{"gene":"KIR2DL5A","run_date":"2026-06-10T02:59:49","timeline":{"discoveries":[{"year":2007,"finding":"KIR2DL5A (KIR2DL5*001 allele) encodes a cell-surface receptor of ~60 kDa detected as a monomer on CD56dim NK cells and a subset of T lymphocytes; upon tyrosine phosphorylation it recruits SHP-2 (and to a lesser extent SHP-1), and antibody-mediated cross-linking inhibits NK cell cytotoxicity against FcR+ P815 target cells.","method":"Monoclonal antibody generation against KIR2DL5A*001; flow cytometry; Western blot; co-immunoprecipitation of SHP-1/SHP-2; NK cell cytotoxicity redirected killing assay","journal":"Journal of immunology","confidence":"High","confidence_rationale":"Tier 2 / Strong — reciprocal co-IP for phosphatase recruitment, functional cytotoxicity assay, surface expression confirmed by multiple methods in a single focused study; findings reviewed/replicated in follow-up paper (PMID:23060877)","pmids":["17371997"],"is_preprint":false},{"year":2002,"finding":"KIR2DL5 variants are encoded by two distinct paralogous loci, KIR2DL5A and KIR2DL5B, mapping to different positions (telomeric vs. centromeric) within the KIR gene cluster on chromosome 19q13.4; their co-occurrence on some haplotypes is consistent with a gene duplication event followed by recombination.","method":"Genomic mapping, DNA sequencing, haplotype segregation analysis in family cohorts","journal":"Immunogenetics","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — direct genomic mapping and sequencing in family-based study; single lab but orthogonal methods (sequencing + haplotype segregation)","pmids":["12185535"],"is_preprint":false},{"year":2012,"finding":"KIR2DL5B alleles show epigenetic silencing via DNA methylation at a RUNX-binding site in the promoter, whereas KIR2DL5A alleles are predominantly transcriptionally active; this provides a mechanistic basis for differential expression between the two paralogs.","method":"Review integrating prior experimental evidence (DNA methylation analysis, promoter studies cited therein)","journal":"Frontiers in immunology","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — mechanistic conclusion supported by cited experimental data (methylation/promoter studies); single review paper but integrates multiple orthogonal findings","pmids":["23060877"],"is_preprint":false},{"year":2017,"finding":"Allelic polymorphism of KIR2DL5A determines whether the receptor reaches the cell surface or is retained intracellularly: the common allele KIR2DL5A*001 is surface-expressed, whereas KIR2DL5A*005 is largely retained intracellularly due primarily to a glycine-174-to-serine substitution; an asparagine-152-to-aspartate change that destroys an N-glycosylation site has only a minor effect on surface trafficking.","method":"Transient transfection of tagged constructs; Western blot; flow cytometry; confocal microscopy; site-directed mutagenesis of individual residues","journal":"Frontiers in immunology","confidence":"High","confidence_rationale":"Tier 1 / Moderate — site-directed mutagenesis with multiple orthogonal readouts (WB, FACS, confocal) in a single rigorous study definitively assigning the trafficking defect to a specific residue","pmids":["28144240"],"is_preprint":false},{"year":2016,"finding":"KIR2DL5A is expressed on peripheral blood NK cells but NOT on uterine NK (uNK) cells, establishing a tissue-specific difference in receptor repertoire between these two NK cell populations.","method":"Flow cytometry of uNK cells isolated from decidual tissue vs. peripheral blood NK cells using KIR2DL5A-specific mAb (UP-R1)","journal":"Journal of immunology","confidence":"Medium","confidence_rationale":"Tier 2 / Weak — direct localization by flow cytometry in primary cells from two distinct compartments; single study, single method","pmids":["27815424"],"is_preprint":false}],"current_model":"KIR2DL5A encodes a ~60 kDa inhibitory receptor expressed on the surface of CD56dim NK cells and a subset of T lymphocytes; upon tyrosine phosphorylation it recruits SHP-2 (and to a lesser extent SHP-1) to suppress NK cytotoxicity, while allelic polymorphism (particularly a Gly174Ser substitution in the *005 allele) and epigenetic silencing of the paralogous KIR2DL5B locus collectively determine the highly variable surface expression observed among individuals; notably, KIR2DL5A is present on peripheral blood NK cells but absent from uterine NK cells, and its cognate ligand remains unidentified."},"narrative":{"mechanistic_narrative":"KIR2DL5A encodes an inhibitory surface receptor expressed on CD56dim peripheral blood NK cells and a subset of T lymphocytes that suppresses NK cell cytotoxicity: upon tyrosine phosphorylation it recruits the phosphatases SHP-2 and, to a lesser extent, SHP-1, and antibody-mediated cross-linking inhibits killing of target cells [PMID:17371997]. The gene is one of two paralogous KIR2DL5 loci (KIR2DL5A and KIR2DL5B) within the KIR cluster on chromosome 19q13.4, with the paralogs arising through duplication and recombination and showing differential expression — KIR2DL5A alleles are predominantly transcriptionally active, whereas KIR2DL5B is epigenetically silenced by DNA methylation at a RUNX-binding promoter site [PMID:12185535, PMID:23060877]. Allelic polymorphism further tunes receptor display: the common KIR2DL5A*001 allele traffics to the cell surface, while the *005 allele is largely retained intracellularly owing principally to a Gly174Ser substitution [PMID:28144240]. Receptor expression is also compartment-specific, present on peripheral blood NK cells but absent from uterine NK cells [PMID:27815424]. The cognate ligand of KIR2DL5A has not been identified in the available corpus.","teleology":[{"year":2002,"claim":"Whether KIR2DL5 was a single gene or multiple loci was unresolved; mapping defined two distinct paralogs, establishing the genomic architecture underlying expression variability.","evidence":"Genomic mapping, DNA sequencing, and haplotype segregation in family cohorts","pmids":["12185535"],"confidence":"Medium","gaps":["Does not establish functional differences between the paralogs","Mechanism driving differential expression not addressed"]},{"year":2007,"claim":"The signaling function of the receptor was undefined; this work showed KIR2DL5A is a surface inhibitory receptor that recruits SHP-2/SHP-1 and dampens NK cytotoxicity, defining it as an ITIM-type inhibitory receptor.","evidence":"Monoclonal antibody generation, flow cytometry, co-IP of SHP-1/SHP-2, and redirected NK cytotoxicity assay","pmids":["17371997"],"confidence":"High","gaps":["Cognate physiological ligand not identified","Cross-linking is antibody-mediated, not by a natural ligand"]},{"year":2012,"claim":"The basis for divergent expression of the two paralogs was unknown; integration of methylation data attributed KIR2DL5B silencing to DNA methylation at a RUNX-binding promoter site, contrasting with active KIR2DL5A.","evidence":"Review integrating DNA methylation and promoter studies","pmids":["23060877"],"confidence":"Medium","gaps":["Review-level synthesis rather than new primary data","Does not address allelic surface expression variation within KIR2DL5A"]},{"year":2016,"claim":"Whether KIR2DL5A is uniformly expressed across NK populations was unknown; flow cytometry showed it is present on peripheral blood NK cells but absent from uterine NK cells, revealing tissue-specific repertoire differences.","evidence":"Flow cytometry of decidual uNK vs. peripheral blood NK cells with KIR2DL5A-specific mAb","pmids":["27815424"],"confidence":"Medium","gaps":["Single method, single study","Functional consequence of compartment-specific absence not determined"]},{"year":2017,"claim":"The cause of variable surface expression among individuals was unclear; mutagenesis assigned the intracellular retention of the *005 allele primarily to a Gly174Ser substitution, defining a molecular determinant of trafficking.","evidence":"Transient transfection of tagged constructs, site-directed mutagenesis, Western blot, flow cytometry, confocal microscopy","pmids":["28144240"],"confidence":"High","gaps":["Mechanism by which Gly174Ser causes retention not resolved","Trafficking studied in transfected cells, not primary NK cells"]},{"year":null,"claim":"The cognate ligand of KIR2DL5A and the physiological context in which it delivers inhibitory signals remain unidentified.","evidence":"","pmids":[],"confidence":"Medium","gaps":["No ligand identified","No structural model of receptor-ligand engagement","Physiological triggering of SHP recruitment uncharacterized"]}],"mechanism_profile":{"molecular_activity":[{"term_id":"GO:0060089","term_label":"molecular transducer activity","supporting_discovery_ids":[0]},{"term_id":"GO:0098772","term_label":"molecular function regulator activity","supporting_discovery_ids":[0]}],"localization":[{"term_id":"GO:0005886","term_label":"plasma membrane","supporting_discovery_ids":[0,3,4]}],"pathway":[{"term_id":"R-HSA-168256","term_label":"Immune System","supporting_discovery_ids":[0]}],"complexes":[],"partners":["PTPN11","PTPN6"],"other_free_text":[]}},"prefetch_data":{"uniprot":{"accession":"Q8N109","full_name":"Killer cell immunoglobulin-like receptor 2DL5A","aliases":[],"length_aa":375,"mass_kda":40.7,"function":"Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis","subcellular_location":"Cell membrane","url":"https://www.uniprot.org/uniprotkb/Q8N109/entry"},"depmap":{"release":"DepMap","has_data":false,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/KIR2DL5A"},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[],"url":"https://opencell.sf.czbiohub.org/search/KIR2DL5A","total_profiled":1310},"omim":[{"mim_id":"615727","title":"KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR, TWO DOMAINS, LONG CYTOPLASMIC TAIL, 5B; KIR2DL5B","url":"https://www.omim.org/entry/615727"},{"mim_id":"610604","title":"KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR, THREE DOMAINS, PSEUDOGENE 1; KIR3DP1","url":"https://www.omim.org/entry/610604"},{"mim_id":"605305","title":"KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR, TWO DOMAINS, LONG CYTOPLASMIC TAIL, 5A; KIR2DL5A","url":"https://www.omim.org/entry/605305"}],"hpa":{"profiled":false,"resolved_as":"","reliability":"","locations":[],"tissue_specificity":"","tissue_distribution":"","driving_tissues":[],"url":"https://www.proteinatlas.org/search/KIR2DL5A"},"hgnc":{"alias_symbol":["KIR2DL5.1","KIR2DL5","CD158F"],"prev_symbol":[]},"alphafold":{"accession":"Q8N109","domains":[{"cath_id":"2.60.40.10","chopping":"29-118","consensus_level":"high","plddt":91.3004,"start":29,"end":118},{"cath_id":"2.60.40.10","chopping":"122-215","consensus_level":"high","plddt":93.5832,"start":122,"end":215}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q8N109","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q8N109-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q8N109-F1-predicted_aligned_error_v6.png","plddt_mean":71.5},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=KIR2DL5A","jax_strain_url":"https://www.jax.org/strain/search?query=KIR2DL5A"},"sequence":{"accession":"Q8N109","fasta_url":"https://rest.uniprot.org/uniprotkb/Q8N109.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q8N109/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q8N109"}},"corpus_meta":[{"pmid":"12185535","id":"PMC_12185535","title":"Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B.","date":"2002","source":"Immunogenetics","url":"https://pubmed.ncbi.nlm.nih.gov/12185535","citation_count":80,"is_preprint":false},{"pmid":"27815424","id":"PMC_27815424","title":"Activating KIR2DS4 Is Expressed by Uterine NK Cells and Contributes to Successful Pregnancy.","date":"2016","source":"Journal of immunology (Baltimore, Md. : 1950)","url":"https://pubmed.ncbi.nlm.nih.gov/27815424","citation_count":78,"is_preprint":false},{"pmid":"20878401","id":"PMC_20878401","title":"Linkage disequilibrium organization of the human KIR superlocus: implications for KIR data analyses.","date":"2010","source":"Immunogenetics","url":"https://pubmed.ncbi.nlm.nih.gov/20878401","citation_count":49,"is_preprint":false},{"pmid":"17371997","id":"PMC_17371997","title":"Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets.","date":"2007","source":"Journal of immunology (Baltimore, Md. : 1950)","url":"https://pubmed.ncbi.nlm.nih.gov/17371997","citation_count":48,"is_preprint":false},{"pmid":"37169596","id":"PMC_37169596","title":"Efficient and accurate KIR and HLA genotyping with massively parallel sequencing data.","date":"2023","source":"Genome research","url":"https://pubmed.ncbi.nlm.nih.gov/37169596","citation_count":44,"is_preprint":false},{"pmid":"21486386","id":"PMC_21486386","title":"Telomeric rather than centromeric activating KIR genes protect from cytomegalovirus infection after kidney transplantation.","date":"2011","source":"American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons","url":"https://pubmed.ncbi.nlm.nih.gov/21486386","citation_count":44,"is_preprint":false},{"pmid":"23060877","id":"PMC_23060877","title":"KIR2DL5: An Orphan Inhibitory Receptor Displaying Complex Patterns of Polymorphism and Expression.","date":"2012","source":"Frontiers in 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Natural Killer Antitumor Activity in Myelogenous Leukemia but Not in Acute Lymphoblastic Leukemia: A Case Control Leukemia Association Study.","date":"2019","source":"Turkish journal of haematology : official journal of Turkish Society of Haematology","url":"https://pubmed.ncbi.nlm.nih.gov/31337191","citation_count":13,"is_preprint":false},{"pmid":"18498296","id":"PMC_18498296","title":"Investigation of killer cell immunoglobulin-like receptor (KIR) gene diversity: KIR2DL2, KIR2DL5 and KIR2DS5.","date":"2008","source":"Tissue antigens","url":"https://pubmed.ncbi.nlm.nih.gov/18498296","citation_count":12,"is_preprint":false},{"pmid":"29446443","id":"PMC_29446443","title":"Association of killer cell immunoglobulin-like receptors with spontaneous clearance of hepatitis C virus in the Chinese population.","date":"2018","source":"Transfusion","url":"https://pubmed.ncbi.nlm.nih.gov/29446443","citation_count":12,"is_preprint":false},{"pmid":"20585770","id":"PMC_20585770","title":"Thirty 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generation against KIR2DL5A*001; flow cytometry; Western blot; co-immunoprecipitation of SHP-1/SHP-2; NK cell cytotoxicity redirected killing assay\",\n      \"journal\": \"Journal of immunology\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Strong — reciprocal co-IP for phosphatase recruitment, functional cytotoxicity assay, surface expression confirmed by multiple methods in a single focused study; findings reviewed/replicated in follow-up paper (PMID:23060877)\",\n      \"pmids\": [\"17371997\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2002,\n      \"finding\": \"KIR2DL5 variants are encoded by two distinct paralogous loci, KIR2DL5A and KIR2DL5B, mapping to different positions (telomeric vs. centromeric) within the KIR gene cluster on chromosome 19q13.4; their co-occurrence on some haplotypes is consistent with a gene duplication event followed by recombination.\",\n      \"method\": \"Genomic mapping, DNA sequencing, haplotype segregation analysis in family cohorts\",\n      \"journal\": \"Immunogenetics\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — direct genomic mapping and sequencing in family-based study; single lab but orthogonal methods (sequencing + haplotype segregation)\",\n      \"pmids\": [\"12185535\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2012,\n      \"finding\": \"KIR2DL5B alleles show epigenetic silencing via DNA methylation at a RUNX-binding site in the promoter, whereas KIR2DL5A alleles are predominantly transcriptionally active; this provides a mechanistic basis for differential expression between the two paralogs.\",\n      \"method\": \"Review integrating prior experimental evidence (DNA methylation analysis, promoter studies cited therein)\",\n      \"journal\": \"Frontiers in immunology\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — mechanistic conclusion supported by cited experimental data (methylation/promoter studies); single review paper but integrates multiple orthogonal findings\",\n      \"pmids\": [\"23060877\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2017,\n      \"finding\": \"Allelic polymorphism of KIR2DL5A determines whether the receptor reaches the cell surface or is retained intracellularly: the common allele KIR2DL5A*001 is surface-expressed, whereas KIR2DL5A*005 is largely retained intracellularly due primarily to a glycine-174-to-serine substitution; an asparagine-152-to-aspartate change that destroys an N-glycosylation site has only a minor effect on surface trafficking.\",\n      \"method\": \"Transient transfection of tagged constructs; Western blot; flow cytometry; confocal microscopy; site-directed mutagenesis of individual residues\",\n      \"journal\": \"Frontiers in immunology\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 1 / Moderate — site-directed mutagenesis with multiple orthogonal readouts (WB, FACS, confocal) in a single rigorous study definitively assigning the trafficking defect to a specific residue\",\n      \"pmids\": [\"28144240\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2016,\n      \"finding\": \"KIR2DL5A is expressed on peripheral blood NK cells but NOT on uterine NK (uNK) cells, establishing a tissue-specific difference in receptor repertoire between these two NK cell populations.\",\n      \"method\": \"Flow cytometry of uNK cells isolated from decidual tissue vs. peripheral blood NK cells using KIR2DL5A-specific mAb (UP-R1)\",\n      \"journal\": \"Journal of immunology\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Weak — direct localization by flow cytometry in primary cells from two distinct compartments; single study, single method\",\n      \"pmids\": [\"27815424\"],\n      \"is_preprint\": false\n    }\n  ],\n  \"current_model\": \"KIR2DL5A encodes a ~60 kDa inhibitory receptor expressed on the surface of CD56dim NK cells and a subset of T lymphocytes; upon tyrosine phosphorylation it recruits SHP-2 (and to a lesser extent SHP-1) to suppress NK cytotoxicity, while allelic polymorphism (particularly a Gly174Ser substitution in the *005 allele) and epigenetic silencing of the paralogous KIR2DL5B locus collectively determine the highly variable surface expression observed among individuals; notably, KIR2DL5A is present on peripheral blood NK cells but absent from uterine NK cells, and its cognate ligand remains unidentified.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"KIR2DL5A encodes an inhibitory surface receptor expressed on CD56dim peripheral blood NK cells and a subset of T lymphocytes that suppresses NK cell cytotoxicity: upon tyrosine phosphorylation it recruits the phosphatases SHP-2 and, to a lesser extent, SHP-1, and antibody-mediated cross-linking inhibits killing of target cells [#0]. The gene is one of two paralogous KIR2DL5 loci (KIR2DL5A and KIR2DL5B) within the KIR cluster on chromosome 19q13.4, with the paralogs arising through duplication and recombination and showing differential expression — KIR2DL5A alleles are predominantly transcriptionally active, whereas KIR2DL5B is epigenetically silenced by DNA methylation at a RUNX-binding promoter site [#1, #2]. Allelic polymorphism further tunes receptor display: the common KIR2DL5A*001 allele traffics to the cell surface, while the *005 allele is largely retained intracellularly owing principally to a Gly174Ser substitution [#3]. Receptor expression is also compartment-specific, present on peripheral blood NK cells but absent from uterine NK cells [#4]. The cognate ligand of KIR2DL5A has not been identified in the available corpus.\",\n  \"teleology\": [\n    {\n      \"year\": 2002,\n      \"claim\": \"Whether KIR2DL5 was a single gene or multiple loci was unresolved; mapping defined two distinct paralogs, establishing the genomic architecture underlying expression variability.\",\n      \"evidence\": \"Genomic mapping, DNA sequencing, and haplotype segregation in family cohorts\",\n      \"pmids\": [\"12185535\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\"Does not establish functional differences between the paralogs\", \"Mechanism driving differential expression not addressed\"]\n    },\n    {\n      \"year\": 2007,\n      \"claim\": \"The signaling function of the receptor was undefined; this work showed KIR2DL5A is a surface inhibitory receptor that recruits SHP-2/SHP-1 and dampens NK cytotoxicity, defining it as an ITIM-type inhibitory receptor.\",\n      \"evidence\": \"Monoclonal antibody generation, flow cytometry, co-IP of SHP-1/SHP-2, and redirected NK cytotoxicity assay\",\n      \"pmids\": [\"17371997\"],\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\"Cognate physiological ligand not identified\", \"Cross-linking is antibody-mediated, not by a natural ligand\"]\n    },\n    {\n      \"year\": 2012,\n      \"claim\": \"The basis for divergent expression of the two paralogs was unknown; integration of methylation data attributed KIR2DL5B silencing to DNA methylation at a RUNX-binding promoter site, contrasting with active KIR2DL5A.\",\n      \"evidence\": \"Review integrating DNA methylation and promoter studies\",\n      \"pmids\": [\"23060877\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\"Review-level synthesis rather than new primary data\", \"Does not address allelic surface expression variation within KIR2DL5A\"]\n    },\n    {\n      \"year\": 2016,\n      \"claim\": \"Whether KIR2DL5A is uniformly expressed across NK populations was unknown; flow cytometry showed it is present on peripheral blood NK cells but absent from uterine NK cells, revealing tissue-specific repertoire differences.\",\n      \"evidence\": \"Flow cytometry of decidual uNK vs. peripheral blood NK cells with KIR2DL5A-specific mAb\",\n      \"pmids\": [\"27815424\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\"Single method, single study\", \"Functional consequence of compartment-specific absence not determined\"]\n    },\n    {\n      \"year\": 2017,\n      \"claim\": \"The cause of variable surface expression among individuals was unclear; mutagenesis assigned the intracellular retention of the *005 allele primarily to a Gly174Ser substitution, defining a molecular determinant of trafficking.\",\n      \"evidence\": \"Transient transfection of tagged constructs, site-directed mutagenesis, Western blot, flow cytometry, confocal microscopy\",\n      \"pmids\": [\"28144240\"],\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\"Mechanism by which Gly174Ser causes retention not resolved\", \"Trafficking studied in transfected cells, not primary NK cells\"]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"The cognate ligand of KIR2DL5A and the physiological context in which it delivers inhibitory signals remain unidentified.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\"No ligand identified\", \"No structural model of receptor-ligand engagement\", \"Physiological triggering of SHP recruitment uncharacterized\"]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\"term_id\": \"GO:0060089\", \"supporting_discovery_ids\": [0]},\n      {\"term_id\": \"GO:0098772\", \"supporting_discovery_ids\": [0]}\n    ],\n    \"localization\": [\n      {\"term_id\": \"GO:0005886\", \"supporting_discovery_ids\": [0, 3, 4]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"R-HSA-168256\", \"supporting_discovery_ids\": [0]}\n    ],\n    \"complexes\": [],\n    \"partners\": [\"PTPN11\", \"PTPN6\"],\n    \"other_free_text\": []\n  }\n}","audit_flag":null,"evaluation":{"pairwise":"win","faith_supported":4,"faith_total":4,"faith_pct":100.0}}