{"gene":"ACTR8","run_date":"2026-06-09T22:02:40","timeline":{"discoveries":[],"current_model":"No mechanistic findings in the available literature."},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null},"prefetch_data":{"uniprot":{"accession":"Q9H981","full_name":"Actin-related protein 8","aliases":["INO80 complex subunit N"],"length_aa":624,"mass_kda":70.5,"function":"Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex","subcellular_location":"Nucleus; Chromosome","url":"https://www.uniprot.org/uniprotkb/Q9H981/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":true,"resolved_as":"","url":"https://depmap.org/portal/gene/ACTR8","classification":"Common Essential","n_dependent_lines":806,"n_total_lines":1208,"dependency_fraction":0.6672185430463576},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[{"gene":"YY1","stoichiometry":0.2}],"url":"https://opencell.sf.czbiohub.org/search/ACTR8","total_profiled":1310},"omim":[{"mim_id":"619730","title":"ACTIN-RELATED PROTEIN 5; ACTR5","url":"https://www.omim.org/entry/619730"},{"mim_id":"619716","title":"ACTIN-RELATED PROTEIN 8; ACTR8","url":"https://www.omim.org/entry/619716"},{"mim_id":"610169","title":"INO80 COMPLEX, ATPase SUBUNIT; INO80","url":"https://www.omim.org/entry/610169"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Supported","locations":[{"location":"Nucleoplasm","reliability":"Supported"},{"location":"Centrosome","reliability":"Additional"}],"tissue_specificity":"Low tissue specificity","tissue_distribution":"Detected in all","driving_tissues":[],"url":"https://www.proteinatlas.org/search/ACTR8"},"hgnc":{"alias_symbol":["INO80N","ARP8"],"prev_symbol":[]},"alphafold":{"accession":"Q9H981","domains":[],"viewer_url":"https://alphafold.ebi.ac.uk/entry/Q9H981","model_url":"https://alphafold.ebi.ac.uk/files/AF-Q9H981-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-Q9H981-F1-predicted_aligned_error_v6.png","plddt_mean":86.75},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=ACTR8","jax_strain_url":"https://www.jax.org/strain/search?query=ACTR8"},"sequence":{"accession":"Q9H981","fasta_url":"https://rest.uniprot.org/uniprotkb/Q9H981.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/Q9H981/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/Q9H981"}},"corpus_meta":[{"pmid":"39179931","id":"PMC_39179931","title":"Mapping spatial organization and genetic cell-state regulators to target immune evasion in ovarian cancer.","date":"2024","source":"Nature immunology","url":"https://pubmed.ncbi.nlm.nih.gov/39179931","citation_count":46,"is_preprint":false},{"pmid":"32503430","id":"PMC_32503430","title":"A single mutation in the ACTR8 gene associated with lineage-specific expression in primates.","date":"2020","source":"BMC evolutionary biology","url":"https://pubmed.ncbi.nlm.nih.gov/32503430","citation_count":7,"is_preprint":false},{"pmid":"34020649","id":"PMC_34020649","title":"The identification of novel gene mutations for degenerative lumbar spinal stenosis using whole-exome sequencing in a Chinese cohort.","date":"2021","source":"BMC medical genomics","url":"https://pubmed.ncbi.nlm.nih.gov/34020649","citation_count":5,"is_preprint":false},{"pmid":"35381488","id":"PMC_35381488","title":"Identification and functional analysis of miRNAs in skeletal muscle of juvenile and adult largemouth bass, Micropterus salmoides.","date":"2022","source":"Comparative biochemistry and physiology. Part D, Genomics & proteomics","url":"https://pubmed.ncbi.nlm.nih.gov/35381488","citation_count":1,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":4246,"output_tokens":34,"usd":0.006624,"stage1_stop_reason":"end_turn"},"stage2":{"model":"","input_tokens":0,"output_tokens":0,"usd":0.0},"total_usd":0.006624,"stage1_batch_id":"msgbatch_0179Z2pxRYBsXi2xADneafRw","stage2_batch_id":"msgbatch_01LaY9ZaVdgjWArcZo9eqQE5","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [],\n  \"current_model\": \"No mechanistic findings in the available literature.\"\n}\n```","stage2_raw":"","audit_flag":null,"evaluation":null}