{"gene":"LRRC46","run_date":"2026-06-10T02:59:50","timeline":{"discoveries":[{"year":2022,"finding":"LRRC46 localizes throughout the sperm flagellum with concentration at the midpiece, and its knockout in mice causes multiple morphological abnormalities of the flagella (MMAF), including short, coiled, and irregular flagella with axonemal and mitochondrial sheath malformations, reduced sperm counts, impaired sperm motility, and complete male infertility, establishing LRRC46 as essential for sperm flagellum biogenesis.","method":"Lrrc46 knockout mouse model; immunofluorescence for localization; scanning electron microscopy and Papanicolaou staining for morphology; transmission electron microscopy for ultrastructure","journal":"International journal of molecular sciences","confidence":"High","confidence_rationale":"Tier 2 / Strong — KO mouse with multiple orthogonal methods (IF, SEM, TEM, motility assay) and a defined cellular/structural phenotype","pmids":["35955660"],"is_preprint":false},{"year":2024,"finding":"CCDC181 physically interacts with LRRC46 and regulates LRRC46 localization within sperm flagella; loss of CCDC181 disrupts LRRC46 positioning and results in MMAF phenotype, placing CCDC181 upstream of LRRC46 in flagellum biogenesis.","method":"Co-immunoprecipitation/interaction assay between CCDC181 and LRRC46; Ccdc181 knockout mice with immunofluorescence analysis of LRRC46 localization","journal":"Zoological research","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — KO mouse with localization readout and interaction identified, single lab","pmids":["39245650"],"is_preprint":false},{"year":2024,"finding":"A loss-of-function mutation in LRRC46 (c.C235T, p.Q79X) decreases LRRC46 protein expression in human corneal epithelial cells, and Lrrc46 knockout mice develop a classical myopia phenotype with thinning of cornea and sclera, decreased limbal stem cell activity, microstructural fibroblast changes, and significant downregulation of collagen synthesis pathways (ECM); LRRC46 specifically influences formation of collagen VIII (Col8a1).","method":"In vitro mutation study in HCE-T cells; Lrrc46 knockout mice phenotyping; RNA-seq of scleral and corneal tissues; in vitro collagen formation assay","journal":"Science China. Life sciences","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — KO mouse plus in vitro cell experiments and RNA-seq, single lab, multiple methods","pmids":["38874710"],"is_preprint":false},{"year":2026,"finding":"In bovine granulosa cells, LRRC46 overexpression promotes cell proliferation and steroidogenesis (E2 and P4 secretion) while inhibiting apoptosis; mechanistically, LRRC46 upregulates COL8A1, which facilitates EGFR phosphorylation and activates the downstream PI3K/AKT signaling cascade; EGFR inhibitor Afatinib abolished these effects, defining a LRRC46–COL8A1–EGFR–PI3K/AKT axis.","method":"Overexpression in bovine granulosa cells; proliferation, apoptosis, and steroidogenesis assays; EGFR inhibitor rescue experiment; signaling pathway analysis","journal":"Theriogenology","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — gain-of-function with pharmacological rescue, multiple functional readouts, single lab","pmids":["42224836"],"is_preprint":false}],"current_model":"LRRC46 is a leucine-rich repeat protein essential for sperm flagellum biogenesis (localizing to the flagella midpiece, downstream of CCDC181), and also promotes collagen synthesis (including Col8a1/COL8A1) in ocular and granulosa cell contexts, where it activates the COL8A1–EGFR–PI3K/AKT signaling axis to regulate cell proliferation and steroidogenesis."},"narrative":{"mechanistic_narrative":"LRRC46 is a leucine-rich repeat protein with two experimentally established roles: it is essential for sperm flagellum biogenesis and it promotes collagen synthesis in connective and reproductive tissues [PMID:35955660, PMID:38874710]. In the male germ line, LRRC46 localizes throughout the sperm flagellum with concentration at the midpiece, and its loss in mice produces multiple morphological abnormalities of the flagella (MMAF) — short, coiled, irregular flagella with axonemal and mitochondrial sheath defects, reduced sperm counts, impaired motility, and complete male infertility [PMID:35955660]. Its correct positioning within the flagellum depends on CCDC181, which physically interacts with LRRC46 and acts upstream of it, since loss of CCDC181 mislocalizes LRRC46 and phenocopies MMAF [PMID:39245650]. Independently, LRRC46 supports extracellular matrix output: a loss-of-function mutation reduces LRRC46 protein in human corneal epithelial cells, and knockout mice display a myopia phenotype with corneal and scleral thinning and downregulated collagen synthesis, with LRRC46 specifically required for collagen VIII (Col8a1) formation [PMID:38874710]. In bovine granulosa cells, LRRC46 drives proliferation, steroidogenesis, and anti-apoptotic responses by upregulating COL8A1, which promotes EGFR phosphorylation and activates PI3K/AKT signaling, an effect abolished by EGFR inhibition [PMID:42224836]. How the same protein links flagellar structural assembly to collagen biogenesis at the molecular level has not been characterized in the available corpus.","teleology":[{"year":2022,"claim":"Established the first functional role of LRRC46 by showing it is required for sperm flagellum biogenesis, defining where it acts and the consequence of its loss.","evidence":"Lrrc46 knockout mice with immunofluorescence localization, SEM/Papanicolaou morphology, TEM ultrastructure, and motility assays","pmids":["35955660"],"confidence":"High","gaps":["Molecular activity of LRRC46 within the flagellum not defined","No direct binding partners identified in this study","Mechanism linking LRRC46 to axonemal/mitochondrial sheath assembly unresolved"]},{"year":2024,"claim":"Placed LRRC46 in a flagellar assembly hierarchy by identifying CCDC181 as a direct interactor that controls LRRC46 positioning.","evidence":"Co-immunoprecipitation between CCDC181 and LRRC46 plus Ccdc181 knockout mice scored for LRRC46 localization","pmids":["39245650"],"confidence":"Medium","gaps":["Interaction not validated reciprocally or structurally","Binding interface and stoichiometry unknown","Whether CCDC181 directly recruits or indirectly stabilizes LRRC46 not distinguished"]},{"year":2024,"claim":"Revealed a distinct collagen-related function by linking LRRC46 loss-of-function to myopia and impaired collagen VIII synthesis in ocular tissue.","evidence":"Human LRRC46 mutation study in HCE-T cells, Lrrc46 knockout mouse phenotyping, RNA-seq of corneal/scleral tissue, and in vitro collagen formation assay","pmids":["38874710"],"confidence":"Medium","gaps":["Direct molecular mechanism by which LRRC46 controls collagen VIII output unknown","Connection between the flagellar role and the collagen role not established","Single-lab finding"]},{"year":2026,"claim":"Defined a downstream signaling axis for the collagen function, showing LRRC46 acts through COL8A1 to engage EGFR and PI3K/AKT signaling controlling proliferation and steroidogenesis.","evidence":"Overexpression in bovine granulosa cells with proliferation, apoptosis, and steroidogenesis readouts and Afatinib EGFR-inhibitor rescue","pmids":["42224836"],"confidence":"Medium","gaps":["Gain-of-function only; no loss-of-function validation in this system","Mechanism by which LRRC46 upregulates COL8A1 unknown","Whether axis operates in non-bovine or in vivo contexts untested"]},{"year":null,"claim":"It remains unknown what biochemical activity LRRC46 carries out and how a single LRR protein reconciles its flagellar structural role with its collagen-biogenesis role.","evidence":"No discovery in the corpus assigns a catalytic or defined molecular activity to LRRC46","pmids":[],"confidence":"Low","gaps":["No molecular activity assigned","No structural model of LRRC46 or its complexes","Mechanistic link between flagellar and ECM functions absent"]}],"mechanism_profile":{"molecular_activity":[],"localization":[{"term_id":"GO:0005929","term_label":"cilium","supporting_discovery_ids":[0,1]}],"pathway":[{"term_id":"R-HSA-1474244","term_label":"Extracellular matrix organization","supporting_discovery_ids":[2]},{"term_id":"R-HSA-162582","term_label":"Signal Transduction","supporting_discovery_ids":[3]}],"complexes":[],"partners":["CCDC181"],"other_free_text":[]}},"prefetch_data":{"uniprot":{"accession":"Q96FV0","full_name":"Leucine-rich repeat-containing protein 46","aliases":[],"length_aa":321,"mass_kda":35.3,"function":"Required for normal spermatogenesis and male fertility. Plays an important role in sperm flagellum biogenesis","subcellular_location":"Cell projection, cilium, flagellum","url":"https://www.uniprot.org/uniprotkb/Q96FV0/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/LRRC46","classification":"Not Classified","n_dependent_lines":5,"n_total_lines":1208,"dependency_fraction":0.0041390728476821195},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[],"url":"https://opencell.sf.czbiohub.org/search/LRRC46","total_profiled":1310},"omim":[{"mim_id":"620927","title":"LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46; LRRC46","url":"https://www.omim.org/entry/620927"},{"mim_id":"615092","title":"LEFT VENTRICULAR NONCOMPACTION 7; LVNC7","url":"https://www.omim.org/entry/615092"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Approved","locations":[{"location":"Plasma membrane","reliability":"Approved"},{"location":"Nuclear bodies","reliability":"Additional"},{"location":"Primary cilium","reliability":"Additional"},{"location":"Basal body","reliability":"Additional"}],"tissue_specificity":"Tissue enhanced","tissue_distribution":"Detected in some","driving_tissues":[{"tissue":"fallopian tube","ntpm":73.8},{"tissue":"testis","ntpm":49.1}],"url":"https://www.proteinatlas.org/search/LRRC46"},"hgnc":{"alias_symbol":["MGC16309"],"prev_symbol":[]},"alphafold":{"accession":"Q96FV0","domains":[{"cath_id":"3.80.10.10","chopping":"15-171","consensus_level":"medium","plddt":80.8126,"start":15,"end":171}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q96FV0","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q96FV0-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q96FV0-F1-predicted_aligned_error_v6.png","plddt_mean":63.91},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=LRRC46","jax_strain_url":"https://www.jax.org/strain/search?query=LRRC46"},"sequence":{"accession":"Q96FV0","fasta_url":"https://rest.uniprot.org/uniprotkb/Q96FV0.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q96FV0/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q96FV0"}},"corpus_meta":[{"pmid":"31043753","id":"PMC_31043753","title":"A transcriptome-wide association study of high-grade serous epithelial ovarian cancer identifies new susceptibility genes and splice variants.","date":"2019","source":"Nature genetics","url":"https://pubmed.ncbi.nlm.nih.gov/31043753","citation_count":89,"is_preprint":false},{"pmid":"30149579","id":"PMC_30149579","title":"Exploring the Role of Fallopian Ciliated Cells in the Pathogenesis of High-Grade Serous Ovarian Cancer.","date":"2018","source":"International journal of molecular sciences","url":"https://pubmed.ncbi.nlm.nih.gov/30149579","citation_count":40,"is_preprint":false},{"pmid":"35955660","id":"PMC_35955660","title":"LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is Essential for Spermiogenesis and Male Fertility in Mouse.","date":"2022","source":"International journal of molecular sciences","url":"https://pubmed.ncbi.nlm.nih.gov/35955660","citation_count":17,"is_preprint":false},{"pmid":"31269894","id":"PMC_31269894","title":"An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse.","date":"2019","source":"BMC evolutionary biology","url":"https://pubmed.ncbi.nlm.nih.gov/31269894","citation_count":12,"is_preprint":false},{"pmid":"37901794","id":"PMC_37901794","title":"Clinical effects of novel susceptibility genes for beta-amyloid: a gene-based association study in the Korean population.","date":"2023","source":"Frontiers in aging neuroscience","url":"https://pubmed.ncbi.nlm.nih.gov/37901794","citation_count":5,"is_preprint":false},{"pmid":"33771330","id":"PMC_33771330","title":"An intrauterine genomic classifier reliably delineates the location of nonviable pregnancies.","date":"2021","source":"Fertility and sterility","url":"https://pubmed.ncbi.nlm.nih.gov/33771330","citation_count":5,"is_preprint":false},{"pmid":"38874710","id":"PMC_38874710","title":"Identification of LRRC46 as a novel candidate gene for high myopia.","date":"2024","source":"Science China. Life sciences","url":"https://pubmed.ncbi.nlm.nih.gov/38874710","citation_count":4,"is_preprint":false},{"pmid":"40008881","id":"PMC_40008881","title":"Identification of immunogenic HLA-A*02:01 epitopes associated with HCC for immunotherapy development.","date":"2025","source":"Hepatology communications","url":"https://pubmed.ncbi.nlm.nih.gov/40008881","citation_count":3,"is_preprint":false},{"pmid":"39245650","id":"PMC_39245650","title":"CCDC181 is required for sperm flagellum biogenesis and male fertility in mice.","date":"2024","source":"Zoological research","url":"https://pubmed.ncbi.nlm.nih.gov/39245650","citation_count":2,"is_preprint":false},{"pmid":"41007398","id":"PMC_41007398","title":"Whole Transcriptome Sequencing and Differential Analysis of Testes in Pre- and Post-Sexual Maturity Bactrian Camels (Camelus bactrianus).","date":"2025","source":"Biology","url":"https://pubmed.ncbi.nlm.nih.gov/41007398","citation_count":2,"is_preprint":false},{"pmid":"42224836","id":"PMC_42224836","title":"LRRC46 regulates bovine granulosa cell functions via the COL8A1-mediated EGFR/PI3K/AKT signaling pathway.","date":"2026","source":"Theriogenology","url":"https://pubmed.ncbi.nlm.nih.gov/42224836","citation_count":0,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":8054,"output_tokens":1179,"usd":0.020924,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":7752,"output_tokens":1982,"usd":0.044155,"stage2_stop_reason":"end_turn"},"total_usd":0.065079,"stage1_batch_id":"msgbatch_01BbTCMyrRPyhtEq6b1MdwCN","stage2_batch_id":"msgbatch_011dEed5bbxYvTAaQWKJevxu","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2022,\n      \"finding\": \"LRRC46 localizes throughout the sperm flagellum with concentration at the midpiece, and its knockout in mice causes multiple morphological abnormalities of the flagella (MMAF), including short, coiled, and irregular flagella with axonemal and mitochondrial sheath malformations, reduced sperm counts, impaired sperm motility, and complete male infertility, establishing LRRC46 as essential for sperm flagellum biogenesis.\",\n      \"method\": \"Lrrc46 knockout mouse model; immunofluorescence for localization; scanning electron microscopy and Papanicolaou staining for morphology; transmission electron microscopy for ultrastructure\",\n      \"journal\": \"International journal of molecular sciences\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Strong — KO mouse with multiple orthogonal methods (IF, SEM, TEM, motility assay) and a defined cellular/structural phenotype\",\n      \"pmids\": [\"35955660\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2024,\n      \"finding\": \"CCDC181 physically interacts with LRRC46 and regulates LRRC46 localization within sperm flagella; loss of CCDC181 disrupts LRRC46 positioning and results in MMAF phenotype, placing CCDC181 upstream of LRRC46 in flagellum biogenesis.\",\n      \"method\": \"Co-immunoprecipitation/interaction assay between CCDC181 and LRRC46; Ccdc181 knockout mice with immunofluorescence analysis of LRRC46 localization\",\n      \"journal\": \"Zoological research\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — KO mouse with localization readout and interaction identified, single lab\",\n      \"pmids\": [\"39245650\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2024,\n      \"finding\": \"A loss-of-function mutation in LRRC46 (c.C235T, p.Q79X) decreases LRRC46 protein expression in human corneal epithelial cells, and Lrrc46 knockout mice develop a classical myopia phenotype with thinning of cornea and sclera, decreased limbal stem cell activity, microstructural fibroblast changes, and significant downregulation of collagen synthesis pathways (ECM); LRRC46 specifically influences formation of collagen VIII (Col8a1).\",\n      \"method\": \"In vitro mutation study in HCE-T cells; Lrrc46 knockout mice phenotyping; RNA-seq of scleral and corneal tissues; in vitro collagen formation assay\",\n      \"journal\": \"Science China. Life sciences\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — KO mouse plus in vitro cell experiments and RNA-seq, single lab, multiple methods\",\n      \"pmids\": [\"38874710\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2026,\n      \"finding\": \"In bovine granulosa cells, LRRC46 overexpression promotes cell proliferation and steroidogenesis (E2 and P4 secretion) while inhibiting apoptosis; mechanistically, LRRC46 upregulates COL8A1, which facilitates EGFR phosphorylation and activates the downstream PI3K/AKT signaling cascade; EGFR inhibitor Afatinib abolished these effects, defining a LRRC46–COL8A1–EGFR–PI3K/AKT axis.\",\n      \"method\": \"Overexpression in bovine granulosa cells; proliferation, apoptosis, and steroidogenesis assays; EGFR inhibitor rescue experiment; signaling pathway analysis\",\n      \"journal\": \"Theriogenology\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — gain-of-function with pharmacological rescue, multiple functional readouts, single lab\",\n      \"pmids\": [\"42224836\"],\n      \"is_preprint\": false\n    }\n  ],\n  \"current_model\": \"LRRC46 is a leucine-rich repeat protein essential for sperm flagellum biogenesis (localizing to the flagella midpiece, downstream of CCDC181), and also promotes collagen synthesis (including Col8a1/COL8A1) in ocular and granulosa cell contexts, where it activates the COL8A1–EGFR–PI3K/AKT signaling axis to regulate cell proliferation and steroidogenesis.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"LRRC46 is a leucine-rich repeat protein with two experimentally established roles: it is essential for sperm flagellum biogenesis and it promotes collagen synthesis in connective and reproductive tissues [#0, #2]. In the male germ line, LRRC46 localizes throughout the sperm flagellum with concentration at the midpiece, and its loss in mice produces multiple morphological abnormalities of the flagella (MMAF) — short, coiled, irregular flagella with axonemal and mitochondrial sheath defects, reduced sperm counts, impaired motility, and complete male infertility [#0]. Its correct positioning within the flagellum depends on CCDC181, which physically interacts with LRRC46 and acts upstream of it, since loss of CCDC181 mislocalizes LRRC46 and phenocopies MMAF [#1]. Independently, LRRC46 supports extracellular matrix output: a loss-of-function mutation reduces LRRC46 protein in human corneal epithelial cells, and knockout mice display a myopia phenotype with corneal and scleral thinning and downregulated collagen synthesis, with LRRC46 specifically required for collagen VIII (Col8a1) formation [#2]. In bovine granulosa cells, LRRC46 drives proliferation, steroidogenesis, and anti-apoptotic responses by upregulating COL8A1, which promotes EGFR phosphorylation and activates PI3K/AKT signaling, an effect abolished by EGFR inhibition [#3]. How the same protein links flagellar structural assembly to collagen biogenesis at the molecular level has not been characterized in the available corpus.\",\n  \"teleology\": [\n    {\n      \"year\": 2022,\n      \"claim\": \"Established the first functional role of LRRC46 by showing it is required for sperm flagellum biogenesis, defining where it acts and the consequence of its loss.\",\n      \"evidence\": \"Lrrc46 knockout mice with immunofluorescence localization, SEM/Papanicolaou morphology, TEM ultrastructure, and motility assays\",\n      \"pmids\": [\"35955660\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"Molecular activity of LRRC46 within the flagellum not defined\", \"No direct binding partners identified in this study\", \"Mechanism linking LRRC46 to axonemal/mitochondrial sheath assembly unresolved\"]\n    },\n    {\n      \"year\": 2024,\n      \"claim\": \"Placed LRRC46 in a flagellar assembly hierarchy by identifying CCDC181 as a direct interactor that controls LRRC46 positioning.\",\n      \"evidence\": \"Co-immunoprecipitation between CCDC181 and LRRC46 plus Ccdc181 knockout mice scored for LRRC46 localization\",\n      \"pmids\": [\"39245650\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Interaction not validated reciprocally or structurally\", \"Binding interface and stoichiometry unknown\", \"Whether CCDC181 directly recruits or indirectly stabilizes LRRC46 not distinguished\"]\n    },\n    {\n      \"year\": 2024,\n      \"claim\": \"Revealed a distinct collagen-related function by linking LRRC46 loss-of-function to myopia and impaired collagen VIII synthesis in ocular tissue.\",\n      \"evidence\": \"Human LRRC46 mutation study in HCE-T cells, Lrrc46 knockout mouse phenotyping, RNA-seq of corneal/scleral tissue, and in vitro collagen formation assay\",\n      \"pmids\": [\"38874710\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Direct molecular mechanism by which LRRC46 controls collagen VIII output unknown\", \"Connection between the flagellar role and the collagen role not established\", \"Single-lab finding\"]\n    },\n    {\n      \"year\": 2026,\n      \"claim\": \"Defined a downstream signaling axis for the collagen function, showing LRRC46 acts through COL8A1 to engage EGFR and PI3K/AKT signaling controlling proliferation and steroidogenesis.\",\n      \"evidence\": \"Overexpression in bovine granulosa cells with proliferation, apoptosis, and steroidogenesis readouts and Afatinib EGFR-inhibitor rescue\",\n      \"pmids\": [\"42224836\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Gain-of-function only; no loss-of-function validation in this system\", \"Mechanism by which LRRC46 upregulates COL8A1 unknown\", \"Whether axis operates in non-bovine or in vivo contexts untested\"]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"It remains unknown what biochemical activity LRRC46 carries out and how a single LRR protein reconciles its flagellar structural role with its collagen-biogenesis role.\",\n      \"evidence\": \"No discovery in the corpus assigns a catalytic or defined molecular activity to LRRC46\",\n      \"pmids\": [],\n      \"confidence\": \"Low\",\n      \"gaps\": [\"No molecular activity assigned\", \"No structural model of LRRC46 or its complexes\", \"Mechanistic link between flagellar and ECM functions absent\"]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [],\n    \"localization\": [\n      {\"term_id\": \"GO:0005929\", \"supporting_discovery_ids\": [0, 1]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"R-HSA-1474244\", \"supporting_discovery_ids\": [2]},\n      {\"term_id\": \"R-HSA-162582\", \"supporting_discovery_ids\": [3]}\n    ],\n    \"complexes\": [],\n    \"partners\": [\"CCDC181\"],\n    \"other_free_text\": []\n  }\n}","audit_flag":null,"evaluation":{"pairwise":"win","faith_supported":5,"faith_total":5,"faith_pct":100.0}}