{"gene":"HAUS7","run_date":"2026-06-10T01:55:21","timeline":{"discoveries":[{"year":2001,"finding":"UIP1 (HAUS7) was identified as a binding partner of UCH37 (UCHL5) via yeast two-hybrid screening; the interaction was confirmed by in vitro binding assay and co-immunoprecipitation. The C-terminal extension of UCH37 is essential for interaction with UIP1. Furthermore, UIP1 blocked the interaction between UCH37 and S14 (a PA700 subunit) in vitro, suggesting a competitive mechanism.","method":"Yeast two-hybrid, in vitro binding assay, co-immunoprecipitation","journal":"FEBS letters","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — reciprocal Co-IP plus in vitro binding assay, single lab, two orthogonal methods","pmids":["11163772"],"is_preprint":false},{"year":2013,"finding":"UCHL5IP (HAUS7) localizes to the meiotic spindle at MI and MII stages in mouse oocytes. Knockdown of UCHL5IP caused spindle defects, chromosome misalignment, and disruption of γ-tubulin localization at spindle poles, establishing a direct role for HAUS7 in spindle organization and γ-tubulin-dependent microtubule nucleation during meiotic maturation.","method":"siRNA knockdown in mouse oocytes, immunofluorescence localization, spindle/chromosome phenotype analysis","journal":"Reproduction, fertility, and development","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — direct localization with functional consequence via loss-of-function, single lab with multiple phenotypic readouts","pmids":["23182369"],"is_preprint":false},{"year":2019,"finding":"Depletion of HAUS7 (augmin subunit) in cultured hippocampal neurons increased the percentage of retrograde MT comets initiated at presynaptic boutons, demonstrating that HAUS7-containing augmin complex is required for activity-dependent de novo nucleation of uniformly distally oriented dynamic microtubules at presynaptic boutons, which in turn controls bidirectional synaptic vesicle transport and evoked exocytosis.","method":"siRNA knockdown of HAUS7 in cultured hippocampal neurons and hippocampal slices, live imaging of EB3-EGFP MT plus-end dynamics, vGlut1-mCherry bouton marker, SV transport and exocytosis assays","journal":"Current biology : CB","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — direct loss-of-function with specific MT nucleation phenotype and functional readout, single lab with multiple orthogonal assays","pmids":["31813605"],"is_preprint":false},{"year":2025,"finding":"HAUS7 was identified as a direct binding partner of DOCK3 (a regulator of neurotrophic factor signaling and axon regeneration). Neuronal HAUS7 is transported from the cell body to the growth cone under DOCK3 control. Phosphorylation of DOCK3 at Y562 by TrkB signaling causes dissociation of HAUS7, an event considered necessary for microtubule assembly. Deletion of Haus7 in mice significantly reduced microtubule formation and axon regeneration after optic nerve crush.","method":"Protein–protein interaction assay (DOCK3–HAUS7 binding), phosphorylation site mutagenesis (Y562), in vivo Haus7 knockout mouse, optic nerve crush model, MT formation assay, transcriptome analysis","journal":"Science advances","confidence":"High","confidence_rationale":"Tier 1–2 / Strong — direct binding confirmation, phosphorylation-dependent dissociation with mutagenesis, in vivo KO with specific MT and axon regeneration phenotype, multiple orthogonal methods in one study","pmids":["40712007"],"is_preprint":false}],"current_model":"HAUS7 is a subunit of the augmin complex that promotes γ-tubulin-dependent microtubule nucleation at presynaptic boutons and meiotic spindle poles; it binds DOCK3 and is transported to neuronal growth cones, where TrkB-mediated phosphorylation of DOCK3 at Y562 dissociates HAUS7 to allow microtubule assembly and axon elongation, and it also interacts with the deubiquitinase UCH37 and competitively blocks UCH37–proteasome (S14) association."},"narrative":{"mechanistic_narrative":"HAUS7 is a subunit of the augmin complex that promotes γ-tubulin-dependent microtubule nucleation across multiple cellular contexts [PMID:23182369, PMID:31813605]. In maturing mouse oocytes it localizes to the meiotic spindle, where its loss disrupts γ-tubulin recruitment to spindle poles, causing spindle disorganization and chromosome misalignment [PMID:23182369]. In hippocampal neurons, HAUS7-containing augmin drives activity-dependent de novo nucleation of correctly oriented dynamic microtubules at presynaptic boutons, thereby controlling bidirectional synaptic vesicle transport and evoked exocytosis [PMID:31813605]. HAUS7 is also a direct binding partner of DOCK3 and is transported under DOCK3 control to the neuronal growth cone, where TrkB-mediated phosphorylation of DOCK3 at Y562 releases HAUS7 to permit microtubule assembly; loss of Haus7 in mice reduces microtubule formation and axon regeneration after optic nerve crush [PMID:40712007]. Separately, HAUS7 binds the deubiquitinase UCH37 (UCHL5) via the UCH37 C-terminal extension and competitively blocks the UCH37–S14/PA700 proteasome interaction in vitro [PMID:11163772].","teleology":[{"year":2001,"claim":"Established the first molecular partner of HAUS7, linking it to deubiquitinase regulation by showing it can competitively interrupt UCH37 association with the proteasome.","evidence":"Yeast two-hybrid, in vitro binding, and co-immunoprecipitation mapping the UCH37 C-terminal extension as the interaction surface","pmids":["11163772"],"confidence":"Medium","gaps":["No cellular consequence of the HAUS7–UCH37 interaction demonstrated in vivo","Relationship between this proteasome-associated role and HAUS7's microtubule functions unresolved","Competitive blocking shown only in vitro"]},{"year":2013,"claim":"Demonstrated a direct cytoskeletal role by showing HAUS7 is required for γ-tubulin-dependent spindle organization during meiotic maturation.","evidence":"siRNA knockdown in mouse oocytes with immunofluorescence and spindle/chromosome phenotype analysis","pmids":["23182369"],"confidence":"Medium","gaps":["Mechanism by which HAUS7 promotes γ-tubulin recruitment not resolved at molecular level","Single-lab loss-of-function without rescue","Augmin complex composition in oocytes not characterized"]},{"year":2019,"claim":"Extended HAUS7-dependent microtubule nucleation to neurons, connecting augmin activity to presynaptic microtubule generation and synaptic vesicle traffic.","evidence":"siRNA knockdown in hippocampal neurons/slices with live EB3-EGFP plus-end imaging and synaptic vesicle transport/exocytosis assays","pmids":["31813605"],"confidence":"Medium","gaps":["How activity signals trigger augmin-dependent nucleation at boutons unknown","Other augmin subunit contributions not dissected","Single-lab study"]},{"year":2025,"claim":"Defined a regulated, signaling-controlled mechanism for HAUS7 in axon regeneration, showing TrkB-driven DOCK3 phosphorylation gates HAUS7 release to permit microtubule assembly.","evidence":"DOCK3–HAUS7 binding assay, Y562 phosphosite mutagenesis, Haus7 knockout mice, optic nerve crush, MT formation and transcriptome analysis","pmids":["40712007"],"confidence":"High","gaps":["Structural basis of phosphorylation-dependent HAUS7 dissociation not determined","Whether augmin complex assembly is required at the growth cone unaddressed","Link to the meiotic/synaptic nucleation roles not integrated"]},{"year":null,"claim":"How HAUS7's proteasome-regulatory interaction with UCH37 relates mechanistically to its augmin-dependent microtubule nucleation functions remains unresolved.","evidence":"","pmids":[],"confidence":"Medium","gaps":["No study reconciles the UCH37/proteasome role with the microtubule role","No structural model of HAUS7 within augmin reported in the corpus"]}],"mechanism_profile":{"molecular_activity":[{"term_id":"GO:0008092","term_label":"cytoskeletal protein binding","supporting_discovery_ids":[1,2]},{"term_id":"GO:0060089","term_label":"molecular transducer activity","supporting_discovery_ids":[3]}],"localization":[{"term_id":"GO:0005815","term_label":"microtubule organizing center","supporting_discovery_ids":[1]},{"term_id":"GO:0005856","term_label":"cytoskeleton","supporting_discovery_ids":[2]}],"pathway":[{"term_id":"R-HSA-1640170","term_label":"Cell Cycle","supporting_discovery_ids":[1]},{"term_id":"R-HSA-112316","term_label":"Neuronal System","supporting_discovery_ids":[2,3]}],"complexes":["augmin"],"partners":["UCHL5","DOCK3"],"other_free_text":[]}},"prefetch_data":{"uniprot":{"accession":"Q99871","full_name":"HAUS augmin-like complex subunit 7","aliases":["26S proteasome-associated UCH37-interacting protein 1","UCHL5-interacting protein","X-linked protein STS1769"],"length_aa":358,"mass_kda":39.8,"function":"Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex","subcellular_location":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, spindle","url":"https://www.uniprot.org/uniprotkb/Q99871/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":true,"resolved_as":"","url":"https://depmap.org/portal/gene/HAUS7","classification":"Common Essential","n_dependent_lines":1182,"n_total_lines":1208,"dependency_fraction":0.9784768211920529},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[{"gene":"ARFIP1","stoichiometry":0.2}],"url":"https://opencell.sf.czbiohub.org/search/HAUS7","total_profiled":1310},"omim":[{"mim_id":"300540","title":"HAUS AUGMIN-LIKE COMPLEX, SUBUNIT 7; HAUS7","url":"https://www.omim.org/entry/300540"},{"mim_id":"258150","title":"SPERMATOGENIC FAILURE 1; SPGF1","url":"https://www.omim.org/entry/258150"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Approved","locations":[{"location":"Plasma membrane","reliability":"Approved"},{"location":"Centrosome","reliability":"Approved"},{"location":"Nucleoli","reliability":"Additional"},{"location":"Basal body","reliability":"Additional"},{"location":"Mid piece","reliability":"Additional"},{"location":"Principal piece","reliability":"Additional"}],"tissue_specificity":"Tissue enhanced","tissue_distribution":"Detected in all","driving_tissues":[{"tissue":"blood vessel","ntpm":100.2}],"url":"https://www.proteinatlas.org/search/HAUS7"},"hgnc":{"alias_symbol":["UIP1"],"prev_symbol":["UCHL5IP"]},"alphafold":{"accession":"Q99871","domains":[{"cath_id":"1.10.418","chopping":"31-170","consensus_level":"high","plddt":89.2833,"start":31,"end":170}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q99871","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q99871-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q99871-F1-predicted_aligned_error_v6.png","plddt_mean":78.0},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=HAUS7","jax_strain_url":"https://www.jax.org/strain/search?query=HAUS7"},"sequence":{"accession":"Q99871","fasta_url":"https://rest.uniprot.org/uniprotkb/Q99871.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q99871/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q99871"}},"corpus_meta":[{"pmid":"11056382","id":"PMC_11056382","title":"Yeast Ulp1, an Smt3-specific protease, associates with nucleoporins.","date":"2000","source":"Journal of biochemistry","url":"https://pubmed.ncbi.nlm.nih.gov/11056382","citation_count":70,"is_preprint":false},{"pmid":"31813605","id":"PMC_31813605","title":"Activity-Dependent Nucleation of Dynamic Microtubules at Presynaptic Boutons Controls Neurotransmission.","date":"2019","source":"Current biology : CB","url":"https://pubmed.ncbi.nlm.nih.gov/31813605","citation_count":51,"is_preprint":false},{"pmid":"29425284","id":"PMC_29425284","title":"Chromosomal instability in women with primary ovarian insufficiency.","date":"2018","source":"Human reproduction (Oxford, England)","url":"https://pubmed.ncbi.nlm.nih.gov/29425284","citation_count":35,"is_preprint":false},{"pmid":"16395595","id":"PMC_16395595","title":"Human-specific nonsense mutations identified by genome sequence comparisons.","date":"2006","source":"Human genetics","url":"https://pubmed.ncbi.nlm.nih.gov/16395595","citation_count":26,"is_preprint":false},{"pmid":"11163772","id":"PMC_11163772","title":"Identification of two proteins, S14 and UIP1, that interact with UCH37.","date":"2001","source":"FEBS letters","url":"https://pubmed.ncbi.nlm.nih.gov/11163772","citation_count":20,"is_preprint":false},{"pmid":"29017965","id":"PMC_29017965","title":"A novel mutation in HAUS7 results in severe oligozoospermia in two brothers.","date":"2017","source":"Gene","url":"https://pubmed.ncbi.nlm.nih.gov/29017965","citation_count":15,"is_preprint":false},{"pmid":"38524437","id":"PMC_38524437","title":"Identifying Biomarkers and Therapeutic Targets by Multiomic Analysis for HNSCC: Precision Medicine and Healthcare Management.","date":"2024","source":"ACS omega","url":"https://pubmed.ncbi.nlm.nih.gov/38524437","citation_count":13,"is_preprint":false},{"pmid":"34552771","id":"PMC_34552771","title":"Current updates and future perspectives in the evaluation of azoospermia: A systematic review.","date":"2021","source":"Arab journal of urology","url":"https://pubmed.ncbi.nlm.nih.gov/34552771","citation_count":9,"is_preprint":false},{"pmid":"29035321","id":"PMC_29035321","title":"A Novel Multi-Epitope Vaccine Based on Urate Transporter 1 Alleviates Streptozotocin-Induced Diabetes by Producing Anti-URAT1 Antibody and an Immunomodulatory Effect in C57BL/6J Mice.","date":"2017","source":"International journal of molecular sciences","url":"https://pubmed.ncbi.nlm.nih.gov/29035321","citation_count":6,"is_preprint":false},{"pmid":"23182369","id":"PMC_23182369","title":"Knockdown of UCHL5IP causes abnormalities in γ-tubulin localisation, spindle organisation and chromosome alignment in mouse oocyte meiotic maturation.","date":"2013","source":"Reproduction, fertility, and development","url":"https://pubmed.ncbi.nlm.nih.gov/23182369","citation_count":3,"is_preprint":false},{"pmid":"40712007","id":"PMC_40712007","title":"Role of HAUS7 as a DOCK3 binding partner in facilitating axon regeneration.","date":"2025","source":"Science advances","url":"https://pubmed.ncbi.nlm.nih.gov/40712007","citation_count":0,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":7268,"output_tokens":1244,"usd":0.020232,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":7871,"output_tokens":2064,"usd":0.045477,"stage2_stop_reason":"end_turn"},"total_usd":0.065709,"stage1_batch_id":"msgbatch_01DUPACZi7AAWwuZiUjseQF4","stage2_batch_id":"msgbatch_018yt7chE3f48PEFtDwtj6AE","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2001,\n      \"finding\": \"UIP1 (HAUS7) was identified as a binding partner of UCH37 (UCHL5) via yeast two-hybrid screening; the interaction was confirmed by in vitro binding assay and co-immunoprecipitation. The C-terminal extension of UCH37 is essential for interaction with UIP1. Furthermore, UIP1 blocked the interaction between UCH37 and S14 (a PA700 subunit) in vitro, suggesting a competitive mechanism.\",\n      \"method\": \"Yeast two-hybrid, in vitro binding assay, co-immunoprecipitation\",\n      \"journal\": \"FEBS letters\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — reciprocal Co-IP plus in vitro binding assay, single lab, two orthogonal methods\",\n      \"pmids\": [\"11163772\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2013,\n      \"finding\": \"UCHL5IP (HAUS7) localizes to the meiotic spindle at MI and MII stages in mouse oocytes. Knockdown of UCHL5IP caused spindle defects, chromosome misalignment, and disruption of γ-tubulin localization at spindle poles, establishing a direct role for HAUS7 in spindle organization and γ-tubulin-dependent microtubule nucleation during meiotic maturation.\",\n      \"method\": \"siRNA knockdown in mouse oocytes, immunofluorescence localization, spindle/chromosome phenotype analysis\",\n      \"journal\": \"Reproduction, fertility, and development\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — direct localization with functional consequence via loss-of-function, single lab with multiple phenotypic readouts\",\n      \"pmids\": [\"23182369\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2019,\n      \"finding\": \"Depletion of HAUS7 (augmin subunit) in cultured hippocampal neurons increased the percentage of retrograde MT comets initiated at presynaptic boutons, demonstrating that HAUS7-containing augmin complex is required for activity-dependent de novo nucleation of uniformly distally oriented dynamic microtubules at presynaptic boutons, which in turn controls bidirectional synaptic vesicle transport and evoked exocytosis.\",\n      \"method\": \"siRNA knockdown of HAUS7 in cultured hippocampal neurons and hippocampal slices, live imaging of EB3-EGFP MT plus-end dynamics, vGlut1-mCherry bouton marker, SV transport and exocytosis assays\",\n      \"journal\": \"Current biology : CB\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — direct loss-of-function with specific MT nucleation phenotype and functional readout, single lab with multiple orthogonal assays\",\n      \"pmids\": [\"31813605\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2025,\n      \"finding\": \"HAUS7 was identified as a direct binding partner of DOCK3 (a regulator of neurotrophic factor signaling and axon regeneration). Neuronal HAUS7 is transported from the cell body to the growth cone under DOCK3 control. Phosphorylation of DOCK3 at Y562 by TrkB signaling causes dissociation of HAUS7, an event considered necessary for microtubule assembly. Deletion of Haus7 in mice significantly reduced microtubule formation and axon regeneration after optic nerve crush.\",\n      \"method\": \"Protein–protein interaction assay (DOCK3–HAUS7 binding), phosphorylation site mutagenesis (Y562), in vivo Haus7 knockout mouse, optic nerve crush model, MT formation assay, transcriptome analysis\",\n      \"journal\": \"Science advances\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 1–2 / Strong — direct binding confirmation, phosphorylation-dependent dissociation with mutagenesis, in vivo KO with specific MT and axon regeneration phenotype, multiple orthogonal methods in one study\",\n      \"pmids\": [\"40712007\"],\n      \"is_preprint\": false\n    }\n  ],\n  \"current_model\": \"HAUS7 is a subunit of the augmin complex that promotes γ-tubulin-dependent microtubule nucleation at presynaptic boutons and meiotic spindle poles; it binds DOCK3 and is transported to neuronal growth cones, where TrkB-mediated phosphorylation of DOCK3 at Y562 dissociates HAUS7 to allow microtubule assembly and axon elongation, and it also interacts with the deubiquitinase UCH37 and competitively blocks UCH37–proteasome (S14) association.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"HAUS7 is a subunit of the augmin complex that promotes γ-tubulin-dependent microtubule nucleation across multiple cellular contexts [#1, #2]. In maturing mouse oocytes it localizes to the meiotic spindle, where its loss disrupts γ-tubulin recruitment to spindle poles, causing spindle disorganization and chromosome misalignment [#1]. In hippocampal neurons, HAUS7-containing augmin drives activity-dependent de novo nucleation of correctly oriented dynamic microtubules at presynaptic boutons, thereby controlling bidirectional synaptic vesicle transport and evoked exocytosis [#2]. HAUS7 is also a direct binding partner of DOCK3 and is transported under DOCK3 control to the neuronal growth cone, where TrkB-mediated phosphorylation of DOCK3 at Y562 releases HAUS7 to permit microtubule assembly; loss of Haus7 in mice reduces microtubule formation and axon regeneration after optic nerve crush [#3]. Separately, HAUS7 binds the deubiquitinase UCH37 (UCHL5) via the UCH37 C-terminal extension and competitively blocks the UCH37–S14/PA700 proteasome interaction in vitro [#0].\",\n  \"teleology\": [\n    {\n      \"year\": 2001,\n      \"claim\": \"Established the first molecular partner of HAUS7, linking it to deubiquitinase regulation by showing it can competitively interrupt UCH37 association with the proteasome.\",\n      \"evidence\": \"Yeast two-hybrid, in vitro binding, and co-immunoprecipitation mapping the UCH37 C-terminal extension as the interaction surface\",\n      \"pmids\": [\"11163772\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\n        \"No cellular consequence of the HAUS7–UCH37 interaction demonstrated in vivo\",\n        \"Relationship between this proteasome-associated role and HAUS7's microtubule functions unresolved\",\n        \"Competitive blocking shown only in vitro\"\n      ]\n    },\n    {\n      \"year\": 2013,\n      \"claim\": \"Demonstrated a direct cytoskeletal role by showing HAUS7 is required for γ-tubulin-dependent spindle organization during meiotic maturation.\",\n      \"evidence\": \"siRNA knockdown in mouse oocytes with immunofluorescence and spindle/chromosome phenotype analysis\",\n      \"pmids\": [\"23182369\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\n        \"Mechanism by which HAUS7 promotes γ-tubulin recruitment not resolved at molecular level\",\n        \"Single-lab loss-of-function without rescue\",\n        \"Augmin complex composition in oocytes not characterized\"\n      ]\n    },\n    {\n      \"year\": 2019,\n      \"claim\": \"Extended HAUS7-dependent microtubule nucleation to neurons, connecting augmin activity to presynaptic microtubule generation and synaptic vesicle traffic.\",\n      \"evidence\": \"siRNA knockdown in hippocampal neurons/slices with live EB3-EGFP plus-end imaging and synaptic vesicle transport/exocytosis assays\",\n      \"pmids\": [\"31813605\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\n        \"How activity signals trigger augmin-dependent nucleation at boutons unknown\",\n        \"Other augmin subunit contributions not dissected\",\n        \"Single-lab study\"\n      ]\n    },\n    {\n      \"year\": 2025,\n      \"claim\": \"Defined a regulated, signaling-controlled mechanism for HAUS7 in axon regeneration, showing TrkB-driven DOCK3 phosphorylation gates HAUS7 release to permit microtubule assembly.\",\n      \"evidence\": \"DOCK3–HAUS7 binding assay, Y562 phosphosite mutagenesis, Haus7 knockout mice, optic nerve crush, MT formation and transcriptome analysis\",\n      \"pmids\": [\"40712007\"],\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\n        \"Structural basis of phosphorylation-dependent HAUS7 dissociation not determined\",\n        \"Whether augmin complex assembly is required at the growth cone unaddressed\",\n        \"Link to the meiotic/synaptic nucleation roles not integrated\"\n      ]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"How HAUS7's proteasome-regulatory interaction with UCH37 relates mechanistically to its augmin-dependent microtubule nucleation functions remains unresolved.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\n        \"No study reconciles the UCH37/proteasome role with the microtubule role\",\n        \"No structural model of HAUS7 within augmin reported in the corpus\"\n      ]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\"term_id\": \"GO:0008092\", \"supporting_discovery_ids\": [1, 2]},\n      {\"term_id\": \"GO:0060089\", \"supporting_discovery_ids\": [3]}\n    ],\n    \"localization\": [\n      {\"term_id\": \"GO:0005815\", \"supporting_discovery_ids\": [1]},\n      {\"term_id\": \"GO:0005856\", \"supporting_discovery_ids\": [2]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"R-HSA-1640170\", \"supporting_discovery_ids\": [1]},\n      {\"term_id\": \"R-HSA-112316\", \"supporting_discovery_ids\": [2, 3]}\n    ],\n    \"complexes\": [\"augmin\"],\n    \"partners\": [\"UCHL5\", \"DOCK3\"],\n    \"other_free_text\": []\n  }\n}","audit_flag":null,"evaluation":{"pairwise":"win","faith_supported":5,"faith_total":5,"faith_pct":100.0}}