{"gene":"POLR2J3","run_date":"2026-06-10T06:43:35","timeline":{"discoveries":[],"current_model":"No mechanistic findings in the available literature."},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null},"prefetch_data":{"uniprot":{"accession":"Q9H1A7","full_name":"DNA-directed RNA polymerase II subunit RPB11-b2","aliases":["DNA-directed RNA polymerase II subunit J3"],"length_aa":115,"mass_kda":13.1,"function":"DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity)","subcellular_location":"Nucleus","url":"https://www.uniprot.org/uniprotkb/Q9H1A7/entry"},"depmap":{"release":"DepMap","has_data":false,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/POLR2J3"},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[],"url":"https://opencell.sf.czbiohub.org/search/POLR2J3","total_profiled":1310},"omim":[],"hpa":{"profiled":true,"resolved_as":"","reliability":"Approved","locations":[{"location":"Nucleoplasm","reliability":"Approved"}],"tissue_specificity":"Low tissue specificity","tissue_distribution":"Detected in all","driving_tissues":[],"url":"https://www.proteinatlas.org/search/POLR2J3"},"hgnc":{"alias_symbol":[],"prev_symbol":[]},"alphafold":{"accession":"Q9H1A7","domains":[{"cath_id":"3.30.1360.10","chopping":"16-113","consensus_level":"high","plddt":94.3231,"start":16,"end":113}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q9H1A7","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q9H1A7-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q9H1A7-F1-predicted_aligned_error_v6.png","plddt_mean":92.88},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=POLR2J3","jax_strain_url":"https://www.jax.org/strain/search?query=POLR2J3"},"sequence":{"accession":"Q9H1A7","fasta_url":"https://rest.uniprot.org/uniprotkb/Q9H1A7.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q9H1A7/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q9H1A7"}},"corpus_meta":[{"pmid":"34846081","id":"PMC_34846081","title":"Comprehensive analyses of microRNA and mRNA expression in colorectal serrated lesions and colorectal cancer with a microsatellite instability phenotype.","date":"2021","source":"Genes, chromosomes & cancer","url":"https://pubmed.ncbi.nlm.nih.gov/34846081","citation_count":5,"is_preprint":false},{"pmid":"41496791","id":"PMC_41496791","title":"The exploration of immunological landscape and drug targets in chronic rhinosinusitis with nasal polyps.","date":"2025","source":"The World Allergy Organization journal","url":"https://pubmed.ncbi.nlm.nih.gov/41496791","citation_count":0,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":3418,"output_tokens":34,"usd":0.005382,"stage1_stop_reason":"end_turn"},"stage2":{"model":"","input_tokens":0,"output_tokens":0,"usd":0.0},"total_usd":0.005382,"stage1_batch_id":"msgbatch_01CNoDbkChHEkgrJnL7BwtGJ","stage2_batch_id":"msgbatch_016Y4x9E9Wg5VQDANj9quSQD","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [],\n  \"current_model\": \"No mechanistic findings in the available literature.\"\n}\n```","stage2_raw":"","audit_flag":null,"evaluation":null}