{"gene":"CCZ1B","run_date":"2026-06-09T22:57:17","timeline":{"discoveries":[],"current_model":"No mechanistic findings in the available literature for the human/mammalian CCZ1B protein; the only mechanistic paper in this corpus describes the rice ortholog (OsCCZ1) forming a MON1-CCZ1 complex that acts as a Rab7 GEF and Rab5 effector in post-Golgi vacuolar trafficking, but this is a plant ortholog study and cannot be assigned as a mechanistic discovery for the human CCZ1B gene based on the available corpus."},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null},"prefetch_data":{"uniprot":{"accession":"P86790","full_name":"Vacuolar fusion protein CCZ1 homolog B","aliases":["Vacuolar fusion protein CCZ1 homolog-like"],"length_aa":482,"mass_kda":55.9,"function":"","subcellular_location":"Lysosome membrane","url":"https://www.uniprot.org/uniprotkb/P86790/entry"},"depmap":{"release":"DepMap","has_data":false,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/CCZ1B"},"opencell":{"profiled":true,"resolved_as":"","ensg_id":"ENSG00000146574","cell_line_id":"CID001846","localizations":[{"compartment":"cytoplasmic","grade":3},{"compartment":"nucleoplasm","grade":3},{"compartment":"vesicles","grade":2}],"interactors":[{"gene":"CCZ1B;CCZ1","stoichiometry":10.0},{"gene":"C18ORF8","stoichiometry":10.0}],"url":"https://opencell.sf.czbiohub.org/target/CID001846","total_profiled":1310},"omim":[{"mim_id":"620660","title":"CCZ1 HOMOLOG, VACUOLAR PROTEIN TRAFFICKING- AND BIOGENESIS-ASSOCIATED PROTEIN; CCZ1","url":"https://www.omim.org/entry/620660"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Enhanced","locations":[{"location":"Vesicles","reliability":"Enhanced"}],"tissue_specificity":"Low tissue specificity","tissue_distribution":"Detected in all","driving_tissues":[],"url":"https://www.proteinatlas.org/search/CCZ1B"},"hgnc":{"alias_symbol":["DKFZP586I1023","H_NH0577018.2","MGC19819"],"prev_symbol":["C7orf28B"]},"alphafold":{"accession":"P86790","domains":[{"cath_id":"3.30.450.70","chopping":"18-185","consensus_level":"high","plddt":94.6949,"start":18,"end":185},{"cath_id":"3.30.450.30","chopping":"201-263_278-369","consensus_level":"high","plddt":91.946,"start":201,"end":369},{"cath_id":"3.30.450","chopping":"377-476","consensus_level":"high","plddt":87.8772,"start":377,"end":476}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/P86790","model_url":"https://alphafold.ebi.ac.uk/files/AF-P86790-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-P86790-F1-predicted_aligned_error_v6.png","plddt_mean":88.12},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=CCZ1B","jax_strain_url":"https://www.jax.org/strain/search?query=CCZ1B"},"sequence":{"accession":"P86790","fasta_url":"https://rest.uniprot.org/uniprotkb/P86790.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/P86790/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/P86790"}},"corpus_meta":[{"pmid":"33871646","id":"PMC_33871646","title":"Post-Golgi trafficking of rice storage proteins requires the small GTPase Rab7 activation complex MON1-CCZ1.","date":"2021","source":"Plant physiology","url":"https://pubmed.ncbi.nlm.nih.gov/33871646","citation_count":28,"is_preprint":false},{"pmid":"41960320","id":"PMC_41960320","title":"Consensus-based Detection of Aetiologic Copy Number Variants For Syndromic Orofacial Clefts Utilising Whole Exome Sequencing of Case Parent Trios.","date":"2026","source":"Research square","url":"https://pubmed.ncbi.nlm.nih.gov/41960320","citation_count":0,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":3587,"output_tokens":139,"usd":0.006423,"stage1_stop_reason":"end_turn"},"stage2":{"model":"","input_tokens":0,"output_tokens":0,"usd":0.0},"total_usd":0.006423,"stage1_batch_id":"msgbatch_01ACAxJQabDsht39JXeWG22d","stage2_batch_id":"msgbatch_01QEU22A9U5sbPTgsMzTmvSf","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [],\n  \"current_model\": \"No mechanistic findings in the available literature for the human/mammalian CCZ1B protein; the only mechanistic paper in this corpus describes the rice ortholog (OsCCZ1) forming a MON1-CCZ1 complex that acts as a Rab7 GEF and Rab5 effector in post-Golgi vacuolar trafficking, but this is a plant ortholog study and cannot be assigned as a mechanistic discovery for the human CCZ1B gene based on the available corpus.\"\n}\n```","stage2_raw":"","audit_flag":null,"evaluation":null}