481","localizations":[{"compartment":"chromatin","grade":3},{"compartment":"nucleoplasm","grade":2}],"interactors":[{"gene":"POLDIP3","stoichiometry":10.0},{"gene":"SAP18","stoichiometry":4.0},{"gene":"PABPN1","stoichiometry":4.0},{"gene":"ZC3H11A","stoichiometry":4.0},{"gene":"DDX39B","stoichiometry":0.2},{"gene":"SNRNP200","stoichiometry":0.2},{"gene":"DDX39A","stoichiometry":0.2},{"gene":"THRAP3","stoichiometry":0.2},{"gene":"THOC1","stoichiometry":0.2},{"gene":"ZC3H14","stoichiometry":0.2}],"url":"https://opencell.sf.czbiohub.org/target/CID001481","total_profiled":1310},"omim":[{"mim_id":"620833","title":"RNA-BINDING MOTIF PROTEIN 33; RBM33","url":"https://www.omim.org/entry/620833"},{"mim_id":"617037","title":"NONCODING RNA ACTIVATED BY DNA DAMAGE; NORAD","url":"https://www.omim.org/entry/617037"},{"mim_id":"613303","title":"AlkB HOMOLOG 5, RNA DEMETHYLASE; ALKBH5","url":"https://www.omim.org/entry/613303"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Approved","locations":[{"location":"Nucleoplasm","reliability":"Approved"}],"tissue_specificity":"Low tissue specificity","tissue_distribution":"Detected in all","driving_tissues":[],"url":"https://www.proteinatlas.org/search/RBM33"},"hgnc":{"alias_symbol":["DKFZp686F102","MGC20460","DKFZp434D1319"],"prev_symbol":["PRR8"]},"alphafold":{"accession":"Q96EV2","domains":[{"cath_id":"3.30.70.330","chopping":"1100-1169","consensus_level":"high","plddt":95.5313,"start":1100,"end":1169}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q96EV2","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q96EV2-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q96EV2-F1-predicted_aligned_error_v6.png","plddt_mean":46.56},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=RBM33","jax_strain_url":"https://www.jax.org/strain/search?query=RBM33"},"sequence":{"accession":"Q96EV2","fasta_url":"https://rest.uniprot.org/uniprotkb/Q96EV2.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q96EV2/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q96EV2"}},"corpus_meta":[{"pmid":"37257451","id":"PMC_37257451","title":"RBM33 is a unique m6A RNA-binding protein that regulates ALKBH5 demethylase activity and substrate selectivity.","date":"2023","source":"Molecular cell","url":"https://pubmed.ncbi.nlm.nih.gov/37257451","citation_count":49,"is_preprint":false},{"pmid":"33398465","id":"PMC_33398465","title":"Circular RNA RBM33 contributes to cervical cancer progression via modulation of the miR-758-3p/PUM2 axis.","date":"2021","source":"Journal of molecular histology","url":"https://pubmed.ncbi.nlm.nih.gov/33398465","citation_count":22,"is_preprint":false},{"pmid":"35589130","id":"PMC_35589130","title":"RBM33 directs the nuclear export of transcripts containing GC-rich elements.","date":"2022","source":"Genes & development","url":"https://pubmed.ncbi.nlm.nih.gov/35589130","citation_count":21,"is_preprint":false},{"pmid":"34820156","id":"PMC_34820156","title":"Circular RNA RBM33 contributes to extracellular matrix degradation via miR-4268/EPHB2 axis in abdominal aortic aneurysm.","date":"2021","source":"PeerJ","url":"https://pubmed.ncbi.nlm.nih.gov/34820156","citation_count":13,"is_preprint":false},{"pmid":"21745575","id":"PMC_21745575","title":"Expression, purification and characterization of refolded rBm-33 (pepsin inhibitor homolog) from Brugia malayi: a human Lymphatic Filarial parasite.","date":"2011","source":"Protein expression and purification","url":"https://pubmed.ncbi.nlm.nih.gov/21745575","citation_count":5,"is_preprint":false},{"pmid":"22484090","id":"PMC_22484090","title":"Recombinant Brugia malayi pepsin inhibitor (rBm33) induced monocyte function and absence of apoptotic cell death: an in vitro study.","date":"2012","source":"Microbial pathogenesis","url":"https://pubmed.ncbi.nlm.nih.gov/22484090","citation_count":3,"is_preprint":false},{"pmid":"28942176","id":"PMC_28942176","title":"Recombinant Brugia malayi pepsin inhibitor (rBm33) exploits host signaling events to regulate inflammatory responses associated with lymphatic filarial infections.","date":"2017","source":"Microbial pathogenesis","url":"https://pubmed.ncbi.nlm.nih.gov/28942176","citation_count":2,"is_preprint":false},{"pmid":"22957693","id":"PMC_22957693","title":"Physicochemical characterization of an aspin (rBm-33) from a filarial parasite Brugia malayi against the important human aspartic proteases.","date":"2012","source":"Journal of enzyme inhibition and medicinal chemistry","url":"https://pubmed.ncbi.nlm.nih.gov/22957693","citation_count":2,"is_preprint":false},{"pmid":"37327770","id":"PMC_37327770","title":"RBM33: A new regulator of N-6-methyladenosine (m6A) methylation.","date":"2023","source":"Molecular cell","url":"https://pubmed.ncbi.nlm.nih.gov/37327770","citation_count":1,"is_preprint":false},{"pmid":"38300798","id":"PMC_38300798","title":"Protocol for detecting RBM33-binding sites in HEK293T cells using PAR-CLIP-seq.","date":"2024","source":"STAR protocols","url":"https://pubmed.ncbi.nlm.nih.gov/38300798","citation_count":0,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":6334,"output_tokens":1070,"usd":0.017526,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":7597,"output_tokens":1865,"usd":0.042305,"stage2_stop_reason":"end_turn"},"total_usd":0.059831,"stage1_batch_id":"msgbatch_01CNoDbkChHEkgrJnL7BwtGJ","stage2_batch_id":"msgbatch_016Y4x9E9Wg5VQDANj9quSQD","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2023,\n      \"finding\": \"RBM33 is an m6A RNA-binding protein that forms a complex with the m6A demethylase ALKBH5, recruits ALKBH5 to m6A-marked substrate mRNAs, and activates ALKBH5 demethylase activity through removal of ALKBH5 SUMOylation, thereby directing selective demethylation of a subset of mRNA transcripts.\",\n      \"method\": \"Co-immunoprecipitation, m6A sequencing, identification of SUMOylation removal, mechanistic epistasis in HNSCC cells\",\n      \"journal\": \"Molecular cell\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — reciprocal complex formation, multiple orthogonal methods (Co-IP, m6A-seq, SUMOylation assay, functional rescue), single lab but comprehensive mechanistic dissection\",\n      \"pmids\": [\"37257451\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2023,\n      \"finding\": \"RBM33 promotes autophagy in head-neck squamous cell carcinoma (HNSCC) cells by recruiting ALKBH5 to demethylate and stabilize DDIT4 mRNA, identifying a specific substrate-pathway axis downstream of RBM33–ALKBH5 complex activity.\",\n      \"method\": \"m6A-seq, mRNA stability assay, RBM33 knockdown/overexpression with autophagy readouts in HNSCC cells\",\n      \"journal\": \"Molecular cell\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Weak — clean KD/OE with defined cellular phenotype (autophagy, DDIT4 stabilization), single lab, single study\",\n      \"pmids\": [\"37257451\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2022,\n      \"finding\": \"RBM33 directly binds GC-rich elements in target transcripts and recruits components of the TREX-NXF1/NXT1 RNA export pathway to direct nuclear export of transcripts with high GC content, including the intronless lncRNA NORAD.\",\n      \"method\": \"Genome-wide CRISPR screen, RNA binding assays, nuclear export assays, identification of TREX-NXF1/NXT1 as recruited effectors\",\n      \"journal\": \"Genes & development\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — genome-wide genetic screen plus direct RNA binding and pathway placement via TREX-NXF1/NXT1 recruitment, multiple orthogonal methods in a single rigorous study\",\n      \"pmids\": [\"35589130\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2024,\n      \"finding\": \"RBM33 binds RNA at specific nucleotide-level sites in HEK293T cells, as demonstrated by PAR-CLIP-seq using a FLAG-RBM33 stable cell line.\",\n      \"method\": \"PAR-CLIP-seq (photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation followed by next-generation sequencing)\",\n      \"journal\": \"STAR protocols\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Weak — single lab, transcriptome-scale direct RNA binding mapping, protocol paper with limited functional follow-up reported in abstract\",\n      \"pmids\": [\"38300798\"],\n      \"is_preprint\": false\n    }\n  ],\n  \"current_model\": \"RBM33 is an m6A RNA-binding protein that (1) directly binds GC-rich RNA elements and recruits the TREX-NXF1/NXT1 export machinery to drive nuclear export of GC-rich transcripts, and (2) forms a complex with the m6A demethylase ALKBH5, recruits it to specific m6A-marked mRNA substrates, and activates its demethylase activity by removing its SUMOylation, thereby enabling selective m6A demethylation and downstream regulation of processes such as autophagy via DDIT4 mRNA stabilization.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"RBM33 is an m6A-binding protein that couples direct RNA recognition to two distinct post-transcriptional control mechanisms: selective m6A demethylation and nuclear RNA export [#0, #2]. In one axis, RBM33 forms a complex with the m6A demethylase ALKBH5, recruits it to specific m6A-marked mRNA substrates, and activates its catalytic activity by removing ALKBH5 SUMOylation, thereby directing demethylation of a defined subset of transcripts [#0]; through this route it stabilizes DDIT4 mRNA to promote autophagy in head-neck squamous cell carcinoma cells [#1]. In a parallel axis, RBM33 binds GC-rich elements in target transcripts and recruits the TREX-NXF1/NXT1 export machinery to drive nuclear export of high-GC-content RNAs, including the intronless lncRNA NORAD [#2]. Nucleotide-resolution mapping of RBM33 RNA-binding sites confirms direct, site-specific RNA engagement [#3].\",\n  \"teleology\": [\n    {\n      \"year\": 2022,\n      \"claim\": \"Establishing how RBM33 acts on RNA, a genome-wide screen placed it as a direct GC-rich RNA binder that channels high-GC transcripts into the nuclear export pathway.\",\n      \"evidence\": \"Genome-wide CRISPR screen with RNA binding and nuclear export assays identifying TREX-NXF1/NXT1 recruitment\",\n      \"pmids\": [\"35589130\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"Sequence/structural basis of GC-rich element recognition not defined\", \"Breadth of the export-dependent transcriptome beyond NORAD not delineated\", \"Relationship between the export function and m6A binding not resolved\"]\n    },\n    {\n      \"year\": 2023,\n      \"claim\": \"To explain selective m6A demethylation, RBM33 was shown to act as a substrate-selecting cofactor for ALKBH5, recruiting and activating the demethylase by removing its SUMOylation.\",\n      \"evidence\": \"Co-IP, m6A-seq, SUMOylation assay, and functional rescue in HNSCC cells\",\n      \"pmids\": [\"37257451\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"Enzyme/mechanism stripping ALKBH5 SUMO not identified\", \"Rules governing which m6A substrates are selected unclear\", \"Whether RBM33 m6A binding and demethylation are coupled to its export role unknown\"]\n    },\n    {\n      \"year\": 2023,\n      \"claim\": \"A concrete substrate-pathway axis was defined: RBM33-directed ALKBH5 demethylation stabilizes DDIT4 mRNA to promote autophagy in HNSCC.\",\n      \"evidence\": \"m6A-seq, mRNA stability assay, and knockdown/overexpression with autophagy readouts in HNSCC cells\",\n      \"pmids\": [\"37257451\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Single cell-context study; generality across tissues untested\", \"Other physiological substrates of the axis not catalogued\", \"Quantitative contribution of DDIT4 stabilization to autophagy phenotype not isolated\"]\n    },\n    {\n      \"year\": 2024,\n      \"claim\": \"Nucleotide-resolution binding maps confirmed direct, site-specific RNA engagement by RBM33 transcriptome-wide.\",\n      \"evidence\": \"PAR-CLIP-seq using a FLAG-RBM33 stable cell line in HEK293T\",\n      \"pmids\": [\"38300798\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Protocol-focused report with limited functional interpretation\", \"Binding-site motifs not linked to specific downstream outcomes here\", \"Overlap between mapped sites and m6A/GC-rich functional targets not analyzed\"]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"How RBM33's two activities — GC-rich export and ALKBH5-dependent demethylation — are mechanistically integrated, and whether they operate on shared transcripts, remains unresolved.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"No structural model of RBM33 RNA recognition\", \"Coordination between export and demethylation functions undefined\", \"Physiological scope beyond HNSCC and cultured cells unknown\"]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\"term_id\": \"GO:0003723\", \"supporting_discovery_ids\": [0, 2, 3]},\n      {\"term_id\": \"GO:0098772\", \"supporting_discovery_ids\": [0]},\n      {\"term_id\": \"GO:0060090\", \"supporting_discovery_ids\": [0, 2]}\n    ],\n    \"localization\": [\n      {\"term_id\": \"GO:0005634\", \"supporting_discovery_ids\": [2]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"R-HSA-8953854\", \"supporting_discovery_ids\": [0, 2]},\n      {\"term_id\": \"R-HSA-9612973\", \"supporting_discovery_ids\": [1]}\n    ],\n    \"complexes\": [\"RBM33-ALKBH5 complex\"],\n    \"partners\": [\"ALKBH5\", \"NXF1\", \"NXT1\"],\n    \"other_free_text\": []\n  }\n}","audit_flag":null,"evaluation":{"pairwise":"win","faith_supported":4,"faith_total":4,"faith_pct":100.0}}