{"gene":"C1ORF50","run_date":"2026-06-09T22:02:45","timeline":{"discoveries":[],"current_model":"No mechanistic findings in the available literature."},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null},"prefetch_data":{"uniprot":{"accession":"Q9BV19","full_name":"Uncharacterized protein C1orf50","aliases":[],"length_aa":199,"mass_kda":21.9,"function":"","subcellular_location":"","url":"https://www.uniprot.org/uniprotkb/Q9BV19/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/C1ORF50"},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[{"gene":"AHCY","stoichiometry":0.2}],"url":"https://opencell.sf.czbiohub.org/search/C1ORF50","total_profiled":1310},"omim":[],"hpa":{"profiled":true,"resolved_as":"","reliability":"","locations":[],"tissue_specificity":"Low tissue specificity","tissue_distribution":"Detected in many","driving_tissues":[],"url":"https://www.proteinatlas.org/search/C1ORF50"},"hgnc":{"alias_symbol":["MGC955"],"prev_symbol":[]},"alphafold":{"accession":"Q9BV19","domains":[{"cath_id":"-","chopping":"110-179","consensus_level":"medium","plddt":94.8974,"start":110,"end":179},{"cath_id":"1.20.5","chopping":"55-108","consensus_level":"medium","plddt":96.472,"start":55,"end":108}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q9BV19","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q9BV19-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q9BV19-F1-predicted_aligned_error_v6.png","plddt_mean":81.94},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=C1ORF50","jax_strain_url":"https://www.jax.org/strain/search?query=C1ORF50"},"sequence":{"accession":"Q9BV19","fasta_url":"https://rest.uniprot.org/uniprotkb/Q9BV19.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q9BV19/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q9BV19"}},"corpus_meta":[{"pmid":"40571314","id":"PMC_40571314","title":"C1orf50 Drives Malignant Melanoma Progression Through the Regulation of Stemness.","date":"2025","source":"Cancer genomics & proteomics","url":"https://pubmed.ncbi.nlm.nih.gov/40571314","citation_count":2,"is_preprint":false},{"pmid":"41151851","id":"PMC_41151851","title":"C1orf50 Accelerates Epithelial-Mesenchymal Transition and the Cell Cycle of Hepatocellular Carcinoma.","date":"2025","source":"Cancer genomics & proteomics","url":"https://pubmed.ncbi.nlm.nih.gov/41151851","citation_count":1,"is_preprint":false},{"pmid":"41361477","id":"PMC_41361477","title":"Pan-cancer profiling links C1orf50 to DNA repair and immune modulation in ovarian cancer.","date":"2025","source":"Journal of ovarian research","url":"https://pubmed.ncbi.nlm.nih.gov/41361477","citation_count":0,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":3995,"output_tokens":34,"usd":0.006247,"stage1_stop_reason":"end_turn"},"stage2":{"model":"","input_tokens":0,"output_tokens":0,"usd":0.0},"total_usd":0.006247,"stage1_batch_id":"msgbatch_0179Z2pxRYBsXi2xADneafRw","stage2_batch_id":"msgbatch_01LaY9ZaVdgjWArcZo9eqQE5","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [],\n  \"current_model\": \"No mechanistic findings in the available literature.\"\n}\n```","stage2_raw":"","audit_flag":null,"evaluation":null}