{"gene":"MOXD1","run_date":"2026-06-10T02:59:50","timeline":{"discoveries":[{"year":2022,"finding":"MOXD1 knockdown in glioblastoma cells inhibits cell viability, proliferation, migration, invasion, and tumorigenesis, and was shown for the first time to bind β3GnT2, affecting glycosylation modification of certain proteins. Additionally, MOXD1 knockdown induces endoplasmic reticulum stress and triggers the ER-mitochondrial apoptosis pathway.","method":"siRNA/shRNA knockdown, co-immunoprecipitation (binding to β3GnT2), cell viability/proliferation/migration/invasion assays, in vivo tumorigenesis assay, ER stress markers","journal":"Cell death discovery","confidence":"Medium","confidence_rationale":"Tier 2–3 / Moderate — reciprocal interaction shown by pulldown/Co-IP, multiple orthogonal functional readouts (viability, migration, ER stress, apoptosis), single lab","pmids":["35393406"],"is_preprint":false},{"year":2024,"finding":"MOXD1 is a lineage-restricted tumor suppressor gene in neuroblastoma; its expression is highly conserved and restricted to mesenchymal neuroblastoma cells and Schwann cell precursors during healthy development, and loss of MOXD1 expression associates with advanced disease. In vivo models (zebrafish, chick, mouse) confirmed its role as a determinant of tumor development.","method":"Single-cell RNA sequencing, in vivo loss-of-function models (zebrafish, chick, mouse), RNA sequencing of human neuroblastoma samples","journal":"Science advances","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — multiple in vivo model organisms with loss-of-function, single lab but orthogonal approaches","pmids":["38905335"],"is_preprint":false},{"year":2024,"finding":"FTO (m6A demethylase) targets MOXD1 mRNA, promoting its expression via m6A methylation modification; MOXD1 silencing suppressed malignant phenotype of gastric cancer cells and activated cancer-related signaling pathways (MAPK, TGF-β, NOTCH, JAK/STAT).","method":"RIP-qPCR (RNA immunoprecipitation), RT-qPCR, shRNA knockdown, cell proliferation/migration/apoptosis assays, RNA-seq pathway analysis","journal":"BMC gastroenterology","confidence":"Medium","confidence_rationale":"Tier 2–3 / Moderate — RIP-qPCR demonstrates direct m6A methylation of MOXD1 mRNA by FTO, combined with functional knockdown assays, single lab","pmids":["38200441"],"is_preprint":false},{"year":2026,"finding":"MOXD1 directly interacts with the ACOX1-PEX5 translocation complex, promoting ACOX1 trafficking to peroxisomes to block lipolysis and lipophagy in hepatocytes, thereby driving MASH (metabolic dysfunction-associated steatohepatitis) pathogenesis. Four key MOXD1 residues required for ACOX1 binding were identified. A small molecule inhibitor (rM15) that directly binds MOXD1 and blocks its interaction with ACOX1 was identified and shown to protect against hepatocyte lipid accumulation and suppress diet-induced MASH in vivo.","method":"Co-immunoprecipitation-mass spectrometry, structural modelling, colocalization analysis, hepatocyte-specific transgenic and knockout mice, AAV8-based knockdown, AI-based inhibitor screening, in vitro and in vivo functional assays","journal":"Gut","confidence":"High","confidence_rationale":"Tier 1–2 / Strong — Co-IP/MS for complex identification, mutagenesis of key residues, multiple orthogonal in vivo models (transgenic, KO, AAV knockdown), structural modelling, small molecule validation in vivo","pmids":["42167911"],"is_preprint":false},{"year":2023,"finding":"Fenofibrate binds tightly to MOXD1 protein (demonstrated by molecular docking) and inhibits hepatic MOXD1 expression independently of PPARα signaling in NIAAA model mice with alcoholic liver disease, ameliorating lipid deposition, oxidative stress, and inflammatory responses.","method":"Molecular docking, gene silencing (Ppar-α siRNA), gene expression analysis, in vivo NIAAA mouse model","journal":"Life sciences","confidence":"Low","confidence_rationale":"Tier 3–4 / Weak — molecular docking is computational; in vivo pharmacology with gene silencing provides functional context but mechanism is inferred, single lab","pmids":["38042280"],"is_preprint":false},{"year":2017,"finding":"Moxd1 expression is restricted to specific sexually dimorphic nuclei (SDN-POA, BNSTpr, MePD) in the mouse brain; neonatal castration of male mice reduced Moxd1-positive cell numbers in the SDN-POA, whereas adult gonadectomy did not affect Moxd1 expression, indicating that its sexual dimorphic expression is organized perinatally by androgen exposure.","method":"In situ hybridization, immunohistochemistry, neonatal castration and adult gonadectomy experiments, Allen brain atlas screening","journal":"Frontiers in neuroanatomy","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — direct experimental manipulation (castration) with defined cellular phenotype readout, combined with ISH localization; single lab","pmids":["28396628"],"is_preprint":false}],"current_model":"MOXD1 (monooxygenase DBH-like 1) is a copper-dependent monooxygenase that acts as a regulator of hepatic fatty-acid homeostasis by directly interacting with the ACOX1-PEX5 complex to promote ACOX1 peroxisomal trafficking and block lipolysis/lipophagy; it also binds β3GnT2 to modulate protein glycosylation, its mRNA expression is positively regulated by m6A demethylase FTO, it functions as a lineage-restricted tumor suppressor in neuroblastoma, and its sexually dimorphic expression in specific hypothalamic and amygdalar nuclei is organized perinatally by androgen exposure."},"narrative":{"mechanistic_narrative":"MOXD1 (monooxygenase DBH-like 1) is a regulator of hepatic lipid homeostasis that also shapes cell-fate and proliferative programs in neural and tumor lineages [PMID:42167911, PMID:38905335]. In hepatocytes, MOXD1 directly interacts with the ACOX1-PEX5 translocation complex through four defined residues, promoting ACOX1 trafficking into peroxisomes and thereby blocking lipolysis and lipophagy; this activity drives metabolic dysfunction-associated steatohepatitis, and a small molecule (rM15) that binds MOXD1 and disrupts the ACOX1 interaction protects against hepatocyte lipid accumulation and diet-induced disease in vivo [PMID:42167911]. MOXD1 mRNA is a target of the m6A demethylase FTO, which promotes its expression [PMID:38200441]. In neuroblastoma, MOXD1 acts as a lineage-restricted tumor suppressor whose expression is confined to mesenchymal neuroblastoma cells and Schwann cell precursors, with loss associating with advanced disease across zebrafish, chick, and mouse models [PMID:38905335]. In glioblastoma, MOXD1 binds β3GnT2 to influence protein glycosylation, and its loss induces ER stress and ER-mitochondrial apoptosis [PMID:35393406]. In the brain, Moxd1 marks specific sexually dimorphic nuclei, and its dimorphic expression is organized perinatally by androgen exposure [PMID:28396628].","teleology":[{"year":2017,"claim":"Established that Moxd1 marks specific sexually dimorphic brain nuclei and that this dimorphism is set during a perinatal hormonal window rather than maintained by circulating adult hormones.","evidence":"In situ hybridization and immunohistochemistry with neonatal castration versus adult gonadectomy in mice","pmids":["28396628"],"confidence":"Medium","gaps":["No molecular function for Moxd1 within these neurons identified","Mechanism linking androgen exposure to Moxd1 cell number not resolved"]},{"year":2022,"claim":"Identified a physical partner and cellular consequence for MOXD1 in tumor cells, linking it to glycosylation and ER-stress-driven apoptosis.","evidence":"siRNA/shRNA knockdown and Co-IP (β3GnT2 binding) with viability, migration, ER-stress, and apoptosis readouts plus in vivo tumorigenesis in glioblastoma cells","pmids":["35393406"],"confidence":"Medium","gaps":["Glycosylation substrates affected by the MOXD1–β3GnT2 interaction not defined","Direct enzymatic role of MOXD1 in glycosylation unclear","Single lab, glioblastoma-specific"]},{"year":2024,"claim":"Defined MOXD1 as a lineage-restricted tumor suppressor in neuroblastoma, reframing it from a pro-tumor factor (as seen in glioblastoma) to a context-dependent determinant of tumor development.","evidence":"Single-cell and bulk RNA-seq of human samples plus loss-of-function in zebrafish, chick, and mouse","pmids":["38905335"],"confidence":"Medium","gaps":["Molecular mechanism of tumor suppression not established","Reconciliation with pro-malignant roles in other cancers unresolved"]},{"year":2024,"claim":"Placed MOXD1 downstream of m6A regulation, showing its mRNA is an FTO target and its silencing alters cancer-related signaling.","evidence":"RIP-qPCR, RT-qPCR, shRNA knockdown, and RNA-seq pathway analysis in gastric cancer cells","pmids":["38200441"],"confidence":"Medium","gaps":["Direct effector mechanism downstream of MOXD1 not identified","How m6A status changes MOXD1 stability/translation not detailed"]},{"year":2026,"claim":"Resolved a direct molecular mechanism for MOXD1 in metabolism: it binds the ACOX1-PEX5 complex via defined residues to control ACOX1 peroxisomal trafficking, blocking lipolysis/lipophagy and driving MASH, and is pharmacologically targetable.","evidence":"Co-IP/MS, structural modelling, residue mutagenesis, hepatocyte-specific transgenic/KO and AAV8 knockdown mice, and AI-based small molecule (rM15) validation in vivo","pmids":["42167911"],"confidence":"High","gaps":["Whether copper-dependent monooxygenase activity is required for ACOX1 binding not shown","Connection between hepatic metabolic role and tumor/neural roles unexplored","Experimental structure of the complex not solved"]},{"year":null,"claim":"How MOXD1's distinct activities—ACOX1 trafficking, β3GnT2-linked glycosylation, and tumor-lineage restriction—derive from a single biochemical function remains unresolved.","evidence":"","pmids":[],"confidence":"Low","gaps":["No catalytic substrate of MOXD1 directly demonstrated","Unifying enzymatic mechanism across tissues unknown","No experimentally determined protein structure"]}],"mechanism_profile":{"molecular_activity":[{"term_id":"GO:0060090","term_label":"molecular adaptor activity","supporting_discovery_ids":[3]}],"localization":[{"term_id":"GO:0005777","term_label":"peroxisome","supporting_discovery_ids":[3]}],"pathway":[{"term_id":"R-HSA-1430728","term_label":"Metabolism","supporting_discovery_ids":[3]},{"term_id":"R-HSA-1643685","term_label":"Disease","supporting_discovery_ids":[1,3]}],"complexes":[],"partners":["ACOX1","PEX5","B3GNT2","FTO"],"other_free_text":[]}},"prefetch_data":{"uniprot":{"accession":"Q6UVY6","full_name":"DBH-like monooxygenase protein 1","aliases":["Monooxygenase X"],"length_aa":613,"mass_kda":69.7,"function":"","subcellular_location":"Endoplasmic reticulum membrane","url":"https://www.uniprot.org/uniprotkb/Q6UVY6/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/MOXD1","classification":"Not Classified","n_dependent_lines":0,"n_total_lines":1208,"dependency_fraction":0.0},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[{"gene":"CANX","stoichiometry":0.2}],"url":"https://opencell.sf.czbiohub.org/search/MOXD1","total_profiled":1310},"omim":[{"mim_id":"609000","title":"MONOOXYGENASE, DBH-LIKE, 1; MOXD1","url":"https://www.omim.org/entry/609000"},{"mim_id":"608923","title":"TRACE AMINE-ASSOCIATED RECEPTOR 6; TAAR6","url":"https://www.omim.org/entry/608923"},{"mim_id":"607405","title":"TRACE AMINE-ASSOCIATED RECEPTOR 5; TAAR5","url":"https://www.omim.org/entry/607405"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Approved","locations":[{"location":"Cytosol","reliability":"Approved"}],"tissue_specificity":"Tissue enhanced","tissue_distribution":"Detected in many","driving_tissues":[{"tissue":"endometrium 1","ntpm":59.9},{"tissue":"smooth muscle","ntpm":73.5}],"url":"https://www.proteinatlas.org/search/MOXD1"},"hgnc":{"alias_symbol":["DKFZP564G202","MOX","dJ248E1.1"],"prev_symbol":[]},"alphafold":{"accession":"Q6UVY6","domains":[{"cath_id":"2.60.40.1210","chopping":"28-170","consensus_level":"high","plddt":95.9984,"start":28,"end":170},{"cath_id":"2.60.120.230","chopping":"187-566","consensus_level":"medium","plddt":93.6785,"start":187,"end":566}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q6UVY6","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q6UVY6-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q6UVY6-F1-predicted_aligned_error_v6.png","plddt_mean":88.88},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=MOXD1","jax_strain_url":"https://www.jax.org/strain/search?query=MOXD1"},"sequence":{"accession":"Q6UVY6","fasta_url":"https://rest.uniprot.org/uniprotkb/Q6UVY6.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q6UVY6/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q6UVY6"}},"corpus_meta":[{"pmid":"1363541","id":"PMC_1363541","title":"Mox-1 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Additionally, MOXD1 knockdown induces endoplasmic reticulum stress and triggers the ER-mitochondrial apoptosis pathway.\",\n      \"method\": \"siRNA/shRNA knockdown, co-immunoprecipitation (binding to β3GnT2), cell viability/proliferation/migration/invasion assays, in vivo tumorigenesis assay, ER stress markers\",\n      \"journal\": \"Cell death discovery\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2–3 / Moderate — reciprocal interaction shown by pulldown/Co-IP, multiple orthogonal functional readouts (viability, migration, ER stress, apoptosis), single lab\",\n      \"pmids\": [\"35393406\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2024,\n      \"finding\": \"MOXD1 is a lineage-restricted tumor suppressor gene in neuroblastoma; its expression is highly conserved and restricted to mesenchymal neuroblastoma cells and Schwann cell precursors during healthy development, and loss of MOXD1 expression associates with advanced disease. In vivo models (zebrafish, chick, mouse) confirmed its role as a determinant of tumor development.\",\n      \"method\": \"Single-cell RNA sequencing, in vivo loss-of-function models (zebrafish, chick, mouse), RNA sequencing of human neuroblastoma samples\",\n      \"journal\": \"Science advances\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — multiple in vivo model organisms with loss-of-function, single lab but orthogonal approaches\",\n      \"pmids\": [\"38905335\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2024,\n      \"finding\": \"FTO (m6A demethylase) targets MOXD1 mRNA, promoting its expression via m6A methylation modification; MOXD1 silencing suppressed malignant phenotype of gastric cancer cells and activated cancer-related signaling pathways (MAPK, TGF-β, NOTCH, JAK/STAT).\",\n      \"method\": \"RIP-qPCR (RNA immunoprecipitation), RT-qPCR, shRNA knockdown, cell proliferation/migration/apoptosis assays, RNA-seq pathway analysis\",\n      \"journal\": \"BMC gastroenterology\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2–3 / Moderate — RIP-qPCR demonstrates direct m6A methylation of MOXD1 mRNA by FTO, combined with functional knockdown assays, single lab\",\n      \"pmids\": [\"38200441\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2026,\n      \"finding\": \"MOXD1 directly interacts with the ACOX1-PEX5 translocation complex, promoting ACOX1 trafficking to peroxisomes to block lipolysis and lipophagy in hepatocytes, thereby driving MASH (metabolic dysfunction-associated steatohepatitis) pathogenesis. Four key MOXD1 residues required for ACOX1 binding were identified. A small molecule inhibitor (rM15) that directly binds MOXD1 and blocks its interaction with ACOX1 was identified and shown to protect against hepatocyte lipid accumulation and suppress diet-induced MASH in vivo.\",\n      \"method\": \"Co-immunoprecipitation-mass spectrometry, structural modelling, colocalization analysis, hepatocyte-specific transgenic and knockout mice, AAV8-based knockdown, AI-based inhibitor screening, in vitro and in vivo functional assays\",\n      \"journal\": \"Gut\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 1–2 / Strong — Co-IP/MS for complex identification, mutagenesis of key residues, multiple orthogonal in vivo models (transgenic, KO, AAV knockdown), structural modelling, small molecule validation in vivo\",\n      \"pmids\": [\"42167911\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2023,\n      \"finding\": \"Fenofibrate binds tightly to MOXD1 protein (demonstrated by molecular docking) and inhibits hepatic MOXD1 expression independently of PPARα signaling in NIAAA model mice with alcoholic liver disease, ameliorating lipid deposition, oxidative stress, and inflammatory responses.\",\n      \"method\": \"Molecular docking, gene silencing (Ppar-α siRNA), gene expression analysis, in vivo NIAAA mouse model\",\n      \"journal\": \"Life sciences\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 3–4 / Weak — molecular docking is computational; in vivo pharmacology with gene silencing provides functional context but mechanism is inferred, single lab\",\n      \"pmids\": [\"38042280\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2017,\n      \"finding\": \"Moxd1 expression is restricted to specific sexually dimorphic nuclei (SDN-POA, BNSTpr, MePD) in the mouse brain; neonatal castration of male mice reduced Moxd1-positive cell numbers in the SDN-POA, whereas adult gonadectomy did not affect Moxd1 expression, indicating that its sexual dimorphic expression is organized perinatally by androgen exposure.\",\n      \"method\": \"In situ hybridization, immunohistochemistry, neonatal castration and adult gonadectomy experiments, Allen brain atlas screening\",\n      \"journal\": \"Frontiers in neuroanatomy\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — direct experimental manipulation (castration) with defined cellular phenotype readout, combined with ISH localization; single lab\",\n      \"pmids\": [\"28396628\"],\n      \"is_preprint\": false\n    }\n  ],\n  \"current_model\": \"MOXD1 (monooxygenase DBH-like 1) is a copper-dependent monooxygenase that acts as a regulator of hepatic fatty-acid homeostasis by directly interacting with the ACOX1-PEX5 complex to promote ACOX1 peroxisomal trafficking and block lipolysis/lipophagy; it also binds β3GnT2 to modulate protein glycosylation, its mRNA expression is positively regulated by m6A demethylase FTO, it functions as a lineage-restricted tumor suppressor in neuroblastoma, and its sexually dimorphic expression in specific hypothalamic and amygdalar nuclei is organized perinatally by androgen exposure.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"MOXD1 (monooxygenase DBH-like 1) is a regulator of hepatic lipid homeostasis that also shapes cell-fate and proliferative programs in neural and tumor lineages [#3, #1]. In hepatocytes, MOXD1 directly interacts with the ACOX1-PEX5 translocation complex through four defined residues, promoting ACOX1 trafficking into peroxisomes and thereby blocking lipolysis and lipophagy; this activity drives metabolic dysfunction-associated steatohepatitis, and a small molecule (rM15) that binds MOXD1 and disrupts the ACOX1 interaction protects against hepatocyte lipid accumulation and diet-induced disease in vivo [#3]. MOXD1 mRNA is a target of the m6A demethylase FTO, which promotes its expression [#2]. In neuroblastoma, MOXD1 acts as a lineage-restricted tumor suppressor whose expression is confined to mesenchymal neuroblastoma cells and Schwann cell precursors, with loss associating with advanced disease across zebrafish, chick, and mouse models [#1]. In glioblastoma, MOXD1 binds \\u03b23GnT2 to influence protein glycosylation, and its loss induces ER stress and ER-mitochondrial apoptosis [#0]. In the brain, Moxd1 marks specific sexually dimorphic nuclei, and its dimorphic expression is organized perinatally by androgen exposure [#5].\",\n  \"teleology\": [\n    {\n      \"year\": 2017,\n      \"claim\": \"Established that Moxd1 marks specific sexually dimorphic brain nuclei and that this dimorphism is set during a perinatal hormonal window rather than maintained by circulating adult hormones.\",\n      \"evidence\": \"In situ hybridization and immunohistochemistry with neonatal castration versus adult gonadectomy in mice\",\n      \"pmids\": [\"28396628\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"No molecular function for Moxd1 within these neurons identified\", \"Mechanism linking androgen exposure to Moxd1 cell number not resolved\"]\n    },\n    {\n      \"year\": 2022,\n      \"claim\": \"Identified a physical partner and cellular consequence for MOXD1 in tumor cells, linking it to glycosylation and ER-stress-driven apoptosis.\",\n      \"evidence\": \"siRNA/shRNA knockdown and Co-IP (\\u03b23GnT2 binding) with viability, migration, ER-stress, and apoptosis readouts plus in vivo tumorigenesis in glioblastoma cells\",\n      \"pmids\": [\"35393406\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Glycosylation substrates affected by the MOXD1\\u2013\\u03b23GnT2 interaction not defined\", \"Direct enzymatic role of MOXD1 in glycosylation unclear\", \"Single lab, glioblastoma-specific\"]\n    },\n    {\n      \"year\": 2024,\n      \"claim\": \"Defined MOXD1 as a lineage-restricted tumor suppressor in neuroblastoma, reframing it from a pro-tumor factor (as seen in glioblastoma) to a context-dependent determinant of tumor development.\",\n      \"evidence\": \"Single-cell and bulk RNA-seq of human samples plus loss-of-function in zebrafish, chick, and mouse\",\n      \"pmids\": [\"38905335\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Molecular mechanism of tumor suppression not established\", \"Reconciliation with pro-malignant roles in other cancers unresolved\"]\n    },\n    {\n      \"year\": 2024,\n      \"claim\": \"Placed MOXD1 downstream of m6A regulation, showing its mRNA is an FTO target and its silencing alters cancer-related signaling.\",\n      \"evidence\": \"RIP-qPCR, RT-qPCR, shRNA knockdown, and RNA-seq pathway analysis in gastric cancer cells\",\n      \"pmids\": [\"38200441\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Direct effector mechanism downstream of MOXD1 not identified\", \"How m6A status changes MOXD1 stability/translation not detailed\"]\n    },\n    {\n      \"year\": 2026,\n      \"claim\": \"Resolved a direct molecular mechanism for MOXD1 in metabolism: it binds the ACOX1-PEX5 complex via defined residues to control ACOX1 peroxisomal trafficking, blocking lipolysis/lipophagy and driving MASH, and is pharmacologically targetable.\",\n      \"evidence\": \"Co-IP/MS, structural modelling, residue mutagenesis, hepatocyte-specific transgenic/KO and AAV8 knockdown mice, and AI-based small molecule (rM15) validation in vivo\",\n      \"pmids\": [\"42167911\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"Whether copper-dependent monooxygenase activity is required for ACOX1 binding not shown\", \"Connection between hepatic metabolic role and tumor/neural roles unexplored\", \"Experimental structure of the complex not solved\"]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"How MOXD1's distinct activities\\u2014ACOX1 trafficking, \\u03b23GnT2-linked glycosylation, and tumor-lineage restriction\\u2014derive from a single biochemical function remains unresolved.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Low\",\n      \"gaps\": [\"No catalytic substrate of MOXD1 directly demonstrated\", \"Unifying enzymatic mechanism across tissues unknown\", \"No experimentally determined protein structure\"]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\"term_id\": \"GO:0060090\", \"supporting_discovery_ids\": [3]}\n    ],\n    \"localization\": [\n      {\"term_id\": \"GO:0005777\", \"supporting_discovery_ids\": [3]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"R-HSA-1430728\", \"supporting_discovery_ids\": [3]},\n      {\"term_id\": \"R-HSA-1643685\", \"supporting_discovery_ids\": [1, 3]}\n    ],\n    \"complexes\": [],\n    \"partners\": [\"ACOX1\", \"PEX5\", \"B3GNT2\", \"FTO\"],\n    \"other_free_text\": []\n  }\n}","audit_flag":null,"evaluation":{"faith_supported":6,"faith_total":6,"faith_pct":100.0}}