{"gene":"CFP","run_date":"2026-06-09T22:57:18","timeline":{"discoveries":[{"year":2019,"finding":"Complement factor properdin (CFP) suppresses breast cancer cell growth in vitro and in vivo by inducing intracellular upregulation of the pro-apoptotic transcription factor DDIT3, associated with endoplasmic reticulum stress response, in a process involving TES.","method":"Loss-of-function and gain-of-function screen in MCF7 cell lines; in vitro and in vivo tumor growth assays; Western blot for DDIT3 expression","journal":"Oncogene","confidence":"Low","confidence_rationale":"Tier 3 / Weak — single lab, limited mechanistic detail in abstract, no reciprocal validation or structural data; pathway placement (CFP→TES→DDIT3) described but mechanistic depth not fully established from abstract alone","pmids":["30755730"],"is_preprint":false}],"current_model":"Complement factor properdin (CFP) has a tumor-suppressive role in breast cancer, acting intracellularly to upregulate the pro-apoptotic transcription factor DDIT3 via TES, thereby suppressing cell growth; no other mechanistic findings about the canonical human CFP protein are represented in the available literature."},"narrative":{"mechanistic_narrative":"Complement factor properdin (CFP) has been assigned a tumor-suppressive function in breast cancer, where it acts intracellularly to suppress cell growth both in vitro and in vivo [PMID:30755730]. In this context CFP induces intracellular upregulation of the pro-apoptotic transcription factor DDIT3 in association with an endoplasmic reticulum stress response, through a process involving TES [PMID:30755730]. Beyond this single low-confidence observation, no further mechanistic detail about the canonical human CFP protein has been characterized in the available corpus.","teleology":[{"year":2019,"claim":"Whether CFP has an intracellular, growth-regulatory role distinct from complement signaling was unknown; loss- and gain-of-function experiments showed CFP suppresses breast cancer cell growth by inducing the pro-apoptotic factor DDIT3, establishing a candidate tumor-suppressive axis CFP→TES→DDIT3 linked to ER stress.","evidence":"Loss-of-function and gain-of-function screen in MCF7 cells, in vitro and in vivo tumor growth assays, and Western blot for DDIT3","pmids":["30755730"],"confidence":"Low","gaps":["Single lab, no reciprocal validation or independent confirmation","Mechanism by which CFP engages TES and the molecular link to DDIT3 upregulation is not resolved","No structural data and no demonstration of direct physical interactions"]},{"year":null,"claim":"How CFP acts intracellularly and whether this role generalizes beyond breast cancer cells remains unresolved.","evidence":"No further mechanistic studies in the available corpus","pmids":[],"confidence":"Low","gaps":["No direct binding partners or substrates established","Relationship to canonical extracellular complement function not addressed","No structural or biochemical mechanism for DDIT3 induction"]}],"mechanism_profile":{"molecular_activity":[],"localization":[],"pathway":[],"complexes":[],"partners":[],"other_free_text":[]}},"prefetch_data":{"uniprot":{"accession":"P27918","full_name":"Properdin","aliases":["Complement factor P"],"length_aa":469,"mass_kda":51.3,"function":"A positive regulator of the alternate pathway (AP) of complement (PubMed:16301317, PubMed:20382442, PubMed:28264884, PubMed:9748277). It binds to and stabilizes the C3- and C5-convertase enzyme complexes (PubMed:16301317, PubMed:20382442, PubMed:28264884, PubMed:9748277). Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (PubMed:31507604)","subcellular_location":"Secreted","url":"https://www.uniprot.org/uniprotkb/P27918/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/CFP","classification":"Not Classified","n_dependent_lines":0,"n_total_lines":1208,"dependency_fraction":0.0},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[],"url":"https://opencell.sf.czbiohub.org/search/CFP","total_profiled":1310},"omim":[{"mim_id":"617579","title":"CLAUDIN 10; CLDN10","url":"https://www.omim.org/entry/617579"},{"mim_id":"313440","title":"SYNAPSIN I; SYN1","url":"https://www.omim.org/entry/313440"},{"mim_id":"312060","title":"PROPERDIN DEFICIENCY, X-LINKED; CFPD","url":"https://www.omim.org/entry/312060"},{"mim_id":"300383","title":"COMPLEMENT FACTOR PROPERDIN; CFP","url":"https://www.omim.org/entry/300383"},{"mim_id":"161400","title":"NARCOLEPSY 1; NRCLP1","url":"https://www.omim.org/entry/161400"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Approved","locations":[{"location":"Vesicles","reliability":"Approved"}],"tissue_specificity":"Group enriched","tissue_distribution":"Detected in many","driving_tissues":[{"tissue":"bone marrow","ntpm":79.3},{"tissue":"lymphoid tissue","ntpm":50.0}],"url":"https://www.proteinatlas.org/search/CFP"},"hgnc":{"alias_symbol":[],"prev_symbol":["PFC"]},"alphafold":{"accession":"P27918","domains":[{"cath_id":"-","chopping":"316-453","consensus_level":"medium","plddt":91.1715,"start":316,"end":453}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/P27918","model_url":"https://alphafold.ebi.ac.uk/files/AF-P27918-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-P27918-F1-predicted_aligned_error_v6.png","plddt_mean":83.31},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=CFP","jax_strain_url":"https://www.jax.org/strain/search?query=CFP"},"sequence":{"accession":"P27918","fasta_url":"https://rest.uniprot.org/uniprotkb/P27918.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/P27918/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/P27918"}},"corpus_meta":[{"pmid":"9846755","id":"PMC_9846755","title":"A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP-10).","date":"1998","source":"Microbiology (Reading, England)","url":"https://pubmed.ncbi.nlm.nih.gov/9846755","citation_count":381,"is_preprint":false},{"pmid":"11940590","id":"PMC_11940590","title":"Conclusive evidence that the major T-cell antigens of the Mycobacterium tuberculosis complex ESAT-6 and CFP-10 form a tight, 1:1 complex and characterization of the structural properties of ESAT-6, CFP-10, and the ESAT-6*CFP-10 complex. 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to single prolonged stress, reduces the level of apoptosis in PFC, and upregulates the expression of MeCP2 and BDNF.","date":"2021","source":"Neurobiology of stress","url":"https://pubmed.ncbi.nlm.nih.gov/33718536","citation_count":23,"is_preprint":false},{"pmid":"27138226","id":"PMC_27138226","title":"Fc-based delivery system enhances immunogenicity of a tuberculosis subunit vaccine candidate consisting of the ESAT-6:CFP-10 complex.","date":"2016","source":"Molecular bioSystems","url":"https://pubmed.ncbi.nlm.nih.gov/27138226","citation_count":23,"is_preprint":false},{"pmid":"11162871","id":"PMC_11162871","title":"Sensitivity of the SRBC PFC assay versus ELISA for detection of immunosuppression by TCDD and TCDD-like congeners.","date":"2000","source":"Toxicology","url":"https://pubmed.ncbi.nlm.nih.gov/11162871","citation_count":23,"is_preprint":false},{"pmid":"21952719","id":"PMC_21952719","title":"Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats.","date":"2011","source":"European journal of human genetics : EJHG","url":"https://pubmed.ncbi.nlm.nih.gov/21952719","citation_count":22,"is_preprint":false},{"pmid":"36555739","id":"PMC_36555739","title":"FAAH Inhibition Restores Early Life Stress-Induced Alterations in PFC microRNAs Associated with Depressive-Like Behavior in Male and Female Rats.","date":"2022","source":"International journal of molecular sciences","url":"https://pubmed.ncbi.nlm.nih.gov/36555739","citation_count":21,"is_preprint":false},{"pmid":"32490745","id":"PMC_32490745","title":"Detection of mycobacterial CFP-10 (Rv3874) protein in tuberculosis patients by gold nanoparticle-based real-time immuno-PCR.","date":"2020","source":"Future microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/32490745","citation_count":20,"is_preprint":false},{"pmid":"23729182","id":"PMC_23729182","title":"Melanopsin-expressing retinal ganglion cell loss and behavioral analysis in the Thy1-CFP-DBA/2J mouse model of glaucoma.","date":"2013","source":"Science China. Life sciences","url":"https://pubmed.ncbi.nlm.nih.gov/23729182","citation_count":20,"is_preprint":false},{"pmid":"20600285","id":"PMC_20600285","title":"Suite of novel vectors for ectopic insertion of GFP, CFP and IYFP transcriptional fusions in single copy at the amyE and bglS loci in Bacillus subtilis.","date":"2010","source":"Plasmid","url":"https://pubmed.ncbi.nlm.nih.gov/20600285","citation_count":20,"is_preprint":false},{"pmid":"24926902","id":"PMC_24926902","title":"Optimization and application of TiO₂/Ti-Pt photo fuel cell (PFC) to effectively generate electricity and degrade organic pollutants simultaneously.","date":"2014","source":"Water research","url":"https://pubmed.ncbi.nlm.nih.gov/24926902","citation_count":19,"is_preprint":false},{"pmid":"10812229","id":"PMC_10812229","title":"Isolation, purification and immunological characterization of novel low molecular weight protein antigen CFP 6 from culture filtrate of M. tuberculosis.","date":"2000","source":"Vaccine","url":"https://pubmed.ncbi.nlm.nih.gov/10812229","citation_count":19,"is_preprint":false},{"pmid":"33540803","id":"PMC_33540803","title":"Estrogen Receptors Alpha and Beta Mediate Synaptic Transmission in the PFC and Hippocampus of Mice.","date":"2021","source":"International journal of molecular sciences","url":"https://pubmed.ncbi.nlm.nih.gov/33540803","citation_count":18,"is_preprint":false},{"pmid":"34008450","id":"PMC_34008450","title":"Sustained NMDA receptor hypofunction impairs brain-derived neurotropic factor signalling in the PFC, but not in the hippocampus, and disturbs PFC-dependent cognition in mice.","date":"2021","source":"Journal of psychopharmacology (Oxford, England)","url":"https://pubmed.ncbi.nlm.nih.gov/34008450","citation_count":18,"is_preprint":false},{"pmid":"17380048","id":"PMC_17380048","title":"Interferon gamma response to combinations 38 kDa/CFP-10, 38 kDa/MPT-64, ESAT-6/MPT-64 and ESAT-6/CFP-10, each related to a single recombinant protein of Mycobacterium tuberculosis in individuals from tuberculosis endemic areas.","date":"2007","source":"Microbiology and immunology","url":"https://pubmed.ncbi.nlm.nih.gov/17380048","citation_count":18,"is_preprint":false},{"pmid":"24027495","id":"PMC_24027495","title":"Multiple effects of β-amyloid on single excitatory synaptic connections in the PFC.","date":"2013","source":"Frontiers in cellular neuroscience","url":"https://pubmed.ncbi.nlm.nih.gov/24027495","citation_count":18,"is_preprint":false},{"pmid":"3488818","id":"PMC_3488818","title":"Comparison of accessory cell functions of endothelial cells and monocytes: IL-2 production by T cells and PFC generation.","date":"1986","source":"Cellular immunology","url":"https://pubmed.ncbi.nlm.nih.gov/3488818","citation_count":18,"is_preprint":false},{"pmid":"28438613","id":"PMC_28438613","title":"Stress-altered synaptic plasticity and DAMP signaling in the hippocampus-PFC axis; elucidating the significance of IGF-1/IGF-1R/CaMKIIα expression in neural changes associated with a prolonged exposure therapy.","date":"2017","source":"Neuroscience","url":"https://pubmed.ncbi.nlm.nih.gov/28438613","citation_count":17,"is_preprint":false},{"pmid":"36255000","id":"PMC_36255000","title":"Blunt dopamine transmission due to decreased GDNF in the PFC evokes cognitive impairment in Parkinson's disease.","date":"2023","source":"Neural regeneration research","url":"https://pubmed.ncbi.nlm.nih.gov/36255000","citation_count":17,"is_preprint":false},{"pmid":"29849577","id":"PMC_29849577","title":"Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress.","date":"2018","source":"Neural plasticity","url":"https://pubmed.ncbi.nlm.nih.gov/29849577","citation_count":17,"is_preprint":false},{"pmid":"36768376","id":"PMC_36768376","title":"Cannabidiol Modulates Alterations in PFC microRNAs in a Rat Model of Depression.","date":"2023","source":"International journal of molecular sciences","url":"https://pubmed.ncbi.nlm.nih.gov/36768376","citation_count":16,"is_preprint":false},{"pmid":"11682184","id":"PMC_11682184","title":"Over-expression of the cercosporin facilitator protein, CFP, in Cercospora kikuchii up-regulates production and secretion of cercosporin.","date":"2001","source":"FEMS microbiology letters","url":"https://pubmed.ncbi.nlm.nih.gov/11682184","citation_count":16,"is_preprint":false},{"pmid":"25520147","id":"PMC_25520147","title":"Measurement of phenotype and absolute number of circulating heparin-binding hemagglutinin, ESAT-6 and CFP-10, and purified protein derivative antigen-specific CD4 T cells can discriminate active from latent tuberculosis infection.","date":"2014","source":"Clinical and vaccine immunology : CVI","url":"https://pubmed.ncbi.nlm.nih.gov/25520147","citation_count":16,"is_preprint":false},{"pmid":"36979566","id":"PMC_36979566","title":"Development of Gold-Nanoparticle-Based Lateral Flow Immunoassays for Rapid Detection of TB ESAT-6 and CFP-10.","date":"2023","source":"Biosensors","url":"https://pubmed.ncbi.nlm.nih.gov/36979566","citation_count":15,"is_preprint":false},{"pmid":"27365551","id":"PMC_27365551","title":"Macrophage Immune Response Suppression by Recombinant Mycobacterium tuberculosis Antigens, the ESAT-6, CFP-10, and ESAT-6/CFP-10 Fusion Proteins.","date":"2016","source":"Iranian journal of medical sciences","url":"https://pubmed.ncbi.nlm.nih.gov/27365551","citation_count":15,"is_preprint":false},{"pmid":"21517110","id":"PMC_21517110","title":"Quantitative measurement of Ca(2+)-dependent calmodulin-target binding by Fura-2 and CFP and YFP FRET imaging in living cells.","date":"2011","source":"Biochemistry","url":"https://pubmed.ncbi.nlm.nih.gov/21517110","citation_count":15,"is_preprint":false},{"pmid":"30243074","id":"PMC_30243074","title":"Evaluation of photocatalytic fuel cell (PFC) for electricity production and simultaneous degradation of methyl green in synthetic and real greywater effluents.","date":"2018","source":"Journal of environmental management","url":"https://pubmed.ncbi.nlm.nih.gov/30243074","citation_count":15,"is_preprint":false},{"pmid":"34626116","id":"PMC_34626116","title":"Distinct Role of Dopamine in the PFC and NAc During Exposure to Cocaine-Associated Cues.","date":"2021","source":"The international journal of neuropsychopharmacology","url":"https://pubmed.ncbi.nlm.nih.gov/34626116","citation_count":14,"is_preprint":false},{"pmid":"22737527","id":"PMC_22737527","title":"Expression and Purification of Recombinant Mycobacterium Tuberculosis (TB) Antigens, ESAT-6, CFP-10 and ESAT- 6/CFP-10 and Their Diagnosis Potential for Detection of TB Patients.","date":"2011","source":"Iranian Red Crescent medical journal","url":"https://pubmed.ncbi.nlm.nih.gov/22737527","citation_count":14,"is_preprint":false},{"pmid":"26742463","id":"PMC_26742463","title":"Imaging the microenvironment of pancreatic cancer patient-derived orthotopic xenografts (PDOX) growing in transgenic nude mice expressing GFP, RFP, or CFP.","date":"2015","source":"Cancer letters","url":"https://pubmed.ncbi.nlm.nih.gov/26742463","citation_count":14,"is_preprint":false},{"pmid":"23845455","id":"PMC_23845455","title":"Limited T cell receptor beta variable repertoire responses to ESAT-6 and CFP-10 in subjects infected with Mycobacterium tuberculosis.","date":"2013","source":"Tuberculosis (Edinburgh, Scotland)","url":"https://pubmed.ncbi.nlm.nih.gov/23845455","citation_count":14,"is_preprint":false},{"pmid":"15139917","id":"PMC_15139917","title":"The Neurospora crassa cfp promoter drives a carbon source-dependent expression of transgenes in filamentous fungi.","date":"2004","source":"Journal of applied microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/15139917","citation_count":14,"is_preprint":false},{"pmid":"28374535","id":"PMC_28374535","title":"Association of ESAT-6/CFP-10-induced IFN-γ, TNF-α and IL-10 with clinical tuberculosis: evidence from cohorts of pulmonary tuberculosis patients, household contacts and community controls in an endemic setting.","date":"2017","source":"Clinical and experimental immunology","url":"https://pubmed.ncbi.nlm.nih.gov/28374535","citation_count":14,"is_preprint":false},{"pmid":"25848507","id":"PMC_25848507","title":"Cloning, expression and purification of Mycobacterium tuberculosis ESAT-6 and CFP-10 antigens.","date":"2013","source":"Iranian journal of microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/25848507","citation_count":13,"is_preprint":false},{"pmid":"30636533","id":"PMC_30636533","title":"Distribution and expression of esat-6 and cfp-10 in non-tuberculous mycobacteria isolated from lymph nodes of slaughtered cattle in Switzerland.","date":"2019","source":"Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc","url":"https://pubmed.ncbi.nlm.nih.gov/30636533","citation_count":13,"is_preprint":false},{"pmid":"33332381","id":"PMC_33332381","title":"Network preservation reveals shared and unique biological processes associated with chronic alcohol abuse in NAc and PFC.","date":"2020","source":"PloS one","url":"https://pubmed.ncbi.nlm.nih.gov/33332381","citation_count":13,"is_preprint":false},{"pmid":"37083635","id":"PMC_37083635","title":"The Antidepressant-like Activity and Cognitive Enhancing Effects of the Combined Administration of (R)-Ketamine and LY341495 in the CUMS Model of Depression in Mice Are Related to the Modulation of Excitatory Synaptic Transmission and LTP in the PFC.","date":"2023","source":"Pharmaceuticals (Basel, Switzerland)","url":"https://pubmed.ncbi.nlm.nih.gov/37083635","citation_count":13,"is_preprint":false},{"pmid":"17434194","id":"PMC_17434194","title":"ESAT-6 and CFP-10 can be combined to reduce the cost of testing for Mycobacterium tuberculosis infection, but CFP-10 responses associate with active disease.","date":"2007","source":"Transactions of the Royal Society of Tropical Medicine and Hygiene","url":"https://pubmed.ncbi.nlm.nih.gov/17434194","citation_count":13,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":52870,"output_tokens":634,"usd":0.08406,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":6571,"output_tokens":800,"usd":0.026427,"stage2_stop_reason":"end_turn"},"total_usd":0.110487,"stage1_batch_id":"msgbatch_01ACAxJQabDsht39JXeWG22d","stage2_batch_id":"msgbatch_01QEU22A9U5sbPTgsMzTmvSf","note":"batch pricing = 50% of standard"},"stage1_raw":"Looking at the corpus, I need to identify which papers are about the human gene CFP (complement factor properdin, also known as PFC). \n\nThe corpus contains many papers about:\n- CFP-10 (a Mycobacterium tuberculosis protein, Rv3874/lhp) - NOT the human CFP gene\n- CFP/YFP as fluorescent protein pairs - NOT the human CFP gene\n- PFC as \"prefrontal cortex\" abbreviation - NOT the human CFP gene\n- PFC as \"photocatalytic fuel cell\" - NOT the human CFP gene\n- Various other unrelated uses of \"CFP\" or \"PFC\"\n\nOnly paper PMID:30755730 (Block et al., 2019) appears to be about the human CFP gene (complement factor properdin). Let me analyze it carefully.\n\nPaper 53 (PMID:30755730): \"CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3\" - This describes complement factor properdin (CFP) having a tumor suppressive role, inducing intracellular upregulation of the pro-apoptotic transcription factor DDIT3 (associated with ER-stress response). This is about the canonical human CFP gene.\n\n```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2019,\n      \"finding\": \"Complement factor properdin (CFP) suppresses breast cancer cell growth in vitro and in vivo by inducing intracellular upregulation of the pro-apoptotic transcription factor DDIT3, associated with endoplasmic reticulum stress response, in a process involving TES.\",\n      \"method\": \"Loss-of-function and gain-of-function screen in MCF7 cell lines; in vitro and in vivo tumor growth assays; Western blot for DDIT3 expression\",\n      \"journal\": \"Oncogene\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 3 / Weak — single lab, limited mechanistic detail in abstract, no reciprocal validation or structural data; pathway placement (CFP→TES→DDIT3) described but mechanistic depth not fully established from abstract alone\",\n      \"pmids\": [\"30755730\"],\n      \"is_preprint\": false\n    }\n  ],\n  \"current_model\": \"Complement factor properdin (CFP) has a tumor-suppressive role in breast cancer, acting intracellularly to upregulate the pro-apoptotic transcription factor DDIT3 via TES, thereby suppressing cell growth; no other mechanistic findings about the canonical human CFP protein are represented in the available literature.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"Complement factor properdin (CFP) has been assigned a tumor-suppressive function in breast cancer, where it acts intracellularly to suppress cell growth both in vitro and in vivo [#0]. In this context CFP induces intracellular upregulation of the pro-apoptotic transcription factor DDIT3 in association with an endoplasmic reticulum stress response, through a process involving TES [#0]. Beyond this single low-confidence observation, no further mechanistic detail about the canonical human CFP protein has been characterized in the available corpus.\",\n  \"teleology\": [\n    {\n      \"year\": 2019,\n      \"claim\": \"Whether CFP has an intracellular, growth-regulatory role distinct from complement signaling was unknown; loss- and gain-of-function experiments showed CFP suppresses breast cancer cell growth by inducing the pro-apoptotic factor DDIT3, establishing a candidate tumor-suppressive axis CFP\\u2192TES\\u2192DDIT3 linked to ER stress.\",\n      \"evidence\": \"Loss-of-function and gain-of-function screen in MCF7 cells, in vitro and in vivo tumor growth assays, and Western blot for DDIT3\",\n      \"pmids\": [\"30755730\"],\n      \"confidence\": \"Low\",\n      \"gaps\": [\n        \"Single lab, no reciprocal validation or independent confirmation\",\n        \"Mechanism by which CFP engages TES and the molecular link to DDIT3 upregulation is not resolved\",\n        \"No structural data and no demonstration of direct physical interactions\"\n      ]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"How CFP acts intracellularly and whether this role generalizes beyond breast cancer cells remains unresolved.\",\n      \"evidence\": \"No further mechanistic studies in the available corpus\",\n      \"pmids\": [],\n      \"confidence\": \"Low\",\n      \"gaps\": [\n        \"No direct binding partners or substrates established\",\n        \"Relationship to canonical extracellular complement function not addressed\",\n        \"No structural or biochemical mechanism for DDIT3 induction\"\n      ]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [],\n    \"localization\": [],\n    \"pathway\": [],\n    \"complexes\": [],\n    \"partners\": [],\n    \"other_free_text\": []\n  }\n}","audit_flag":null,"evaluation":{"pairwise":"loss","faith_supported":1,"faith_total":2,"faith_pct":50.0}}