{"gene":"CPNE2","run_date":"2026-06-09T22:57:19","timeline":{"discoveries":[],"current_model":"No mechanistic findings in the available literature."},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null},"prefetch_data":{"uniprot":{"accession":"Q96FN4","full_name":"Copine-2","aliases":["Copine II"],"length_aa":548,"mass_kda":61.2,"function":"Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties","subcellular_location":"Cytoplasm; Nucleus; Cell membrane","url":"https://www.uniprot.org/uniprotkb/Q96FN4/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/CPNE2","classification":"Not Classified","n_dependent_lines":7,"n_total_lines":1208,"dependency_fraction":0.005794701986754967},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[{"gene":"EWSR1","stoichiometry":0.2}],"url":"https://opencell.sf.czbiohub.org/search/CPNE2","total_profiled":1310},"omim":[{"mim_id":"604206","title":"COPINE II; CPNE2","url":"https://www.omim.org/entry/604206"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Approved","locations":[{"location":"Nucleoplasm","reliability":"Approved"},{"location":"Mitochondria","reliability":"Approved"},{"location":"Cytosol","reliability":"Approved"}],"tissue_specificity":"Low tissue specificity","tissue_distribution":"Detected in all","driving_tissues":[],"url":"https://www.proteinatlas.org/search/CPNE2"},"hgnc":{"alias_symbol":["CPN2"],"prev_symbol":[]},"alphafold":{"accession":"Q96FN4","domains":[{"cath_id":"2.60.40.150","chopping":"25-152","consensus_level":"high","plddt":94.1559,"start":25,"end":152},{"cath_id":"2.60.40.150","chopping":"156-293","consensus_level":"high","plddt":93.9057,"start":156,"end":293},{"cath_id":"3.40.50.410","chopping":"305-494","consensus_level":"high","plddt":94.079,"start":305,"end":494}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q96FN4","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q96FN4-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q96FN4-F1-predicted_aligned_error_v6.png","plddt_mean":91.06},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=CPNE2","jax_strain_url":"https://www.jax.org/strain/search?query=CPNE2"},"sequence":{"accession":"Q96FN4","fasta_url":"https://rest.uniprot.org/uniprotkb/Q96FN4.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q96FN4/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q96FN4"}},"corpus_meta":[{"pmid":"31722236","id":"PMC_31722236","title":"Micro RNA 181c-5p: A promising target for post-stroke recovery in socially isolated mice.","date":"2019","source":"Neuroscience letters","url":"https://pubmed.ncbi.nlm.nih.gov/31722236","citation_count":12,"is_preprint":false},{"pmid":"36979157","id":"PMC_36979157","title":"Antineoplastic Nature of WWOX in Glioblastoma Is Mainly a Consequence of Reduced Cell Viability and Invasion.","date":"2023","source":"Biology","url":"https://pubmed.ncbi.nlm.nih.gov/36979157","citation_count":4,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":3358,"output_tokens":34,"usd":0.005292,"stage1_stop_reason":"end_turn"},"stage2":{"model":"","input_tokens":0,"output_tokens":0,"usd":0.0},"total_usd":0.005292,"stage1_batch_id":"msgbatch_01ACAxJQabDsht39JXeWG22d","stage2_batch_id":"msgbatch_01QEU22A9U5sbPTgsMzTmvSf","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [],\n  \"current_model\": \"No mechanistic findings in the available literature.\"\n}\n```","stage2_raw":"","audit_flag":null,"evaluation":null}