{"gene":"CCZ1B","run_date":"2026-04-28T17:28:52","timeline":{"discoveries":[],"current_model":"No mechanistic findings about CCZ1B in the available literature (corpus appears contaminated with off-target papers)."},"narrative":{"teleology":[],"mechanism_profile":null,"mechanistic_narrative":"No mechanistic findings about CCZ1B in the available literature (corpus appears contaminated with off-target papers)."},"prefetch_data":{"uniprot":{"accession":"P86790","full_name":"Vacuolar fusion protein CCZ1 homolog B","aliases":["Vacuolar fusion protein CCZ1 homolog-like"],"length_aa":482,"mass_kda":55.9,"function":"","subcellular_location":"Lysosome 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all","driving_tissues":[],"url":"https://www.proteinatlas.org/search/CCZ1B"},"hgnc":{"alias_symbol":["DKFZP586I1023","H_NH0577018.2","MGC19819"],"prev_symbol":["C7orf28B"]},"alphafold":{"accession":"P86790","domains":[{"cath_id":"3.30.450.70","chopping":"18-185","consensus_level":"high","plddt":94.6949,"start":18,"end":185},{"cath_id":"3.30.450.30","chopping":"201-263_278-369","consensus_level":"high","plddt":91.946,"start":201,"end":369},{"cath_id":"3.30.450","chopping":"377-476","consensus_level":"high","plddt":87.8772,"start":377,"end":476}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/P86790","model_url":"https://alphafold.ebi.ac.uk/files/AF-P86790-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-P86790-F1-predicted_aligned_error_v6.png","plddt_mean":88.12},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=CCZ1B","jax_strain_url":"https://www.jax.org/strain/search?query=CCZ1B"},"sequence":{"accession":"P86790","fasta_url":"https://rest.uniprot.org/uniprotkb/P86790.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/P86790/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/P86790"}},"corpus_meta":[{"pmid":"33871646","id":"PMC_33871646","title":"Post-Golgi 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The gene symbol \"CCZ1b\" here refers to an Arabidopsis protein, not the human gene. This is a SYMBOL COLLISION in plants (Arabidopsis/rice context fundamentally incompatible). EXCLUDE.\n\n- Paper [2] (PMID:41960320): CNV study mentioning CCZ1B as a gene in a deletion region associated with orofacial clefts — no mechanistic findings, purely association/expression-based. EXCLUDE (no mechanism even if KEEP).\n\n- PMID:34432599 (C5orf51/MON1-CCZ1 paper): Describes the human MON1-CCZ1 GEF complex for RAB7A during mitophagy. CCZ1 here is the human CCZ1 (CCZ1 homolog). This paper mentions \"CCZ1\" and \"MON1-CCZ1 complex\" in the context of human cells — this is about CCZ1 (the paralog/homolog), but CCZ1B is distinct from CCZ1. Need to verify — the abstract says \"CCZ1\" not \"CCZ1B\" specifically. This likely refers to CCZ1 (the main paralog), not CCZ1B specifically. EXCLUDE (refers to CCZ1, not CCZ1B).\n\n- PMID:40437099 (EndoMAP): General endosomal interactome, no specific CCZ1B findings mentioned. EXCLUDE.\n\n- All other gene2pubmed papers: cDNA sequencing projects, chromosome sequencing, GO annotations, proteomics resources — no mechanistic findings about CCZ1B specifically. EXCLUDE.\n\nAfter classification, **zero papers** contain mechanistic findings specifically about human CCZ1B.\n\n```json\n{\n  \"discoveries\": [],\n  \"current_model\": \"No mechanistic findings about CCZ1B in the available literature (corpus appears contaminated with off-target papers).\"\n}\n```","stage2_raw":"\n\n--- ROUND 2 (refusal — no on-target evidence) ---\n"}