{"gene":"INS","run_date":"2026-06-10T01:55:23","timeline":{"discoveries":[{"year":1997,"finding":"INS VNTR class III alleles (IDDM2 locus) are associated with 2- to 3-fold higher INS mRNA levels in human fetal thymus compared to class I alleles, suggesting that higher thymic insulin expression facilitates immune tolerance induction and underlies the dominant protective effect of class III alleles against type 1 diabetes.","method":"RT-PCR quantification of INS mRNA in human fetal thymus tissue stratified by VNTR genotype","journal":"Nature genetics","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — direct mRNA quantification in human tissue with defined genotyping, single lab, one primary method","pmids":["9054944"],"is_preprint":false},{"year":1996,"finding":"In human fetal pancreas, INS transcripts from chromosomes carrying a class III VNTR allele are slightly but significantly lower (~13%) than those from class I alleles, demonstrating a cis-acting transcriptional effect of the VNTR on INS expression in pancreas.","method":"Allele-specific RT-PCR using 3' UTR transcribed polymorphisms in human fetal pancreas samples to measure relative mRNA levels from each chromosome","journal":"Journal of autoimmunity","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — allele-specific RT-PCR with internal controls in 10 human fetal pancreas samples, single lab, one primary method","pmids":["8816977"],"is_preprint":false},{"year":2000,"finding":"The insulin-linked polymorphic region (ILPR/IDDM2), a G-rich minisatellite in the INS promoter, can form G-quartet DNA structures in vitro, and both inter- and intramolecular G-quartet formation influence transcriptional activity of the human insulin gene; single nucleotide differences in ILPR repeats that affect insulin transcription correlate with ability to form these unusual DNA structures.","method":"In vitro G-quartet formation assays combined with transcriptional reporter assays using designed high-activity ILPR repeat constructs","journal":"Proceedings of the National Academy of Sciences of the United States of America","confidence":"Medium","confidence_rationale":"Tier 1 / Moderate — in vitro biochemical reconstitution of G-quartet formation combined with transcriptional activity assays, single lab, two orthogonal methods","pmids":["11070077"],"is_preprint":false},{"year":2004,"finding":"Type 1 diabetes susceptibility at the IDDM2 locus maps to a ~2-kb region containing three candidate causal variants: the VNTR itself, -23HphI, and +1140A/C; fine mapping could not definitively exclude the latter two single nucleotide variants as having independent etiological effects on INS expression and disease susceptibility.","method":"Genotyping of 177 polymorphisms in up to 2,960 pedigrees with robust regression mapping and transmission disequilibrium testing","journal":"Diabetes","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — large-scale family-based genetic mapping with multiple polymorphisms in thousands of pedigrees, single study, genetic rather than direct biochemical method","pmids":["15220214"],"is_preprint":false}],"current_model":"The INS gene's susceptibility to type 1 diabetes (IDDM2 locus) is mechanistically linked to VNTR minisatellite alleles in its promoter region: class III alleles drive higher insulin mRNA expression in the thymus (facilitating central immune tolerance) but slightly lower expression in fetal pancreas compared to class I alleles, with transcriptional activity further modulated by G-quartet DNA structure formation at the ILPR; fine mapping localizes the causal variant(s) to a ~2-kb region containing the VNTR, -23HphI, and +1140A/C polymorphisms."},"narrative":{"mechanistic_narrative":"INS encodes insulin, but the available corpus characterizes the gene chiefly through the regulation of its own expression by a polymorphic promoter element that links it to type 1 diabetes susceptibility at the IDDM2 locus [PMID:9054944, PMID:15220214]. The insulin-linked polymorphic region (ILPR), a G-rich VNTR minisatellite upstream of INS, acts as a cis-acting transcriptional regulator whose VNTR class alleles set INS mRNA levels in a tissue-specific manner: class III alleles drive 2- to 3-fold higher insulin transcription in fetal thymus while producing slightly lower (~13%) transcript levels from the corresponding chromosome in fetal pancreas relative to class I alleles [PMID:9054944, PMID:8816977]. The elevated thymic expression conferred by class III alleles provides the mechanistic basis for the dominant protection these alleles confer against type 1 diabetes, consistent with enhanced central immune tolerance to insulin [PMID:9054944]. At the molecular level, the ILPR repeats can fold into intra- and intermolecular G-quartet DNA structures in vitro, and the propensity to form these structures correlates with transcriptional output, providing a structural mechanism by which single-nucleotide differences between repeats tune insulin gene transcription [PMID:11070077]. Fine mapping localizes the causal IDDM2 signal to a ~2-kb interval that contains the VNTR alongside the -23HphI and +1140A/C variants, which could not be excluded as independent contributors [PMID:15220214]. The corpus does not address the biochemistry, processing, secretion, or receptor signaling of the insulin protein itself.","teleology":[{"year":1996,"claim":"Establishing that the IDDM2 VNTR exerts a direct cis-acting effect on INS transcription tied the diabetes susceptibility locus to allele-specific control of insulin gene expression in the disease-relevant pancreas.","evidence":"allele-specific RT-PCR using 3' UTR transcribed polymorphisms in human fetal pancreas","pmids":["8816977"],"confidence":"Medium","gaps":["Single small sample set (10 fetal pancreata); not confirmed in adult or beta-cell-specific tissue","Does not establish the molecular mechanism by which the VNTR alters transcription","Modest (~13%) effect size leaves causal sufficiency unresolved"]},{"year":1997,"claim":"Demonstrating that protective class III alleles raise INS expression in the thymus provided a tolerance-based mechanism for IDDM2 protection, addressing why a non-coding promoter variant alters autoimmune risk.","evidence":"RT-PCR quantification of INS mRNA in human fetal thymus stratified by VNTR genotype","pmids":["9054944"],"confidence":"Medium","gaps":["Functional link between thymic insulin levels and actual tolerance induction is inferred, not directly tested","Single lab, single primary method","Opposite-direction effects in thymus versus pancreas not mechanistically reconciled"]},{"year":2000,"claim":"Showing that ILPR repeats fold into G-quartet structures that modulate transcription supplied a structural-DNA mechanism for how repeat sequence variation tunes insulin gene output.","evidence":"in vitro G-quartet formation assays combined with transcriptional reporter assays using designed ILPR constructs","pmids":["11070077"],"confidence":"Medium","gaps":["G-quartet formation demonstrated in vitro; in vivo occurrence at the endogenous locus not established","Trans-acting factors that read or resolve the G-quartet not identified","Link between structure-forming designed repeats and natural class I/III alleles incomplete"]},{"year":2004,"claim":"Fine mapping narrowed the IDDM2 causal signal to a ~2-kb interval but could not isolate a single causal variant, defining the boundary of genetic resolution at the locus.","evidence":"genotyping of 177 polymorphisms in up to 2,960 pedigrees with regression mapping and transmission disequilibrium testing","pmids":["15220214"],"confidence":"Medium","gaps":["VNTR, -23HphI, and +1140A/C remain statistically inseparable as causal candidates","Genetic rather than direct biochemical/functional discrimination of variants","Independent etiological effects of the SNVs not excluded"]},{"year":null,"claim":"It remains unresolved which variant(s) in the ~2-kb IDDM2 interval are causal and how G-quartet structure, tissue-specific transcription, and tolerance induction are mechanistically connected at the endogenous locus.","evidence":"no discovery in the corpus resolves causal variant identity or in vivo structural mechanism","pmids":[],"confidence":"Medium","gaps":["No identification of trans-acting factors binding the ILPR/G-quartet","No direct demonstration of thymic-insulin-driven tolerance","No characterization of insulin protein biochemistry or signaling in this corpus"]}],"mechanism_profile":{"molecular_activity":[],"localization":[],"pathway":[{"term_id":"R-HSA-74160","term_label":"Gene expression (Transcription)","supporting_discovery_ids":[0,1,2]},{"term_id":"R-HSA-1643685","term_label":"Disease","supporting_discovery_ids":[0,3]}],"complexes":[],"partners":[],"other_free_text":[]}},"prefetch_data":{"uniprot":{"accession":"P01308","full_name":"Insulin","aliases":[],"length_aa":110,"mass_kda":12.0,"function":"Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver","subcellular_location":"Secreted","url":"https://www.uniprot.org/uniprotkb/P01308/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/INS","classification":"Not Classified","n_dependent_lines":193,"n_total_lines":1208,"dependency_fraction":0.1597682119205298},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[],"url":"https://opencell.sf.czbiohub.org/search/INS","total_profiled":1310},"omim":[{"mim_id":"621494","title":"RNA, U6 SMALL NUCLEAR 9; RNU6-9","url":"https://www.omim.org/entry/621494"},{"mim_id":"621493","title":"RNA, U6 SMALL NUCLEAR 8; RNU6-8","url":"https://www.omim.org/entry/621493"},{"mim_id":"621491","title":"RNA, U6 SMALL NUCLEAR 2; RNU6-2","url":"https://www.omim.org/entry/621491"},{"mim_id":"621355","title":"KRI1 HOMOLOG; KRI1","url":"https://www.omim.org/entry/621355"},{"mim_id":"621173","title":"G PROTEIN-COUPLED RECEPTOR 146; GPR146","url":"https://www.omim.org/entry/621173"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"","locations":[],"tissue_specificity":"Tissue enriched","tissue_distribution":"Detected in many","driving_tissues":[{"tissue":"pancreas","ntpm":12197.1}],"url":"https://www.proteinatlas.org/search/INS"},"hgnc":{"alias_symbol":[],"prev_symbol":["IDDM2","IDDM1"]},"alphafold":{"accession":"P01308","domains":[],"viewer_url":"https://alphafold.ebi.ac.uk/entry/P01308","model_url":"https://alphafold.ebi.ac.uk/files/AF-P01308-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-P01308-F1-predicted_aligned_error_v6.png","plddt_mean":52.91},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=INS","jax_strain_url":"https://www.jax.org/strain/search?query=INS"},"sequence":{"accession":"P01308","fasta_url":"https://rest.uniprot.org/uniprotkb/P01308.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/P01308/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/P01308"}},"corpus_meta":[{"pmid":"20064460","id":"PMC_20064460","title":"Eukaryotic stress granules: the ins and outs of translation.","date":"2009","source":"Molecular cell","url":"https://pubmed.ncbi.nlm.nih.gov/20064460","citation_count":1177,"is_preprint":false},{"pmid":"21697900","id":"PMC_21697900","title":"The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function.","date":"2011","source":"Nature reviews. 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of Bacillus proteases: activities, functions and commercial significance.","date":"2022","source":"FEMS microbiology reviews","url":"https://pubmed.ncbi.nlm.nih.gov/34410368","citation_count":56,"is_preprint":false},{"pmid":"12915721","id":"PMC_12915721","title":"The ins and outs of STAT1 nuclear transport.","date":"2003","source":"Science's STKE : signal transduction knowledge environment","url":"https://pubmed.ncbi.nlm.nih.gov/12915721","citation_count":55,"is_preprint":false},{"pmid":"33865114","id":"PMC_33865114","title":"Ins and outs of cadmium-induced carcinogenesis: Mechanism and prevention.","date":"2021","source":"Cancer treatment and research communications","url":"https://pubmed.ncbi.nlm.nih.gov/33865114","citation_count":54,"is_preprint":false},{"pmid":"32748538","id":"PMC_32748538","title":"The ins and outs of host-microsporidia interactions during invasion, proliferation and exit.","date":"2020","source":"Cellular 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autoimmunity; the ins and outs.","date":"2017","source":"Immunology letters","url":"https://pubmed.ncbi.nlm.nih.gov/29155234","citation_count":39,"is_preprint":false},{"pmid":"37938774","id":"PMC_37938774","title":"Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements.","date":"2023","source":"Nature","url":"https://pubmed.ncbi.nlm.nih.gov/37938774","citation_count":37,"is_preprint":false},{"pmid":"15544492","id":"PMC_15544492","title":"The ins and outs of RNAi in mammalian cells.","date":"2004","source":"Current pharmaceutical biotechnology","url":"https://pubmed.ncbi.nlm.nih.gov/15544492","citation_count":36,"is_preprint":false},{"pmid":"11021807","id":"PMC_11021807","title":"The ins and outs of body surface immunology.","date":"2000","source":"Science (New York, N.Y.)","url":"https://pubmed.ncbi.nlm.nih.gov/11021807","citation_count":35,"is_preprint":false},{"pmid":"19348590","id":"PMC_19348590","title":"The ins and outs of nuclear trafficking: unusual aspects in apicomplexan parasites.","date":"2009","source":"DNA and cell biology","url":"https://pubmed.ncbi.nlm.nih.gov/19348590","citation_count":33,"is_preprint":false},{"pmid":"9313762","id":"PMC_9313762","title":"Evidence for association between the class I subset of the insulin gene minisatellite (IDDM2 locus) and IDDM in the Japanese population.","date":"1997","source":"Diabetes","url":"https://pubmed.ncbi.nlm.nih.gov/9313762","citation_count":33,"is_preprint":false},{"pmid":"15839891","id":"PMC_15839891","title":"The ins and outs of HIV replication.","date":"2005","source":"Cellular microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/15839891","citation_count":32,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":34560,"output_tokens":1293,"usd":0.061538,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":7647,"output_tokens":2047,"usd":0.044705,"stage2_stop_reason":"end_turn"},"total_usd":0.106243,"stage1_batch_id":"msgbatch_01DUPACZi7AAWwuZiUjseQF4","stage2_batch_id":"msgbatch_018yt7chE3f48PEFtDwtj6AE","note":"batch pricing = 50% of standard"},"stage1_raw":"Looking through these 100 abstracts, I need to identify papers about the canonical INS (insulin) gene and extract mechanistic findings.\n\nPapers directly relevant to INS/IDDM2:\n- [4] PMID 9054944: INS VNTR alleles affect thymic insulin expression\n- [35] PMID 15220214: Remapping IDDM2 locus\n- [46] PMID 8816977: VNTR genotype effect on INS mRNA in fetal pancreas\n- [54] PMID 11070077: ILPR/IDDM2 G-quartet structures affect INS transcription\n- [99] PMID 9313762: Class I VNTR subset association with IDDM in Japanese\n\nAll other papers are about unrelated topics using \"ins and outs\" metaphorically in their titles, or are about completely unrelated genes/processes.\n\n```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 1997,\n      \"finding\": \"INS VNTR class III alleles (IDDM2 locus) are associated with 2- to 3-fold higher INS mRNA levels in human fetal thymus compared to class I alleles, suggesting that higher thymic insulin expression facilitates immune tolerance induction and underlies the dominant protective effect of class III alleles against type 1 diabetes.\",\n      \"method\": \"RT-PCR quantification of INS mRNA in human fetal thymus tissue stratified by VNTR genotype\",\n      \"journal\": \"Nature genetics\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — direct mRNA quantification in human tissue with defined genotyping, single lab, one primary method\",\n      \"pmids\": [\"9054944\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 1996,\n      \"finding\": \"In human fetal pancreas, INS transcripts from chromosomes carrying a class III VNTR allele are slightly but significantly lower (~13%) than those from class I alleles, demonstrating a cis-acting transcriptional effect of the VNTR on INS expression in pancreas.\",\n      \"method\": \"Allele-specific RT-PCR using 3' UTR transcribed polymorphisms in human fetal pancreas samples to measure relative mRNA levels from each chromosome\",\n      \"journal\": \"Journal of autoimmunity\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — allele-specific RT-PCR with internal controls in 10 human fetal pancreas samples, single lab, one primary method\",\n      \"pmids\": [\"8816977\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2000,\n      \"finding\": \"The insulin-linked polymorphic region (ILPR/IDDM2), a G-rich minisatellite in the INS promoter, can form G-quartet DNA structures in vitro, and both inter- and intramolecular G-quartet formation influence transcriptional activity of the human insulin gene; single nucleotide differences in ILPR repeats that affect insulin transcription correlate with ability to form these unusual DNA structures.\",\n      \"method\": \"In vitro G-quartet formation assays combined with transcriptional reporter assays using designed high-activity ILPR repeat constructs\",\n      \"journal\": \"Proceedings of the National Academy of Sciences of the United States of America\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 1 / Moderate — in vitro biochemical reconstitution of G-quartet formation combined with transcriptional activity assays, single lab, two orthogonal methods\",\n      \"pmids\": [\"11070077\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2004,\n      \"finding\": \"Type 1 diabetes susceptibility at the IDDM2 locus maps to a ~2-kb region containing three candidate causal variants: the VNTR itself, -23HphI, and +1140A/C; fine mapping could not definitively exclude the latter two single nucleotide variants as having independent etiological effects on INS expression and disease susceptibility.\",\n      \"method\": \"Genotyping of 177 polymorphisms in up to 2,960 pedigrees with robust regression mapping and transmission disequilibrium testing\",\n      \"journal\": \"Diabetes\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — large-scale family-based genetic mapping with multiple polymorphisms in thousands of pedigrees, single study, genetic rather than direct biochemical method\",\n      \"pmids\": [\"15220214\"],\n      \"is_preprint\": false\n    }\n  ],\n  \"current_model\": \"The INS gene's susceptibility to type 1 diabetes (IDDM2 locus) is mechanistically linked to VNTR minisatellite alleles in its promoter region: class III alleles drive higher insulin mRNA expression in the thymus (facilitating central immune tolerance) but slightly lower expression in fetal pancreas compared to class I alleles, with transcriptional activity further modulated by G-quartet DNA structure formation at the ILPR; fine mapping localizes the causal variant(s) to a ~2-kb region containing the VNTR, -23HphI, and +1140A/C polymorphisms.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"INS encodes insulin, but the available corpus characterizes the gene chiefly through the regulation of its own expression by a polymorphic promoter element that links it to type 1 diabetes susceptibility at the IDDM2 locus [#0, #3]. The insulin-linked polymorphic region (ILPR), a G-rich VNTR minisatellite upstream of INS, acts as a cis-acting transcriptional regulator whose VNTR class alleles set INS mRNA levels in a tissue-specific manner: class III alleles drive 2- to 3-fold higher insulin transcription in fetal thymus while producing slightly lower (~13%) transcript levels from the corresponding chromosome in fetal pancreas relative to class I alleles [#0, #1]. The elevated thymic expression conferred by class III alleles provides the mechanistic basis for the dominant protection these alleles confer against type 1 diabetes, consistent with enhanced central immune tolerance to insulin [#0]. At the molecular level, the ILPR repeats can fold into intra- and intermolecular G-quartet DNA structures in vitro, and the propensity to form these structures correlates with transcriptional output, providing a structural mechanism by which single-nucleotide differences between repeats tune insulin gene transcription [#2]. Fine mapping localizes the causal IDDM2 signal to a ~2-kb interval that contains the VNTR alongside the -23HphI and +1140A/C variants, which could not be excluded as independent contributors [#3]. The corpus does not address the biochemistry, processing, secretion, or receptor signaling of the insulin protein itself.\",\n  \"teleology\": [\n    {\n      \"year\": 1996,\n      \"claim\": \"Establishing that the IDDM2 VNTR exerts a direct cis-acting effect on INS transcription tied the diabetes susceptibility locus to allele-specific control of insulin gene expression in the disease-relevant pancreas.\",\n      \"evidence\": \"allele-specific RT-PCR using 3' UTR transcribed polymorphisms in human fetal pancreas\",\n      \"pmids\": [\"8816977\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\n        \"Single small sample set (10 fetal pancreata); not confirmed in adult or beta-cell-specific tissue\",\n        \"Does not establish the molecular mechanism by which the VNTR alters transcription\",\n        \"Modest (~13%) effect size leaves causal sufficiency unresolved\"\n      ]\n    },\n    {\n      \"year\": 1997,\n      \"claim\": \"Demonstrating that protective class III alleles raise INS expression in the thymus provided a tolerance-based mechanism for IDDM2 protection, addressing why a non-coding promoter variant alters autoimmune risk.\",\n      \"evidence\": \"RT-PCR quantification of INS mRNA in human fetal thymus stratified by VNTR genotype\",\n      \"pmids\": [\"9054944\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\n        \"Functional link between thymic insulin levels and actual tolerance induction is inferred, not directly tested\",\n        \"Single lab, single primary method\",\n        \"Opposite-direction effects in thymus versus pancreas not mechanistically reconciled\"\n      ]\n    },\n    {\n      \"year\": 2000,\n      \"claim\": \"Showing that ILPR repeats fold into G-quartet structures that modulate transcription supplied a structural-DNA mechanism for how repeat sequence variation tunes insulin gene output.\",\n      \"evidence\": \"in vitro G-quartet formation assays combined with transcriptional reporter assays using designed ILPR constructs\",\n      \"pmids\": [\"11070077\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\n        \"G-quartet formation demonstrated in vitro; in vivo occurrence at the endogenous locus not established\",\n        \"Trans-acting factors that read or resolve the G-quartet not identified\",\n        \"Link between structure-forming designed repeats and natural class I/III alleles incomplete\"\n      ]\n    },\n    {\n      \"year\": 2004,\n      \"claim\": \"Fine mapping narrowed the IDDM2 causal signal to a ~2-kb interval but could not isolate a single causal variant, defining the boundary of genetic resolution at the locus.\",\n      \"evidence\": \"genotyping of 177 polymorphisms in up to 2,960 pedigrees with regression mapping and transmission disequilibrium testing\",\n      \"pmids\": [\"15220214\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\n        \"VNTR, -23HphI, and +1140A/C remain statistically inseparable as causal candidates\",\n        \"Genetic rather than direct biochemical/functional discrimination of variants\",\n        \"Independent etiological effects of the SNVs not excluded\"\n      ]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"It remains unresolved which variant(s) in the ~2-kb IDDM2 interval are causal and how G-quartet structure, tissue-specific transcription, and tolerance induction are mechanistically connected at the endogenous locus.\",\n      \"evidence\": \"no discovery in the corpus resolves causal variant identity or in vivo structural mechanism\",\n      \"pmids\": [],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\n        \"No identification of trans-acting factors binding the ILPR/G-quartet\",\n        \"No direct demonstration of thymic-insulin-driven tolerance\",\n        \"No characterization of insulin protein biochemistry or signaling in this corpus\"\n      ]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [],\n    \"localization\": [],\n    \"pathway\": [\n      {\"term_id\": \"R-HSA-74160\", \"supporting_discovery_ids\": [0, 1, 2]},\n      {\"term_id\": \"R-HSA-1643685\", \"supporting_discovery_ids\": [0, 3]}\n    ],\n    \"complexes\": [],\n    \"partners\": [],\n    \"other_free_text\": []\n  }\n}","audit_flag":null,"evaluation":{"pairwise":"win","faith_supported":5,"faith_total":5,"faith_pct":100.0}}