{"gene":"H2BC26","run_date":"2026-06-10T01:55:21","timeline":{"discoveries":[],"current_model":"No mechanistic findings in the available literature."},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null},"prefetch_data":{"uniprot":{"accession":"Q8N257","full_name":"Histone H2B type 3-B","aliases":["H2B type 12","H2B-clustered histone 26","H2B.U histone 1"],"length_aa":126,"mass_kda":13.9,"function":"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling","subcellular_location":"Nucleus; Chromosome","url":"https://www.uniprot.org/uniprotkb/Q8N257/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/H2BC26","classification":"Not Classified","n_dependent_lines":114,"n_total_lines":1208,"dependency_fraction":0.09437086092715231},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[{"gene":"H1F0","stoichiometry":10.0},{"gene":"HIST2H2BE","stoichiometry":10.0},{"gene":"MED27","stoichiometry":10.0},{"gene":"NCK1","stoichiometry":10.0},{"gene":"NUMA1","stoichiometry":10.0},{"gene":"NECAP1","stoichiometry":4.0},{"gene":"PARP1","stoichiometry":4.0},{"gene":"SSRP1","stoichiometry":4.0},{"gene":"MAP4K4","stoichiometry":0.2},{"gene":"PPM1G","stoichiometry":0.2}],"url":"https://opencell.sf.czbiohub.org/search/H2BC26","total_profiled":1310},"omim":[],"hpa":{"profiled":true,"resolved_as":"","reliability":"Approved","locations":[{"location":"Nucleoplasm","reliability":"Approved"},{"location":"Cytosol","reliability":"Additional"}],"tissue_specificity":"Tissue enhanced","tissue_distribution":"Detected in some","driving_tissues":[{"tissue":"brain","ntpm":6.1},{"tissue":"choroid plexus","ntpm":3.4}],"url":"https://www.proteinatlas.org/search/H2BC26"},"hgnc":{"alias_symbol":[],"prev_symbol":["HIST3H2BB","H2BU1"]},"alphafold":{"accession":"Q8N257","domains":[{"cath_id":"1.10.20.10","chopping":"38-124","consensus_level":"medium","plddt":95.9967,"start":38,"end":124}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q8N257","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q8N257-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q8N257-F1-predicted_aligned_error_v6.png","plddt_mean":87.56},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=H2BC26","jax_strain_url":"https://www.jax.org/strain/search?query=H2BC26"},"sequence":{"accession":"Q8N257","fasta_url":"https://rest.uniprot.org/uniprotkb/Q8N257.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q8N257/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q8N257"}},"corpus_meta":[{"pmid":"29182684","id":"PMC_29182684","title":"Colorectal cancer stages transcriptome analysis.","date":"2017","source":"PloS one","url":"https://pubmed.ncbi.nlm.nih.gov/29182684","citation_count":31,"is_preprint":false},{"pmid":"39806458","id":"PMC_39806458","title":"Phosphatidylinositol promoted the proliferation and invasion of pituitary adenoma cells by regulating POU1F1 expression.","date":"2025","source":"Cancer & metabolism","url":"https://pubmed.ncbi.nlm.nih.gov/39806458","citation_count":3,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":3457,"output_tokens":34,"usd":0.005441,"stage1_stop_reason":"end_turn"},"stage2":{"model":"","input_tokens":0,"output_tokens":0,"usd":0.0},"total_usd":0.005441,"stage1_batch_id":"msgbatch_01DUPACZi7AAWwuZiUjseQF4","stage2_batch_id":"msgbatch_018yt7chE3f48PEFtDwtj6AE","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [],\n  \"current_model\": \"No mechanistic findings in the available literature.\"\n}\n```","stage2_raw":"","audit_flag":null,"evaluation":null}