{"gene":"AP5S1","run_date":"2026-06-09T22:02:43","timeline":{"discoveries":[],"current_model":"No mechanistic findings in the available literature."},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null},"prefetch_data":{"uniprot":{"accession":"Q9NUS5","full_name":"AP-5 complex subunit sigma-1","aliases":["Adaptor-related protein complex 5 sigma subunit","Sigma5"],"length_aa":200,"mass_kda":22.5,"function":"As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862, it is required for efficient homologous recombination DNA double-strand break repair","subcellular_location":"Cytoplasm, cytosol; Late endosome membrane; Lysosome membrane","url":"https://www.uniprot.org/uniprotkb/Q9NUS5/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/AP5S1","classification":"Not Classified","n_dependent_lines":1,"n_total_lines":1208,"dependency_fraction":0.0008278145695364238},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[],"url":"https://opencell.sf.czbiohub.org/search/AP5S1","total_profiled":1310},"omim":[{"mim_id":"614824","title":"ADAPTOR-RELATED PROTEIN COMPLEX 5, SIGMA-1 SUBUNIT; AP5S1","url":"https://www.omim.org/entry/614824"},{"mim_id":"614368","title":"ADAPTOR-RELATED PROTEIN COMPLEX 5, MU-1 SUBUNIT; AP5M1","url":"https://www.omim.org/entry/614368"},{"mim_id":"614367","title":"ADAPTOR-RELATED PROTEIN COMPLEX 5, BETA-1 SUBUNIT; AP5B1","url":"https://www.omim.org/entry/614367"},{"mim_id":"613653","title":"ADAPTOR-RELATED PROTEIN COMPLEX 5, ZETA-1 SUBUNIT; AP5Z1","url":"https://www.omim.org/entry/613653"},{"mim_id":"612012","title":"ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26; ZFYVE26","url":"https://www.omim.org/entry/612012"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Approved","locations":[{"location":"Nucleoplasm","reliability":"Approved"},{"location":"Cytosol","reliability":"Approved"}],"tissue_specificity":"Low tissue specificity","tissue_distribution":"Detected in all","driving_tissues":[],"url":"https://www.proteinatlas.org/search/AP5S1"},"hgnc":{"alias_symbol":["FLJ11168"],"prev_symbol":["C20orf29"]},"alphafold":{"accession":"Q9NUS5","domains":[{"cath_id":"3.30.450.60","chopping":"1-196","consensus_level":"medium","plddt":80.7439,"start":1,"end":196}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q9NUS5","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q9NUS5-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q9NUS5-F1-predicted_aligned_error_v6.png","plddt_mean":80.44},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=AP5S1","jax_strain_url":"https://www.jax.org/strain/search?query=AP5S1"},"sequence":{"accession":"Q9NUS5","fasta_url":"https://rest.uniprot.org/uniprotkb/Q9NUS5.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q9NUS5/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q9NUS5"}},"corpus_meta":[],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":2277,"output_tokens":34,"usd":0.003671,"stage1_stop_reason":"end_turn"},"stage2":{"model":"","input_tokens":0,"output_tokens":0,"usd":0.0},"total_usd":0.003671,"stage1_batch_id":"msgbatch_0179Z2pxRYBsXi2xADneafRw","stage2_batch_id":"msgbatch_01LaY9ZaVdgjWArcZo9eqQE5","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [],\n  \"current_model\": \"No mechanistic findings in the available literature.\"\n}\n```","stage2_raw":"","audit_flag":null,"evaluation":null}