{"gene":"CCDC38","run_date":"2026-06-09T22:57:17","timeline":{"discoveries":[{"year":2014,"finding":"CCDC38 localizes to the centrosome in cultured mammalian cells, identified as a centrosome-associated protein by mass spectrometry of sperm centrioles followed by localization assessment.","method":"Mass spectrometry of sperm centrioles; localization assessment in cultured cells","journal":"Journal of cell science","confidence":"Medium","confidence_rationale":"Tier 2 / Weak — direct localization experiment in cultured cells, single lab, limited functional follow-up for CCDC38 specifically","pmids":["25074808"],"is_preprint":false},{"year":2016,"finding":"CCDC38 interacts with ubiquitinated histone H2A in mouse testes, as demonstrated by immunofluorescence co-localization and co-immunoprecipitation.","method":"Co-immunoprecipitation; immunofluorescence","journal":"Molecular medicine reports","confidence":"Low","confidence_rationale":"Tier 3 / Weak — single Co-IP from one lab, no mutagenesis or functional rescue, limited mechanistic follow-up","pmids":["27278724"],"is_preprint":false},{"year":2022,"finding":"CCDC38 is a testis-specific protein that localizes on the manchette and sperm tail during spermiogenesis; it physically interacts with CCDC42, IFT88, and ODF2, and its knockout in male mice results in distorted manchette, multiple morphological abnormalities of the flagella (MMAF), and male sterility, with reduced transport of ODF2 to the flagellum.","method":"Ccdc38 knockout mice (loss-of-function); co-immunoprecipitation; immunofluorescence localization; Western blot for ODF2 levels in flagellum","journal":"Development (Cambridge, England)","confidence":"High","confidence_rationale":"Tier 2 / Strong — reciprocal Co-IP for multiple partners, clean KO with defined cellular phenotypes, direct localization, and transport assay in single focused study","pmids":["35587122"],"is_preprint":false},{"year":2023,"finding":"CCDC38 is required for acrosome biogenesis and fibrous sheath assembly during spermiogenesis; Ccdc38-knockout mice (base-edited nonsense mutation) display acrosomal hypoplasia, loosely anchored acrosomal membrane, disorganized fibrous sheaths, and MMAF phenotypes. CCDC38 loss reduces TEKT3 (an acrosome biogenesis-associated protein) levels in testes and causes aberrant TEKT3 distribution in sperm.","method":"Base-editing-derived Ccdc38 knockout mice; Western blot; immunofluorescence; electron microscopy; intracytoplasmic sperm injection rescue","journal":"Journal of genetics and genomics = Yi chuan xue bao","confidence":"High","confidence_rationale":"Tier 2 / Moderate — clean KO with multiple orthogonal morphological and molecular readouts, functional rescue by ICSI, single lab","pmids":["37709195"],"is_preprint":false},{"year":2023,"finding":"CCDC146 physically interacts with CCDC38 (and CCDC42), and interaction models at the atomic level were predicted and validated; CCDC38 protein levels are not affected by Ccdc146 knockout, placing CCDC38 upstream of or parallel to CCDC146 in the flagellum biogenesis pathway.","method":"Co-immunoprecipitation; computational interaction modeling with experimental validation; Western blot in Ccdc146-KO mice","journal":"Cellular and molecular life sciences : CMLS","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — reciprocal Co-IP with structural modeling and KO genetic epistasis, single lab","pmids":["38038747"],"is_preprint":false}],"current_model":"CCDC38 is a testis-specific coiled-coil domain protein that localizes to the manchette and sperm tail during spermiogenesis, where it interacts with CCDC42, IFT88, ODF2, CCDC146, and ubiquitinated histone H2A, and is required for intraflagellar transport of structural proteins (ODF2), acrosome biogenesis, and fibrous sheath assembly, such that its loss causes MMAF, acrosomal hypoplasia, and complete male sterility in mice."},"narrative":{"mechanistic_narrative":"CCDC38 is a testis-specific coiled-coil protein that functions in sperm flagellum and acrosome biogenesis during spermiogenesis, where it localizes to the manchette and sperm tail [PMID:35587122]. It acts as a scaffold within the intraflagellar transport machinery, physically interacting with CCDC42, IFT88, and ODF2, and its loss reduces delivery of ODF2 to the flagellum and produces a distorted manchette, multiple morphological abnormalities of the flagella (MMAF), and male sterility in knockout mice [PMID:35587122]. CCDC38 is additionally required for acrosome biogenesis and fibrous sheath assembly; its loss causes acrosomal hypoplasia, loosely anchored acrosomal membrane, disorganized fibrous sheaths, and reduced and mislocalized TEKT3 [PMID:37709195]. It further interacts with CCDC146 and lies upstream of or parallel to it in the flagellum biogenesis pathway, since CCDC38 levels are unaffected by Ccdc146 loss [PMID:38038747]. An earlier proteomic study placed CCDC38 at the centrosome/sperm centriole [PMID:25074808], and a single report links it to ubiquitinated histone H2A in testes [PMID:27278724]; beyond these interactions and the structural-transport role, no further mechanistic detail has been characterized in the available corpus.","teleology":[{"year":2014,"claim":"Establishing where CCDC38 acts first required identifying its subcellular home, which proteomics of sperm centrioles placed at the centrosome.","evidence":"Mass spectrometry of sperm centrioles with localization assessment in cultured cells","pmids":["25074808"],"confidence":"Medium","gaps":["No functional role assigned at this stage","Centrosomal localization not linked to a spermiogenesis phenotype","Single lab, limited follow-up for CCDC38 specifically"]},{"year":2016,"claim":"A candidate molecular link was tested by asking whether CCDC38 associates with chromatin marks, identifying an interaction with ubiquitinated histone H2A in testes.","evidence":"Co-immunoprecipitation and immunofluorescence co-localization in mouse testes","pmids":["27278724"],"confidence":"Low","gaps":["Single Co-IP without mutagenesis or functional rescue","Functional significance of the H2A association unresolved","Not reconciled with later cytoskeletal/flagellar role"]},{"year":2022,"claim":"The core function was defined by knockout, showing CCDC38 is testis-specific, localizes to the manchette and sperm tail, and is required for intraflagellar transport of ODF2 and normal flagellum formation.","evidence":"Ccdc38 knockout mice with reciprocal Co-IP (CCDC42, IFT88, ODF2), immunofluorescence, and Western blot for flagellar ODF2","pmids":["35587122"],"confidence":"High","gaps":["Direct demonstration that CCDC38 itself moves as IFT cargo not shown","Molecular basis of partner selectivity in the complex unresolved","Stoichiometry and assembly order of the CCDC42/IFT88/ODF2 interactions undefined"]},{"year":2023,"claim":"The scope of CCDC38 function was extended beyond the flagellum to acrosome biogenesis and fibrous sheath assembly, with TEKT3 identified as a downstream cargo affected by its loss.","evidence":"Base-editing-derived Ccdc38 knockout mice analyzed by EM, immunofluorescence, Western blot, with ICSI rescue","pmids":["37709195"],"confidence":"High","gaps":["Whether TEKT3 is a direct CCDC38 interactor not established","Mechanism connecting manchette transport to acrosome anchoring unclear","Single lab"]},{"year":2023,"claim":"Genetic and physical epistasis was tested against CCDC146, placing CCDC38 upstream of or parallel to it in flagellum biogenesis.","evidence":"Co-immunoprecipitation, atomic-level interaction modeling with validation, and Western blot in Ccdc146-KO mice","pmids":["38038747"],"confidence":"Medium","gaps":["Directionality (upstream vs parallel) not fully resolved","Functional consequence of the CCDC38–CCDC146 interaction untested by double perturbation","Single lab"]},{"year":null,"claim":"How CCDC38 mechanically couples manchette-based transport to both flagellar structural protein delivery and acrosome anchoring, and whether it functions as IFT cargo or adaptor, remains unresolved.","evidence":"No direct cargo/adaptor reconstitution in the available corpus","pmids":[],"confidence":"Low","gaps":["No structural model of CCDC38 within an assembled transport complex","Direct substrate/cargo binding versus indirect stabilization not distinguished","No human patient mutation evidence in the corpus"]}],"mechanism_profile":{"molecular_activity":[{"term_id":"GO:0060090","term_label":"molecular adaptor activity","supporting_discovery_ids":[2,4]},{"term_id":"GO:0008092","term_label":"cytoskeletal protein binding","supporting_discovery_ids":[2]}],"localization":[{"term_id":"GO:0005856","term_label":"cytoskeleton","supporting_discovery_ids":[2]},{"term_id":"GO:0005815","term_label":"microtubule organizing center","supporting_discovery_ids":[0]}],"pathway":[{"term_id":"R-HSA-1474165","term_label":"Reproduction","supporting_discovery_ids":[2,3]},{"term_id":"R-HSA-1852241","term_label":"Organelle biogenesis and maintenance","supporting_discovery_ids":[2,3]}],"complexes":[],"partners":["CCDC42","IFT88","ODF2","CCDC146"],"other_free_text":[]}},"prefetch_data":{"uniprot":{"accession":"Q502W7","full_name":"Coiled-coil domain-containing protein 38","aliases":[],"length_aa":563,"mass_kda":65.3,"function":"Essential for male fertility. Required for sperm flagellum biogenesis. Also required for acrosome biogenesis. Required for the attachment of developing acrosomes to the nucleus during spermiogenesis and may be involved in the transport of fibrous sheath components","subcellular_location":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, perinuclear region; Cell projection, cilium, flagellum; Cytoplasm, cytoskeleton","url":"https://www.uniprot.org/uniprotkb/Q502W7/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/CCDC38","classification":"Not Classified","n_dependent_lines":7,"n_total_lines":1208,"dependency_fraction":0.005794701986754967},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[],"url":"https://opencell.sf.czbiohub.org/search/CCDC38","total_profiled":1310},"omim":[],"hpa":{"profiled":true,"resolved_as":"","reliability":"","locations":[],"tissue_specificity":"Tissue enriched","tissue_distribution":"Detected in some","driving_tissues":[{"tissue":"testis","ntpm":15.7}],"url":"https://www.proteinatlas.org/search/CCDC38"},"hgnc":{"alias_symbol":["FLJ40089"],"prev_symbol":[]},"alphafold":{"accession":"Q502W7","domains":[{"cath_id":"1.20.5","chopping":"337-418","consensus_level":"medium","plddt":93.9362,"start":337,"end":418},{"cath_id":"4.10.290","chopping":"449-519","consensus_level":"medium","plddt":86.2776,"start":449,"end":519}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q502W7","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q502W7-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q502W7-F1-predicted_aligned_error_v6.png","plddt_mean":73.0},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=CCDC38","jax_strain_url":"https://www.jax.org/strain/search?query=CCDC38"},"sequence":{"accession":"Q502W7","fasta_url":"https://rest.uniprot.org/uniprotkb/Q502W7.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q502W7/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q502W7"}},"corpus_meta":[{"pmid":"25074808","id":"PMC_25074808","title":"Proteomic analysis of mammalian sperm cells identifies new components of the centrosome.","date":"2014","source":"Journal of cell science","url":"https://pubmed.ncbi.nlm.nih.gov/25074808","citation_count":93,"is_preprint":false},{"pmid":"31255637","id":"PMC_31255637","title":"Proteomics and single-cell RNA analysis of Akap4-knockout mice model confirm indispensable role of Akap4 in spermatogenesis.","date":"2019","source":"Developmental biology","url":"https://pubmed.ncbi.nlm.nih.gov/31255637","citation_count":61,"is_preprint":false},{"pmid":"35587122","id":"PMC_35587122","title":"CCDC38 is required for sperm flagellum biogenesis and male fertility in mice.","date":"2022","source":"Development (Cambridge, England)","url":"https://pubmed.ncbi.nlm.nih.gov/35587122","citation_count":38,"is_preprint":false},{"pmid":"24786987","id":"PMC_24786987","title":"Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction.","date":"2014","source":"PLoS genetics","url":"https://pubmed.ncbi.nlm.nih.gov/24786987","citation_count":30,"is_preprint":false},{"pmid":"38038747","id":"PMC_38038747","title":"CCDC146 is required for sperm flagellum biogenesis and male fertility in mice.","date":"2023","source":"Cellular and molecular life sciences : CMLS","url":"https://pubmed.ncbi.nlm.nih.gov/38038747","citation_count":18,"is_preprint":false},{"pmid":"27278724","id":"PMC_27278724","title":"Identification and characteristics of the testes-specific gene, Ccdc38, in mice.","date":"2016","source":"Molecular medicine reports","url":"https://pubmed.ncbi.nlm.nih.gov/27278724","citation_count":7,"is_preprint":false},{"pmid":"37709195","id":"PMC_37709195","title":"Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice.","date":"2023","source":"Journal of genetics and genomics = Yi chuan xue bao","url":"https://pubmed.ncbi.nlm.nih.gov/37709195","citation_count":7,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":5297,"output_tokens":1241,"usd":0.017253,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":7861,"output_tokens":2346,"usd":0.048978,"stage2_stop_reason":"end_turn"},"total_usd":0.066231,"stage1_batch_id":"msgbatch_01ACAxJQabDsht39JXeWG22d","stage2_batch_id":"msgbatch_01QEU22A9U5sbPTgsMzTmvSf","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2014,\n      \"finding\": \"CCDC38 localizes to the centrosome in cultured mammalian cells, identified as a centrosome-associated protein by mass spectrometry of sperm centrioles followed by localization assessment.\",\n      \"method\": \"Mass spectrometry of sperm centrioles; localization assessment in cultured cells\",\n      \"journal\": \"Journal of cell science\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Weak — direct localization experiment in cultured cells, single lab, limited functional follow-up for CCDC38 specifically\",\n      \"pmids\": [\"25074808\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2016,\n      \"finding\": \"CCDC38 interacts with ubiquitinated histone H2A in mouse testes, as demonstrated by immunofluorescence co-localization and co-immunoprecipitation.\",\n      \"method\": \"Co-immunoprecipitation; immunofluorescence\",\n      \"journal\": \"Molecular medicine reports\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 3 / Weak — single Co-IP from one lab, no mutagenesis or functional rescue, limited mechanistic follow-up\",\n      \"pmids\": [\"27278724\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2022,\n      \"finding\": \"CCDC38 is a testis-specific protein that localizes on the manchette and sperm tail during spermiogenesis; it physically interacts with CCDC42, IFT88, and ODF2, and its knockout in male mice results in distorted manchette, multiple morphological abnormalities of the flagella (MMAF), and male sterility, with reduced transport of ODF2 to the flagellum.\",\n      \"method\": \"Ccdc38 knockout mice (loss-of-function); co-immunoprecipitation; immunofluorescence localization; Western blot for ODF2 levels in flagellum\",\n      \"journal\": \"Development (Cambridge, England)\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Strong — reciprocal Co-IP for multiple partners, clean KO with defined cellular phenotypes, direct localization, and transport assay in single focused study\",\n      \"pmids\": [\"35587122\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2023,\n      \"finding\": \"CCDC38 is required for acrosome biogenesis and fibrous sheath assembly during spermiogenesis; Ccdc38-knockout mice (base-edited nonsense mutation) display acrosomal hypoplasia, loosely anchored acrosomal membrane, disorganized fibrous sheaths, and MMAF phenotypes. CCDC38 loss reduces TEKT3 (an acrosome biogenesis-associated protein) levels in testes and causes aberrant TEKT3 distribution in sperm.\",\n      \"method\": \"Base-editing-derived Ccdc38 knockout mice; Western blot; immunofluorescence; electron microscopy; intracytoplasmic sperm injection rescue\",\n      \"journal\": \"Journal of genetics and genomics = Yi chuan xue bao\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — clean KO with multiple orthogonal morphological and molecular readouts, functional rescue by ICSI, single lab\",\n      \"pmids\": [\"37709195\"],\n      \"is_preprint\": false\n    },\n    {\n      \"year\": 2023,\n      \"finding\": \"CCDC146 physically interacts with CCDC38 (and CCDC42), and interaction models at the atomic level were predicted and validated; CCDC38 protein levels are not affected by Ccdc146 knockout, placing CCDC38 upstream of or parallel to CCDC146 in the flagellum biogenesis pathway.\",\n      \"method\": \"Co-immunoprecipitation; computational interaction modeling with experimental validation; Western blot in Ccdc146-KO mice\",\n      \"journal\": \"Cellular and molecular life sciences : CMLS\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — reciprocal Co-IP with structural modeling and KO genetic epistasis, single lab\",\n      \"pmids\": [\"38038747\"],\n      \"is_preprint\": false\n    }\n  ],\n  \"current_model\": \"CCDC38 is a testis-specific coiled-coil domain protein that localizes to the manchette and sperm tail during spermiogenesis, where it interacts with CCDC42, IFT88, ODF2, CCDC146, and ubiquitinated histone H2A, and is required for intraflagellar transport of structural proteins (ODF2), acrosome biogenesis, and fibrous sheath assembly, such that its loss causes MMAF, acrosomal hypoplasia, and complete male sterility in mice.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"CCDC38 is a testis-specific coiled-coil protein that functions in sperm flagellum and acrosome biogenesis during spermiogenesis, where it localizes to the manchette and sperm tail [#2]. It acts as a scaffold within the intraflagellar transport machinery, physically interacting with CCDC42, IFT88, and ODF2, and its loss reduces delivery of ODF2 to the flagellum and produces a distorted manchette, multiple morphological abnormalities of the flagella (MMAF), and male sterility in knockout mice [#2]. CCDC38 is additionally required for acrosome biogenesis and fibrous sheath assembly; its loss causes acrosomal hypoplasia, loosely anchored acrosomal membrane, disorganized fibrous sheaths, and reduced and mislocalized TEKT3 [#3]. It further interacts with CCDC146 and lies upstream of or parallel to it in the flagellum biogenesis pathway, since CCDC38 levels are unaffected by Ccdc146 loss [#4]. An earlier proteomic study placed CCDC38 at the centrosome/sperm centriole [#0], and a single report links it to ubiquitinated histone H2A in testes [#1]; beyond these interactions and the structural-transport role, no further mechanistic detail has been characterized in the available corpus.\",\n  \"teleology\": [\n    {\n      \"year\": 2014,\n      \"claim\": \"Establishing where CCDC38 acts first required identifying its subcellular home, which proteomics of sperm centrioles placed at the centrosome.\",\n      \"evidence\": \"Mass spectrometry of sperm centrioles with localization assessment in cultured cells\",\n      \"pmids\": [\n        \"25074808\"\n      ],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\n        \"No functional role assigned at this stage\",\n        \"Centrosomal localization not linked to a spermiogenesis phenotype\",\n        \"Single lab, limited follow-up for CCDC38 specifically\"\n      ]\n    },\n    {\n      \"year\": 2016,\n      \"claim\": \"A candidate molecular link was tested by asking whether CCDC38 associates with chromatin marks, identifying an interaction with ubiquitinated histone H2A in testes.\",\n      \"evidence\": \"Co-immunoprecipitation and immunofluorescence co-localization in mouse testes\",\n      \"pmids\": [\n        \"27278724\"\n      ],\n      \"confidence\": \"Low\",\n      \"gaps\": [\n        \"Single Co-IP without mutagenesis or functional rescue\",\n        \"Functional significance of the H2A association unresolved\",\n        \"Not reconciled with later cytoskeletal/flagellar role\"\n      ]\n    },\n    {\n      \"year\": 2022,\n      \"claim\": \"The core function was defined by knockout, showing CCDC38 is testis-specific, localizes to the manchette and sperm tail, and is required for intraflagellar transport of ODF2 and normal flagellum formation.\",\n      \"evidence\": \"Ccdc38 knockout mice with reciprocal Co-IP (CCDC42, IFT88, ODF2), immunofluorescence, and Western blot for flagellar ODF2\",\n      \"pmids\": [\n        \"35587122\"\n      ],\n      \"confidence\": \"High\",\n      \"gaps\": [\n        \"Direct demonstration that CCDC38 itself moves as IFT cargo not shown\",\n        \"Molecular basis of partner selectivity in the complex unresolved\",\n        \"Stoichiometry and assembly order of the CCDC42/IFT88/ODF2 interactions undefined\"\n      ]\n    },\n    {\n      \"year\": 2023,\n      \"claim\": \"The scope of CCDC38 function was extended beyond the flagellum to acrosome biogenesis and fibrous sheath assembly, with TEKT3 identified as a downstream cargo affected by its loss.\",\n      \"evidence\": \"Base-editing-derived Ccdc38 knockout mice analyzed by EM, immunofluorescence, Western blot, with ICSI rescue\",\n      \"pmids\": [\n        \"37709195\"\n      ],\n      \"confidence\": \"High\",\n      \"gaps\": [\n        \"Whether TEKT3 is a direct CCDC38 interactor not established\",\n        \"Mechanism connecting manchette transport to acrosome anchoring unclear\",\n        \"Single lab\"\n      ]\n    },\n    {\n      \"year\": 2023,\n      \"claim\": \"Genetic and physical epistasis was tested against CCDC146, placing CCDC38 upstream of or parallel to it in flagellum biogenesis.\",\n      \"evidence\": \"Co-immunoprecipitation, atomic-level interaction modeling with validation, and Western blot in Ccdc146-KO mice\",\n      \"pmids\": [\n        \"38038747\"\n      ],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\n        \"Directionality (upstream vs parallel) not fully resolved\",\n        \"Functional consequence of the CCDC38\\u2013CCDC146 interaction untested by double perturbation\",\n        \"Single lab\"\n      ]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"How CCDC38 mechanically couples manchette-based transport to both flagellar structural protein delivery and acrosome anchoring, and whether it functions as IFT cargo or adaptor, remains unresolved.\",\n      \"evidence\": \"No direct cargo/adaptor reconstitution in the available corpus\",\n      \"pmids\": [],\n      \"confidence\": \"Low\",\n      \"gaps\": [\n        \"No structural model of CCDC38 within an assembled transport complex\",\n        \"Direct substrate/cargo binding versus indirect stabilization not distinguished\",\n        \"No human patient mutation evidence in the corpus\"\n      ]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\n        \"term_id\": \"GO:0060090\",\n        \"supporting_discovery_ids\": [\n          2,\n          4\n        ]\n      },\n      {\n        \"term_id\": \"GO:0008092\",\n        \"supporting_discovery_ids\": [\n          2\n        ]\n      }\n    ],\n    \"localization\": [\n      {\n        \"term_id\": \"GO:0005856\",\n        \"supporting_discovery_ids\": [\n          2\n        ]\n      },\n      {\n        \"term_id\": \"GO:0005815\",\n        \"supporting_discovery_ids\": [\n          0\n        ]\n      }\n    ],\n    \"pathway\": [\n      {\n        \"term_id\": \"R-HSA-1474165\",\n        \"supporting_discovery_ids\": [\n          2,\n          3\n        ]\n      },\n      {\n        \"term_id\": \"R-HSA-1852241\",\n        \"supporting_discovery_ids\": [\n          2,\n          3\n        ]\n      }\n    ],\n    \"complexes\": [],\n    \"partners\": [\n      \"CCDC42\",\n      \"IFT88\",\n      \"ODF2\",\n      \"CCDC146\"\n    ],\n    \"other_free_text\": []\n  }\n}","audit_flag":null,"evaluation":{"pairwise":"win","faith_supported":3,"faith_total":4,"faith_pct":75.0}}