{"gene":"FAM167A","run_date":"2026-06-09T23:54:43","timeline":{"discoveries":[{"year":2022,"finding":"FAM167A activates the noncanonical NF-κB pathway by binding to the cell adhesion protein desmoglein-1 (DSG1), which upregulates NF-κB-inducing kinase (NIK) by blocking its ubiquitination, thereby inducing BCR-ABL-independent TKI resistance in CML.","method":"Tandem mass spectrometry (receptor identification), Co-IP/binding assays, in vitro and in vivo mouse tumor models, neutralization experiments, flow cytometry, qRT-PCR","journal":"Journal of experimental & clinical cancer research : CR","confidence":"High","confidence_rationale":"Tier 2 / Moderate — reciprocal binding identified by MS, in vitro mechanistic follow-up (NIK ubiquitination blockade), in vivo mouse model rescue, and patient cell validation in a single lab with multiple orthogonal methods","pmids":["35241148"],"is_preprint":false},{"year":2018,"finding":"FAM167A (DIORA-1) encodes a protein characterized by high intrinsic disorder content, with its highest expression in the lung (bronchial epithelium and alveolar macrophages), where it displays an endosomal localization pattern. The FAM167 gene family (FAM167A and FAM167B) is not homologous to any other annotated gene but is evolutionarily conserved.","method":"Cloning from human PBMCs, immunohistochemistry of human tissues, protein disorder analysis by online tools, qPCR in mouse organs, eQTL analysis in immune cells","journal":"Clinical and experimental immunology","confidence":"Medium","confidence_rationale":"Tier 3 / Moderate — direct localization by IHC with tissue expression mapping, cloning and bioinformatic characterization, but no functional perturbation experiment; single lab","pmids":["29663334"],"is_preprint":false},{"year":2008,"finding":"The risk allele at rs13277113, upstream of FAM167A (C8orf13) and BLK, is associated with reduced BLK expression and increased FAM167A (C8orf13) mRNA expression in B-cell lines, suggesting a regulatory relationship between the locus genotype and FAM167A expression levels.","method":"eQTL analysis in B-cell lines (mRNA expression measurement correlated with genotype)","journal":"The New England journal of medicine","confidence":"Medium","confidence_rationale":"Tier 3 / Strong — eQTL measurement in B-cell lines replicated across large cohorts, but single method (expression correlation), no functional perturbation","pmids":["18204098"],"is_preprint":false},{"year":2025,"finding":"Four functional SNPs at the FAM167A-BLK locus exhibit allele-specific enhancing effects on BLK expression but show no discernible regulatory influence on FAM167A expression. BLK was shown to regulate FAM167A expression (knockdown of BLK altered FAM167A expression).","method":"Dual-luciferase reporter assays, shRNA knockdown experiments, CRISPR/dCas9 knockdown experiments, GCTA and fnGWAS functional annotation","journal":"Yi chuan = Hereditas","confidence":"Medium","confidence_rationale":"Tier 2 / Weak — dual-luciferase reporter and CRISPR perturbation are Tier 1–2 methods, but single lab, single study with no replication","pmids":["41250293"],"is_preprint":false}],"current_model":"FAM167A (DIORA-1) is a highly disordered protein with endosomal localization in bronchial epithelium and alveolar macrophages whose expression is upregulated by risk alleles at the FAM167A-BLK locus (partly through BLK-mediated regulation); at a molecular level, FAM167A activates the noncanonical NF-κB pathway by binding DSG1 to block NIK ubiquitination, thereby promoting TKI resistance in CML cells."},"narrative":{"mechanistic_narrative":"FAM167A (DIORA-1) is a highly intrinsically disordered protein, conserved across species and belonging to a small gene family (FAM167A/FAM167B) with no homology to other annotated genes, that is most highly expressed in lung bronchial epithelium and alveolar macrophages where it shows an endosomal localization pattern [PMID:29663334]. Functionally, FAM167A activates the noncanonical NF-κB pathway: it binds the cell adhesion protein desmoglein-1 (DSG1) and blocks ubiquitination of NF-κB-inducing kinase (NIK), stabilizing NIK and driving BCR-ABL-independent tyrosine kinase inhibitor resistance in chronic myeloid leukemia [PMID:35241148]. Its expression is governed by the FAM167A-BLK risk locus, where risk genotypes are associated with elevated FAM167A mRNA and reduced BLK expression in B cells [PMID:18204098], and BLK itself regulates FAM167A expression levels [PMID:41250293]. Beyond these findings, the structural basis of FAM167A's interactions and its physiological role in its endosomal context remain uncharacterized in the available corpus.","teleology":[{"year":2008,"claim":"Establishing why FAM167A first drew attention required linking it to disease genetics, and an autoimmune-associated risk allele at the FAM167A-BLK locus was found to track with FAM167A expression, implicating the gene as a candidate effector of locus genotype.","evidence":"eQTL analysis in B-cell lines correlating rs13277113 genotype with mRNA levels","pmids":["18204098"],"confidence":"Medium","gaps":["Correlation does not establish which gene at the locus drives the disease phenotype","No functional perturbation to test causality","Does not address FAM167A protein function"]},{"year":2018,"claim":"With no known homologs, the basic biochemical and cellular identity of FAM167A was unknown; cloning and tissue mapping defined it as a highly disordered protein with lung-predominant expression and endosomal localization.","evidence":"Cloning from human PBMCs, IHC of human tissues, protein disorder prediction, qPCR in mouse organs","pmids":["29663334"],"confidence":"Medium","gaps":["No molecular function or binding partner identified","Disorder predicted bioinformatically, not validated structurally","Endosomal role not functionally tested"]},{"year":2022,"claim":"The molecular activity of FAM167A was undefined until it was shown to act as a noncanonical NF-κB activator, binding DSG1 to stabilize NIK and confer kinase-inhibitor resistance, giving the protein a concrete signaling mechanism.","evidence":"MS-based receptor identification, Co-IP, NIK ubiquitination assays, in vivo mouse tumor models and CML patient cell validation","pmids":["35241148"],"confidence":"High","gaps":["Structural basis of the FAM167A-DSG1 interaction not defined","Mechanism by which DSG1 binding blocks NIK ubiquitination unresolved","Connection to the endosomal localization reported earlier not addressed"]},{"year":2025,"claim":"Whether the FAM167A-BLK risk locus acts directly on FAM167A or through BLK was unresolved; fine-mapping showed the functional SNPs drive BLK rather than FAM167A, and that BLK in turn regulates FAM167A expression.","evidence":"Dual-luciferase reporters, shRNA and CRISPR/dCas9 knockdown, functional GWAS annotation","pmids":["41250293"],"confidence":"Medium","gaps":["Mechanism of BLK-mediated regulation of FAM167A not defined","Apparent tension with earlier eQTL linking risk allele directly to FAM167A mRNA","Single study, no independent replication"]},{"year":null,"claim":"How FAM167A's intrinsic disorder, endosomal localization, and DSG1/NIK signaling activity integrate into a single physiological function remains unresolved.","evidence":"","pmids":[],"confidence":"Medium","gaps":["No structural model of FAM167A or its complexes","Physiological role in lung epithelium/macrophages versus its leukemia signaling role not reconciled","Function of FAM167B and the family more broadly uncharacterized"]}],"mechanism_profile":{"molecular_activity":[{"term_id":"GO:0098772","term_label":"molecular function regulator activity","supporting_discovery_ids":[0]}],"localization":[{"term_id":"GO:0005768","term_label":"endosome","supporting_discovery_ids":[1]}],"pathway":[{"term_id":"R-HSA-162582","term_label":"Signal Transduction","supporting_discovery_ids":[0]}],"complexes":[],"partners":["DSG1"],"other_free_text":[]}},"prefetch_data":{"uniprot":{"accession":"Q96KS9","full_name":"Protein FAM167A","aliases":[],"length_aa":214,"mass_kda":24.2,"function":"","subcellular_location":"","url":"https://www.uniprot.org/uniprotkb/Q96KS9/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/FAM167A","classification":"Not Classified","n_dependent_lines":1,"n_total_lines":1208,"dependency_fraction":0.0008278145695364238},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[{"gene":"CDC42BPB","stoichiometry":0.2}],"url":"https://opencell.sf.czbiohub.org/search/FAM167A","total_profiled":1310},"omim":[{"mim_id":"612254","title":"SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 12; SLEB12","url":"https://www.omim.org/entry/612254"},{"mim_id":"611775","title":"KAWASAKI DISEASE","url":"https://www.omim.org/entry/611775"},{"mim_id":"610085","title":"FAMILY WITH SEQUENCE SIMILARITY 167, MEMBER A; FAM167A","url":"https://www.omim.org/entry/610085"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Approved","locations":[{"location":"Mitochondria","reliability":"Approved"}],"tissue_specificity":"Tissue enhanced","tissue_distribution":"Detected in many","driving_tissues":[{"tissue":"brain","ntpm":23.9},{"tissue":"thyroid gland","ntpm":49.9}],"url":"https://www.proteinatlas.org/search/FAM167A"},"hgnc":{"alias_symbol":["DIORA-1"],"prev_symbol":["C8orf13"]},"alphafold":{"accession":"Q96KS9","domains":[{"cath_id":"1.20.5","chopping":"116-181","consensus_level":"medium","plddt":95.1617,"start":116,"end":181}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q96KS9","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q96KS9-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q96KS9-F1-predicted_aligned_error_v6.png","plddt_mean":70.12},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=FAM167A","jax_strain_url":"https://www.jax.org/strain/search?query=FAM167A"},"sequence":{"accession":"Q96KS9","fasta_url":"https://rest.uniprot.org/uniprotkb/Q96KS9.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q96KS9/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q96KS9"}},"corpus_meta":[{"pmid":"18204098","id":"PMC_18204098","title":"Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.","date":"2008","source":"The New England journal of medicine","url":"https://pubmed.ncbi.nlm.nih.gov/18204098","citation_count":743,"is_preprint":false},{"pmid":"19796918","id":"PMC_19796918","title":"Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations.","date":"2009","source":"Journal of autoimmunity","url":"https://pubmed.ncbi.nlm.nih.gov/19796918","citation_count":106,"is_preprint":false},{"pmid":"20861858","id":"PMC_20861858","title":"Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome.","date":"2010","source":"Genes and immunity","url":"https://pubmed.ncbi.nlm.nih.gov/20861858","citation_count":98,"is_preprint":false},{"pmid":"19180478","id":"PMC_19180478","title":"Replication of the association between the C8orf13-BLK region and systemic lupus erythematosus in a Japanese population.","date":"2009","source":"Arthritis and rheumatism","url":"https://pubmed.ncbi.nlm.nih.gov/19180478","citation_count":48,"is_preprint":false},{"pmid":"21480188","id":"PMC_21480188","title":"C8orf13-BLK is a genetic risk locus for systemic sclerosis and has additive effects with BANK1: results from a large french cohort and meta-analysis.","date":"2011","source":"Arthritis and rheumatism","url":"https://pubmed.ncbi.nlm.nih.gov/21480188","citation_count":43,"is_preprint":false},{"pmid":"23635951","id":"PMC_23635951","title":"Association studies of TNFSF4, TNFAIP3 and FAM167A-BLK polymorphisms with primary Sjogren's syndrome in Han Chinese.","date":"2013","source":"Journal of human genetics","url":"https://pubmed.ncbi.nlm.nih.gov/23635951","citation_count":36,"is_preprint":false},{"pmid":"35241148","id":"PMC_35241148","title":"FAM167A is a key molecule to induce BCR-ABL-independent TKI resistance in CML via noncanonical NF-κB signaling activation.","date":"2022","source":"Journal of experimental & clinical cancer research : CR","url":"https://pubmed.ncbi.nlm.nih.gov/35241148","citation_count":19,"is_preprint":false},{"pmid":"27105348","id":"PMC_27105348","title":"Association of FAM167A-BLK rs2736340 Polymorphism with Susceptibility to Autoimmune Diseases: A Meta-Analysis.","date":"2016","source":"Immunological investigations","url":"https://pubmed.ncbi.nlm.nih.gov/27105348","citation_count":17,"is_preprint":false},{"pmid":"25846585","id":"PMC_25846585","title":"Single nucleotide polymorphisms in the FAM167A-BLK gene are associated with polymyositis/dermatomyositis in the Han Chinese population.","date":"2015","source":"Immunologic research","url":"https://pubmed.ncbi.nlm.nih.gov/25846585","citation_count":17,"is_preprint":false},{"pmid":"29663334","id":"PMC_29663334","title":"The rheumatic disease-associated FAM167A-BLK locus encodes DIORA-1, a novel disordered protein expressed highly in bronchial epithelium and alveolar macrophages.","date":"2018","source":"Clinical and experimental immunology","url":"https://pubmed.ncbi.nlm.nih.gov/29663334","citation_count":16,"is_preprint":false},{"pmid":"23899688","id":"PMC_23899688","title":"Polymorphisms in the FAM167A-BLK, but not BANK1, are associated with primary Sjögren's syndrome in a Han Chinese population.","date":"2013","source":"Clinical and experimental rheumatology","url":"https://pubmed.ncbi.nlm.nih.gov/23899688","citation_count":13,"is_preprint":false},{"pmid":"24632671","id":"PMC_24632671","title":"Association between a C8orf13-BLK polymorphism and polymyositis/dermatomyositis in the Japanese population: an additive effect with STAT4 on disease susceptibility.","date":"2014","source":"PloS one","url":"https://pubmed.ncbi.nlm.nih.gov/24632671","citation_count":10,"is_preprint":false},{"pmid":"20156505","id":"PMC_20156505","title":"Role of the C8orf13-BLK region in biopsy-proven giant cell arteritis.","date":"2010","source":"Human immunology","url":"https://pubmed.ncbi.nlm.nih.gov/20156505","citation_count":9,"is_preprint":false},{"pmid":"27088737","id":"PMC_27088737","title":"Genetic risk of TNFSF4 and FAM167A-BLK polymorphisms in children with asthma and allergic rhinitis in a Han Chinese population.","date":"2016","source":"The Journal of asthma : official journal of the Association for the Care of Asthma","url":"https://pubmed.ncbi.nlm.nih.gov/27088737","citation_count":6,"is_preprint":false},{"pmid":"41250293","id":"PMC_41250293","title":"Exploration of the regulatory function of genetic variants at FAM167A-BLK locus in systemic lupus erythematosus.","date":"2025","source":"Yi chuan = Hereditas","url":"https://pubmed.ncbi.nlm.nih.gov/41250293","citation_count":0,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":11049,"output_tokens":1114,"usd":0.024928,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":7666,"output_tokens":1995,"usd":0.044103,"stage2_stop_reason":"end_turn"},"total_usd":0.069031,"stage1_batch_id":"msgbatch_01AsR7g8dGTEiEw9U83bJeWn","stage2_batch_id":"msgbatch_01YV5ZyxtFNUZEjxRcpd9jzb","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2022,\n      \"finding\": \"FAM167A activates the noncanonical NF-κB pathway by binding to the cell adhesion protein desmoglein-1 (DSG1), which upregulates NF-κB-inducing kinase (NIK) by blocking its ubiquitination, thereby inducing BCR-ABL-independent TKI resistance in CML.\",\n      \"method\": \"Tandem mass spectrometry (receptor identification), Co-IP/binding assays, in vitro and in vivo mouse tumor models, neutralization experiments, flow cytometry, qRT-PCR\",\n      \"journal\": \"Journal of experimental & clinical cancer research : CR\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — reciprocal binding identified by MS, in vitro mechanistic follow-up (NIK ubiquitination blockade), in vivo mouse model rescue, and patient cell validation in a single lab with multiple orthogonal methods\",\n      \"pmids\": [\"35241148\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2018,\n      \"finding\": \"FAM167A (DIORA-1) encodes a protein characterized by high intrinsic disorder content, with its highest expression in the lung (bronchial epithelium and alveolar macrophages), where it displays an endosomal localization pattern. The FAM167 gene family (FAM167A and FAM167B) is not homologous to any other annotated gene but is evolutionarily conserved.\",\n      \"method\": \"Cloning from human PBMCs, immunohistochemistry of human tissues, protein disorder analysis by online tools, qPCR in mouse organs, eQTL analysis in immune cells\",\n      \"journal\": \"Clinical and experimental immunology\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 3 / Moderate — direct localization by IHC with tissue expression mapping, cloning and bioinformatic characterization, but no functional perturbation experiment; single lab\",\n      \"pmids\": [\"29663334\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2008,\n      \"finding\": \"The risk allele at rs13277113, upstream of FAM167A (C8orf13) and BLK, is associated with reduced BLK expression and increased FAM167A (C8orf13) mRNA expression in B-cell lines, suggesting a regulatory relationship between the locus genotype and FAM167A expression levels.\",\n      \"method\": \"eQTL analysis in B-cell lines (mRNA expression measurement correlated with genotype)\",\n      \"journal\": \"The New England journal of medicine\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 3 / Strong — eQTL measurement in B-cell lines replicated across large cohorts, but single method (expression correlation), no functional perturbation\",\n      \"pmids\": [\"18204098\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2025,\n      \"finding\": \"Four functional SNPs at the FAM167A-BLK locus exhibit allele-specific enhancing effects on BLK expression but show no discernible regulatory influence on FAM167A expression. BLK was shown to regulate FAM167A expression (knockdown of BLK altered FAM167A expression).\",\n      \"method\": \"Dual-luciferase reporter assays, shRNA knockdown experiments, CRISPR/dCas9 knockdown experiments, GCTA and fnGWAS functional annotation\",\n      \"journal\": \"Yi chuan = Hereditas\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Weak — dual-luciferase reporter and CRISPR perturbation are Tier 1–2 methods, but single lab, single study with no replication\",\n      \"pmids\": [\"41250293\"],\n      \"is_preprint\": false\n    }\n  ],\n  \"current_model\": \"FAM167A (DIORA-1) is a highly disordered protein with endosomal localization in bronchial epithelium and alveolar macrophages whose expression is upregulated by risk alleles at the FAM167A-BLK locus (partly through BLK-mediated regulation); at a molecular level, FAM167A activates the noncanonical NF-κB pathway by binding DSG1 to block NIK ubiquitination, thereby promoting TKI resistance in CML cells.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"FAM167A (DIORA-1) is a highly intrinsically disordered protein, conserved across species and belonging to a small gene family (FAM167A/FAM167B) with no homology to other annotated genes, that is most highly expressed in lung bronchial epithelium and alveolar macrophages where it shows an endosomal localization pattern [#1]. Functionally, FAM167A activates the noncanonical NF-\\u03baB pathway: it binds the cell adhesion protein desmoglein-1 (DSG1) and blocks ubiquitination of NF-\\u03baB-inducing kinase (NIK), stabilizing NIK and driving BCR-ABL-independent tyrosine kinase inhibitor resistance in chronic myeloid leukemia [#0]. Its expression is governed by the FAM167A-BLK risk locus, where risk genotypes are associated with elevated FAM167A mRNA and reduced BLK expression in B cells [#2], and BLK itself regulates FAM167A expression levels [#3]. Beyond these findings, the structural basis of FAM167A's interactions and its physiological role in its endosomal context remain uncharacterized in the available corpus.\",\n  \"teleology\": [\n    {\n      \"year\": 2008,\n      \"claim\": \"Establishing why FAM167A first drew attention required linking it to disease genetics, and an autoimmune-associated risk allele at the FAM167A-BLK locus was found to track with FAM167A expression, implicating the gene as a candidate effector of locus genotype.\",\n      \"evidence\": \"eQTL analysis in B-cell lines correlating rs13277113 genotype with mRNA levels\",\n      \"pmids\": [\"18204098\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"single method, expression correlation only\",\n      \"gaps\": [\n        \"Correlation does not establish which gene at the locus drives the disease phenotype\",\n        \"No functional perturbation to test causality\",\n        \"Does not address FAM167A protein function\"\n      ]\n    },\n    {\n      \"year\": 2018,\n      \"claim\": \"With no known homologs, the basic biochemical and cellular identity of FAM167A was unknown; cloning and tissue mapping defined it as a highly disordered protein with lung-predominant expression and endosomal localization.\",\n      \"evidence\": \"Cloning from human PBMCs, IHC of human tissues, protein disorder prediction, qPCR in mouse organs\",\n      \"pmids\": [\"29663334\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"direct localization and characterization but no functional perturbation\",\n      \"gaps\": [\n        \"No molecular function or binding partner identified\",\n        \"Disorder predicted bioinformatically, not validated structurally\",\n        \"Endosomal role not functionally tested\"\n      ]\n    },\n    {\n      \"year\": 2022,\n      \"claim\": \"The molecular activity of FAM167A was undefined until it was shown to act as a noncanonical NF-\\u03baB activator, binding DSG1 to stabilize NIK and confer kinase-inhibitor resistance, giving the protein a concrete signaling mechanism.\",\n      \"evidence\": \"MS-based receptor identification, Co-IP, NIK ubiquitination assays, in vivo mouse tumor models and CML patient cell validation\",\n      \"pmids\": [\"35241148\"],\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"multiple orthogonal methods with in vivo and patient validation in a single lab\",\n      \"gaps\": [\n        \"Structural basis of the FAM167A-DSG1 interaction not defined\",\n        \"Mechanism by which DSG1 binding blocks NIK ubiquitination unresolved\",\n        \"Connection to the endosomal localization reported earlier not addressed\"\n      ]\n    },\n    {\n      \"year\": 2025,\n      \"claim\": \"Whether the FAM167A-BLK risk locus acts directly on FAM167A or through BLK was unresolved; fine-mapping showed the functional SNPs drive BLK rather than FAM167A, and that BLK in turn regulates FAM167A expression.\",\n      \"evidence\": \"Dual-luciferase reporters, shRNA and CRISPR/dCas9 knockdown, functional GWAS annotation\",\n      \"pmids\": [\"41250293\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 1-2 perturbation methods but single unreplicated study\",\n      \"gaps\": [\n        \"Mechanism of BLK-mediated regulation of FAM167A not defined\",\n        \"Apparent tension with earlier eQTL linking risk allele directly to FAM167A mRNA\",\n        \"Single study, no independent replication\"\n      ]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"How FAM167A's intrinsic disorder, endosomal localization, and DSG1/NIK signaling activity integrate into a single physiological function remains unresolved.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\n        \"No structural model of FAM167A or its complexes\",\n        \"Physiological role in lung epithelium/macrophages versus its leukemia signaling role not reconciled\",\n        \"Function of FAM167B and the family more broadly uncharacterized\"\n      ]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\"term_id\": \"GO:0098772\", \"supporting_discovery_ids\": [0]}\n    ],\n    \"localization\": [\n      {\"term_id\": \"GO:0005768\", \"supporting_discovery_ids\": [1]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"R-HSA-162582\", \"supporting_discovery_ids\": [0]}\n    ],\n    \"complexes\": [],\n    \"partners\": [\"DSG1\"],\n    \"other_free_text\": []\n  }\n}","audit_flag":null,"evaluation":{"faith_supported":3,"faith_total":3,"faith_pct":100.0}}