{"gene":"COMMD6","run_date":"2026-06-09T22:57:19","timeline":{"discoveries":[{"year":2006,"finding":"COMMD6 directly interacts with COMMD1, and this interaction was detected throughout the whole cell including the nucleus, as shown by co-immunoprecipitation using specific antisera and verified by independent techniques. The interaction is direct. Both COMMD6 and COMMD1 inhibit TNF-induced NF-κB activation, but in a non-synergistic manner. Mutation of residues Trp24 and Pro41 in the COMM domain of COMMD6 completely abolished its inhibitory effect on TNF-induced NF-κB activation without abolishing interaction with COMMD1, COMMD6 itself, or RelA. Unlike COMMD1, COMMD6 does not bind IκBα, indicating overlapping but distinct mechanisms of NF-κB inhibition.","method":"Co-immunoprecipitation with specific antisera (endogenous proteins), independent verification techniques, site-directed mutagenesis of COMM domain residues, NF-κB reporter assay, TNF stimulation","journal":"The Biochemical journal","confidence":"High","confidence_rationale":"Tier 1–2 / Moderate — reciprocal Co-IP with endogenous proteins, independent verification, active-site mutagenesis with functional readout, single lab with multiple orthogonal methods","pmids":["16573520"],"is_preprint":false},{"year":2018,"finding":"Hepatic COMMD6 deficiency (liver-specific Commd6 knockout mice) results in massive reduction in the protein levels of all 10 COMMD family members, destabilization of the core CCC complex (CCDC22, CCDC93, C16orf62), reduced cell surface levels of LDLR and LRP1, and elevated plasma LDL cholesterol levels. This phenotype is shared with COMMD1 and COMMD9 deficiency, demonstrating a strong interrelationship between COMMD proteins and the CCC complex in endosomal LDLR trafficking.","method":"Liver-specific Commd6 knockout mice, quantitative targeted proteomics, biochemical fractionation, cell surface receptor measurement, plasma cholesterol measurement","journal":"Circulation research","confidence":"High","confidence_rationale":"Tier 2 / Strong — in vivo genetic KO with multiple orthogonal methods (proteomics, biochemistry, receptor surface levels, plasma lipid measurement), replicated across three COMMD family members in same study","pmids":["29545368"],"is_preprint":false},{"year":2021,"finding":"Hepatocyte-specific deficiency of Commd6 (as well as Commd1 or Commd9) results in hepatic copper accumulation under high-copper diet conditions. Each of these deficiencies caused destabilization of the entire CCC complex, suggesting the CCC complex plays an important role in ATP7B endosomal recycling and function. In contrast, enterocyte-specific COMMD deficiency did not alter intestinal copper absorption or ATP7A levels in vivo.","method":"Enterocyte-specific and hepatocyte-specific Commd gene-deficient mice, copper level measurement under low- and high-copper diets, CCC complex stability assessment by biochemical methods","journal":"Disease models & mechanisms","confidence":"High","confidence_rationale":"Tier 2 / Strong — in vivo tissue-specific KO in multiple COMMD-deficient mouse lines with defined metabolic phenotype and biochemical readout, replicated across three COMMD genes","pmids":["33262129"],"is_preprint":false},{"year":2009,"finding":"Amphioxus (Branchiostoma belcheri) COMMD6 (BbCOMMD6) interacts with creatine kinase (CK) to form a heterodimer, and inhibits CK enzymatic activity in a dose-dependent manner. BbCOMMD6 is mainly cytosolic, and unlike COMMD1, Cu(II) does not enhance its dimerization.","method":"Pull-down and reverse pull-down assays, enzymatic activity assays with recombinant protein, subcellular fractionation","journal":"The international journal of biochemistry & cell biology","confidence":"Medium","confidence_rationale":"Tier 2–3 / Moderate — reciprocal pull-down with enzymatic activity assay, single lab, non-mammalian ortholog (amphioxus), two orthogonal methods","pmids":["19638315"],"is_preprint":false}],"current_model":"COMMD6 is a COMM domain-containing protein that functions as part of the CCC (COMMD/CCDC22/CCDC93) complex to regulate endosomal recycling of cell surface receptors including LDLR and ATP7B; it directly interacts with COMMD1 and other COMMD family members to stabilize the entire COMMD protein family and the CCC complex, inhibits TNF-induced NF-κB activation through a mechanism requiring COMM domain residues Trp24 and Pro41 (but distinct from COMMD1 in that it does not bind IκBα), and its hepatic deficiency causes CCC complex destabilization, reduced LDLR surface levels, hypercholesterolemia, and hepatic copper accumulation."},"narrative":{"mechanistic_narrative":"COMMD6 is a COMM domain-containing protein that operates within the COMMD/CCDC22/CCDC93 (CCC) complex to control endosomal recycling of cell surface receptors [PMID:29545368]. It directly binds COMMD1 and, through the broader COMMD family, is required for the structural integrity of the entire COMMD protein family and the core CCC complex: hepatic Commd6 loss collapses the protein levels of all ten COMMD members and destabilizes CCDC22, CCDC93, and C16orf62 [PMID:16573520, PMID:29545368]. This destabilization reduces cell-surface LDLR and LRP1, producing elevated plasma LDL cholesterol, and impairs ATP7B-dependent copper handling, causing hepatic copper accumulation under high-copper conditions [PMID:29545368, PMID:33262129]. Independently of its trafficking role, COMMD6 inhibits TNF-induced NF-κB activation through a mechanism requiring COMM domain residues Trp24 and Pro41; unlike COMMD1, it does not bind IκBα, marking an overlapping but mechanistically distinct route of NF-κB suppression [PMID:16573520].","teleology":[{"year":2006,"claim":"Established COMMD6 as a direct COMMD1-interacting NF-κB regulator and mapped the COMM domain residues required for its inhibitory activity, defining its functional autonomy from COMMD1.","evidence":"Endogenous reciprocal co-immunoprecipitation, COMM domain site-directed mutagenesis (Trp24, Pro41), and NF-κB reporter assays under TNF stimulation","pmids":["16573520"],"confidence":"High","gaps":["Does not identify the molecular target through which COMMD6 suppresses NF-κB, since it does not bind IκBα","No structural basis for the Trp24/Pro41 requirement"]},{"year":2018,"claim":"Demonstrated in vivo that COMMD6 is required for COMMD family and CCC complex stability and for LDLR-mediated cholesterol homeostasis, placing it at the core of endosomal receptor recycling.","evidence":"Liver-specific Commd6 knockout mice with targeted proteomics, biochemical fractionation, cell-surface receptor and plasma cholesterol measurement","pmids":["29545368"],"confidence":"High","gaps":["Does not resolve how COMMD6 is incorporated into or stabilizes the CCC complex mechanistically","Whether NF-κB regulation and CCC stabilization are coupled functions is not addressed"]},{"year":2021,"claim":"Extended COMMD6's CCC-dependent role to copper metabolism, showing hepatic but not enterocyte COMMD6 loss disrupts ATP7B-dependent copper handling.","evidence":"Tissue-specific Commd6/Commd1/Commd9 knockout mice with copper measurement under defined dietary copper and biochemical CCC stability assays","pmids":["33262129"],"confidence":"High","gaps":["Direct interaction between the CCC complex and ATP7B not demonstrated","Tissue-specific basis for enterocyte versus hepatocyte difference unexplained"]},{"year":2009,"claim":"Characterized an invertebrate COMMD6 ortholog as a creatine kinase-binding inhibitor, indicating a possible CCC-independent biochemical activity, though in a non-mammalian system.","evidence":"Reciprocal pull-down and creatine kinase enzymatic activity assays with recombinant amphioxus BbCOMMD6 and subcellular fractionation","pmids":["19638315"],"confidence":"Medium","gaps":["Non-mammalian ortholog; relevance to human COMMD6 not established","Single lab, not independently confirmed","Functional consequence of creatine kinase inhibition in vivo unknown"]},{"year":null,"claim":"How COMMD6 stabilizes the CCC complex at the molecular level and how its NF-κB-inhibitory function relates to its endosomal trafficking role remain unresolved.","evidence":"","pmids":[],"confidence":"High","gaps":["No structural model of COMMD6 within the CCC complex","Mechanism linking COMM domain residues to NF-κB inhibition undefined","Direct molecular target of NF-κB suppression unidentified"]}],"mechanism_profile":{"molecular_activity":[{"term_id":"GO:0060090","term_label":"molecular adaptor activity","supporting_discovery_ids":[0,1]},{"term_id":"GO:0098772","term_label":"molecular function regulator activity","supporting_discovery_ids":[0,3]}],"localization":[{"term_id":"GO:0005829","term_label":"cytosol","supporting_discovery_ids":[3]},{"term_id":"GO:0005768","term_label":"endosome","supporting_discovery_ids":[1,2]},{"term_id":"GO:0005634","term_label":"nucleus","supporting_discovery_ids":[0]}],"pathway":[{"term_id":"R-HSA-5653656","term_label":"Vesicle-mediated transport","supporting_discovery_ids":[1,2]},{"term_id":"R-HSA-382551","term_label":"Transport of small molecules","supporting_discovery_ids":[2]},{"term_id":"R-HSA-162582","term_label":"Signal Transduction","supporting_discovery_ids":[0]}],"complexes":["CCC complex (COMMD/CCDC22/CCDC93)"],"partners":["COMMD1","CCDC22","CCDC93","C16ORF62","COMMD9"],"other_free_text":[]}},"prefetch_data":{"uniprot":{"accession":"Q7Z4G1","full_name":"COMM domain-containing protein 6","aliases":[],"length_aa":85,"mass_kda":9.6,"function":"Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B (PubMed:15799966, PubMed:16573520). Inhibits TNF-induced NFKB1 activation (PubMed:15799966, PubMed:16573520)","subcellular_location":"Nucleus; Cytoplasm","url":"https://www.uniprot.org/uniprotkb/Q7Z4G1/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/COMMD6","classification":"Not Classified","n_dependent_lines":27,"n_total_lines":1208,"dependency_fraction":0.022350993377483443},"opencell":{"profiled":true,"resolved_as":"","ensg_id":"ENSG00000188243","cell_line_id":"CID000269","localizations":[{"compartment":"vesicles","grade":3}],"interactors":[{"gene":"CCDC22","stoichiometry":10.0},{"gene":"CCDC93","stoichiometry":10.0},{"gene":"COMMD1","stoichiometry":10.0},{"gene":"COMMD2","stoichiometry":10.0},{"gene":"COMMD4","stoichiometry":10.0},{"gene":"SF3B1","stoichiometry":10.0},{"gene":"U2SURP","stoichiometry":10.0},{"gene":"CHERP","stoichiometry":10.0},{"gene":"COMMD10","stoichiometry":10.0},{"gene":"RBMX2","stoichiometry":10.0}],"url":"https://opencell.sf.czbiohub.org/target/CID000269","total_profiled":1310},"omim":[{"mim_id":"616704","title":"COMM DOMAIN-CONTAINING PROTEIN 10; COMMD10","url":"https://www.omim.org/entry/616704"},{"mim_id":"612377","title":"COMM DOMAIN-CONTAINING PROTEIN 6; COMMD6","url":"https://www.omim.org/entry/612377"},{"mim_id":"612299","title":"COMM DOMAIN-CONTAINING PROTEIN 9; COMMD9","url":"https://www.omim.org/entry/612299"},{"mim_id":"607238","title":"COMM DOMAIN-CONTAINING PROTEIN 1; COMMD1","url":"https://www.omim.org/entry/607238"},{"mim_id":"300859","title":"COILED-COIL DOMAIN-CONTAINING PROTEIN 22; CCDC22","url":"https://www.omim.org/entry/300859"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"","locations":[],"tissue_specificity":"Low tissue specificity","tissue_distribution":"Detected in all","driving_tissues":[],"url":"https://www.proteinatlas.org/search/COMMD6"},"hgnc":{"alias_symbol":["Acrg"],"prev_symbol":[]},"alphafold":{"accession":"Q7Z4G1","domains":[{"cath_id":"3.10.450,2.30.31","chopping":"19-85","consensus_level":"high","plddt":92.2555,"start":19,"end":85}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q7Z4G1","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q7Z4G1-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q7Z4G1-F1-predicted_aligned_error_v6.png","plddt_mean":84.62},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=COMMD6","jax_strain_url":"https://www.jax.org/strain/search?query=COMMD6"},"sequence":{"accession":"Q7Z4G1","fasta_url":"https://rest.uniprot.org/uniprotkb/Q7Z4G1.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q7Z4G1/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q7Z4G1"}},"corpus_meta":[{"pmid":"32725377","id":"PMC_32725377","title":"Targeted Therapies in Advanced 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Cancer.","date":"2026","source":"Cells","url":"https://pubmed.ncbi.nlm.nih.gov/41744798","citation_count":0,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":39869,"output_tokens":1389,"usd":0.070221,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":8113,"output_tokens":2071,"usd":0.04617,"stage2_stop_reason":"end_turn"},"total_usd":0.116391,"stage1_batch_id":"msgbatch_01ACAxJQabDsht39JXeWG22d","stage2_batch_id":"msgbatch_01QEU22A9U5sbPTgsMzTmvSf","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2006,\n      \"finding\": \"COMMD6 directly interacts with COMMD1, and this interaction was detected throughout the whole cell including the nucleus, as shown by co-immunoprecipitation using specific antisera and verified by independent techniques. The interaction is direct. Both COMMD6 and COMMD1 inhibit TNF-induced NF-κB activation, but in a non-synergistic manner. Mutation of residues Trp24 and Pro41 in the COMM domain of COMMD6 completely abolished its inhibitory effect on TNF-induced NF-κB activation without abolishing interaction with COMMD1, COMMD6 itself, or RelA. Unlike COMMD1, COMMD6 does not bind IκBα, indicating overlapping but distinct mechanisms of NF-κB inhibition.\",\n      \"method\": \"Co-immunoprecipitation with specific antisera (endogenous proteins), independent verification techniques, site-directed mutagenesis of COMM domain residues, NF-κB reporter assay, TNF stimulation\",\n      \"journal\": \"The Biochemical journal\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 1–2 / Moderate — reciprocal Co-IP with endogenous proteins, independent verification, active-site mutagenesis with functional readout, single lab with multiple orthogonal methods\",\n      \"pmids\": [\"16573520\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2018,\n      \"finding\": \"Hepatic COMMD6 deficiency (liver-specific Commd6 knockout mice) results in massive reduction in the protein levels of all 10 COMMD family members, destabilization of the core CCC complex (CCDC22, CCDC93, C16orf62), reduced cell surface levels of LDLR and LRP1, and elevated plasma LDL cholesterol levels. This phenotype is shared with COMMD1 and COMMD9 deficiency, demonstrating a strong interrelationship between COMMD proteins and the CCC complex in endosomal LDLR trafficking.\",\n      \"method\": \"Liver-specific Commd6 knockout mice, quantitative targeted proteomics, biochemical fractionation, cell surface receptor measurement, plasma cholesterol measurement\",\n      \"journal\": \"Circulation research\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Strong — in vivo genetic KO with multiple orthogonal methods (proteomics, biochemistry, receptor surface levels, plasma lipid measurement), replicated across three COMMD family members in same study\",\n      \"pmids\": [\"29545368\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2021,\n      \"finding\": \"Hepatocyte-specific deficiency of Commd6 (as well as Commd1 or Commd9) results in hepatic copper accumulation under high-copper diet conditions. Each of these deficiencies caused destabilization of the entire CCC complex, suggesting the CCC complex plays an important role in ATP7B endosomal recycling and function. In contrast, enterocyte-specific COMMD deficiency did not alter intestinal copper absorption or ATP7A levels in vivo.\",\n      \"method\": \"Enterocyte-specific and hepatocyte-specific Commd gene-deficient mice, copper level measurement under low- and high-copper diets, CCC complex stability assessment by biochemical methods\",\n      \"journal\": \"Disease models & mechanisms\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Strong — in vivo tissue-specific KO in multiple COMMD-deficient mouse lines with defined metabolic phenotype and biochemical readout, replicated across three COMMD genes\",\n      \"pmids\": [\"33262129\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2009,\n      \"finding\": \"Amphioxus (Branchiostoma belcheri) COMMD6 (BbCOMMD6) interacts with creatine kinase (CK) to form a heterodimer, and inhibits CK enzymatic activity in a dose-dependent manner. BbCOMMD6 is mainly cytosolic, and unlike COMMD1, Cu(II) does not enhance its dimerization.\",\n      \"method\": \"Pull-down and reverse pull-down assays, enzymatic activity assays with recombinant protein, subcellular fractionation\",\n      \"journal\": \"The international journal of biochemistry & cell biology\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2–3 / Moderate — reciprocal pull-down with enzymatic activity assay, single lab, non-mammalian ortholog (amphioxus), two orthogonal methods\",\n      \"pmids\": [\"19638315\"],\n      \"is_preprint\": false\n    }\n  ],\n  \"current_model\": \"COMMD6 is a COMM domain-containing protein that functions as part of the CCC (COMMD/CCDC22/CCDC93) complex to regulate endosomal recycling of cell surface receptors including LDLR and ATP7B; it directly interacts with COMMD1 and other COMMD family members to stabilize the entire COMMD protein family and the CCC complex, inhibits TNF-induced NF-κB activation through a mechanism requiring COMM domain residues Trp24 and Pro41 (but distinct from COMMD1 in that it does not bind IκBα), and its hepatic deficiency causes CCC complex destabilization, reduced LDLR surface levels, hypercholesterolemia, and hepatic copper accumulation.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"COMMD6 is a COMM domain-containing protein that operates within the COMMD/CCDC22/CCDC93 (CCC) complex to control endosomal recycling of cell surface receptors [#1]. It directly binds COMMD1 and, through the broader COMMD family, is required for the structural integrity of the entire COMMD protein family and the core CCC complex: hepatic Commd6 loss collapses the protein levels of all ten COMMD members and destabilizes CCDC22, CCDC93, and C16orf62 [#0, #1]. This destabilization reduces cell-surface LDLR and LRP1, producing elevated plasma LDL cholesterol, and impairs ATP7B-dependent copper handling, causing hepatic copper accumulation under high-copper conditions [#1, #2]. Independently of its trafficking role, COMMD6 inhibits TNF-induced NF-\\u03baB activation through a mechanism requiring COMM domain residues Trp24 and Pro41; unlike COMMD1, it does not bind I\\u03baB\\u03b1, marking an overlapping but mechanistically distinct route of NF-\\u03baB suppression [#0].\",\n  \"teleology\": [\n    {\n      \"year\": 2006,\n      \"claim\": \"Established COMMD6 as a direct COMMD1-interacting NF-\\u03baB regulator and mapped the COMM domain residues required for its inhibitory activity, defining its functional autonomy from COMMD1.\",\n      \"evidence\": \"Endogenous reciprocal co-immunoprecipitation, COMM domain site-directed mutagenesis (Trp24, Pro41), and NF-\\u03baB reporter assays under TNF stimulation\",\n      \"pmids\": [\"16573520\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"Does not identify the molecular target through which COMMD6 suppresses NF-\\u03baB, since it does not bind I\\u03baB\\u03b1\", \"No structural basis for the Trp24/Pro41 requirement\"]\n    },\n    {\n      \"year\": 2018,\n      \"claim\": \"Demonstrated in vivo that COMMD6 is required for COMMD family and CCC complex stability and for LDLR-mediated cholesterol homeostasis, placing it at the core of endosomal receptor recycling.\",\n      \"evidence\": \"Liver-specific Commd6 knockout mice with targeted proteomics, biochemical fractionation, cell-surface receptor and plasma cholesterol measurement\",\n      \"pmids\": [\"29545368\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"Does not resolve how COMMD6 is incorporated into or stabilizes the CCC complex mechanistically\", \"Whether NF-\\u03baB regulation and CCC stabilization are coupled functions is not addressed\"]\n    },\n    {\n      \"year\": 2021,\n      \"claim\": \"Extended COMMD6's CCC-dependent role to copper metabolism, showing hepatic but not enterocyte COMMD6 loss disrupts ATP7B-dependent copper handling.\",\n      \"evidence\": \"Tissue-specific Commd6/Commd1/Commd9 knockout mice with copper measurement under defined dietary copper and biochemical CCC stability assays\",\n      \"pmids\": [\"33262129\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"Direct interaction between the CCC complex and ATP7B not demonstrated\", \"Tissue-specific basis for enterocyte versus hepatocyte difference unexplained\"]\n    },\n    {\n      \"year\": 2009,\n      \"claim\": \"Characterized an invertebrate COMMD6 ortholog as a creatine kinase-binding inhibitor, indicating a possible CCC-independent biochemical activity, though in a non-mammalian system.\",\n      \"evidence\": \"Reciprocal pull-down and creatine kinase enzymatic activity assays with recombinant amphioxus BbCOMMD6 and subcellular fractionation\",\n      \"pmids\": [\"19638315\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Non-mammalian ortholog; relevance to human COMMD6 not established\", \"Single lab, not independently confirmed\", \"Functional consequence of creatine kinase inhibition in vivo unknown\"]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"How COMMD6 stabilizes the CCC complex at the molecular level and how its NF-\\u03baB-inhibitory function relates to its endosomal trafficking role remain unresolved.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"High\",\n      \"gaps\": [\"No structural model of COMMD6 within the CCC complex\", \"Mechanism linking COMM domain residues to NF-\\u03baB inhibition undefined\", \"Direct molecular target of NF-\\u03baB suppression unidentified\"]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\"term_id\": \"GO:0060090\", \"supporting_discovery_ids\": [0, 1]},\n      {\"term_id\": \"GO:0098772\", \"supporting_discovery_ids\": [0, 3]}\n    ],\n    \"localization\": [\n      {\"term_id\": \"GO:0005829\", \"supporting_discovery_ids\": [3]},\n      {\"term_id\": \"GO:0005768\", \"supporting_discovery_ids\": [1, 2]},\n      {\"term_id\": \"GO:0005634\", \"supporting_discovery_ids\": [0]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"R-HSA-5653656\", \"supporting_discovery_ids\": [1, 2]},\n      {\"term_id\": \"R-HSA-382551\", \"supporting_discovery_ids\": [2]},\n      {\"term_id\": \"R-HSA-162582\", \"supporting_discovery_ids\": [0]}\n    ],\n    \"complexes\": [\"CCC complex (COMMD/CCDC22/CCDC93)\"],\n    \"partners\": [\"COMMD1\", \"CCDC22\", \"CCDC93\", \"C16orf62\", \"COMMD9\"],\n    \"other_free_text\": []\n  }\n}","audit_flag":null,"evaluation":{"pairwise":"win","faith_supported":4,"faith_total":4,"faith_pct":100.0}}