{"gene":"NODAL","run_date":"2026-06-10T05:19:52","timeline":{"discoveries":[],"current_model":"No mechanistic findings in the available literature."},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null},"prefetch_data":{"uniprot":{"accession":"Q96S42","full_name":"Nodal homolog","aliases":[],"length_aa":347,"mass_kda":39.6,"function":"Essential for mesoderm formation and axial patterning during embryonic development","subcellular_location":"Secreted","url":"https://www.uniprot.org/uniprotkb/Q96S42/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/NODAL","classification":"Not Classified","n_dependent_lines":6,"n_total_lines":1208,"dependency_fraction":0.004966887417218543},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[],"url":"https://opencell.sf.czbiohub.org/search/NODAL","total_profiled":1310},"omim":[{"mim_id":"621079","title":"HETEROTAXY, VISCERAL, 13, AUTOSOMAL; HTX13","url":"https://www.omim.org/entry/621079"},{"mim_id":"620506","title":"INTRAFLAGELLAR TRANSPORT 46; IFT46","url":"https://www.omim.org/entry/620506"},{"mim_id":"619726","title":"HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 2; HAPLN2","url":"https://www.omim.org/entry/619726"},{"mim_id":"619564","title":"CALAXIN; CLXN","url":"https://www.omim.org/entry/619564"},{"mim_id":"619342","title":"POST-GPI ATTACHMENT TO PROTEINS 6; PGAP6","url":"https://www.omim.org/entry/619342"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"","locations":[],"tissue_specificity":"Tissue enhanced","tissue_distribution":"Detected in some","driving_tissues":[{"tissue":"skeletal muscle","ntpm":2.6}],"url":"https://www.proteinatlas.org/search/NODAL"},"hgnc":{"alias_symbol":[],"prev_symbol":[]},"alphafold":{"accession":"Q96S42","domains":[{"cath_id":"-","chopping":"52-120_130-206","consensus_level":"high","plddt":78.588,"start":52,"end":206},{"cath_id":"2.10.90.10","chopping":"244-347","consensus_level":"high","plddt":94.8853,"start":244,"end":347}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q96S42","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q96S42-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q96S42-F1-predicted_aligned_error_v6.png","plddt_mean":75.44},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=NODAL","jax_strain_url":"https://www.jax.org/strain/search?query=NODAL"},"sequence":{"accession":"Q96S42","fasta_url":"https://rest.uniprot.org/uniprotkb/Q96S42.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q96S42/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q96S42"}},"corpus_meta":[],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":2229,"output_tokens":34,"usd":0.003599,"stage1_stop_reason":"end_turn"},"stage2":{"model":"","input_tokens":0,"output_tokens":0,"usd":0.0},"total_usd":0.003599,"stage1_batch_id":"msgbatch_013a8chtv3AWyTqv4z4sEF4C","stage2_batch_id":"msgbatch_01AHsuW63vinsvuTgzmQ3n62","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [],\n  \"current_model\": \"No mechanistic findings in the available literature.\"\n}\n```","stage2_raw":"","audit_flag":null,"evaluation":null}